Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes. / Thomsen, Stine B; Gjesing, Anette Marianne Prior; Rathcke, Camilla N; Ekstrøm, Claus T; Eiberg, Hans; Hansen, Torben; Pedersen, Oluf; Vestergaard, Henrik.

In: PLOS ONE, Vol. 10, No. 7, e0133672, 21.07.2015, p. 1-10.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Thomsen, SB, Gjesing, AMP, Rathcke, CN, Ekstrøm, CT, Eiberg, H, Hansen, T, Pedersen, O & Vestergaard, H 2015, 'Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes', PLOS ONE, vol. 10, no. 7, e0133672, pp. 1-10. https://doi.org/10.1371/journal.pone.0133672

APA

Thomsen, S. B., Gjesing, A. M. P., Rathcke, C. N., Ekstrøm, C. T., Eiberg, H., Hansen, T., Pedersen, O., & Vestergaard, H. (2015). Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes. PLOS ONE, 10(7), 1-10. [e0133672]. https://doi.org/10.1371/journal.pone.0133672

Vancouver

Thomsen SB, Gjesing AMP, Rathcke CN, Ekstrøm CT, Eiberg H, Hansen T et al. Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes. PLOS ONE. 2015 Jul 21;10(7):1-10. e0133672. https://doi.org/10.1371/journal.pone.0133672

Author

Thomsen, Stine B ; Gjesing, Anette Marianne Prior ; Rathcke, Camilla N ; Ekstrøm, Claus T ; Eiberg, Hans ; Hansen, Torben ; Pedersen, Oluf ; Vestergaard, Henrik. / Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes. In: PLOS ONE. 2015 ; Vol. 10, No. 7. pp. 1-10.

Bibtex

@article{9f624d6e72354e55a86bfbea6d922bb7,
title = "Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes",
abstract = "INTRODUCTION: Circulating levels of the inflammatory marker YKL-40 are elevated in cardiovascular disease and obesity-related type 2 diabetes (T2D), and serum YKL-40 levels are related to elements of dyslipidaemia.OBJECTIVE: We aimed to investigate the associations between serum YKL-40 and obesity-related traits in a Danish sample of non-diabetic relatives to T2D patients and, furthermore, to estimate the heritability of YKL-40.RESEARCH DESIGN AND METHODS: 324 non-diabetic individuals with family relation to a T2D patient were included in the study. The participants underwent oral- and intravenous glucose tolerance tests for estimation of glucose tolerance and surrogate measures of insulin sensitivity. Anthropometric measures were retrieved and biochemical measures of the plasma lipid profile and serum YKL-40 levels were obtained. Association-analyses between serum YKL-40 and obesity-related traits and estimates of the narrow sense heritability of YKL-40 were based on a polygenic variance component model.RESULTS: Fasting serum levels of YKL-40 were positively associated with waist-hip-ratio (p<0.001) and fasting plasma triglyceride levels (p<0.001). None of the insulin sensitivity indexes were significantly associated with YKL-40. According to the AE model, the familiality-estimate h2 of YKL-40 was 0.45 (SE 0.13). When the ACE-model was applied, the heritability-estimate h2 of YKL-40 did not reach statistical significance.CONCLUSIONS: Our results suggest a role of serum YKL-40 in obesity-related low grade inflammation, but do not indicate that YKL-40 is directly involved in the development of T2D.",
author = "Thomsen, {Stine B} and Gjesing, {Anette Marianne Prior} and Rathcke, {Camilla N} and Ekstr{\o}m, {Claus T} and Hans Eiberg and Torben Hansen and Oluf Pedersen and Henrik Vestergaard",
year = "2015",
month = jul,
day = "21",
doi = "10.1371/journal.pone.0133672",
language = "English",
volume = "10",
pages = "1--10",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "7",

}

RIS

TY - JOUR

T1 - Associations of the Inflammatory Marker YKL-40 with Measures of Obesity and Dyslipidaemia in Individuals at High Risk of Type 2 Diabetes

AU - Thomsen, Stine B

AU - Gjesing, Anette Marianne Prior

AU - Rathcke, Camilla N

AU - Ekstrøm, Claus T

AU - Eiberg, Hans

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Vestergaard, Henrik

PY - 2015/7/21

Y1 - 2015/7/21

N2 - INTRODUCTION: Circulating levels of the inflammatory marker YKL-40 are elevated in cardiovascular disease and obesity-related type 2 diabetes (T2D), and serum YKL-40 levels are related to elements of dyslipidaemia.OBJECTIVE: We aimed to investigate the associations between serum YKL-40 and obesity-related traits in a Danish sample of non-diabetic relatives to T2D patients and, furthermore, to estimate the heritability of YKL-40.RESEARCH DESIGN AND METHODS: 324 non-diabetic individuals with family relation to a T2D patient were included in the study. The participants underwent oral- and intravenous glucose tolerance tests for estimation of glucose tolerance and surrogate measures of insulin sensitivity. Anthropometric measures were retrieved and biochemical measures of the plasma lipid profile and serum YKL-40 levels were obtained. Association-analyses between serum YKL-40 and obesity-related traits and estimates of the narrow sense heritability of YKL-40 were based on a polygenic variance component model.RESULTS: Fasting serum levels of YKL-40 were positively associated with waist-hip-ratio (p<0.001) and fasting plasma triglyceride levels (p<0.001). None of the insulin sensitivity indexes were significantly associated with YKL-40. According to the AE model, the familiality-estimate h2 of YKL-40 was 0.45 (SE 0.13). When the ACE-model was applied, the heritability-estimate h2 of YKL-40 did not reach statistical significance.CONCLUSIONS: Our results suggest a role of serum YKL-40 in obesity-related low grade inflammation, but do not indicate that YKL-40 is directly involved in the development of T2D.

AB - INTRODUCTION: Circulating levels of the inflammatory marker YKL-40 are elevated in cardiovascular disease and obesity-related type 2 diabetes (T2D), and serum YKL-40 levels are related to elements of dyslipidaemia.OBJECTIVE: We aimed to investigate the associations between serum YKL-40 and obesity-related traits in a Danish sample of non-diabetic relatives to T2D patients and, furthermore, to estimate the heritability of YKL-40.RESEARCH DESIGN AND METHODS: 324 non-diabetic individuals with family relation to a T2D patient were included in the study. The participants underwent oral- and intravenous glucose tolerance tests for estimation of glucose tolerance and surrogate measures of insulin sensitivity. Anthropometric measures were retrieved and biochemical measures of the plasma lipid profile and serum YKL-40 levels were obtained. Association-analyses between serum YKL-40 and obesity-related traits and estimates of the narrow sense heritability of YKL-40 were based on a polygenic variance component model.RESULTS: Fasting serum levels of YKL-40 were positively associated with waist-hip-ratio (p<0.001) and fasting plasma triglyceride levels (p<0.001). None of the insulin sensitivity indexes were significantly associated with YKL-40. According to the AE model, the familiality-estimate h2 of YKL-40 was 0.45 (SE 0.13). When the ACE-model was applied, the heritability-estimate h2 of YKL-40 did not reach statistical significance.CONCLUSIONS: Our results suggest a role of serum YKL-40 in obesity-related low grade inflammation, but do not indicate that YKL-40 is directly involved in the development of T2D.

U2 - 10.1371/journal.pone.0133672

DO - 10.1371/journal.pone.0133672

M3 - Journal article

C2 - 26197239

VL - 10

SP - 1

EP - 10

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 7

M1 - e0133672

ER -

ID: 143666427