Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation-related markers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation-related markers. / Stankevic, Evelina; Israelsen, Mads; Juel, Helene Bæk; Madsen, Anne Lundager; Ängquist, Lars; Aldiss, Peter Stuart Jacob; Torp, Nikolaj; Johansen, Stine; Hansen, Camilla Dalby; Hansen, Johanne Kragh; Thorhauge, Katrine Holtz; Lindvig, Katrine Prier; Madsen, Bjørn Stæhr; Sulek, Karolina; Legido-Quigley, Cristina; Thiele, Maja Sofie; Krag, Aleksander; Hansen, Torben.

In: Liver International, Vol. 43, No. 12, 2023, p. 2680–2691.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stankevic, E, Israelsen, M, Juel, HB, Madsen, AL, Ängquist, L, Aldiss, PSJ, Torp, N, Johansen, S, Hansen, CD, Hansen, JK, Thorhauge, KH, Lindvig, KP, Madsen, BS, Sulek, K, Legido-Quigley, C, Thiele, MS, Krag, A & Hansen, T 2023, 'Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation-related markers', Liver International, vol. 43, no. 12, pp. 2680–2691. https://doi.org/10.1111/liv.15692

APA

Stankevic, E., Israelsen, M., Juel, H. B., Madsen, A. L., Ängquist, L., Aldiss, P. S. J., Torp, N., Johansen, S., Hansen, C. D., Hansen, J. K., Thorhauge, K. H., Lindvig, K. P., Madsen, B. S., Sulek, K., Legido-Quigley, C., Thiele, M. S., Krag, A., & Hansen, T. (2023). Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation-related markers. Liver International, 43(12), 2680–2691. https://doi.org/10.1111/liv.15692

Vancouver

Stankevic E, Israelsen M, Juel HB, Madsen AL, Ängquist L, Aldiss PSJ et al. Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation-related markers. Liver International. 2023;43(12):2680–2691. https://doi.org/10.1111/liv.15692

Author

Stankevic, Evelina ; Israelsen, Mads ; Juel, Helene Bæk ; Madsen, Anne Lundager ; Ängquist, Lars ; Aldiss, Peter Stuart Jacob ; Torp, Nikolaj ; Johansen, Stine ; Hansen, Camilla Dalby ; Hansen, Johanne Kragh ; Thorhauge, Katrine Holtz ; Lindvig, Katrine Prier ; Madsen, Bjørn Stæhr ; Sulek, Karolina ; Legido-Quigley, Cristina ; Thiele, Maja Sofie ; Krag, Aleksander ; Hansen, Torben. / Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation-related markers. In: Liver International. 2023 ; Vol. 43, No. 12. pp. 2680–2691.

Bibtex

@article{2bd74850fc124c3aa32264f0864d2467,
title = "Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation-related markers",
abstract = "Background: Frequent binge drinking is a known contributor to alcohol-related harm, but its impact on systemic and hepatic inflammation is not fully understood. We hypothesize that changes in immune markers play a central role in adverse effects of acute alcohol intake, especially in patients with early liver disease. Aim: To investigate the effects of acute alcohol intoxication on inflammation-related markers in hepatic and systemic venous plasma in people with alcohol-related liver disease (ArLD), non-alcoholic fatty liver disease (NAFLD) and healthy controls. Methods: Thirty-eight participants (13 with ArLD, 15 with NAFLD and 10 healthy controls) received 2.5 mL of 40% ethanol per kg body weight via a nasogastric tube. Seventy-two inflammation-related markers were quantified in plasma from hepatic and systemic venous blood, at baseline, 60 and 180 min after intervention. Results: Alcohol intervention altered the levels of 31 of 72 and 14 of 72 markers in the systemic and hepatic circulation. All changes observed in the hepatic circulation were also identified in the systemic circulation after 180 min. Only FGF21 and IL6 were increased after alcohol intervention, while the remaining 29 markers decreased. Differences in response to acute alcohol between the groups were observed for 8 markers, and FGF21 response was blunted in individuals with steatosis. Conclusion: Acute alcohol intoxication induced changes in multiple inflammation-related markers, implicated in alcohol metabolism and hepatocellular damage. Differences identified between marker response to binge drinking in ArLD, NAFLD and healthy controls may provide important clues to disease mechanisms and potential targets for treatment. Clinical trial number: NCT03018990.",
keywords = "alcohol, inflammation, liver disease, proteomics",
author = "Evelina Stankevic and Mads Israelsen and Juel, {Helene B{\ae}k} and Madsen, {Anne Lundager} and Lars {\"A}ngquist and Aldiss, {Peter Stuart Jacob} and Nikolaj Torp and Stine Johansen and Hansen, {Camilla Dalby} and Hansen, {Johanne Kragh} and Thorhauge, {Katrine Holtz} and Lindvig, {Katrine Prier} and Madsen, {Bj{\o}rn St{\ae}hr} and Karolina Sulek and Cristina Legido-Quigley and Thiele, {Maja Sofie} and Aleksander Krag and Torben Hansen",
note = "Publisher Copyright: Liver International{\textcopyright} 2023 The Authors. Liver International published by John Wiley & Sons Ltd.",
year = "2023",
doi = "10.1111/liv.15692",
language = "English",
volume = "43",
pages = "2680–2691",
journal = "Liver International",
issn = "1478-3223",
publisher = "Wiley-Blackwell",
number = "12",

}

RIS

TY - JOUR

T1 - Binge drinking episode causes acute, specific alterations in systemic and hepatic inflammation-related markers

AU - Stankevic, Evelina

AU - Israelsen, Mads

AU - Juel, Helene Bæk

AU - Madsen, Anne Lundager

AU - Ängquist, Lars

AU - Aldiss, Peter Stuart Jacob

AU - Torp, Nikolaj

AU - Johansen, Stine

AU - Hansen, Camilla Dalby

AU - Hansen, Johanne Kragh

AU - Thorhauge, Katrine Holtz

AU - Lindvig, Katrine Prier

AU - Madsen, Bjørn Stæhr

AU - Sulek, Karolina

AU - Legido-Quigley, Cristina

AU - Thiele, Maja Sofie

AU - Krag, Aleksander

AU - Hansen, Torben

N1 - Publisher Copyright: Liver International© 2023 The Authors. Liver International published by John Wiley & Sons Ltd.

PY - 2023

Y1 - 2023

N2 - Background: Frequent binge drinking is a known contributor to alcohol-related harm, but its impact on systemic and hepatic inflammation is not fully understood. We hypothesize that changes in immune markers play a central role in adverse effects of acute alcohol intake, especially in patients with early liver disease. Aim: To investigate the effects of acute alcohol intoxication on inflammation-related markers in hepatic and systemic venous plasma in people with alcohol-related liver disease (ArLD), non-alcoholic fatty liver disease (NAFLD) and healthy controls. Methods: Thirty-eight participants (13 with ArLD, 15 with NAFLD and 10 healthy controls) received 2.5 mL of 40% ethanol per kg body weight via a nasogastric tube. Seventy-two inflammation-related markers were quantified in plasma from hepatic and systemic venous blood, at baseline, 60 and 180 min after intervention. Results: Alcohol intervention altered the levels of 31 of 72 and 14 of 72 markers in the systemic and hepatic circulation. All changes observed in the hepatic circulation were also identified in the systemic circulation after 180 min. Only FGF21 and IL6 were increased after alcohol intervention, while the remaining 29 markers decreased. Differences in response to acute alcohol between the groups were observed for 8 markers, and FGF21 response was blunted in individuals with steatosis. Conclusion: Acute alcohol intoxication induced changes in multiple inflammation-related markers, implicated in alcohol metabolism and hepatocellular damage. Differences identified between marker response to binge drinking in ArLD, NAFLD and healthy controls may provide important clues to disease mechanisms and potential targets for treatment. Clinical trial number: NCT03018990.

AB - Background: Frequent binge drinking is a known contributor to alcohol-related harm, but its impact on systemic and hepatic inflammation is not fully understood. We hypothesize that changes in immune markers play a central role in adverse effects of acute alcohol intake, especially in patients with early liver disease. Aim: To investigate the effects of acute alcohol intoxication on inflammation-related markers in hepatic and systemic venous plasma in people with alcohol-related liver disease (ArLD), non-alcoholic fatty liver disease (NAFLD) and healthy controls. Methods: Thirty-eight participants (13 with ArLD, 15 with NAFLD and 10 healthy controls) received 2.5 mL of 40% ethanol per kg body weight via a nasogastric tube. Seventy-two inflammation-related markers were quantified in plasma from hepatic and systemic venous blood, at baseline, 60 and 180 min after intervention. Results: Alcohol intervention altered the levels of 31 of 72 and 14 of 72 markers in the systemic and hepatic circulation. All changes observed in the hepatic circulation were also identified in the systemic circulation after 180 min. Only FGF21 and IL6 were increased after alcohol intervention, while the remaining 29 markers decreased. Differences in response to acute alcohol between the groups were observed for 8 markers, and FGF21 response was blunted in individuals with steatosis. Conclusion: Acute alcohol intoxication induced changes in multiple inflammation-related markers, implicated in alcohol metabolism and hepatocellular damage. Differences identified between marker response to binge drinking in ArLD, NAFLD and healthy controls may provide important clues to disease mechanisms and potential targets for treatment. Clinical trial number: NCT03018990.

KW - alcohol

KW - inflammation

KW - liver disease

KW - proteomics

U2 - 10.1111/liv.15692

DO - 10.1111/liv.15692

M3 - Journal article

C2 - 37592403

AN - SCOPUS:85168296277

VL - 43

SP - 2680

EP - 2691

JO - Liver International

JF - Liver International

SN - 1478-3223

IS - 12

ER -

ID: 365548856