Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

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Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes. / Bacos, Karl; Gillberg, Linn; Volkov, Petr; Olsson, Anders H; Hansen, Torben; Pedersen, Oluf; Gjesing, Anette Marianne Prior; Eiberg, Hans; Tuomi, Tiinamaija; Almgren, Peter; Groop, Leif; Eliasson, Lena; Vaag, Allan; Dayeh, Tasnim; Ling, Charlotte.

In: Nature Communications, Vol. 7, 11089, 2016.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Bacos, K, Gillberg, L, Volkov, P, Olsson, AH, Hansen, T, Pedersen, O, Gjesing, AMP, Eiberg, H, Tuomi, T, Almgren, P, Groop, L, Eliasson, L, Vaag, A, Dayeh, T & Ling, C 2016, 'Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes', Nature Communications, vol. 7, 11089. https://doi.org/10.1038/ncomms11089

APA

Bacos, K., Gillberg, L., Volkov, P., Olsson, A. H., Hansen, T., Pedersen, O., Gjesing, A. M. P., Eiberg, H., Tuomi, T., Almgren, P., Groop, L., Eliasson, L., Vaag, A., Dayeh, T., & Ling, C. (2016). Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes. Nature Communications, 7, [11089]. https://doi.org/10.1038/ncomms11089

Vancouver

Bacos K, Gillberg L, Volkov P, Olsson AH, Hansen T, Pedersen O et al. Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes. Nature Communications. 2016;7. 11089. https://doi.org/10.1038/ncomms11089

Author

Bacos, Karl ; Gillberg, Linn ; Volkov, Petr ; Olsson, Anders H ; Hansen, Torben ; Pedersen, Oluf ; Gjesing, Anette Marianne Prior ; Eiberg, Hans ; Tuomi, Tiinamaija ; Almgren, Peter ; Groop, Leif ; Eliasson, Lena ; Vaag, Allan ; Dayeh, Tasnim ; Ling, Charlotte. / Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes. In: Nature Communications. 2016 ; Vol. 7.

Bibtex

@article{0a27bade8184423fa52f3add8951115b,
title = "Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes",
abstract = "Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylation genome-wide in islets from 87 non-diabetic donors, aged 26-74 years. Aging associates with increased DNA methylation of 241 sites. These sites cover loci previously associated with T2D, for example, KLF14. Blood-based epigenetic biomarkers reflect age-related methylation changes in 83 genes identified in human islets (for example, KLF14, FHL2, ZNF518B and FAM123C) and some associate with insulin secretion and T2D. DNA methylation correlates with islet expression of multiple genes, including FHL2, ZNF518B, GNPNAT1 and HLTF. Silencing these genes in β-cells alter insulin secretion. Together, we demonstrate that blood-based epigenetic biomarkers reflect age-related DNA methylation changes in human islets, and associate with insulin secretion in vivo and T2D.",
author = "Karl Bacos and Linn Gillberg and Petr Volkov and Olsson, {Anders H} and Torben Hansen and Oluf Pedersen and Gjesing, {Anette Marianne Prior} and Hans Eiberg and Tiinamaija Tuomi and Peter Almgren and Leif Groop and Lena Eliasson and Allan Vaag and Tasnim Dayeh and Charlotte Ling",
year = "2016",
doi = "10.1038/ncomms11089",
language = "English",
volume = "7",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Blood-based biomarkers of age-associated epigenetic changes in human islets associate with insulin secretion and diabetes

AU - Bacos, Karl

AU - Gillberg, Linn

AU - Volkov, Petr

AU - Olsson, Anders H

AU - Hansen, Torben

AU - Pedersen, Oluf

AU - Gjesing, Anette Marianne Prior

AU - Eiberg, Hans

AU - Tuomi, Tiinamaija

AU - Almgren, Peter

AU - Groop, Leif

AU - Eliasson, Lena

AU - Vaag, Allan

AU - Dayeh, Tasnim

AU - Ling, Charlotte

PY - 2016

Y1 - 2016

N2 - Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylation genome-wide in islets from 87 non-diabetic donors, aged 26-74 years. Aging associates with increased DNA methylation of 241 sites. These sites cover loci previously associated with T2D, for example, KLF14. Blood-based epigenetic biomarkers reflect age-related methylation changes in 83 genes identified in human islets (for example, KLF14, FHL2, ZNF518B and FAM123C) and some associate with insulin secretion and T2D. DNA methylation correlates with islet expression of multiple genes, including FHL2, ZNF518B, GNPNAT1 and HLTF. Silencing these genes in β-cells alter insulin secretion. Together, we demonstrate that blood-based epigenetic biomarkers reflect age-related DNA methylation changes in human islets, and associate with insulin secretion in vivo and T2D.

AB - Aging associates with impaired pancreatic islet function and increased type 2 diabetes (T2D) risk. Here we examine whether age-related epigenetic changes affect human islet function and if blood-based epigenetic biomarkers reflect these changes and associate with future T2D. We analyse DNA methylation genome-wide in islets from 87 non-diabetic donors, aged 26-74 years. Aging associates with increased DNA methylation of 241 sites. These sites cover loci previously associated with T2D, for example, KLF14. Blood-based epigenetic biomarkers reflect age-related methylation changes in 83 genes identified in human islets (for example, KLF14, FHL2, ZNF518B and FAM123C) and some associate with insulin secretion and T2D. DNA methylation correlates with islet expression of multiple genes, including FHL2, ZNF518B, GNPNAT1 and HLTF. Silencing these genes in β-cells alter insulin secretion. Together, we demonstrate that blood-based epigenetic biomarkers reflect age-related DNA methylation changes in human islets, and associate with insulin secretion in vivo and T2D.

U2 - 10.1038/ncomms11089

DO - 10.1038/ncomms11089

M3 - Journal article

C2 - 27029739

VL - 7

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

M1 - 11089

ER -

ID: 160444066