Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection
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Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection. / Kays Mohammed Ali, Younes; Dolin, Troels Gammeltoft; Damm Nybing, Janus; Lykke, Jakob; Hvid Linden, Frederik; Høgh-Schmidt, Erik; Sørensen, Thorkild I.A.; Christensen, Jesper Frank; Nielsen, Yousef J.W.; Stenfatt Larsen, Jim; Madsbad, Sten; Sidenius Johansen, Julia; Svane, Maria Saur; Lang Lehrskov, Louise.
In: International Journal of Obesity, Vol. 48, No. 4, 2024, p. 533-541.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Change in abdominal obesity after colon cancer surgery – effects of left-sided and right-sided colonic resection
AU - Kays Mohammed Ali, Younes
AU - Dolin, Troels Gammeltoft
AU - Damm Nybing, Janus
AU - Lykke, Jakob
AU - Hvid Linden, Frederik
AU - Høgh-Schmidt, Erik
AU - Sørensen, Thorkild I.A.
AU - Christensen, Jesper Frank
AU - Nielsen, Yousef J.W.
AU - Stenfatt Larsen, Jim
AU - Madsbad, Sten
AU - Sidenius Johansen, Julia
AU - Svane, Maria Saur
AU - Lang Lehrskov, Louise
N1 - Publisher Copyright: © 2023, The Author(s).
PY - 2024
Y1 - 2024
N2 - Background: Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots. Material and methods: Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between patients who had undergone left-sided and right-sided colonic resection in the total population and in men and women separately. Results: A total of 134 patients with stage I-III CC undergoing cancer surgery were included. Patients who had undergone left-sided colonic resection had after 3 years follow-up a 5% (95% CI: 2–9%, p < 0.01) increase in abdominal VAT, a 4% (95% CI: 2–6%, p < 0.001) increase in SAT and a 5% increase (95% CI: 2–7%, p < 0.01) in TAT. Patients who had undergone right-sided colonic resection had no change in VAT, but a 6% (95% CI: 4–9%, p < 0.001) increase in SAT and a 4% (95% CI: 1–7%, p < 0.01) increase in TAT after 3 years. Stratified by sex, only males undergoing left-sided colonic resection had a significant VAT increase of 6% (95% CI: 2–10%, p < 0.01) after 3 years. Conclusion: After 3 years follow-up survivors of CC accumulated abdominal adipose tissue. Notably, those who underwent left-sided colonic resection had increased VAT and SAT, whereas those who underwent right-sided colonic resection demonstrated solely increased SAT. [Figure not available: see fulltext.]
AB - Background: Excess abdominal visceral adipose tissue (VAT) is associated with metabolic diseases and poor survival in colon cancer (CC). We assessed the impact of different types of CC surgery on changes in abdominal fat depots. Material and methods: Computed tomography (CT)-scans performed preoperative and 3 years after CC surgery were analyzed at L3-level for VAT, subcutaneous adipose tissue (SAT) and total adipose tissue (TAT) areas. We assessed changes in VAT, SAT, TAT and VAT/SAT ratio after 3 years and compared the changes between patients who had undergone left-sided and right-sided colonic resection in the total population and in men and women separately. Results: A total of 134 patients with stage I-III CC undergoing cancer surgery were included. Patients who had undergone left-sided colonic resection had after 3 years follow-up a 5% (95% CI: 2–9%, p < 0.01) increase in abdominal VAT, a 4% (95% CI: 2–6%, p < 0.001) increase in SAT and a 5% increase (95% CI: 2–7%, p < 0.01) in TAT. Patients who had undergone right-sided colonic resection had no change in VAT, but a 6% (95% CI: 4–9%, p < 0.001) increase in SAT and a 4% (95% CI: 1–7%, p < 0.01) increase in TAT after 3 years. Stratified by sex, only males undergoing left-sided colonic resection had a significant VAT increase of 6% (95% CI: 2–10%, p < 0.01) after 3 years. Conclusion: After 3 years follow-up survivors of CC accumulated abdominal adipose tissue. Notably, those who underwent left-sided colonic resection had increased VAT and SAT, whereas those who underwent right-sided colonic resection demonstrated solely increased SAT. [Figure not available: see fulltext.]
U2 - 10.1038/s41366-023-01445-8
DO - 10.1038/s41366-023-01445-8
M3 - Journal article
C2 - 38172335
AN - SCOPUS:85181255445
VL - 48
SP - 533
EP - 541
JO - International Journal of Obesity
JF - International Journal of Obesity
SN - 0307-0565
IS - 4
ER -
ID: 378967398