Standard
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation. / Budu-Aggrey, Ashley; Kilanowski, Anna; Sobczyk, Maria K.; Shringarpure, Suyash S.; Mitchell, Ruth; Reis, Kadri; Reigo, Anu; Mägi, Reedik; Nelis, Mari; Tanaka, Nao; Brumpton, Ben M.; Thomas, Laurent F.; Sole-Navais, Pol; Flatley, Christopher; Espuela-Ortiz, Antonio; Herrera-Luis, Esther; Lominchar, Jesus V.T.; Bork-Jensen, Jette; Marenholz, Ingo; Arnau-Soler, Aleix; Jeong, Ayoung; Fawcett, Katherine A.; Baurecht, Hansjorg; Rodriguez, Elke; Alves, Alexessander Couto; Kumar, Ashish; Sleiman, Patrick M.; Chang, Xiao; Medina-Gomez, Carolina; Hu, Chen; Xu, Cheng jian; Qi, Cancan; El-Heis, Sarah; Titcombe, Philip; Antoun, Elie; Fadista, João; Wang, Carol A.; Thiering, Elisabeth; Wu, Baojun; Kress, Sara; Kothalawala, Dilini M.; Kadalayil, Latha; Duan, Jiasong; Zhang, Hongmei; Hadebe, Sabelo; Hoffmann, Thomas; Jorgenson, Eric; Choquet, Hélène; Risch, Neil; Njølstad, Pål; Andreassen, Ole A.; Johansson, Stefan; Almqvist, Catarina; Gong, Tong; Ullemar, Vilhelmina; Karlsson, Robert; Magnusson, Patrik K.E.; Szwajda, Agnieszka; Burchard, Esteban G.; Thyssen, Jacob P.; Hansen, Torben; Kårhus, Line L.; Dantoft, Thomas M.; Jeanrenaud, Alexander C.S.N.; Ghauri, Ahla; Arnold, Andreas; Homuth, Georg; Lau, Susanne; Nöthen, Markus M.; Hübner, Norbert; Imboden, Medea; Visconti, Alessia; Falchi, Mario; Bataille, Veronique; Hysi, Pirro; Ballardini, Natalia; Boomsma, Dorret I.; Hottenga, Jouke J.; Müller-Nurasyid, Martina; Ahluwalia, Tarunveer S.; Stokholm, Jakob; Chawes, Bo; Schoos, Ann Marie M.; Esplugues, Ana; Bustamante, Mariona; Raby, Benjamin; Arshad, Syed; German, Chris; Esko, Tõnu; Milani, Lili A.; Metspalu, Andres; Terao, Chikashi; Abuabara, Katrina; Løset, Mari; Hveem, Kristian; Jacobsson, Bo; Pino-Yanes, Maria; Strachan, David P.; Grarup, Niels; Linneberg, Allan; Lee, Young Ae; Probst-Hensch, Nicole; Weidinger, Stephan; Jarvelin, Marjo Riitta; Melén, Erik; Hakonarson, Hakon; Irvine, Alan D.; Jarvis, Deborah; Nijsten, Tamar; Duijts, Liesbeth; Vonk, Judith M.; Koppelmann, Gerard H.; Godfrey, Keith M.; Barton, Sheila J.; Feenstra, Bjarke; Pennell, Craig E.; Sly, Peter D.; Holt, Patrick G.; Williams, L. Keoki; Bisgaard, Hans; Bønnelykke, Klaus; Curtin, John; Simpson, Angela; Murray, Clare; Schikowski, Tamara; Bunyavanich, Supinda; Weiss, Scott T.; Holloway, John W.; Min, Josine L.; Brown, Sara J.; Standl, Marie; Paternoster, Lavinia.
In:
Nature Communications, Vol. 14, 6172, 2023.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Budu-Aggrey, A, Kilanowski, A, Sobczyk, MK, Shringarpure, SS, Mitchell, R, Reis, K, Reigo, A, Mägi, R, Nelis, M, Tanaka, N, Brumpton, BM, Thomas, LF, Sole-Navais, P, Flatley, C, Espuela-Ortiz, A, Herrera-Luis, E, Lominchar, JVT, Bork-Jensen, J, Marenholz, I, Arnau-Soler, A, Jeong, A, Fawcett, KA, Baurecht, H, Rodriguez, E, Alves, AC, Kumar, A, Sleiman, PM, Chang, X, Medina-Gomez, C, Hu, C, Xu, CJ, Qi, C, El-Heis, S, Titcombe, P, Antoun, E, Fadista, J, Wang, CA, Thiering, E, Wu, B, Kress, S, Kothalawala, DM, Kadalayil, L, Duan, J, Zhang, H, Hadebe, S, Hoffmann, T, Jorgenson, E, Choquet, H, Risch, N, Njølstad, P, Andreassen, OA, Johansson, S, Almqvist, C, Gong, T, Ullemar, V, Karlsson, R, Magnusson, PKE, Szwajda, A, Burchard, EG
, Thyssen, JP, Hansen, T, Kårhus, LL, Dantoft, TM, Jeanrenaud, ACSN, Ghauri, A, Arnold, A, Homuth, G, Lau, S, Nöthen, MM, Hübner, N, Imboden, M, Visconti, A, Falchi, M, Bataille, V, Hysi, P, Ballardini, N, Boomsma, DI, Hottenga, JJ, Müller-Nurasyid, M, Ahluwalia, TS, Stokholm, J
, Chawes, B, Schoos, AMM, Esplugues, A, Bustamante, M, Raby, B, Arshad, S, German, C, Esko, T, Milani, LA, Metspalu, A, Terao, C, Abuabara, K, Løset, M, Hveem, K, Jacobsson, B, Pino-Yanes, M, Strachan, DP
, Grarup, N, Linneberg, A, Lee, YA, Probst-Hensch, N, Weidinger, S, Jarvelin, MR, Melén, E, Hakonarson, H, Irvine, AD, Jarvis, D, Nijsten, T, Duijts, L, Vonk, JM, Koppelmann, GH, Godfrey, KM, Barton, SJ, Feenstra, B, Pennell, CE, Sly, PD, Holt, PG, Williams, LK, Bisgaard, H
, Bønnelykke, K, Curtin, J, Simpson, A, Murray, C, Schikowski, T, Bunyavanich, S, Weiss, ST, Holloway, JW, Min, JL, Brown, SJ, Standl, M & Paternoster, L 2023, '
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation',
Nature Communications, vol. 14, 6172.
https://doi.org/10.1038/s41467-023-41180-2APA
Budu-Aggrey, A., Kilanowski, A., Sobczyk, M. K., Shringarpure, S. S., Mitchell, R., Reis, K., Reigo, A., Mägi, R., Nelis, M., Tanaka, N., Brumpton, B. M., Thomas, L. F., Sole-Navais, P., Flatley, C., Espuela-Ortiz, A., Herrera-Luis, E., Lominchar, J. V. T., Bork-Jensen, J., Marenholz, I., ... Paternoster, L. (2023).
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Nature Communications,
14, [6172].
https://doi.org/10.1038/s41467-023-41180-2Vancouver
Budu-Aggrey A, Kilanowski A, Sobczyk MK, Shringarpure SS, Mitchell R, Reis K et al.
European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation.
Nature Communications. 2023;14. 6172.
https://doi.org/10.1038/s41467-023-41180-2Author
Budu-Aggrey, Ashley ; Kilanowski, Anna ; Sobczyk, Maria K. ; Shringarpure, Suyash S. ; Mitchell, Ruth ; Reis, Kadri ; Reigo, Anu ; Mägi, Reedik ; Nelis, Mari ; Tanaka, Nao ; Brumpton, Ben M. ; Thomas, Laurent F. ; Sole-Navais, Pol ; Flatley, Christopher ; Espuela-Ortiz, Antonio ; Herrera-Luis, Esther ; Lominchar, Jesus V.T. ; Bork-Jensen, Jette ; Marenholz, Ingo ; Arnau-Soler, Aleix ; Jeong, Ayoung ; Fawcett, Katherine A. ; Baurecht, Hansjorg ; Rodriguez, Elke ; Alves, Alexessander Couto ; Kumar, Ashish ; Sleiman, Patrick M. ; Chang, Xiao ; Medina-Gomez, Carolina ; Hu, Chen ; Xu, Cheng jian ; Qi, Cancan ; El-Heis, Sarah ; Titcombe, Philip ; Antoun, Elie ; Fadista, João ; Wang, Carol A. ; Thiering, Elisabeth ; Wu, Baojun ; Kress, Sara ; Kothalawala, Dilini M. ; Kadalayil, Latha ; Duan, Jiasong ; Zhang, Hongmei ; Hadebe, Sabelo ; Hoffmann, Thomas ; Jorgenson, Eric ; Choquet, Hélène ; Risch, Neil ; Njølstad, Pål ; Andreassen, Ole A. ; Johansson, Stefan ; Almqvist, Catarina ; Gong, Tong ; Ullemar, Vilhelmina ; Karlsson, Robert ; Magnusson, Patrik K.E. ; Szwajda, Agnieszka ; Burchard, Esteban G. ; Thyssen, Jacob P. ; Hansen, Torben ; Kårhus, Line L. ; Dantoft, Thomas M. ; Jeanrenaud, Alexander C.S.N. ; Ghauri, Ahla ; Arnold, Andreas ; Homuth, Georg ; Lau, Susanne ; Nöthen, Markus M. ; Hübner, Norbert ; Imboden, Medea ; Visconti, Alessia ; Falchi, Mario ; Bataille, Veronique ; Hysi, Pirro ; Ballardini, Natalia ; Boomsma, Dorret I. ; Hottenga, Jouke J. ; Müller-Nurasyid, Martina ; Ahluwalia, Tarunveer S. ; Stokholm, Jakob ; Chawes, Bo ; Schoos, Ann Marie M. ; Esplugues, Ana ; Bustamante, Mariona ; Raby, Benjamin ; Arshad, Syed ; German, Chris ; Esko, Tõnu ; Milani, Lili A. ; Metspalu, Andres ; Terao, Chikashi ; Abuabara, Katrina ; Løset, Mari ; Hveem, Kristian ; Jacobsson, Bo ; Pino-Yanes, Maria ; Strachan, David P. ; Grarup, Niels ; Linneberg, Allan ; Lee, Young Ae ; Probst-Hensch, Nicole ; Weidinger, Stephan ; Jarvelin, Marjo Riitta ; Melén, Erik ; Hakonarson, Hakon ; Irvine, Alan D. ; Jarvis, Deborah ; Nijsten, Tamar ; Duijts, Liesbeth ; Vonk, Judith M. ; Koppelmann, Gerard H. ; Godfrey, Keith M. ; Barton, Sheila J. ; Feenstra, Bjarke ; Pennell, Craig E. ; Sly, Peter D. ; Holt, Patrick G. ; Williams, L. Keoki ; Bisgaard, Hans ; Bønnelykke, Klaus ; Curtin, John ; Simpson, Angela ; Murray, Clare ; Schikowski, Tamara ; Bunyavanich, Supinda ; Weiss, Scott T. ; Holloway, John W. ; Min, Josine L. ; Brown, Sara J. ; Standl, Marie ; Paternoster, Lavinia. / European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation. In: Nature Communications. 2023 ; Vol. 14.
Bibtex
@article{92ad54d5a2ad408d9ef13575296c0de7,
title = "European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation",
abstract = "Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.",
author = "Ashley Budu-Aggrey and Anna Kilanowski and Sobczyk, {Maria K.} and Shringarpure, {Suyash S.} and Ruth Mitchell and Kadri Reis and Anu Reigo and Reedik M{\"a}gi and Mari Nelis and Nao Tanaka and Brumpton, {Ben M.} and Thomas, {Laurent F.} and Pol Sole-Navais and Christopher Flatley and Antonio Espuela-Ortiz and Esther Herrera-Luis and Lominchar, {Jesus V.T.} and Jette Bork-Jensen and Ingo Marenholz and Aleix Arnau-Soler and Ayoung Jeong and Fawcett, {Katherine A.} and Hansjorg Baurecht and Elke Rodriguez and Alves, {Alexessander Couto} and Ashish Kumar and Sleiman, {Patrick M.} and Xiao Chang and Carolina Medina-Gomez and Chen Hu and Xu, {Cheng jian} and Cancan Qi and Sarah El-Heis and Philip Titcombe and Elie Antoun and Jo{\~a}o Fadista and Wang, {Carol A.} and Elisabeth Thiering and Baojun Wu and Sara Kress and Kothalawala, {Dilini M.} and Latha Kadalayil and Jiasong Duan and Hongmei Zhang and Sabelo Hadebe and Thomas Hoffmann and Eric Jorgenson and H{\'e}l{\`e}ne Choquet and Neil Risch and P{\aa}l Nj{\o}lstad and Andreassen, {Ole A.} and Stefan Johansson and Catarina Almqvist and Tong Gong and Vilhelmina Ullemar and Robert Karlsson and Magnusson, {Patrik K.E.} and Agnieszka Szwajda and Burchard, {Esteban G.} and Thyssen, {Jacob P.} and Torben Hansen and K{\aa}rhus, {Line L.} and Dantoft, {Thomas M.} and Jeanrenaud, {Alexander C.S.N.} and Ahla Ghauri and Andreas Arnold and Georg Homuth and Susanne Lau and N{\"o}then, {Markus M.} and Norbert H{\"u}bner and Medea Imboden and Alessia Visconti and Mario Falchi and Veronique Bataille and Pirro Hysi and Natalia Ballardini and Boomsma, {Dorret I.} and Hottenga, {Jouke J.} and Martina M{\"u}ller-Nurasyid and Ahluwalia, {Tarunveer S.} and Jakob Stokholm and Bo Chawes and Schoos, {Ann Marie M.} and Ana Esplugues and Mariona Bustamante and Benjamin Raby and Syed Arshad and Chris German and T{\~o}nu Esko and Milani, {Lili A.} and Andres Metspalu and Chikashi Terao and Katrina Abuabara and Mari L{\o}set and Kristian Hveem and Bo Jacobsson and Maria Pino-Yanes and Strachan, {David P.} and Niels Grarup and Allan Linneberg and Lee, {Young Ae} and Nicole Probst-Hensch and Stephan Weidinger and Jarvelin, {Marjo Riitta} and Erik Mel{\'e}n and Hakon Hakonarson and Irvine, {Alan D.} and Deborah Jarvis and Tamar Nijsten and Liesbeth Duijts and Vonk, {Judith M.} and Koppelmann, {Gerard H.} and Godfrey, {Keith M.} and Barton, {Sheila J.} and Bjarke Feenstra and Pennell, {Craig E.} and Sly, {Peter D.} and Holt, {Patrick G.} and Williams, {L. Keoki} and Hans Bisgaard and Klaus B{\o}nnelykke and John Curtin and Angela Simpson and Clare Murray and Tamara Schikowski and Supinda Bunyavanich and Weiss, {Scott T.} and Holloway, {John W.} and Min, {Josine L.} and Brown, {Sara J.} and Marie Standl and Lavinia Paternoster",
note = "Publisher Copyright: {\textcopyright} 2023, Springer Nature Limited.",
year = "2023",
doi = "10.1038/s41467-023-41180-2",
language = "English",
volume = "14",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - European and multi-ancestry genome-wide association meta-analysis of atopic dermatitis highlights importance of systemic immune regulation
AU - Budu-Aggrey, Ashley
AU - Kilanowski, Anna
AU - Sobczyk, Maria K.
AU - Shringarpure, Suyash S.
AU - Mitchell, Ruth
AU - Reis, Kadri
AU - Reigo, Anu
AU - Mägi, Reedik
AU - Nelis, Mari
AU - Tanaka, Nao
AU - Brumpton, Ben M.
AU - Thomas, Laurent F.
AU - Sole-Navais, Pol
AU - Flatley, Christopher
AU - Espuela-Ortiz, Antonio
AU - Herrera-Luis, Esther
AU - Lominchar, Jesus V.T.
AU - Bork-Jensen, Jette
AU - Marenholz, Ingo
AU - Arnau-Soler, Aleix
AU - Jeong, Ayoung
AU - Fawcett, Katherine A.
AU - Baurecht, Hansjorg
AU - Rodriguez, Elke
AU - Alves, Alexessander Couto
AU - Kumar, Ashish
AU - Sleiman, Patrick M.
AU - Chang, Xiao
AU - Medina-Gomez, Carolina
AU - Hu, Chen
AU - Xu, Cheng jian
AU - Qi, Cancan
AU - El-Heis, Sarah
AU - Titcombe, Philip
AU - Antoun, Elie
AU - Fadista, João
AU - Wang, Carol A.
AU - Thiering, Elisabeth
AU - Wu, Baojun
AU - Kress, Sara
AU - Kothalawala, Dilini M.
AU - Kadalayil, Latha
AU - Duan, Jiasong
AU - Zhang, Hongmei
AU - Hadebe, Sabelo
AU - Hoffmann, Thomas
AU - Jorgenson, Eric
AU - Choquet, Hélène
AU - Risch, Neil
AU - Njølstad, Pål
AU - Andreassen, Ole A.
AU - Johansson, Stefan
AU - Almqvist, Catarina
AU - Gong, Tong
AU - Ullemar, Vilhelmina
AU - Karlsson, Robert
AU - Magnusson, Patrik K.E.
AU - Szwajda, Agnieszka
AU - Burchard, Esteban G.
AU - Thyssen, Jacob P.
AU - Hansen, Torben
AU - Kårhus, Line L.
AU - Dantoft, Thomas M.
AU - Jeanrenaud, Alexander C.S.N.
AU - Ghauri, Ahla
AU - Arnold, Andreas
AU - Homuth, Georg
AU - Lau, Susanne
AU - Nöthen, Markus M.
AU - Hübner, Norbert
AU - Imboden, Medea
AU - Visconti, Alessia
AU - Falchi, Mario
AU - Bataille, Veronique
AU - Hysi, Pirro
AU - Ballardini, Natalia
AU - Boomsma, Dorret I.
AU - Hottenga, Jouke J.
AU - Müller-Nurasyid, Martina
AU - Ahluwalia, Tarunveer S.
AU - Stokholm, Jakob
AU - Chawes, Bo
AU - Schoos, Ann Marie M.
AU - Esplugues, Ana
AU - Bustamante, Mariona
AU - Raby, Benjamin
AU - Arshad, Syed
AU - German, Chris
AU - Esko, Tõnu
AU - Milani, Lili A.
AU - Metspalu, Andres
AU - Terao, Chikashi
AU - Abuabara, Katrina
AU - Løset, Mari
AU - Hveem, Kristian
AU - Jacobsson, Bo
AU - Pino-Yanes, Maria
AU - Strachan, David P.
AU - Grarup, Niels
AU - Linneberg, Allan
AU - Lee, Young Ae
AU - Probst-Hensch, Nicole
AU - Weidinger, Stephan
AU - Jarvelin, Marjo Riitta
AU - Melén, Erik
AU - Hakonarson, Hakon
AU - Irvine, Alan D.
AU - Jarvis, Deborah
AU - Nijsten, Tamar
AU - Duijts, Liesbeth
AU - Vonk, Judith M.
AU - Koppelmann, Gerard H.
AU - Godfrey, Keith M.
AU - Barton, Sheila J.
AU - Feenstra, Bjarke
AU - Pennell, Craig E.
AU - Sly, Peter D.
AU - Holt, Patrick G.
AU - Williams, L. Keoki
AU - Bisgaard, Hans
AU - Bønnelykke, Klaus
AU - Curtin, John
AU - Simpson, Angela
AU - Murray, Clare
AU - Schikowski, Tamara
AU - Bunyavanich, Supinda
AU - Weiss, Scott T.
AU - Holloway, John W.
AU - Min, Josine L.
AU - Brown, Sara J.
AU - Standl, Marie
AU - Paternoster, Lavinia
N1 - Publisher Copyright:
© 2023, Springer Nature Limited.
PY - 2023
Y1 - 2023
N2 - Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.
AB - Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide association studies (GWAS) have identified 71 associated loci. In the current study we conducted the largest AD GWAS to date (discovery N = 1,086,394, replication N = 3,604,027), combining previously reported cohorts with additional available data. We identified 81 loci (29 novel) in the European-only analysis (which all replicated in a separate European analysis) and 10 additional loci in the multi-ancestry analysis (3 novel). Eight variants from the multi-ancestry analysis replicated in at least one of the populations tested (European, Latino or African), while two may be specific to individuals of Japanese ancestry. AD loci showed enrichment for DNAse I hypersensitivity and eQTL associations in blood. At each locus we prioritised candidate genes by integrating multi-omic data. The implicated genes are predominantly in immune pathways of relevance to atopic inflammation and some offer drug repurposing opportunities.
U2 - 10.1038/s41467-023-41180-2
DO - 10.1038/s41467-023-41180-2
M3 - Journal article
C2 - 37794016
AN - SCOPUS:85173731134
VL - 14
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 6172
ER -
