Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up

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Standard

Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up. / Galijatovic, Ehm Astrid Andersson; Allin, Kristine H; Sandholt, Camilla H; Borglykke, Anders; Lau, Cathrine J; Ribel-Madsen, Rasmus; Sparsø, Thomas; Justesen, Johanne M; Harder, Marie N; Jørgensen, Marit E; Jørgensen, Torben; Hansen, Torben; Pedersen, Oluf.

In: Diabetes, Vol. 62, No. 10, 08.07.2013, p. 3610.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Galijatovic, EAA, Allin, KH, Sandholt, CH, Borglykke, A, Lau, CJ, Ribel-Madsen, R, Sparsø, T, Justesen, JM, Harder, MN, Jørgensen, ME, Jørgensen, T, Hansen, T & Pedersen, O 2013, 'Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up', Diabetes, vol. 62, no. 10, pp. 3610. https://doi.org/10.2337/db13-0362

APA

Galijatovic, E. A. A., Allin, K. H., Sandholt, C. H., Borglykke, A., Lau, C. J., Ribel-Madsen, R., Sparsø, T., Justesen, J. M., Harder, M. N., Jørgensen, M. E., Jørgensen, T., Hansen, T., & Pedersen, O. (2013). Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up. Diabetes, 62(10), 3610. https://doi.org/10.2337/db13-0362

Vancouver

Galijatovic EAA, Allin KH, Sandholt CH, Borglykke A, Lau CJ, Ribel-Madsen R et al. Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up. Diabetes. 2013 Jul 8;62(10):3610. https://doi.org/10.2337/db13-0362

Author

Galijatovic, Ehm Astrid Andersson ; Allin, Kristine H ; Sandholt, Camilla H ; Borglykke, Anders ; Lau, Cathrine J ; Ribel-Madsen, Rasmus ; Sparsø, Thomas ; Justesen, Johanne M ; Harder, Marie N ; Jørgensen, Marit E ; Jørgensen, Torben ; Hansen, Torben ; Pedersen, Oluf. / Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up. In: Diabetes. 2013 ; Vol. 62, No. 10. pp. 3610.

Bibtex

@article{9baf71783d7740e1a56cd515e16e30a7,
title = "Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up",
abstract = "More than 40 genetic risk variants for type 2 diabetes have been validated. We aimed to test if a genetic risk score associates with the incidence of type 2 diabetes and with 5-year changes in glycemic traits and if the effects were modulated by changes in BMI and lifestyle.The Inter99 study population was genotyped for 46 variants and a genetic risk score was constructed. During a median follow-up of 11 years 327 of 5,850 individuals developed diabetes. Physical examinations and oral glucose tolerance tests were performed at baseline and after 5 years (n=3,727).The risk of incident type 2 diabetes was increased with a hazard ratio of 1.06 [95%CI 1.03-1.08] per risk allele. While the population in general improved their glucose regulation during the 5-year follow-up period, each additional allele in the genetic risk score was associated with a relative increase in fasting, 30-min and 120-min plasma glucose values and a relative decrease in measures of beta-cell function over the 5-year period, whereas indices of insulin sensitivity were unaffected. The effect of the genetic risk score on 5-year changes in fasting plasma glucose was stronger in individuals who increased their BMI.In conclusion, a genetic risk score based on 46 variants associated strongly with incident type 2 diabetes and 5-year changes in plasma glucose and beta-cell function. Individuals who gain weight may be more susceptible to the cumulative impact of type 2 diabetes risk variants on fasting plasma glucose.",
author = "Galijatovic, {Ehm Astrid Andersson} and Allin, {Kristine H} and Sandholt, {Camilla H} and Anders Borglykke and Lau, {Cathrine J} and Rasmus Ribel-Madsen and Thomas Spars{\o} and Justesen, {Johanne M} and Harder, {Marie N} and J{\o}rgensen, {Marit E} and Torben J{\o}rgensen and Torben Hansen and Oluf Pedersen",
year = "2013",
month = jul,
day = "8",
doi = "10.2337/db13-0362",
language = "English",
volume = "62",
pages = "3610",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "10",

}

RIS

TY - JOUR

T1 - Genetic risk score of 46 type 2 diabetes risk variants associates with changes in plasma glucose and estimates of pancreatic beta-cell function over 5 years of follow-up

AU - Galijatovic, Ehm Astrid Andersson

AU - Allin, Kristine H

AU - Sandholt, Camilla H

AU - Borglykke, Anders

AU - Lau, Cathrine J

AU - Ribel-Madsen, Rasmus

AU - Sparsø, Thomas

AU - Justesen, Johanne M

AU - Harder, Marie N

AU - Jørgensen, Marit E

AU - Jørgensen, Torben

AU - Hansen, Torben

AU - Pedersen, Oluf

PY - 2013/7/8

Y1 - 2013/7/8

N2 - More than 40 genetic risk variants for type 2 diabetes have been validated. We aimed to test if a genetic risk score associates with the incidence of type 2 diabetes and with 5-year changes in glycemic traits and if the effects were modulated by changes in BMI and lifestyle.The Inter99 study population was genotyped for 46 variants and a genetic risk score was constructed. During a median follow-up of 11 years 327 of 5,850 individuals developed diabetes. Physical examinations and oral glucose tolerance tests were performed at baseline and after 5 years (n=3,727).The risk of incident type 2 diabetes was increased with a hazard ratio of 1.06 [95%CI 1.03-1.08] per risk allele. While the population in general improved their glucose regulation during the 5-year follow-up period, each additional allele in the genetic risk score was associated with a relative increase in fasting, 30-min and 120-min plasma glucose values and a relative decrease in measures of beta-cell function over the 5-year period, whereas indices of insulin sensitivity were unaffected. The effect of the genetic risk score on 5-year changes in fasting plasma glucose was stronger in individuals who increased their BMI.In conclusion, a genetic risk score based on 46 variants associated strongly with incident type 2 diabetes and 5-year changes in plasma glucose and beta-cell function. Individuals who gain weight may be more susceptible to the cumulative impact of type 2 diabetes risk variants on fasting plasma glucose.

AB - More than 40 genetic risk variants for type 2 diabetes have been validated. We aimed to test if a genetic risk score associates with the incidence of type 2 diabetes and with 5-year changes in glycemic traits and if the effects were modulated by changes in BMI and lifestyle.The Inter99 study population was genotyped for 46 variants and a genetic risk score was constructed. During a median follow-up of 11 years 327 of 5,850 individuals developed diabetes. Physical examinations and oral glucose tolerance tests were performed at baseline and after 5 years (n=3,727).The risk of incident type 2 diabetes was increased with a hazard ratio of 1.06 [95%CI 1.03-1.08] per risk allele. While the population in general improved their glucose regulation during the 5-year follow-up period, each additional allele in the genetic risk score was associated with a relative increase in fasting, 30-min and 120-min plasma glucose values and a relative decrease in measures of beta-cell function over the 5-year period, whereas indices of insulin sensitivity were unaffected. The effect of the genetic risk score on 5-year changes in fasting plasma glucose was stronger in individuals who increased their BMI.In conclusion, a genetic risk score based on 46 variants associated strongly with incident type 2 diabetes and 5-year changes in plasma glucose and beta-cell function. Individuals who gain weight may be more susceptible to the cumulative impact of type 2 diabetes risk variants on fasting plasma glucose.

U2 - 10.2337/db13-0362

DO - 10.2337/db13-0362

M3 - Journal article

C2 - 23835328

VL - 62

SP - 3610

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 10

ER -

ID: 47256038