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Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. / Okbay, Aysu; Baselmans, Bart M L; De Neve, Jan-Emmanuel; Turley, Patrick; Nivard, Michel G; Fontana, Mark Alan; Meddens, S Fleur W; Linnér, Richard Karlsson; Rietveld, Cornelius A; Derringer, Jaime; Gratten, Jacob; Lee, James J; Liu, Jimmy Z; de Vlaming, Ronald; Ahluwalia, Tarun Veer Singh; Buchwald, Jadwiga; Cavadino, Alana; Frazier-Wood, Alexis C; Furlotte, Nicholas A; Garfield, Victoria; Geisel, Marie Henrike; Gonzalez, Juan R; Haitjema, Saskia; Karlsson, Robert; van der Laan, Sander W; Ladwig, Karl-Heinz; Lahti, Jari; van der Lee, Sven J; Lind, Penelope A; Liu, Tian; Matteson, Lindsay; Mihailov, Evelin; Miller, Michael B; Minica, Camelia C; Nolte, Ilja M; Mook-Kanamori, Dennis; van der Most, Peter J; Oldmeadow, Christopher; Qian, Yong; Raitakari, Olli; Rawal, Rajesh; Realo, Anu; Rueedi, Rico; Schmidt, Börge; Smith, Albert V; Stergiakouli, Evie; Tanaka, Toshiko; Bültmann, Ute; Hansen, Torben; Sørensen, Thorkild I A; LifeLines Cohort Study.
In:
Nature Genetics, Vol. 48, No. 6, 06.2016, p. 624-33.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Okbay, A, Baselmans, BML, De Neve, J-E, Turley, P, Nivard, MG, Fontana, MA, Meddens, SFW, Linnér, RK, Rietveld, CA, Derringer, J, Gratten, J, Lee, JJ, Liu, JZ, de Vlaming, R
, Ahluwalia, TVS, Buchwald, J, Cavadino, A, Frazier-Wood, AC, Furlotte, NA, Garfield, V, Geisel, MH, Gonzalez, JR, Haitjema, S, Karlsson, R, van der Laan, SW, Ladwig, K-H, Lahti, J, van der Lee, SJ, Lind, PA, Liu, T, Matteson, L, Mihailov, E, Miller, MB, Minica, CC, Nolte, IM, Mook-Kanamori, D, van der Most, PJ, Oldmeadow, C, Qian, Y, Raitakari, O, Rawal, R, Realo, A, Rueedi, R, Schmidt, B, Smith, AV, Stergiakouli, E, Tanaka, T, Bültmann, U
, Hansen, T, Sørensen, TIA & LifeLines Cohort Study 2016, '
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses',
Nature Genetics, vol. 48, no. 6, pp. 624-33.
https://doi.org/10.1038/ng.3552APA
Okbay, A., Baselmans, B. M. L., De Neve, J-E., Turley, P., Nivard, M. G., Fontana, M. A., Meddens, S. F. W., Linnér, R. K., Rietveld, C. A., Derringer, J., Gratten, J., Lee, J. J., Liu, J. Z., de Vlaming, R.
, Ahluwalia, T. V. S., Buchwald, J., Cavadino, A., Frazier-Wood, A. C., Furlotte, N. A., ... LifeLines Cohort Study (2016).
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Nature Genetics,
48(6), 624-33.
https://doi.org/10.1038/ng.3552Vancouver
Okbay A, Baselmans BML, De Neve J-E, Turley P, Nivard MG, Fontana MA et al.
Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses.
Nature Genetics. 2016 Jun;48(6):624-33.
https://doi.org/10.1038/ng.3552Author
Okbay, Aysu ; Baselmans, Bart M L ; De Neve, Jan-Emmanuel ; Turley, Patrick ; Nivard, Michel G ; Fontana, Mark Alan ; Meddens, S Fleur W ; Linnér, Richard Karlsson ; Rietveld, Cornelius A ; Derringer, Jaime ; Gratten, Jacob ; Lee, James J ; Liu, Jimmy Z ; de Vlaming, Ronald ; Ahluwalia, Tarun Veer Singh ; Buchwald, Jadwiga ; Cavadino, Alana ; Frazier-Wood, Alexis C ; Furlotte, Nicholas A ; Garfield, Victoria ; Geisel, Marie Henrike ; Gonzalez, Juan R ; Haitjema, Saskia ; Karlsson, Robert ; van der Laan, Sander W ; Ladwig, Karl-Heinz ; Lahti, Jari ; van der Lee, Sven J ; Lind, Penelope A ; Liu, Tian ; Matteson, Lindsay ; Mihailov, Evelin ; Miller, Michael B ; Minica, Camelia C ; Nolte, Ilja M ; Mook-Kanamori, Dennis ; van der Most, Peter J ; Oldmeadow, Christopher ; Qian, Yong ; Raitakari, Olli ; Rawal, Rajesh ; Realo, Anu ; Rueedi, Rico ; Schmidt, Börge ; Smith, Albert V ; Stergiakouli, Evie ; Tanaka, Toshiko ; Bültmann, Ute ; Hansen, Torben ; Sørensen, Thorkild I A ; LifeLines Cohort Study. / Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses. In: Nature Genetics. 2016 ; Vol. 48, No. 6. pp. 624-33.
Bibtex
@article{7fb68d0ef3664fc6a922ecdeab90278a,
title = "Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses",
abstract = "Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.",
keywords = "Journal Article",
author = "Aysu Okbay and Baselmans, {Bart M L} and {De Neve}, Jan-Emmanuel and Patrick Turley and Nivard, {Michel G} and Fontana, {Mark Alan} and Meddens, {S Fleur W} and Linn{\'e}r, {Richard Karlsson} and Rietveld, {Cornelius A} and Jaime Derringer and Jacob Gratten and Lee, {James J} and Liu, {Jimmy Z} and {de Vlaming}, Ronald and Ahluwalia, {Tarun Veer Singh} and Jadwiga Buchwald and Alana Cavadino and Frazier-Wood, {Alexis C} and Furlotte, {Nicholas A} and Victoria Garfield and Geisel, {Marie Henrike} and Gonzalez, {Juan R} and Saskia Haitjema and Robert Karlsson and {van der Laan}, {Sander W} and Karl-Heinz Ladwig and Jari Lahti and {van der Lee}, {Sven J} and Lind, {Penelope A} and Tian Liu and Lindsay Matteson and Evelin Mihailov and Miller, {Michael B} and Minica, {Camelia C} and Nolte, {Ilja M} and Dennis Mook-Kanamori and {van der Most}, {Peter J} and Christopher Oldmeadow and Yong Qian and Olli Raitakari and Rajesh Rawal and Anu Realo and Rico Rueedi and B{\"o}rge Schmidt and Smith, {Albert V} and Evie Stergiakouli and Toshiko Tanaka and Ute B{\"u}ltmann and Torben Hansen and S{\o}rensen, {Thorkild I A} and {LifeLines Cohort Study}",
year = "2016",
month = jun,
doi = "10.1038/ng.3552",
language = "English",
volume = "48",
pages = "624--33",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "6",
}
RIS
TY - JOUR
T1 - Genetic variants associated with subjective well-being, depressive symptoms, and neuroticism identified through genome-wide analyses
AU - Okbay, Aysu
AU - Baselmans, Bart M L
AU - De Neve, Jan-Emmanuel
AU - Turley, Patrick
AU - Nivard, Michel G
AU - Fontana, Mark Alan
AU - Meddens, S Fleur W
AU - Linnér, Richard Karlsson
AU - Rietveld, Cornelius A
AU - Derringer, Jaime
AU - Gratten, Jacob
AU - Lee, James J
AU - Liu, Jimmy Z
AU - de Vlaming, Ronald
AU - Ahluwalia, Tarun Veer Singh
AU - Buchwald, Jadwiga
AU - Cavadino, Alana
AU - Frazier-Wood, Alexis C
AU - Furlotte, Nicholas A
AU - Garfield, Victoria
AU - Geisel, Marie Henrike
AU - Gonzalez, Juan R
AU - Haitjema, Saskia
AU - Karlsson, Robert
AU - van der Laan, Sander W
AU - Ladwig, Karl-Heinz
AU - Lahti, Jari
AU - van der Lee, Sven J
AU - Lind, Penelope A
AU - Liu, Tian
AU - Matteson, Lindsay
AU - Mihailov, Evelin
AU - Miller, Michael B
AU - Minica, Camelia C
AU - Nolte, Ilja M
AU - Mook-Kanamori, Dennis
AU - van der Most, Peter J
AU - Oldmeadow, Christopher
AU - Qian, Yong
AU - Raitakari, Olli
AU - Rawal, Rajesh
AU - Realo, Anu
AU - Rueedi, Rico
AU - Schmidt, Börge
AU - Smith, Albert V
AU - Stergiakouli, Evie
AU - Tanaka, Toshiko
AU - Bültmann, Ute
AU - Hansen, Torben
AU - Sørensen, Thorkild I A
AU - LifeLines Cohort Study
PY - 2016/6
Y1 - 2016/6
N2 - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
AB - Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.
KW - Journal Article
U2 - 10.1038/ng.3552
DO - 10.1038/ng.3552
M3 - Journal article
C2 - 27089181
VL - 48
SP - 624
EP - 633
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 6
ER -
