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Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. / Waage, Johannes; Standl, Marie; Curtin, John A; Jessen, Leon E; Thorsen, Jonathan; Tian, Chao; Schoettler, Nathan; 23andMe Research Team; AAGC collaborators; Flores, Carlos; Abdellaoui, Abdel; Ahluwalia, Tarunveer S; Alves, Alexessander C; Amaral, Andre F S; Antó, Josep M; Arnold, Andreas; Barreto-Luis, Amalia; Baurecht, Hansjörg; van Beijsterveldt, Catharina E M; Bleecker, Eugene R; Bonàs-Guarch, Sílvia; Boomsma, Dorret I; Brix, Susanne; Bunyavanich, Supinda; Burchard, Esteban G; Chen, Zhanghua; Curjuric, Ivan; Custovic, Adnan; den Dekker, Herman T; Dharmage, Shyamali C; Dmitrieva, Julia; Duijts, Liesbeth; Ege, Markus J; Gauderman, W James; Georges, Michel; Gieger, Christian; Gilliland, Frank; Granell, Raquel; Gui, Hongsheng; Hansen, Torben; Heinrich, Joachim; Henderson, John; Hernandez-Pacheco, Natalia; Holt, Patrick; Imboden, Medea; Jaddoe, Vincent W V; Jarvelin, Marjo-Riitta; Jarvis, Deborah L; Jensen, Kamilla K; Nohr, Ellen A; Bisgaard, Hans; Strachan, David P; Bønnelykke, Klaus.
In:
Nature Genetics, Vol. 50, No. 8, 2018, p. 1072-1080.
Research output: Contribution to journal › Letter › Research › peer-review
Harvard
Waage, J, Standl, M, Curtin, JA, Jessen, LE
, Thorsen, J, Tian, C, Schoettler, N, 23andMe Research Team, AAGC collaborators, Flores, C, Abdellaoui, A, Ahluwalia, TS, Alves, AC, Amaral, AFS, Antó, JM, Arnold, A, Barreto-Luis, A, Baurecht, H, van Beijsterveldt, CEM, Bleecker, ER, Bonàs-Guarch, S, Boomsma, DI, Brix, S, Bunyavanich, S, Burchard, EG, Chen, Z, Curjuric, I, Custovic, A, den Dekker, HT, Dharmage, SC, Dmitrieva, J, Duijts, L, Ege, MJ, Gauderman, WJ, Georges, M, Gieger, C, Gilliland, F, Granell, R, Gui, H
, Hansen, T, Heinrich, J, Henderson, J, Hernandez-Pacheco, N, Holt, P, Imboden, M, Jaddoe, VWV, Jarvelin, M-R, Jarvis, DL, Jensen, KK, Nohr, EA, Bisgaard, H, Strachan, DP
& Bønnelykke, K 2018, '
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis',
Nature Genetics, vol. 50, no. 8, pp. 1072-1080.
https://doi.org/10.1038/s41588-018-0157-1APA
Waage, J., Standl, M., Curtin, J. A., Jessen, L. E.
, Thorsen, J., Tian, C., Schoettler, N., 23andMe Research Team, AAGC collaborators, Flores, C., Abdellaoui, A., Ahluwalia, T. S., Alves, A. C., Amaral, A. F. S., Antó, J. M., Arnold, A., Barreto-Luis, A., Baurecht, H., van Beijsterveldt, C. E. M.
, ... Bønnelykke, K. (2018).
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Nature Genetics,
50(8), 1072-1080.
https://doi.org/10.1038/s41588-018-0157-1Vancouver
Waage J, Standl M, Curtin JA, Jessen LE
, Thorsen J, Tian C et al.
Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis.
Nature Genetics. 2018;50(8):1072-1080.
https://doi.org/10.1038/s41588-018-0157-1Author
Waage, Johannes ; Standl, Marie ; Curtin, John A ; Jessen, Leon E ; Thorsen, Jonathan ; Tian, Chao ; Schoettler, Nathan ; 23andMe Research Team ; AAGC collaborators ; Flores, Carlos ; Abdellaoui, Abdel ; Ahluwalia, Tarunveer S ; Alves, Alexessander C ; Amaral, Andre F S ; Antó, Josep M ; Arnold, Andreas ; Barreto-Luis, Amalia ; Baurecht, Hansjörg ; van Beijsterveldt, Catharina E M ; Bleecker, Eugene R ; Bonàs-Guarch, Sílvia ; Boomsma, Dorret I ; Brix, Susanne ; Bunyavanich, Supinda ; Burchard, Esteban G ; Chen, Zhanghua ; Curjuric, Ivan ; Custovic, Adnan ; den Dekker, Herman T ; Dharmage, Shyamali C ; Dmitrieva, Julia ; Duijts, Liesbeth ; Ege, Markus J ; Gauderman, W James ; Georges, Michel ; Gieger, Christian ; Gilliland, Frank ; Granell, Raquel ; Gui, Hongsheng ; Hansen, Torben ; Heinrich, Joachim ; Henderson, John ; Hernandez-Pacheco, Natalia ; Holt, Patrick ; Imboden, Medea ; Jaddoe, Vincent W V ; Jarvelin, Marjo-Riitta ; Jarvis, Deborah L ; Jensen, Kamilla K ; Nohr, Ellen A ; Bisgaard, Hans ; Strachan, David P ; Bønnelykke, Klaus. / Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis. In: Nature Genetics. 2018 ; Vol. 50, No. 8. pp. 1072-1080.
Bibtex
@article{8a20890e5577464cabe7b0896a61d933,
title = "Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis",
abstract = "Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.",
author = "Johannes Waage and Marie Standl and Curtin, {John A} and Jessen, {Leon E} and Jonathan Thorsen and Chao Tian and Nathan Schoettler and {23andMe Research Team} and {AAGC collaborators} and Carlos Flores and Abdel Abdellaoui and Ahluwalia, {Tarunveer S} and Alves, {Alexessander C} and Amaral, {Andre F S} and Ant{\'o}, {Josep M} and Andreas Arnold and Amalia Barreto-Luis and Hansj{\"o}rg Baurecht and {van Beijsterveldt}, {Catharina E M} and Bleecker, {Eugene R} and S{\'i}lvia Bon{\`a}s-Guarch and Boomsma, {Dorret I} and Susanne Brix and Supinda Bunyavanich and Burchard, {Esteban G} and Zhanghua Chen and Ivan Curjuric and Adnan Custovic and {den Dekker}, {Herman T} and Dharmage, {Shyamali C} and Julia Dmitrieva and Liesbeth Duijts and Ege, {Markus J} and Gauderman, {W James} and Michel Georges and Christian Gieger and Frank Gilliland and Raquel Granell and Hongsheng Gui and Torben Hansen and Joachim Heinrich and John Henderson and Natalia Hernandez-Pacheco and Patrick Holt and Medea Imboden and Jaddoe, {Vincent W V} and Marjo-Riitta Jarvelin and Jarvis, {Deborah L} and Jensen, {Kamilla K} and Nohr, {Ellen A} and Hans Bisgaard and Strachan, {David P} and Klaus B{\o}nnelykke",
year = "2018",
doi = "10.1038/s41588-018-0157-1",
language = "English",
volume = "50",
pages = "1072--1080",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "8",
}
RIS
TY - JOUR
T1 - Genome-wide association and HLA fine-mapping studies identify risk loci and genetic pathways underlying allergic rhinitis
AU - Waage, Johannes
AU - Standl, Marie
AU - Curtin, John A
AU - Jessen, Leon E
AU - Thorsen, Jonathan
AU - Tian, Chao
AU - Schoettler, Nathan
AU - 23andMe Research Team
AU - AAGC collaborators
AU - Flores, Carlos
AU - Abdellaoui, Abdel
AU - Ahluwalia, Tarunveer S
AU - Alves, Alexessander C
AU - Amaral, Andre F S
AU - Antó, Josep M
AU - Arnold, Andreas
AU - Barreto-Luis, Amalia
AU - Baurecht, Hansjörg
AU - van Beijsterveldt, Catharina E M
AU - Bleecker, Eugene R
AU - Bonàs-Guarch, Sílvia
AU - Boomsma, Dorret I
AU - Brix, Susanne
AU - Bunyavanich, Supinda
AU - Burchard, Esteban G
AU - Chen, Zhanghua
AU - Curjuric, Ivan
AU - Custovic, Adnan
AU - den Dekker, Herman T
AU - Dharmage, Shyamali C
AU - Dmitrieva, Julia
AU - Duijts, Liesbeth
AU - Ege, Markus J
AU - Gauderman, W James
AU - Georges, Michel
AU - Gieger, Christian
AU - Gilliland, Frank
AU - Granell, Raquel
AU - Gui, Hongsheng
AU - Hansen, Torben
AU - Heinrich, Joachim
AU - Henderson, John
AU - Hernandez-Pacheco, Natalia
AU - Holt, Patrick
AU - Imboden, Medea
AU - Jaddoe, Vincent W V
AU - Jarvelin, Marjo-Riitta
AU - Jarvis, Deborah L
AU - Jensen, Kamilla K
AU - Nohr, Ellen A
AU - Bisgaard, Hans
AU - Strachan, David P
AU - Bønnelykke, Klaus
PY - 2018
Y1 - 2018
N2 - Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.
AB - Allergic rhinitis is the most common clinical presentation of allergy, affecting 400 million people worldwide, with increasing incidence in westernized countries1,2. To elucidate the genetic architecture and understand the underlying disease mechanisms, we carried out a meta-analysis of allergic rhinitis in 59,762 cases and 152,358 controls of European ancestry and identified a total of 41 risk loci for allergic rhinitis, including 20 loci not previously associated with allergic rhinitis, which were confirmed in a replication phase of 60,720 cases and 618,527 controls. Functional annotation implicated genes involved in various immune pathways, and fine mapping of the HLA region suggested amino acid variants important for antigen binding. We further performed genome-wide association study (GWAS) analyses of allergic sensitization against inhalant allergens and nonallergic rhinitis, which suggested shared genetic mechanisms across rhinitis-related traits. Future studies of the identified loci and genes might identify novel targets for treatment and prevention of allergic rhinitis.
U2 - 10.1038/s41588-018-0157-1
DO - 10.1038/s41588-018-0157-1
M3 - Letter
C2 - 30013184
VL - 50
SP - 1072
EP - 1080
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 8
ER -
