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Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. / Beaumont, Robin N.; Flatley, Christopher; Vaudel, Marc; Wu, Xiaoping; Chen, Jing; Moen, Gunn Helen; Skotte, Line; Helgeland, Øyvind; Solé-Navais, Pol; Banasik, Karina; Albiñana, Clara; Ronkainen, Justiina; Fadista, João; Stinson, Sara Elizabeth; Trajanoska, Katerina; Wang, Carol A.; Westergaard, David; Srinivasan, Sundararajan; Sánchez-Soriano, Carlos; Bilbao, Jose Ramon; Allard, Catherine; Groleau, Marika; Kuulasmaa, Teemu; Leirer, Daniel J.; White, Frédérique; Jacques, Pierre Étienne; Cheng, Haoxiang; Hao, Ke; Andreassen, Ole A.; Åsvold, Bjørn Olav; Atalay, Mustafa; Bhatta, Laxmi; Bouchard, Luigi; Brumpton, Ben Michael; Brunak, Søren; Bybjerg-Grauholm, Jonas; Ebbing, Cathrine; Elliott, Paul; Engelbrechtsen, Line; Erikstrup, Christian; Estarlich, Marisa; Franks, Stephen; Gaillard, Romy; Geller, Frank; Grove, Jakob; Hougaard, David M.; Kajantie, Eero; Morgen, Camilla S.; Nohr, Ellen A.; Nyegaard, Mette; Palmer, Colin N.A.; Pedersen, Ole Birger; Rivadeneira, Fernando; Sebert, Sylvain; Shields, Beverley M.; Stoltenberg, Camilla; Surakka, Ida; Thørner, Lise Wegner; Ullum, Henrik; Vaarasmaki, Marja; Vilhjalmsson, Bjarni J.; Willer, Cristen J.; Lakka, Timo A.; Gybel-Brask, Dorte; Bustamante, Mariona; Hansen, Torben; Pearson, Ewan R.; Reynolds, Rebecca M.; Ostrowski, Sisse R.; Pennell, Craig E.; Jaddoe, Vincent W.V.; Felix, Janine F.; Hattersley, Andrew T.; Melbye, Mads; Lawlor, Deborah A.; Hveem, Kristian; Werge, Thomas; Nielsen, Henriette Svarre; Magnus, Per; Evans, David M.; Jacobsson, Bo; Järvelin, Marjo Riitta; Zhang, Ge; Hivert, Marie France; Johansson, Stefan; Freathy, Rachel M.; Feenstra, Bjarke; Njølstad, Pål R.
In:
Nature Genetics, Vol. 55, No. 11, 2023, p. 1807-1819.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Beaumont, RN, Flatley, C, Vaudel, M, Wu, X, Chen, J, Moen, GH, Skotte, L, Helgeland, Ø, Solé-Navais, P
, Banasik, K, Albiñana, C, Ronkainen, J, Fadista, J
, Stinson, SE, Trajanoska, K, Wang, CA
, Westergaard, D, Srinivasan, S, Sánchez-Soriano, C, Bilbao, JR, Allard, C, Groleau, M, Kuulasmaa, T, Leirer, DJ, White, F, Jacques, PÉ, Cheng, H, Hao, K, Andreassen, OA, Åsvold, BO, Atalay, M, Bhatta, L, Bouchard, L, Brumpton, BM
, Brunak, S, Bybjerg-Grauholm, J, Ebbing, C, Elliott, P
, Engelbrechtsen, L, Erikstrup, C, Estarlich, M, Franks, S, Gaillard, R, Geller, F, Grove, J, Hougaard, DM, Kajantie, E, Morgen, CS, Nohr, EA
, Nyegaard, M, Palmer, CNA
, Pedersen, OB, Rivadeneira, F, Sebert, S, Shields, BM, Stoltenberg, C, Surakka, I, Thørner, LW, Ullum, H, Vaarasmaki, M, Vilhjalmsson, BJ, Willer, CJ, Lakka, TA, Gybel-Brask, D, Bustamante, M
, Hansen, T, Pearson, ER, Reynolds, RM
, Ostrowski, SR, Pennell, CE, Jaddoe, VWV, Felix, JF, Hattersley, AT, Melbye, M, Lawlor, DA, Hveem, K
, Werge, T, Nielsen, HS, Magnus, P, Evans, DM, Jacobsson, B, Järvelin, MR, Zhang, G, Hivert, MF, Johansson, S, Freathy, RM, Feenstra, B & Njølstad, PR 2023, '
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth',
Nature Genetics, vol. 55, no. 11, pp. 1807-1819.
https://doi.org/10.1038/s41588-023-01520-wAPA
Beaumont, R. N., Flatley, C., Vaudel, M., Wu, X., Chen, J., Moen, G. H., Skotte, L., Helgeland, Ø., Solé-Navais, P.
, Banasik, K., Albiñana, C., Ronkainen, J., Fadista, J.
, Stinson, S. E., Trajanoska, K., Wang, C. A.
, Westergaard, D., Srinivasan, S., Sánchez-Soriano, C., ... Njølstad, P. R. (2023).
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.
Nature Genetics,
55(11), 1807-1819.
https://doi.org/10.1038/s41588-023-01520-wVancouver
Beaumont RN, Flatley C, Vaudel M, Wu X, Chen J, Moen GH et al.
Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth.
Nature Genetics. 2023;55(11):1807-1819.
https://doi.org/10.1038/s41588-023-01520-wAuthor
Beaumont, Robin N. ; Flatley, Christopher ; Vaudel, Marc ; Wu, Xiaoping ; Chen, Jing ; Moen, Gunn Helen ; Skotte, Line ; Helgeland, Øyvind ; Solé-Navais, Pol ; Banasik, Karina ; Albiñana, Clara ; Ronkainen, Justiina ; Fadista, João ; Stinson, Sara Elizabeth ; Trajanoska, Katerina ; Wang, Carol A. ; Westergaard, David ; Srinivasan, Sundararajan ; Sánchez-Soriano, Carlos ; Bilbao, Jose Ramon ; Allard, Catherine ; Groleau, Marika ; Kuulasmaa, Teemu ; Leirer, Daniel J. ; White, Frédérique ; Jacques, Pierre Étienne ; Cheng, Haoxiang ; Hao, Ke ; Andreassen, Ole A. ; Åsvold, Bjørn Olav ; Atalay, Mustafa ; Bhatta, Laxmi ; Bouchard, Luigi ; Brumpton, Ben Michael ; Brunak, Søren ; Bybjerg-Grauholm, Jonas ; Ebbing, Cathrine ; Elliott, Paul ; Engelbrechtsen, Line ; Erikstrup, Christian ; Estarlich, Marisa ; Franks, Stephen ; Gaillard, Romy ; Geller, Frank ; Grove, Jakob ; Hougaard, David M. ; Kajantie, Eero ; Morgen, Camilla S. ; Nohr, Ellen A. ; Nyegaard, Mette ; Palmer, Colin N.A. ; Pedersen, Ole Birger ; Rivadeneira, Fernando ; Sebert, Sylvain ; Shields, Beverley M. ; Stoltenberg, Camilla ; Surakka, Ida ; Thørner, Lise Wegner ; Ullum, Henrik ; Vaarasmaki, Marja ; Vilhjalmsson, Bjarni J. ; Willer, Cristen J. ; Lakka, Timo A. ; Gybel-Brask, Dorte ; Bustamante, Mariona ; Hansen, Torben ; Pearson, Ewan R. ; Reynolds, Rebecca M. ; Ostrowski, Sisse R. ; Pennell, Craig E. ; Jaddoe, Vincent W.V. ; Felix, Janine F. ; Hattersley, Andrew T. ; Melbye, Mads ; Lawlor, Deborah A. ; Hveem, Kristian ; Werge, Thomas ; Nielsen, Henriette Svarre ; Magnus, Per ; Evans, David M. ; Jacobsson, Bo ; Järvelin, Marjo Riitta ; Zhang, Ge ; Hivert, Marie France ; Johansson, Stefan ; Freathy, Rachel M. ; Feenstra, Bjarke ; Njølstad, Pål R. / Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth. In: Nature Genetics. 2023 ; Vol. 55, No. 11. pp. 1807-1819.
Bibtex
@article{aa1e7826d02940a78619c046d27e4317,
title = "Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth",
abstract = "A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.",
author = "Beaumont, {Robin N.} and Christopher Flatley and Marc Vaudel and Xiaoping Wu and Jing Chen and Moen, {Gunn Helen} and Line Skotte and {\O}yvind Helgeland and Pol Sol{\'e}-Navais and Karina Banasik and Clara Albi{\~n}ana and Justiina Ronkainen and Jo{\~a}o Fadista and Stinson, {Sara Elizabeth} and Katerina Trajanoska and Wang, {Carol A.} and David Westergaard and Sundararajan Srinivasan and Carlos S{\'a}nchez-Soriano and Bilbao, {Jose Ramon} and Catherine Allard and Marika Groleau and Teemu Kuulasmaa and Leirer, {Daniel J.} and Fr{\'e}d{\'e}rique White and Jacques, {Pierre {\'E}tienne} and Haoxiang Cheng and Ke Hao and Andreassen, {Ole A.} and {\AA}svold, {Bj{\o}rn Olav} and Mustafa Atalay and Laxmi Bhatta and Luigi Bouchard and Brumpton, {Ben Michael} and S{\o}ren Brunak and Jonas Bybjerg-Grauholm and Cathrine Ebbing and Paul Elliott and Line Engelbrechtsen and Christian Erikstrup and Marisa Estarlich and Stephen Franks and Romy Gaillard and Frank Geller and Jakob Grove and Hougaard, {David M.} and Eero Kajantie and Morgen, {Camilla S.} and Nohr, {Ellen A.} and Mette Nyegaard and Palmer, {Colin N.A.} and Pedersen, {Ole Birger} and Fernando Rivadeneira and Sylvain Sebert and Shields, {Beverley M.} and Camilla Stoltenberg and Ida Surakka and Th{\o}rner, {Lise Wegner} and Henrik Ullum and Marja Vaarasmaki and Vilhjalmsson, {Bjarni J.} and Willer, {Cristen J.} and Lakka, {Timo A.} and Dorte Gybel-Brask and Mariona Bustamante and Torben Hansen and Pearson, {Ewan R.} and Reynolds, {Rebecca M.} and Ostrowski, {Sisse R.} and Pennell, {Craig E.} and Jaddoe, {Vincent W.V.} and Felix, {Janine F.} and Hattersley, {Andrew T.} and Mads Melbye and Lawlor, {Deborah A.} and Kristian Hveem and Thomas Werge and Nielsen, {Henriette Svarre} and Per Magnus and Evans, {David M.} and Bo Jacobsson and J{\"a}rvelin, {Marjo Riitta} and Ge Zhang and Hivert, {Marie France} and Stefan Johansson and Freathy, {Rachel M.} and Bjarke Feenstra and Nj{\o}lstad, {P{\aa}l R.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1038/s41588-023-01520-w",
language = "English",
volume = "55",
pages = "1807--1819",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "11",
}
RIS
TY - JOUR
T1 - Genome-wide association study of placental weight identifies distinct and shared genetic influences between placental and fetal growth
AU - Beaumont, Robin N.
AU - Flatley, Christopher
AU - Vaudel, Marc
AU - Wu, Xiaoping
AU - Chen, Jing
AU - Moen, Gunn Helen
AU - Skotte, Line
AU - Helgeland, Øyvind
AU - Solé-Navais, Pol
AU - Banasik, Karina
AU - Albiñana, Clara
AU - Ronkainen, Justiina
AU - Fadista, João
AU - Stinson, Sara Elizabeth
AU - Trajanoska, Katerina
AU - Wang, Carol A.
AU - Westergaard, David
AU - Srinivasan, Sundararajan
AU - Sánchez-Soriano, Carlos
AU - Bilbao, Jose Ramon
AU - Allard, Catherine
AU - Groleau, Marika
AU - Kuulasmaa, Teemu
AU - Leirer, Daniel J.
AU - White, Frédérique
AU - Jacques, Pierre Étienne
AU - Cheng, Haoxiang
AU - Hao, Ke
AU - Andreassen, Ole A.
AU - Åsvold, Bjørn Olav
AU - Atalay, Mustafa
AU - Bhatta, Laxmi
AU - Bouchard, Luigi
AU - Brumpton, Ben Michael
AU - Brunak, Søren
AU - Bybjerg-Grauholm, Jonas
AU - Ebbing, Cathrine
AU - Elliott, Paul
AU - Engelbrechtsen, Line
AU - Erikstrup, Christian
AU - Estarlich, Marisa
AU - Franks, Stephen
AU - Gaillard, Romy
AU - Geller, Frank
AU - Grove, Jakob
AU - Hougaard, David M.
AU - Kajantie, Eero
AU - Morgen, Camilla S.
AU - Nohr, Ellen A.
AU - Nyegaard, Mette
AU - Palmer, Colin N.A.
AU - Pedersen, Ole Birger
AU - Rivadeneira, Fernando
AU - Sebert, Sylvain
AU - Shields, Beverley M.
AU - Stoltenberg, Camilla
AU - Surakka, Ida
AU - Thørner, Lise Wegner
AU - Ullum, Henrik
AU - Vaarasmaki, Marja
AU - Vilhjalmsson, Bjarni J.
AU - Willer, Cristen J.
AU - Lakka, Timo A.
AU - Gybel-Brask, Dorte
AU - Bustamante, Mariona
AU - Hansen, Torben
AU - Pearson, Ewan R.
AU - Reynolds, Rebecca M.
AU - Ostrowski, Sisse R.
AU - Pennell, Craig E.
AU - Jaddoe, Vincent W.V.
AU - Felix, Janine F.
AU - Hattersley, Andrew T.
AU - Melbye, Mads
AU - Lawlor, Deborah A.
AU - Hveem, Kristian
AU - Werge, Thomas
AU - Nielsen, Henriette Svarre
AU - Magnus, Per
AU - Evans, David M.
AU - Jacobsson, Bo
AU - Järvelin, Marjo Riitta
AU - Zhang, Ge
AU - Hivert, Marie France
AU - Johansson, Stefan
AU - Freathy, Rachel M.
AU - Feenstra, Bjarke
AU - Njølstad, Pål R.
N1 - Publisher Copyright:
© 2023, The Author(s).
PY - 2023
Y1 - 2023
N2 - A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.
AB - A well-functioning placenta is essential for fetal and maternal health throughout pregnancy. Using placental weight as a proxy for placental growth, we report genome-wide association analyses in the fetal (n = 65,405), maternal (n = 61,228) and paternal (n = 52,392) genomes, yielding 40 independent association signals. Twenty-six signals are classified as fetal, four maternal and three fetal and maternal. A maternal parent-of-origin effect is seen near KCNQ1. Genetic correlation and colocalization analyses reveal overlap with birth weight genetics, but 12 loci are classified as predominantly or only affecting placental weight, with connections to placental development and morphology, and transport of antibodies and amino acids. Mendelian randomization analyses indicate that fetal genetically mediated higher placental weight is causally associated with preeclampsia risk and shorter gestational duration. Moreover, these analyses support the role of fetal insulin in regulating placental weight, providing a key link between fetal and placental growth.
U2 - 10.1038/s41588-023-01520-w
DO - 10.1038/s41588-023-01520-w
M3 - Journal article
C2 - 37798380
AN - SCOPUS:85173791824
VL - 55
SP - 1807
EP - 1819
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -
