High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity. / Stinson, Sara E.; Jonsson, Anna E.; Andersen, Mette K.; Lund, Morten A.V.; Holm, Louise Aas; Fonvig, Cilius E.; Huang, Yun; Stankevič, Evelina; Juel, Helene Bæk; Ängquist, Lars; Sørensen, Thorkild I.A.; Ongstad, Emily L.; Gaddipati, Ranjitha; Grimsby, Joseph; Rhodes, Christopher J.; Pedersen, Oluf; Christiansen, Michael; Holm, Jens Christian; Hansen, Torben.

In: Journal of the American Heart Association, Vol. 12, No. 3, e8145, 2023, p. 538-544.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Stinson, SE, Jonsson, AE, Andersen, MK, Lund, MAV, Holm, LA, Fonvig, CE, Huang, Y, Stankevič, E, Juel, HB, Ängquist, L, Sørensen, TIA, Ongstad, EL, Gaddipati, R, Grimsby, J, Rhodes, CJ, Pedersen, O, Christiansen, M, Holm, JC & Hansen, T 2023, 'High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity', Journal of the American Heart Association, vol. 12, no. 3, e8145, pp. 538-544. https://doi.org/10.1161/JAHA.122.027042

APA

Stinson, S. E., Jonsson, A. E., Andersen, M. K., Lund, M. A. V., Holm, L. A., Fonvig, C. E., Huang, Y., Stankevič, E., Juel, H. B., Ängquist, L., Sørensen, T. I. A., Ongstad, E. L., Gaddipati, R., Grimsby, J., Rhodes, C. J., Pedersen, O., Christiansen, M., Holm, J. C., & Hansen, T. (2023). High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity. Journal of the American Heart Association, 12(3), 538-544. [e8145]. https://doi.org/10.1161/JAHA.122.027042

Vancouver

Stinson SE, Jonsson AE, Andersen MK, Lund MAV, Holm LA, Fonvig CE et al. High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity. Journal of the American Heart Association. 2023;12(3):538-544. e8145. https://doi.org/10.1161/JAHA.122.027042

Author

Stinson, Sara E. ; Jonsson, Anna E. ; Andersen, Mette K. ; Lund, Morten A.V. ; Holm, Louise Aas ; Fonvig, Cilius E. ; Huang, Yun ; Stankevič, Evelina ; Juel, Helene Bæk ; Ängquist, Lars ; Sørensen, Thorkild I.A. ; Ongstad, Emily L. ; Gaddipati, Ranjitha ; Grimsby, Joseph ; Rhodes, Christopher J. ; Pedersen, Oluf ; Christiansen, Michael ; Holm, Jens Christian ; Hansen, Torben. / High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity. In: Journal of the American Heart Association. 2023 ; Vol. 12, No. 3. pp. 538-544.

Bibtex

@article{c40a2b802c4945a4958a03e4e08402f5,
title = "High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity",
abstract = "Background Lectin-like oxidized low-density lipoprotein (ox-LDL) receptor-1 is a scavenger receptor for oxidized low-density lipoprotein. In adults, higher soluble lectin-like ox-LDL receptor-1 (sLOX-1) levels are associated with cardiovascular disease, type 2 diabetes, and obesity, but a similar link in pediatric overweight/obesity remains uncertain. Methods and Results Analyses were based on the cross-sectional HOLBAEK Study, including 4- to 19-year-olds from an obesity clinic group with body mass index >90th percentile (n=1815) and from a population-based group (n=2039). Fasting plasma levels of sLOX-1 and inflammatory markers were quantified, cardiometabolic risk profiles were assessed, and linear and logistic regression analyses were performed. Pubertal/postpubertal children and adolescents from the obesity clinic group exhibited higher sLOX-1 levels compared with the population (P<0.001). sLOX-1 positively associated with proinflammatory cytokines, matrix metalloproteinases, body mass index SD score, waist SD score, body fat %, plasma alanine aminotransferase, serum high-sensitivity C-reactive protein, plasma low-density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure SD score, and inversely associated with plasma high-density lipoprotein cholesterol (all P<0.05). sLOX-1 positively associated with high alanine aminotransferase (odds ratio [OR], 1.16, P=4.1 E-04), insulin resistance (OR, 1.16, P=8.6 E-04), dyslipidemia (OR, 1.25, P=1.8 E-07), and hypertension (OR, 1.12, P=0.02). Conclusions sLOX-1 levels were elevated during and after puberty in children and adolescents with overweight/obesity compared with population-based peers and associated with inflammatory markers and worsened cardiometabolic risk profiles. sLOX-1 may serve as an early marker of cardiometabolic risk and inflammation in pediatric overweight/obesity. Registration The HOLBAEK Study, formerly known as The Danish Childhood Obesity Biobank, ClinicalTrials.gov identifier number NCT00928473, https://clinicaltrials.gov/ct2/show/NCT00928473 (registered June 2009).",
keywords = "adolescent, child, obesity, overweight, soluble lectin‐like oxidized low‐density lipoprotein receptor‐1",
author = "Stinson, {Sara E.} and Jonsson, {Anna E.} and Andersen, {Mette K.} and Lund, {Morten A.V.} and Holm, {Louise Aas} and Fonvig, {Cilius E.} and Yun Huang and Evelina Stankevi{\v c} and Juel, {Helene B{\ae}k} and Lars {\"A}ngquist and S{\o}rensen, {Thorkild I.A.} and Ongstad, {Emily L.} and Ranjitha Gaddipati and Joseph Grimsby and Rhodes, {Christopher J.} and Oluf Pedersen and Michael Christiansen and Holm, {Jens Christian} and Torben Hansen",
year = "2023",
doi = "10.1161/JAHA.122.027042",
language = "English",
volume = "12",
pages = "538--544",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "3",

}

RIS

TY - JOUR

T1 - High Plasma Levels of Soluble Lectin-like Oxidized Low-Density Lipoprotein Receptor-1 Are Associated With Inflammation and Cardiometabolic Risk Profiles in Pediatric Overweight and Obesity

AU - Stinson, Sara E.

AU - Jonsson, Anna E.

AU - Andersen, Mette K.

AU - Lund, Morten A.V.

AU - Holm, Louise Aas

AU - Fonvig, Cilius E.

AU - Huang, Yun

AU - Stankevič, Evelina

AU - Juel, Helene Bæk

AU - Ängquist, Lars

AU - Sørensen, Thorkild I.A.

AU - Ongstad, Emily L.

AU - Gaddipati, Ranjitha

AU - Grimsby, Joseph

AU - Rhodes, Christopher J.

AU - Pedersen, Oluf

AU - Christiansen, Michael

AU - Holm, Jens Christian

AU - Hansen, Torben

PY - 2023

Y1 - 2023

N2 - Background Lectin-like oxidized low-density lipoprotein (ox-LDL) receptor-1 is a scavenger receptor for oxidized low-density lipoprotein. In adults, higher soluble lectin-like ox-LDL receptor-1 (sLOX-1) levels are associated with cardiovascular disease, type 2 diabetes, and obesity, but a similar link in pediatric overweight/obesity remains uncertain. Methods and Results Analyses were based on the cross-sectional HOLBAEK Study, including 4- to 19-year-olds from an obesity clinic group with body mass index >90th percentile (n=1815) and from a population-based group (n=2039). Fasting plasma levels of sLOX-1 and inflammatory markers were quantified, cardiometabolic risk profiles were assessed, and linear and logistic regression analyses were performed. Pubertal/postpubertal children and adolescents from the obesity clinic group exhibited higher sLOX-1 levels compared with the population (P<0.001). sLOX-1 positively associated with proinflammatory cytokines, matrix metalloproteinases, body mass index SD score, waist SD score, body fat %, plasma alanine aminotransferase, serum high-sensitivity C-reactive protein, plasma low-density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure SD score, and inversely associated with plasma high-density lipoprotein cholesterol (all P<0.05). sLOX-1 positively associated with high alanine aminotransferase (odds ratio [OR], 1.16, P=4.1 E-04), insulin resistance (OR, 1.16, P=8.6 E-04), dyslipidemia (OR, 1.25, P=1.8 E-07), and hypertension (OR, 1.12, P=0.02). Conclusions sLOX-1 levels were elevated during and after puberty in children and adolescents with overweight/obesity compared with population-based peers and associated with inflammatory markers and worsened cardiometabolic risk profiles. sLOX-1 may serve as an early marker of cardiometabolic risk and inflammation in pediatric overweight/obesity. Registration The HOLBAEK Study, formerly known as The Danish Childhood Obesity Biobank, ClinicalTrials.gov identifier number NCT00928473, https://clinicaltrials.gov/ct2/show/NCT00928473 (registered June 2009).

AB - Background Lectin-like oxidized low-density lipoprotein (ox-LDL) receptor-1 is a scavenger receptor for oxidized low-density lipoprotein. In adults, higher soluble lectin-like ox-LDL receptor-1 (sLOX-1) levels are associated with cardiovascular disease, type 2 diabetes, and obesity, but a similar link in pediatric overweight/obesity remains uncertain. Methods and Results Analyses were based on the cross-sectional HOLBAEK Study, including 4- to 19-year-olds from an obesity clinic group with body mass index >90th percentile (n=1815) and from a population-based group (n=2039). Fasting plasma levels of sLOX-1 and inflammatory markers were quantified, cardiometabolic risk profiles were assessed, and linear and logistic regression analyses were performed. Pubertal/postpubertal children and adolescents from the obesity clinic group exhibited higher sLOX-1 levels compared with the population (P<0.001). sLOX-1 positively associated with proinflammatory cytokines, matrix metalloproteinases, body mass index SD score, waist SD score, body fat %, plasma alanine aminotransferase, serum high-sensitivity C-reactive protein, plasma low-density lipoprotein cholesterol, triglycerides, systolic and diastolic blood pressure SD score, and inversely associated with plasma high-density lipoprotein cholesterol (all P<0.05). sLOX-1 positively associated with high alanine aminotransferase (odds ratio [OR], 1.16, P=4.1 E-04), insulin resistance (OR, 1.16, P=8.6 E-04), dyslipidemia (OR, 1.25, P=1.8 E-07), and hypertension (OR, 1.12, P=0.02). Conclusions sLOX-1 levels were elevated during and after puberty in children and adolescents with overweight/obesity compared with population-based peers and associated with inflammatory markers and worsened cardiometabolic risk profiles. sLOX-1 may serve as an early marker of cardiometabolic risk and inflammation in pediatric overweight/obesity. Registration The HOLBAEK Study, formerly known as The Danish Childhood Obesity Biobank, ClinicalTrials.gov identifier number NCT00928473, https://clinicaltrials.gov/ct2/show/NCT00928473 (registered June 2009).

KW - adolescent

KW - child

KW - obesity

KW - overweight

KW - soluble lectin‐like oxidized low‐density lipoprotein receptor‐1

U2 - 10.1161/JAHA.122.027042

DO - 10.1161/JAHA.122.027042

M3 - Journal article

C2 - 36695299

AN - SCOPUS:85147536246

VL - 12

SP - 538

EP - 544

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 3

M1 - e8145

ER -

ID: 336454294