Standard
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis. / Kanoni, Stavroula; Graham, Sarah E.; Wang, Yuxuan; Surakka, Ida; Ramdas, Shweta; Zhu, Xiang; Clarke, Shoa L.; Bhatti, Konain Fatima; Vedantam, Sailaja; Winkler, Thomas W.; Locke, Adam E.; Marouli, Eirini; Zajac, Greg J.M.; Wu, Kuan Han H.; Ntalla, Ioanna; Hui, Qin; Klarin, Derek; Hilliard, Austin T.; Wang, Zeyuan; Xue, Chao; Thorleifsson, Gudmar; Helgadottir, Anna; Gudbjartsson, Daniel F.; Holm, Hilma; Olafsson, Isleifur; Hwang, Mi Yeong; Han, Sohee; Akiyama, Masato; Sakaue, Saori; Terao, Chikashi; Kanai, Masahiro; Zhou, Wei; Brumpton, Ben M.; Rasheed, Humaira; Havulinna, Aki S.; Veturi, Yogasudha; Pacheco, Jennifer Allen; Rosenthal, Elisabeth A.; Lingren, Todd; Feng, Qi Ping; Kullo, Iftikhar J.; Narita, Akira; Takayama, Jun; Martin, Hilary C.; Hunt, Karen A.; Trivedi, Bhavi; Haessler, Jeffrey; Giulianini, Franco; Bradford, Yuki; Miller, Jason E.; Campbell, Archie; Lin, Kuang; Millwood, Iona Y.; Rasheed, Asif; Hindy, George; Faul, Jessica D.; Zhao, Wei; Weir, David R.; Turman, Constance; Huang, Hongyan; Graff, Mariaelisa; Choudhury, Ananyo; Sengupta, Dhriti; Mahajan, Anubha; Brown, Michael R.; Zhang, Weihua; Yu, Ketian; Schmidt, Ellen M.; Pandit, Anita; Gustafsson, Stefan; Yin, Xianyong; Luan, Jian'an; Zhao, Jing Hua; Matsuda, Fumihiko; Jang, Hye Mi; Yoon, Kyungheon; Medina-Gomez, Carolina; Pitsillides, Achilleas; Hottenga, Jouke Jan; Wood, Andrew R.; Ji, Yingji; Gao, Zishan; Haworth, Simon; Yousri, Noha A.; Mitchell, Ruth E.; Chai, Jin Fang; Aadahl, Mette; Bjerregaard, Anne A.; Yao, Jie; Manichaikul, Ani; Hwu, Chii Min; Hung, Yi Jen; Warren, Helen R.; Ramirez, Julia; Bork-Jensen, Jette; Kårhus, Line L.; Goel, Anuj; Sabater-Lleal, Maria; Noordam, Raymond; Mauro, Pala; Matteo, Floris; McDaid, Aaron F.; Marques-Vidal, Pedro; Wielscher, Matthias; Trompet, Stella; Sattar, Naveed; Møllehave, Line T.; Munz, Matthias; Zeng, Lingyao; Huang, Jianfeng; Yang, Bin; Poveda, Alaitz; Kurbasic, Azra; Lamina, Claudia; Forer, Lukas; Scholz, Markus; Galesloot, Tessel E.; Bradfield, Jonathan P.; Ruotsalainen, Sanni E.; Daw, EWarwick; Zmuda, Joseph M.; Mitchell, Jonathan S.; Fuchsberger, Christian; Christensen, Henry; Brody, Jennifer A.; Vazquez-Moreno, Miguel; Feitosa, Mary F.; Wojczynski, Mary K.; Wang, Zhe; Preuss, Michael H.; Mangino, Massimo; Christofidou, Paraskevi; Verweij, Niek; Benjamins, Jan W.; Engmann, Jorgen; Tsao, Noah L.; Verma, Anurag; Slieker, Roderick C.; Lo, Ken Sin; Zilhao, Nuno R.; Le, Phuong; Kleber, Marcus E.; Delgado, Graciela E.; Huo, Shaofeng; Ikeda, Daisuke D.; Iha, Hiroyuki; Yang, Jian; Liu, Jun; Demirkan, Ayşe; Leonard, Hampton L.; Marten, Jonathan; Frank, Mirjam; Schmidt, Börge; Smyth, Laura J.; Cañadas-Garre, Marisa; Wang, Chaolong; Nakatochi, Masahiro; Wong, Andrew; Hutri-Kähönen, Nina; Sim, Xueling; Xia, Rui; Huerta-Chagoya, Alicia; Fernandez-Lopez, Juan Carlos; Lyssenko, Valeriya; Nongmaithem, Suraj S.; Bayyana, Swati; Stringham, Heather M.; Irvin, Marguerite R.; Oldmeadow, Christopher; Kim, Han Na; Ryu, Seungho; Timmers, Paul R.H.J.; Arbeeva, Liubov; Dorajoo, Rajkumar; Lange, Leslie A.; Prasad, Gauri; Lorés-Motta, Laura; Pauper, Marc; Long, Jirong; Li, Xiaohui; Theusch, Elizabeth; Takeuchi, Fumihiko; Spracklen, Cassandra N.; Loukola, Anu; Bollepalli, Sailalitha; Warner, Sophie C.; Wang, Ya Xing; Wei, Wen B.; Nutile, Teresa; Ruggiero, Daniela; Sung, Yun Ju; Chen, Shufeng; Liu, Fangchao; Yang, Jingyun; Kentistou, Katherine A.; Banas, Bernhard; Nardone, Giuseppe Giovanni; Meidtner, Karina; Bielak, Lawrence F.; Smith, Jennifer A.; Hebbar, Prashantha; Farmaki, Aliki Eleni; Hofer, Edith; Lin, Maoxuan; Concas, Maria Pina; Vaccargiu, Simona; van der Most, Peter J.; Pitkänen, Niina; Cade, Brian E.; van der Laan, Sander W.; Chitrala, Kumaraswamy Naidu; Weiss, Stefan; Bentley, Amy R.; Doumatey, Ayo P.; Adeyemo, Adebowale A.; Lee, Jong Young; Petersen, Eva R.B.; Nielsen, Aneta A.; Choi, Hyeok Sun; Nethander, Maria; Freitag-Wolf, Sandra; Southam, Lorraine; Rayner, Nigel W.; Wang, Carol A.; Lin, Shih Yi; Wang, Jun Sing; Couture, Christian; Lyytikäinen, Leo Pekka; Nikus, Kjell; Cuellar-Partida, Gabriel; Vestergaard, Henrik; Hidalgo, Bertha; Giannakopoulou, Olga; Cai, Qiuyin; Obura, Morgan O.; van Setten, Jessica; Li, Xiaoyin; Liang, Jingjing; Tang, Hua; Terzikhan, Natalie; Shin, Jae Hun; Jackson, Rebecca D.; Reiner, Alexander P.; Martin, Lisa Warsinger; Chen, Zhengming; Li, Liming; Kawaguchi, Takahisa; Thiery, Joachim; Bis, Joshua C.; Launer, Lenore J.; Li, Huaixing; Nalls, Mike A.; Raitakari, Olli T.; Ichihara, Sahoko; Wild, Sarah H.; Nelson, Christopher P.; Campbell, Harry; Jäger, Susanne; Nabika, Toru; Al-Mulla, Fahd; Niinikoski, Harri; Braund, Peter S.; Kolcic, Ivana; Kovacs, Peter; Giardoglou, Tota; Katsuya, Tomohiro; de Kleijn, Dominique; de Borst, Gert J.; Kim, Eung Kweon; Adams, Hieab H.H.; Ikram, M. Arfan; Zhu, Xiaofeng; Asselbergs, Folkert W.; Kraaijeveld, Adriaan O.; Beulens, Joline W.J.; Shu, Xiao Ou; Rallidis, Loukianos S.; Pedersen, Oluf; Hansen, Torben; Mitchell, Paul; Hewitt, Alex W.; Kähönen, Mika; Pérusse, Louis; Bouchard, Claude; Tönjes, Anke; Chen, Yii Der Ida; Pennell, Craig E.; Mori, Trevor A.; Lieb, Wolfgang; Franke, Andre; Ohlsson, Claes; Mellström, Dan; Cho, Yoon Shin; Lee, Hyejin; Yuan, Jian Min; Koh, Woon Puay; Rhee, Sang Youl; Woo, Jeong Taek; Heid, Iris M.; Stark, Klaus J.; Zimmermann, Martina E.; Völzke, Henry; Homuth, Georg; Evans, Michele K.; Zonderman, Alan B.; Polasek, Ozren; Pasterkamp, Gerard; Hoefer, Imo E.; Redline, Susan; Pahkala, Katja; Oldehinkel, Albertine J.; Snieder, Harold; Biino, Ginevra; Schmidt, Reinhold; Schmidt, Helena; Bandinelli, Stefania; Dedoussis, George; Thanaraj, Thangavel Alphonse; Kardia, Sharon L.R.; Peyser, Patricia A.; Kato, Norihiro; Schulze, Matthias B.; Girotto, Giorgia; Böger, Carsten A.; Jung, Bettina; Joshi, Peter K.; Bennett, David A.; De Jager, Philip L.; Lu, Xiangfeng; Mamakou, Vasiliki; Brown, Morris; Caulfield, Mark J.; Munroe, Patricia B.; Guo, Xiuqing; Ciullo, Marina; Jonas, Jost B.; Samani, Nilesh J.; Kaprio, Jaakko; Pajukanta, Päivi; Tusié-Luna, Teresa; Aguilar-Salinas, Carlos A.; Adair, Linda S.; Bechayda, Sonny Augustin; de Silva, H. Janaka; Wickremasinghe, Ananda R.; Krauss, Ronald M.; Wu, Jer Yuarn; Zheng, Wei; Hollander, Anneke Iden; Bharadwaj, Dwaipayan; Correa, Adolfo; Wilson, James G.; Lind, Lars; Heng, Chew Kiat; Nelson, Amanda E.; Golightly, Yvonne M.; Wilson, James F.; Penninx, Brenda; Kim, Hyung Lae; Attia, John; Scott, Rodney J.; Rao, D. C.; Arnett, Donna K.; Hunt, Steven C.; Walker, Mark; Koistinen, Heikki A.; Chandak, Giriraj R.; Mercader, Josep M.; Costanzo, Maria C.; Jang, Dongkeun; Burtt, Noël P.; Villalpando, Clicerio Gonzalez; Orozco, Lorena; Fornage, Myriam; Tai, EShyong; van Dam, Rob M.; Lehtimäki, Terho; Chaturvedi, Nish; Yokota, Mitsuhiro; Liu, Jianjun; Reilly, Dermot F.; McKnight, Amy Jayne; Kee, Frank; Jöckel, Karl Heinz; McCarthy, Mark I.; Palmer, Colin N.A.; Vitart, Veronique; Hayward, Caroline; Simonsick, Eleanor; van Duijn, Cornelia M.; Jin, Zi Bing; Qu, Jia; Hishigaki, Haretsugu; Lin, Xu; März, Winfried; Gudnason, Vilmundur; Tardif, Jean Claude; Lettre, Guillaume; Hart, Leen M.t.; Elders, Petra J.M.; Damrauer, Scott M.; Kumari, Meena; Kivimaki, Mika; van der Harst, Pim; Spector, Tim D.; Loos, Ruth J.F.; Province, Michael A.; Parra, Esteban J.; Cruz, Miguel; Psaty, Bruce M.; Brandslund, Ivan; Pramstaller, Peter P.; Rotimi, Charles N.; Christensen, Kaare; Ripatti, Samuli; Widén, Elisabeth; Hakonarson, Hakon; Grant, Struan F.A.; Kiemeney, Lambertus A.L.M.; de Graaf, Jacqueline; Loeffler, Markus; Kronenberg, Florian; Gu, Dongfeng; Erdmann, Jeanette; Schunkert, Heribert; Franks, Paul W.; Linneberg, Allan; Jukema, J. Wouter; Khera, Amit V.; Männikkö, Minna; Jarvelin, Marjo Riitta; Kutalik, Zoltan; Francesco, Cucca; Mook-Kanamori, Dennis O.; van Dijk, Ko Willems; Watkins, Hugh; Strachan, David P.; Grarup, Niels; Sever, Peter; Poulter, Neil; Chuang, Lee Ming; Rotter, Jerome I.; Dantoft, Thomas M.; Karpe, Fredrik; Neville, Matt J.; Timpson, Nicholas J.; Cheng, Ching Yu; Wong, Tien Yin; Khor, Chiea Chuen; Li, Hengtong; Sabanayagam, Charumathi; Peters, Annette; Gieger, Christian; Hattersley, Andrew T.; Pedersen, Nancy L.; Magnusson, Patrik K.E.; Boomsma, Dorret I.; Willemsen, Allegonda H.M.; Cupples, LAdrienne; van Meurs, Joyce B.J.; Ghanbari, Mohsen; Gordon-Larsen, Penny; Huang, Wei; Kim, Young Jin; Tabara, Yasuharu; Wareham, Nicholas J.; Langenberg, Claudia; Zeggini, Eleftheria; Kuusisto, Johanna; Laakso, Markku; Ingelsson, Erik; Abecasis, Goncalo; Chambers, John C.; Kooner, Jaspal S.; de Vries, Paul S.; Morrison, Alanna C.; Hazelhurst, Scott; Ramsay, Michèle; North, Kari E.; Daviglus, Martha; Kraft, Peter; Martin, Nicholas G.; Whitfield, John B.; Abbas, Shahid; Saleheen, Danish; Walters, Robin G.; Holmes, Michael V.; Black, Corri; Smith, Blair H.; Baras, Aris; Justice, Anne E.; Buring, Julie E.; Ridker, Paul M.; Chasman, Daniel I.; Kooperberg, Charles; Tamiya, Gen; Yamamoto, Masayuki; van Heel, David A.; Trembath, Richard C.; Wei, Wei Qi; Jarvik, Gail P.; Namjou, Bahram; Hayes, M. Geoffrey; Ritchie, Marylyn D.; Jousilahti, Pekka; Salomaa, Veikko; Hveem, Kristian; Åsvold, Bjørn Olav; Kubo, Michiaki; Kamatani, Yoichiro; Okada, Yukinori; Murakami, Yoshinori; Kim, Bong Jo; Thorsteinsdottir, Unnur; Stefansson, Kari; Zhang, Jifeng; Chen, YEugene; Ho, Yuk Lam; Lynch, Julie A.; Rader, Daniel J.; Tsao, Philip S.; Chang, Kyong Mi; Cho, Kelly; O'Donnell, Christopher J.; Gaziano, John M.; Wilson, Peter W.F.; Frayling, Timothy M.; Hirschhorn, Joel N.; Kathiresan, Sekar; Mohlke, Karen L.; Sun, Yan V.; Morris, Andrew P.; Boehnke, Michael; Brown, Christopher D.; Natarajan, Pradeep; Deloukas, Panos; Willer, Cristen J.; Assimes, Themistocles L.; Peloso, Gina M.
In:
Genome Biology, Vol. 23, No. 1, 268, 2022.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Kanoni, S, Graham, SE, Wang, Y, Surakka, I, Ramdas, S, Zhu, X, Clarke, SL, Bhatti, KF, Vedantam, S, Winkler, TW, Locke, AE, Marouli, E, Zajac, GJM, Wu, KHH, Ntalla, I, Hui, Q, Klarin, D, Hilliard, AT, Wang, Z, Xue, C, Thorleifsson, G, Helgadottir, A, Gudbjartsson, DF, Holm, H, Olafsson, I, Hwang, MY, Han, S, Akiyama, M, Sakaue, S, Terao, C, Kanai, M, Zhou, W, Brumpton, BM, Rasheed, H, Havulinna, AS, Veturi, Y, Pacheco, JA, Rosenthal, EA, Lingren, T, Feng, QP, Kullo, IJ, Narita, A, Takayama, J, Martin, HC, Hunt, KA, Trivedi, B, Haessler, J, Giulianini, F, Bradford, Y, Miller, JE, Campbell, A, Lin, K, Millwood, IY, Rasheed, A, Hindy, G, Faul, JD, Zhao, W, Weir, DR, Turman, C, Huang, H, Graff, M, Choudhury, A, Sengupta, D, Mahajan, A, Brown, MR, Zhang, W, Yu, K, Schmidt, EM, Pandit, A, Gustafsson, S, Yin, X, Luan, J, Zhao, JH, Matsuda, F, Jang, HM, Yoon, K, Medina-Gomez, C, Pitsillides, A, Hottenga, JJ, Wood, AR, Ji, Y, Gao, Z, Haworth, S, Yousri, NA, Mitchell, RE, Chai, JF
, Aadahl, M, Bjerregaard, AA, Yao, J, Manichaikul, A, Hwu, CM, Hung, YJ, Warren, HR, Ramirez, J, Bork-Jensen, J, Kårhus, LL, Goel, A, Sabater-Lleal, M, Noordam, R, Mauro, P, Matteo, F, McDaid, AF, Marques-Vidal, P, Wielscher, M, Trompet, S, Sattar, N, Møllehave, LT, Munz, M, Zeng, L, Huang, J, Yang, B, Poveda, A, Kurbasic, A, Lamina, C, Forer, L, Scholz, M, Galesloot, TE, Bradfield, JP, Ruotsalainen, SE, Daw, EW, Zmuda, JM, Mitchell, JS, Fuchsberger, C, Christensen, H, Brody, JA, Vazquez-Moreno, M, Feitosa, MF, Wojczynski, MK, Wang, Z, Preuss, MH, Mangino, M, Christofidou, P, Verweij, N, Benjamins, JW, Engmann, J, Tsao, NL, Verma, A, Slieker, RC, Lo, KS, Zilhao, NR, Le, P, Kleber, ME, Delgado, GE, Huo, S, Ikeda, DD, Iha, H, Yang, J, Liu, J, Demirkan, A, Leonard, HL, Marten, J, Frank, M, Schmidt, B, Smyth, LJ, Cañadas-Garre, M, Wang, C, Nakatochi, M, Wong, A, Hutri-Kähönen, N, Sim, X, Xia, R, Huerta-Chagoya, A, Fernandez-Lopez, JC, Lyssenko, V, Nongmaithem, SS, Bayyana, S, Stringham, HM, Irvin, MR, Oldmeadow, C, Kim, HN, Ryu, S, Timmers, PRHJ, Arbeeva, L, Dorajoo, R, Lange, LA, Prasad, G, Lorés-Motta, L, Pauper, M, Long, J, Li, X, Theusch, E, Takeuchi, F, Spracklen, CN, Loukola, A, Bollepalli, S, Warner, SC, Wang, YX, Wei, WB, Nutile, T, Ruggiero, D, Sung, YJ, Chen, S, Liu, F, Yang, J, Kentistou, KA, Banas, B, Nardone, GG, Meidtner, K, Bielak, LF, Smith, JA, Hebbar, P, Farmaki, AE, Hofer, E, Lin, M, Concas, MP, Vaccargiu, S, van der Most, PJ, Pitkänen, N, Cade, BE, van der Laan, SW, Chitrala, KN, Weiss, S, Bentley, AR, Doumatey, AP, Adeyemo, AA, Lee, JY, Petersen, ERB, Nielsen, AA, Choi, HS, Nethander, M, Freitag-Wolf, S, Southam, L, Rayner, NW, Wang, CA, Lin, SY, Wang, JS, Couture, C, Lyytikäinen, LP, Nikus, K, Cuellar-Partida, G, Vestergaard, H, Hidalgo, B, Giannakopoulou, O, Cai, Q, Obura, MO, van Setten, J, Li, X, Liang, J, Tang, H, Terzikhan, N, Shin, JH, Jackson, RD, Reiner, AP, Martin, LW, Chen, Z, Li, L, Kawaguchi, T, Thiery, J, Bis, JC, Launer, LJ, Li, H, Nalls, MA, Raitakari, OT, Ichihara, S, Wild, SH, Nelson, CP, Campbell, H, Jäger, S, Nabika, T, Al-Mulla, F, Niinikoski, H, Braund, PS, Kolcic, I, Kovacs, P, Giardoglou, T, Katsuya, T, de Kleijn, D, de Borst, GJ, Kim, EK, Adams, HHH, Ikram, MA, Zhu, X, Asselbergs, FW, Kraaijeveld, AO, Beulens, JWJ, Shu, XO, Rallidis, LS
, Pedersen, O, Hansen, T, Mitchell, P, Hewitt, AW, Kähönen, M, Pérusse, L, Bouchard, C, Tönjes, A, Chen, YDI, Pennell, CE, Mori, TA, Lieb, W, Franke, A, Ohlsson, C, Mellström, D, Cho, YS, Lee, H, Yuan, JM, Koh, WP, Rhee, SY, Woo, JT, Heid, IM, Stark, KJ, Zimmermann, ME, Völzke, H, Homuth, G, Evans, MK, Zonderman, AB, Polasek, O, Pasterkamp, G, Hoefer, IE, Redline, S, Pahkala, K, Oldehinkel, AJ, Snieder, H, Biino, G, Schmidt, R, Schmidt, H, Bandinelli, S, Dedoussis, G, Thanaraj, TA, Kardia, SLR, Peyser, PA, Kato, N, Schulze, MB, Girotto, G, Böger, CA, Jung, B, Joshi, PK, Bennett, DA, De Jager, PL, Lu, X, Mamakou, V, Brown, M, Caulfield, MJ, Munroe, PB, Guo, X, Ciullo, M, Jonas, JB, Samani, NJ, Kaprio, J, Pajukanta, P, Tusié-Luna, T, Aguilar-Salinas, CA, Adair, LS, Bechayda, SA, de Silva, HJ, Wickremasinghe, AR, Krauss, RM, Wu, JY, Zheng, W, Hollander, AI, Bharadwaj, D, Correa, A, Wilson, JG, Lind, L, Heng, CK, Nelson, AE, Golightly, YM, Wilson, JF, Penninx, B, Kim, HL, Attia, J, Scott, RJ, Rao, DC, Arnett, DK, Hunt, SC, Walker, M, Koistinen, HA, Chandak, GR, Mercader, JM, Costanzo, MC, Jang, D, Burtt, NP, Villalpando, CG, Orozco, L, Fornage, M, Tai, ES, van Dam, RM, Lehtimäki, T, Chaturvedi, N, Yokota, M, Liu, J, Reilly, DF, McKnight, AJ, Kee, F, Jöckel, KH, McCarthy, MI, Palmer, CNA, Vitart, V, Hayward, C, Simonsick, E, van Duijn, CM, Jin, ZB, Qu, J, Hishigaki, H, Lin, X, März, W, Gudnason, V, Tardif, JC, Lettre, G, Hart, LMT, Elders, PJM, Damrauer, SM, Kumari, M, Kivimaki, M, van der Harst, P, Spector, TD
, Loos, RJF, Province, MA, Parra, EJ, Cruz, M, Psaty, BM, Brandslund, I, Pramstaller, PP, Rotimi, CN, Christensen, K, Ripatti, S, Widén, E, Hakonarson, H, Grant, SFA, Kiemeney, LALM, de Graaf, J, Loeffler, M, Kronenberg, F, Gu, D, Erdmann, J, Schunkert, H, Franks, PW
, Linneberg, A, Jukema, JW, Khera, AV, Männikkö, M, Jarvelin, MR, Kutalik, Z, Francesco, C, Mook-Kanamori, DO, van Dijk, KW, Watkins, H, Strachan, DP
, Grarup, N, Sever, P, Poulter, N, Chuang, LM, Rotter, JI, Dantoft, TM, Karpe, F, Neville, MJ, Timpson, NJ, Cheng, CY, Wong, TY, Khor, CC, Li, H, Sabanayagam, C, Peters, A, Gieger, C, Hattersley, AT, Pedersen, NL, Magnusson, PKE, Boomsma, DI, Willemsen, AHM, Cupples, LA, van Meurs, JBJ, Ghanbari, M, Gordon-Larsen, P, Huang, W, Kim, YJ, Tabara, Y, Wareham, NJ, Langenberg, C, Zeggini, E, Kuusisto, J, Laakso, M, Ingelsson, E, Abecasis, G, Chambers, JC, Kooner, JS, de Vries, PS, Morrison, AC, Hazelhurst, S, Ramsay, M, North, KE, Daviglus, M, Kraft, P, Martin, NG, Whitfield, JB, Abbas, S, Saleheen, D, Walters, RG, Holmes, MV, Black, C, Smith, BH, Baras, A, Justice, AE, Buring, JE, Ridker, PM, Chasman, DI, Kooperberg, C, Tamiya, G, Yamamoto, M, van Heel, DA, Trembath, RC, Wei, WQ, Jarvik, GP, Namjou, B, Hayes, MG, Ritchie, MD, Jousilahti, P, Salomaa, V, Hveem, K, Åsvold, BO, Kubo, M, Kamatani, Y, Okada, Y, Murakami, Y, Kim, BJ, Thorsteinsdottir, U, Stefansson, K, Zhang, J, Chen, YE, Ho, YL, Lynch, JA, Rader, DJ, Tsao, PS, Chang, KM, Cho, K, O'Donnell, CJ, Gaziano, JM, Wilson, PWF, Frayling, TM, Hirschhorn, JN, Kathiresan, S, Mohlke, KL, Sun, YV, Morris, AP, Boehnke, M, Brown, CD, Natarajan, P, Deloukas, P, Willer, CJ, Assimes, TL & Peloso, GM 2022, '
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis',
Genome Biology, vol. 23, no. 1, 268.
https://doi.org/10.1186/s13059-022-02837-1APA
Kanoni, S., Graham, S. E., Wang, Y., Surakka, I., Ramdas, S., Zhu, X., Clarke, S. L., Bhatti, K. F., Vedantam, S., Winkler, T. W., Locke, A. E., Marouli, E., Zajac, G. J. M., Wu, K. H. H., Ntalla, I., Hui, Q., Klarin, D., Hilliard, A. T., Wang, Z., ... Peloso, G. M. (2022).
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Genome Biology,
23(1), [268].
https://doi.org/10.1186/s13059-022-02837-1Vancouver
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X et al.
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis.
Genome Biology. 2022;23(1). 268.
https://doi.org/10.1186/s13059-022-02837-1Author
Kanoni, Stavroula ; Graham, Sarah E. ; Wang, Yuxuan ; Surakka, Ida ; Ramdas, Shweta ; Zhu, Xiang ; Clarke, Shoa L. ; Bhatti, Konain Fatima ; Vedantam, Sailaja ; Winkler, Thomas W. ; Locke, Adam E. ; Marouli, Eirini ; Zajac, Greg J.M. ; Wu, Kuan Han H. ; Ntalla, Ioanna ; Hui, Qin ; Klarin, Derek ; Hilliard, Austin T. ; Wang, Zeyuan ; Xue, Chao ; Thorleifsson, Gudmar ; Helgadottir, Anna ; Gudbjartsson, Daniel F. ; Holm, Hilma ; Olafsson, Isleifur ; Hwang, Mi Yeong ; Han, Sohee ; Akiyama, Masato ; Sakaue, Saori ; Terao, Chikashi ; Kanai, Masahiro ; Zhou, Wei ; Brumpton, Ben M. ; Rasheed, Humaira ; Havulinna, Aki S. ; Veturi, Yogasudha ; Pacheco, Jennifer Allen ; Rosenthal, Elisabeth A. ; Lingren, Todd ; Feng, Qi Ping ; Kullo, Iftikhar J. ; Narita, Akira ; Takayama, Jun ; Martin, Hilary C. ; Hunt, Karen A. ; Trivedi, Bhavi ; Haessler, Jeffrey ; Giulianini, Franco ; Bradford, Yuki ; Miller, Jason E. ; Campbell, Archie ; Lin, Kuang ; Millwood, Iona Y. ; Rasheed, Asif ; Hindy, George ; Faul, Jessica D. ; Zhao, Wei ; Weir, David R. ; Turman, Constance ; Huang, Hongyan ; Graff, Mariaelisa ; Choudhury, Ananyo ; Sengupta, Dhriti ; Mahajan, Anubha ; Brown, Michael R. ; Zhang, Weihua ; Yu, Ketian ; Schmidt, Ellen M. ; Pandit, Anita ; Gustafsson, Stefan ; Yin, Xianyong ; Luan, Jian'an ; Zhao, Jing Hua ; Matsuda, Fumihiko ; Jang, Hye Mi ; Yoon, Kyungheon ; Medina-Gomez, Carolina ; Pitsillides, Achilleas ; Hottenga, Jouke Jan ; Wood, Andrew R. ; Ji, Yingji ; Gao, Zishan ; Haworth, Simon ; Yousri, Noha A. ; Mitchell, Ruth E. ; Chai, Jin Fang ; Aadahl, Mette ; Bjerregaard, Anne A. ; Yao, Jie ; Manichaikul, Ani ; Hwu, Chii Min ; Hung, Yi Jen ; Warren, Helen R. ; Ramirez, Julia ; Bork-Jensen, Jette ; Kårhus, Line L. ; Goel, Anuj ; Sabater-Lleal, Maria ; Noordam, Raymond ; Mauro, Pala ; Matteo, Floris ; McDaid, Aaron F. ; Marques-Vidal, Pedro ; Wielscher, Matthias ; Trompet, Stella ; Sattar, Naveed ; Møllehave, Line T. ; Munz, Matthias ; Zeng, Lingyao ; Huang, Jianfeng ; Yang, Bin ; Poveda, Alaitz ; Kurbasic, Azra ; Lamina, Claudia ; Forer, Lukas ; Scholz, Markus ; Galesloot, Tessel E. ; Bradfield, Jonathan P. ; Ruotsalainen, Sanni E. ; Daw, EWarwick ; Zmuda, Joseph M. ; Mitchell, Jonathan S. ; Fuchsberger, Christian ; Christensen, Henry ; Brody, Jennifer A. ; Vazquez-Moreno, Miguel ; Feitosa, Mary F. ; Wojczynski, Mary K. ; Wang, Zhe ; Preuss, Michael H. ; Mangino, Massimo ; Christofidou, Paraskevi ; Verweij, Niek ; Benjamins, Jan W. ; Engmann, Jorgen ; Tsao, Noah L. ; Verma, Anurag ; Slieker, Roderick C. ; Lo, Ken Sin ; Zilhao, Nuno R. ; Le, Phuong ; Kleber, Marcus E. ; Delgado, Graciela E. ; Huo, Shaofeng ; Ikeda, Daisuke D. ; Iha, Hiroyuki ; Yang, Jian ; Liu, Jun ; Demirkan, Ayşe ; Leonard, Hampton L. ; Marten, Jonathan ; Frank, Mirjam ; Schmidt, Börge ; Smyth, Laura J. ; Cañadas-Garre, Marisa ; Wang, Chaolong ; Nakatochi, Masahiro ; Wong, Andrew ; Hutri-Kähönen, Nina ; Sim, Xueling ; Xia, Rui ; Huerta-Chagoya, Alicia ; Fernandez-Lopez, Juan Carlos ; Lyssenko, Valeriya ; Nongmaithem, Suraj S. ; 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Bibtex
@article{e7bba4777adc4e319042ab6d9ff0d9a2,
title = "Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis",
abstract = "BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. RESULTS: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. CONCLUSIONS: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.",
keywords = "Cholesterol, Genetics, Genome-wide association study, GWAS, Lipids",
author = "Stavroula Kanoni and Graham, {Sarah E.} and Yuxuan Wang and Ida Surakka and Shweta Ramdas and Xiang Zhu and Clarke, {Shoa L.} and Bhatti, {Konain Fatima} and Sailaja Vedantam and Winkler, {Thomas W.} and Locke, {Adam E.} and Eirini Marouli and Zajac, {Greg J.M.} and Wu, {Kuan Han H.} and Ioanna Ntalla and Qin Hui and Derek Klarin and Hilliard, {Austin T.} and Zeyuan Wang and Chao Xue and Gudmar Thorleifsson and Anna Helgadottir and Gudbjartsson, {Daniel F.} and Hilma Holm and Isleifur Olafsson and Hwang, {Mi Yeong} and Sohee Han and Masato Akiyama and Saori Sakaue and Chikashi Terao and Masahiro Kanai and Wei Zhou and Brumpton, {Ben M.} and Humaira Rasheed and Havulinna, {Aki S.} and Yogasudha Veturi and Pacheco, {Jennifer Allen} and Rosenthal, {Elisabeth A.} and Todd Lingren and Feng, {Qi Ping} and Kullo, {Iftikhar J.} and Akira Narita and Jun Takayama and Martin, {Hilary C.} and Hunt, {Karen A.} and Bhavi Trivedi and Jeffrey Haessler and Franco Giulianini and Yuki Bradford and Miller, {Jason E.} and Archie Campbell and Kuang Lin and Millwood, {Iona Y.} and Asif Rasheed and George Hindy and Faul, {Jessica D.} and Wei Zhao and Weir, {David R.} and Constance Turman and Hongyan Huang and Mariaelisa Graff and Ananyo Choudhury and Dhriti Sengupta and Anubha Mahajan and Brown, {Michael R.} and Weihua Zhang and Ketian Yu and Schmidt, {Ellen M.} and Anita Pandit and Stefan Gustafsson and Xianyong Yin and Jian'an Luan and Zhao, {Jing Hua} and Fumihiko Matsuda and Jang, {Hye Mi} and Kyungheon Yoon and Carolina Medina-Gomez and Achilleas Pitsillides and Hottenga, {Jouke Jan} and Wood, {Andrew R.} and Yingji Ji and Zishan Gao and Simon Haworth and Yousri, {Noha A.} and Mitchell, {Ruth E.} and Chai, {Jin Fang} and Mette Aadahl and Bjerregaard, {Anne A.} and Jie Yao and Ani Manichaikul and Hwu, {Chii Min} and Hung, {Yi Jen} and Warren, {Helen R.} and Julia Ramirez and Jette Bork-Jensen and K{\aa}rhus, {Line L.} and Anuj Goel and Maria Sabater-Lleal and Raymond Noordam and Pala Mauro and Floris Matteo and McDaid, {Aaron F.} and Pedro Marques-Vidal and Matthias Wielscher and Stella Trompet and Naveed Sattar and M{\o}llehave, {Line T.} and Matthias Munz and Lingyao Zeng and Jianfeng Huang and Bin Yang and Alaitz Poveda and Azra Kurbasic and Claudia Lamina and Lukas Forer and Markus Scholz and Galesloot, {Tessel E.} and Bradfield, {Jonathan P.} and Ruotsalainen, {Sanni E.} and EWarwick Daw and Zmuda, {Joseph M.} and Mitchell, {Jonathan S.} and Christian Fuchsberger and Henry Christensen and Brody, {Jennifer A.} and Miguel Vazquez-Moreno and Feitosa, {Mary F.} and Wojczynski, {Mary K.} and Zhe Wang and Preuss, {Michael H.} and Massimo Mangino and Paraskevi Christofidou and Niek Verweij and Benjamins, {Jan W.} and Jorgen Engmann and Tsao, {Noah L.} and Anurag Verma and Slieker, {Roderick C.} and Lo, {Ken Sin} and Zilhao, {Nuno R.} and Phuong Le and Kleber, {Marcus E.} and Delgado, {Graciela E.} and Shaofeng Huo and Ikeda, {Daisuke D.} and Hiroyuki Iha and Jian Yang and Jun Liu and Ay{\c s}e Demirkan and Leonard, {Hampton L.} and Jonathan Marten and Mirjam Frank and B{\"o}rge Schmidt and Smyth, {Laura J.} and Marisa Ca{\~n}adas-Garre and Chaolong Wang and Masahiro Nakatochi and Andrew Wong and Nina Hutri-K{\"a}h{\"o}nen and Xueling Sim and Rui Xia and Alicia Huerta-Chagoya and Fernandez-Lopez, {Juan Carlos} and Valeriya Lyssenko and Nongmaithem, {Suraj S.} and Swati Bayyana and Stringham, {Heather M.} and Irvin, {Marguerite R.} and Christopher Oldmeadow and Kim, {Han Na} and Seungho Ryu and Timmers, {Paul R.H.J.} and Liubov Arbeeva and Rajkumar Dorajoo and Lange, {Leslie A.} and Gauri Prasad and Laura Lor{\'e}s-Motta and Marc Pauper and Jirong Long and Xiaohui Li and Elizabeth Theusch and Fumihiko Takeuchi and Spracklen, {Cassandra N.} and Anu Loukola and Sailalitha Bollepalli and Warner, {Sophie C.} and Wang, {Ya Xing} and Wei, {Wen B.} and Teresa Nutile and Daniela Ruggiero and Sung, {Yun Ju} and Shufeng Chen and Fangchao Liu and Jingyun Yang and Kentistou, {Katherine A.} and Bernhard Banas and Nardone, {Giuseppe Giovanni} and Karina Meidtner and Bielak, {Lawrence F.} and Smith, {Jennifer A.} and Prashantha Hebbar and Farmaki, {Aliki Eleni} and Edith Hofer and Maoxuan Lin and Concas, {Maria Pina} and Simona Vaccargiu and {van der Most}, {Peter J.} and Niina Pitk{\"a}nen and Cade, {Brian E.} and {van der Laan}, {Sander W.} and Chitrala, {Kumaraswamy Naidu} and Stefan Weiss and Bentley, {Amy R.} and Doumatey, {Ayo P.} and Adeyemo, {Adebowale A.} and Lee, {Jong Young} and Petersen, {Eva R.B.} and Nielsen, {Aneta A.} and Choi, {Hyeok Sun} and Maria Nethander and Sandra Freitag-Wolf and Lorraine Southam and Rayner, {Nigel W.} and Wang, {Carol A.} and Lin, {Shih Yi} and Wang, {Jun Sing} and Christian Couture and Lyytik{\"a}inen, {Leo Pekka} and Kjell Nikus and Gabriel Cuellar-Partida and Henrik Vestergaard and Bertha Hidalgo and Olga Giannakopoulou and Qiuyin Cai and Obura, {Morgan O.} and {van Setten}, Jessica and Xiaoyin Li and Jingjing Liang and Hua Tang and Natalie Terzikhan and Shin, {Jae Hun} and Jackson, {Rebecca D.} and Reiner, {Alexander P.} and Martin, {Lisa Warsinger} and Zhengming Chen and Liming Li and Takahisa Kawaguchi and Joachim Thiery and Bis, {Joshua C.} and Launer, {Lenore J.} and Huaixing Li and Nalls, {Mike A.} and Raitakari, {Olli T.} and Sahoko Ichihara and Wild, {Sarah H.} and Nelson, {Christopher P.} and Harry Campbell and Susanne J{\"a}ger and Toru Nabika and Fahd Al-Mulla and Harri Niinikoski and Braund, {Peter S.} and Ivana Kolcic and Peter Kovacs and Tota Giardoglou and Tomohiro Katsuya and {de Kleijn}, Dominique and {de Borst}, {Gert J.} and Kim, {Eung Kweon} and Adams, {Hieab H.H.} and Ikram, {M. Arfan} and Xiaofeng Zhu and Asselbergs, {Folkert W.} and Kraaijeveld, {Adriaan O.} and Beulens, {Joline W.J.} and Shu, {Xiao Ou} and Rallidis, {Loukianos S.} and Oluf Pedersen and Torben Hansen and Paul Mitchell and Hewitt, {Alex W.} and Mika K{\"a}h{\"o}nen and Louis P{\'e}russe and Claude Bouchard and Anke T{\"o}njes and Chen, {Yii Der Ida} and Pennell, {Craig E.} and Mori, {Trevor A.} and Wolfgang Lieb and Andre Franke and Claes Ohlsson and Dan Mellstr{\"o}m and Cho, {Yoon Shin} and Hyejin Lee and Yuan, {Jian Min} and Koh, {Woon Puay} and Rhee, {Sang Youl} and Woo, {Jeong Taek} and Heid, {Iris M.} and Stark, {Klaus J.} and Zimmermann, {Martina E.} and Henry V{\"o}lzke and Georg Homuth and Evans, {Michele K.} and Zonderman, {Alan B.} and Ozren Polasek and Gerard Pasterkamp and Hoefer, {Imo E.} and Susan Redline and Katja Pahkala and Oldehinkel, {Albertine J.} and Harold Snieder and Ginevra Biino and Reinhold Schmidt and Helena Schmidt and Stefania Bandinelli and George Dedoussis and Thanaraj, {Thangavel Alphonse} and Kardia, {Sharon L.R.} and Peyser, {Patricia A.} and Norihiro Kato and Schulze, {Matthias B.} and Giorgia Girotto and B{\"o}ger, {Carsten A.} and Bettina Jung and Joshi, {Peter K.} and Bennett, {David A.} and {De Jager}, {Philip L.} and Xiangfeng Lu and Vasiliki Mamakou and Morris Brown and Caulfield, {Mark J.} and Munroe, {Patricia B.} and Xiuqing Guo and Marina Ciullo and Jonas, {Jost B.} and Samani, {Nilesh J.} and Jaakko Kaprio and P{\"a}ivi Pajukanta and Teresa Tusi{\'e}-Luna and Aguilar-Salinas, {Carlos A.} and Adair, {Linda S.} and Bechayda, {Sonny Augustin} and {de Silva}, {H. Janaka} and Wickremasinghe, {Ananda R.} and Krauss, {Ronald M.} and Wu, {Jer Yuarn} and Wei Zheng and Hollander, {Anneke Iden} and Dwaipayan Bharadwaj and Adolfo Correa and Wilson, {James G.} and Lars Lind and Heng, {Chew Kiat} and Nelson, {Amanda E.} and Golightly, {Yvonne M.} and Wilson, {James F.} and Brenda Penninx and Kim, {Hyung Lae} and John Attia and Scott, {Rodney J.} and Rao, {D. C.} and Arnett, {Donna K.} and Hunt, {Steven C.} and Mark Walker and Koistinen, {Heikki A.} and Chandak, {Giriraj R.} and Mercader, {Josep M.} and Costanzo, {Maria C.} and Dongkeun Jang and Burtt, {No{\"e}l P.} and Villalpando, {Clicerio Gonzalez} and Lorena Orozco and Myriam Fornage and EShyong Tai and {van Dam}, {Rob M.} and Terho Lehtim{\"a}ki and Nish Chaturvedi and Mitsuhiro Yokota and Jianjun Liu and Reilly, {Dermot F.} and McKnight, {Amy Jayne} and Frank Kee and J{\"o}ckel, {Karl Heinz} and McCarthy, {Mark I.} and Palmer, {Colin N.A.} and Veronique Vitart and Caroline Hayward and Eleanor Simonsick and {van Duijn}, {Cornelia M.} and Jin, {Zi Bing} and Jia Qu and Haretsugu Hishigaki and Xu Lin and Winfried M{\"a}rz and Vilmundur Gudnason and Tardif, {Jean Claude} and Guillaume Lettre and Hart, {Leen M.t.} and Elders, {Petra J.M.} and Damrauer, {Scott M.} and Meena Kumari and Mika Kivimaki and {van der Harst}, Pim and Spector, {Tim D.} and Loos, {Ruth J.F.} and Province, {Michael A.} and Parra, {Esteban J.} and Miguel Cruz and Psaty, {Bruce M.} and Ivan Brandslund and Pramstaller, {Peter P.} and Rotimi, {Charles N.} and Kaare Christensen and Samuli Ripatti and Elisabeth Wid{\'e}n and Hakon Hakonarson and Grant, {Struan F.A.} and Kiemeney, {Lambertus A.L.M.} and {de Graaf}, Jacqueline and Markus Loeffler and Florian Kronenberg and Dongfeng Gu and Jeanette Erdmann and Heribert Schunkert and Franks, {Paul W.} and Allan Linneberg and Jukema, {J. Wouter} and Khera, {Amit V.} and Minna M{\"a}nnikk{\"o} and Jarvelin, {Marjo Riitta} and Zoltan Kutalik and Cucca Francesco and Mook-Kanamori, {Dennis O.} and {van Dijk}, {Ko Willems} and Hugh Watkins and Strachan, {David P.} and Niels Grarup and Peter Sever and Neil Poulter and Chuang, {Lee Ming} and Rotter, {Jerome I.} and Dantoft, {Thomas M.} and Fredrik Karpe and Neville, {Matt J.} and Timpson, {Nicholas J.} and Cheng, {Ching Yu} and Wong, {Tien Yin} and Khor, {Chiea Chuen} and Hengtong Li and Charumathi Sabanayagam and Annette Peters and Christian Gieger and Hattersley, {Andrew T.} and Pedersen, {Nancy L.} and Magnusson, {Patrik K.E.} and Boomsma, {Dorret I.} and Willemsen, {Allegonda H.M.} and LAdrienne Cupples and {van Meurs}, {Joyce B.J.} and Mohsen Ghanbari and Penny Gordon-Larsen and Wei Huang and Kim, {Young Jin} and Yasuharu Tabara and Wareham, {Nicholas J.} and Claudia Langenberg and Eleftheria Zeggini and Johanna Kuusisto and Markku Laakso and Erik Ingelsson and Goncalo Abecasis and Chambers, {John C.} and Kooner, {Jaspal S.} and {de Vries}, {Paul S.} and Morrison, {Alanna C.} and Scott Hazelhurst and Mich{\`e}le Ramsay and North, {Kari E.} and Martha Daviglus and Peter Kraft and Martin, {Nicholas G.} and Whitfield, {John B.} and Shahid Abbas and Danish Saleheen and Walters, {Robin G.} and Holmes, {Michael V.} and Corri Black and Smith, {Blair H.} and Aris Baras and Justice, {Anne E.} and Buring, {Julie E.} and Ridker, {Paul M.} and Chasman, {Daniel I.} and Charles Kooperberg and Gen Tamiya and Masayuki Yamamoto and {van Heel}, {David A.} and Trembath, {Richard C.} and Wei, {Wei Qi} and Jarvik, {Gail P.} and Bahram Namjou and Hayes, {M. Geoffrey} and Ritchie, {Marylyn D.} and Pekka Jousilahti and Veikko Salomaa and Kristian Hveem and {\AA}svold, {Bj{\o}rn Olav} and Michiaki Kubo and Yoichiro Kamatani and Yukinori Okada and Yoshinori Murakami and Kim, {Bong Jo} and Unnur Thorsteinsdottir and Kari Stefansson and Jifeng Zhang and YEugene Chen and Ho, {Yuk Lam} and Lynch, {Julie A.} and Rader, {Daniel J.} and Tsao, {Philip S.} and Chang, {Kyong Mi} and Kelly Cho and O'Donnell, {Christopher J.} and Gaziano, {John M.} and Wilson, {Peter W.F.} and Frayling, {Timothy M.} and Hirschhorn, {Joel N.} and Sekar Kathiresan and Mohlke, {Karen L.} and Sun, {Yan V.} and Morris, {Andrew P.} and Michael Boehnke and Brown, {Christopher D.} and Pradeep Natarajan and Panos Deloukas and Willer, {Cristen J.} and Assimes, {Themistocles L.} and Peloso, {Gina M.}",
note = "Publisher Copyright: {\textcopyright} 2022. The Author(s).",
year = "2022",
doi = "10.1186/s13059-022-02837-1",
language = "English",
volume = "23",
journal = "Genome Biology (Online Edition)",
issn = "1474-7596",
publisher = "BioMed Central Ltd.",
number = "1",
}
RIS
TY - JOUR
T1 - Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
AU - Kanoni, Stavroula
AU - Graham, Sarah E.
AU - Wang, Yuxuan
AU - Surakka, Ida
AU - Ramdas, Shweta
AU - Zhu, Xiang
AU - Clarke, Shoa L.
AU - Bhatti, Konain Fatima
AU - Vedantam, Sailaja
AU - Winkler, Thomas W.
AU - Locke, Adam E.
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AU - Wu, Kuan Han H.
AU - Ntalla, Ioanna
AU - Hui, Qin
AU - Klarin, Derek
AU - Hilliard, Austin T.
AU - Wang, Zeyuan
AU - Xue, Chao
AU - Thorleifsson, Gudmar
AU - Helgadottir, Anna
AU - Gudbjartsson, Daniel F.
AU - Holm, Hilma
AU - Olafsson, Isleifur
AU - Hwang, Mi Yeong
AU - Han, Sohee
AU - Akiyama, Masato
AU - Sakaue, Saori
AU - Terao, Chikashi
AU - Kanai, Masahiro
AU - Zhou, Wei
AU - Brumpton, Ben M.
AU - Rasheed, Humaira
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AU - Takayama, Jun
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AU - Hunt, Karen A.
AU - Trivedi, Bhavi
AU - Haessler, Jeffrey
AU - Giulianini, Franco
AU - Bradford, Yuki
AU - Miller, Jason E.
AU - Campbell, Archie
AU - Lin, Kuang
AU - Millwood, Iona Y.
AU - Rasheed, Asif
AU - Hindy, George
AU - Faul, Jessica D.
AU - Zhao, Wei
AU - Weir, David R.
AU - Turman, Constance
AU - Huang, Hongyan
AU - Graff, Mariaelisa
AU - Choudhury, Ananyo
AU - Sengupta, Dhriti
AU - Mahajan, Anubha
AU - Brown, Michael R.
AU - Zhang, Weihua
AU - Yu, Ketian
AU - Schmidt, Ellen M.
AU - Pandit, Anita
AU - Gustafsson, Stefan
AU - Yin, Xianyong
AU - Luan, Jian'an
AU - Zhao, Jing Hua
AU - Matsuda, Fumihiko
AU - Jang, Hye Mi
AU - Yoon, Kyungheon
AU - Medina-Gomez, Carolina
AU - Pitsillides, Achilleas
AU - Hottenga, Jouke Jan
AU - Wood, Andrew R.
AU - Ji, Yingji
AU - Gao, Zishan
AU - Haworth, Simon
AU - Yousri, Noha A.
AU - Mitchell, Ruth E.
AU - Chai, Jin Fang
AU - Aadahl, Mette
AU - Bjerregaard, Anne A.
AU - Yao, Jie
AU - Manichaikul, Ani
AU - Hwu, Chii Min
AU - Hung, Yi Jen
AU - Warren, Helen R.
AU - Ramirez, Julia
AU - Bork-Jensen, Jette
AU - Kårhus, Line L.
AU - Goel, Anuj
AU - Sabater-Lleal, Maria
AU - Noordam, Raymond
AU - Mauro, Pala
AU - Matteo, Floris
AU - McDaid, Aaron F.
AU - Marques-Vidal, Pedro
AU - Wielscher, Matthias
AU - Trompet, Stella
AU - Sattar, Naveed
AU - Møllehave, Line T.
AU - Munz, Matthias
AU - Zeng, Lingyao
AU - Huang, Jianfeng
AU - Yang, Bin
AU - Poveda, Alaitz
AU - Kurbasic, Azra
AU - Lamina, Claudia
AU - Forer, Lukas
AU - Scholz, Markus
AU - Galesloot, Tessel E.
AU - Bradfield, Jonathan P.
AU - Ruotsalainen, Sanni E.
AU - Daw, EWarwick
AU - Zmuda, Joseph M.
AU - Mitchell, Jonathan S.
AU - Fuchsberger, Christian
AU - Christensen, Henry
AU - Brody, Jennifer A.
AU - Vazquez-Moreno, Miguel
AU - Feitosa, Mary F.
AU - Wojczynski, Mary K.
AU - Wang, Zhe
AU - Preuss, Michael H.
AU - Mangino, Massimo
AU - Christofidou, Paraskevi
AU - Verweij, Niek
AU - Benjamins, Jan W.
AU - Engmann, Jorgen
AU - Tsao, Noah L.
AU - Verma, Anurag
AU - Slieker, Roderick C.
AU - Lo, Ken Sin
AU - Zilhao, Nuno R.
AU - Le, Phuong
AU - Kleber, Marcus E.
AU - Delgado, Graciela E.
AU - Huo, Shaofeng
AU - Ikeda, Daisuke D.
AU - Iha, Hiroyuki
AU - Yang, Jian
AU - Liu, Jun
AU - Demirkan, Ayşe
AU - Leonard, Hampton L.
AU - Marten, Jonathan
AU - Frank, Mirjam
AU - Schmidt, Börge
AU - Smyth, Laura J.
AU - Cañadas-Garre, Marisa
AU - Wang, Chaolong
AU - Nakatochi, Masahiro
AU - Wong, Andrew
AU - Hutri-Kähönen, Nina
AU - Sim, Xueling
AU - Xia, Rui
AU - Huerta-Chagoya, Alicia
AU - Fernandez-Lopez, Juan Carlos
AU - Lyssenko, Valeriya
AU - Nongmaithem, Suraj S.
AU - Bayyana, Swati
AU - Stringham, Heather M.
AU - Irvin, Marguerite R.
AU - Oldmeadow, Christopher
AU - Kim, Han Na
AU - Ryu, Seungho
AU - Timmers, Paul R.H.J.
AU - Arbeeva, Liubov
AU - Dorajoo, Rajkumar
AU - Lange, Leslie A.
AU - Prasad, Gauri
AU - Lorés-Motta, Laura
AU - Pauper, Marc
AU - Long, Jirong
AU - Li, Xiaohui
AU - Theusch, Elizabeth
AU - Takeuchi, Fumihiko
AU - Spracklen, Cassandra N.
AU - Loukola, Anu
AU - Bollepalli, Sailalitha
AU - Warner, Sophie C.
AU - Wang, Ya Xing
AU - Wei, Wen B.
AU - Nutile, Teresa
AU - Ruggiero, Daniela
AU - Sung, Yun Ju
AU - Chen, Shufeng
AU - Liu, Fangchao
AU - Yang, Jingyun
AU - Kentistou, Katherine A.
AU - Banas, Bernhard
AU - Nardone, Giuseppe Giovanni
AU - Meidtner, Karina
AU - Bielak, Lawrence F.
AU - Smith, Jennifer A.
AU - Hebbar, Prashantha
AU - Farmaki, Aliki Eleni
AU - Hofer, Edith
AU - Lin, Maoxuan
AU - Concas, Maria Pina
AU - Vaccargiu, Simona
AU - van der Most, Peter J.
AU - Pitkänen, Niina
AU - Cade, Brian E.
AU - van der Laan, Sander W.
AU - Chitrala, Kumaraswamy Naidu
AU - Weiss, Stefan
AU - Bentley, Amy R.
AU - Doumatey, Ayo P.
AU - Adeyemo, Adebowale A.
AU - Lee, Jong Young
AU - Petersen, Eva R.B.
AU - Nielsen, Aneta A.
AU - Choi, Hyeok Sun
AU - Nethander, Maria
AU - Freitag-Wolf, Sandra
AU - Southam, Lorraine
AU - Rayner, Nigel W.
AU - Wang, Carol A.
AU - Lin, Shih Yi
AU - Wang, Jun Sing
AU - Couture, Christian
AU - Lyytikäinen, Leo Pekka
AU - Nikus, Kjell
AU - Cuellar-Partida, Gabriel
AU - Vestergaard, Henrik
AU - Hidalgo, Bertha
AU - Giannakopoulou, Olga
AU - Cai, Qiuyin
AU - Obura, Morgan O.
AU - van Setten, Jessica
AU - Li, Xiaoyin
AU - Liang, Jingjing
AU - Tang, Hua
AU - Terzikhan, Natalie
AU - Shin, Jae Hun
AU - Jackson, Rebecca D.
AU - Reiner, Alexander P.
AU - Martin, Lisa Warsinger
AU - Chen, Zhengming
AU - Li, Liming
AU - Kawaguchi, Takahisa
AU - Thiery, Joachim
AU - Bis, Joshua C.
AU - Launer, Lenore J.
AU - Li, Huaixing
AU - Nalls, Mike A.
AU - Raitakari, Olli T.
AU - Ichihara, Sahoko
AU - Wild, Sarah H.
AU - Nelson, Christopher P.
AU - Campbell, Harry
AU - Jäger, Susanne
AU - Nabika, Toru
AU - Al-Mulla, Fahd
AU - Niinikoski, Harri
AU - Braund, Peter S.
AU - Kolcic, Ivana
AU - Kovacs, Peter
AU - Giardoglou, Tota
AU - Katsuya, Tomohiro
AU - de Kleijn, Dominique
AU - de Borst, Gert J.
AU - Kim, Eung Kweon
AU - Adams, Hieab H.H.
AU - Ikram, M. Arfan
AU - Zhu, Xiaofeng
AU - Asselbergs, Folkert W.
AU - Kraaijeveld, Adriaan O.
AU - Beulens, Joline W.J.
AU - Shu, Xiao Ou
AU - Rallidis, Loukianos S.
AU - Pedersen, Oluf
AU - Hansen, Torben
AU - Mitchell, Paul
AU - Hewitt, Alex W.
AU - Kähönen, Mika
AU - Pérusse, Louis
AU - Bouchard, Claude
AU - Tönjes, Anke
AU - Chen, Yii Der Ida
AU - Pennell, Craig E.
AU - Mori, Trevor A.
AU - Lieb, Wolfgang
AU - Franke, Andre
AU - Ohlsson, Claes
AU - Mellström, Dan
AU - Cho, Yoon Shin
AU - Lee, Hyejin
AU - Yuan, Jian Min
AU - Koh, Woon Puay
AU - Rhee, Sang Youl
AU - Woo, Jeong Taek
AU - Heid, Iris M.
AU - Stark, Klaus J.
AU - Zimmermann, Martina E.
AU - Völzke, Henry
AU - Homuth, Georg
AU - Evans, Michele K.
AU - Zonderman, Alan B.
AU - Polasek, Ozren
AU - Pasterkamp, Gerard
AU - Hoefer, Imo E.
AU - Redline, Susan
AU - Pahkala, Katja
AU - Oldehinkel, Albertine J.
AU - Snieder, Harold
AU - Biino, Ginevra
AU - Schmidt, Reinhold
AU - Schmidt, Helena
AU - Bandinelli, Stefania
AU - Dedoussis, George
AU - Thanaraj, Thangavel Alphonse
AU - Kardia, Sharon L.R.
AU - Peyser, Patricia A.
AU - Kato, Norihiro
AU - Schulze, Matthias B.
AU - Girotto, Giorgia
AU - Böger, Carsten A.
AU - Jung, Bettina
AU - Joshi, Peter K.
AU - Bennett, David A.
AU - De Jager, Philip L.
AU - Lu, Xiangfeng
AU - Mamakou, Vasiliki
AU - Brown, Morris
AU - Caulfield, Mark J.
AU - Munroe, Patricia B.
AU - Guo, Xiuqing
AU - Ciullo, Marina
AU - Jonas, Jost B.
AU - Samani, Nilesh J.
AU - Kaprio, Jaakko
AU - Pajukanta, Päivi
AU - Tusié-Luna, Teresa
AU - Aguilar-Salinas, Carlos A.
AU - Adair, Linda S.
AU - Bechayda, Sonny Augustin
AU - de Silva, H. Janaka
AU - Wickremasinghe, Ananda R.
AU - Krauss, Ronald M.
AU - Wu, Jer Yuarn
AU - Zheng, Wei
AU - Hollander, Anneke Iden
AU - Bharadwaj, Dwaipayan
AU - Correa, Adolfo
AU - Wilson, James G.
AU - Lind, Lars
AU - Heng, Chew Kiat
AU - Nelson, Amanda E.
AU - Golightly, Yvonne M.
AU - Wilson, James F.
AU - Penninx, Brenda
AU - Kim, Hyung Lae
AU - Attia, John
AU - Scott, Rodney J.
AU - Rao, D. C.
AU - Arnett, Donna K.
AU - Hunt, Steven C.
AU - Walker, Mark
AU - Koistinen, Heikki A.
AU - Chandak, Giriraj R.
AU - Mercader, Josep M.
AU - Costanzo, Maria C.
AU - Jang, Dongkeun
AU - Burtt, Noël P.
AU - Villalpando, Clicerio Gonzalez
AU - Orozco, Lorena
AU - Fornage, Myriam
AU - Tai, EShyong
AU - van Dam, Rob M.
AU - Lehtimäki, Terho
AU - Chaturvedi, Nish
AU - Yokota, Mitsuhiro
AU - Liu, Jianjun
AU - Reilly, Dermot F.
AU - McKnight, Amy Jayne
AU - Kee, Frank
AU - Jöckel, Karl Heinz
AU - McCarthy, Mark I.
AU - Palmer, Colin N.A.
AU - Vitart, Veronique
AU - Hayward, Caroline
AU - Simonsick, Eleanor
AU - van Duijn, Cornelia M.
AU - Jin, Zi Bing
AU - Qu, Jia
AU - Hishigaki, Haretsugu
AU - Lin, Xu
AU - März, Winfried
AU - Gudnason, Vilmundur
AU - Tardif, Jean Claude
AU - Lettre, Guillaume
AU - Hart, Leen M.t.
AU - Elders, Petra J.M.
AU - Damrauer, Scott M.
AU - Kumari, Meena
AU - Kivimaki, Mika
AU - van der Harst, Pim
AU - Spector, Tim D.
AU - Loos, Ruth J.F.
AU - Province, Michael A.
AU - Parra, Esteban J.
AU - Cruz, Miguel
AU - Psaty, Bruce M.
AU - Brandslund, Ivan
AU - Pramstaller, Peter P.
AU - Rotimi, Charles N.
AU - Christensen, Kaare
AU - Ripatti, Samuli
AU - Widén, Elisabeth
AU - Hakonarson, Hakon
AU - Grant, Struan F.A.
AU - Kiemeney, Lambertus A.L.M.
AU - de Graaf, Jacqueline
AU - Loeffler, Markus
AU - Kronenberg, Florian
AU - Gu, Dongfeng
AU - Erdmann, Jeanette
AU - Schunkert, Heribert
AU - Franks, Paul W.
AU - Linneberg, Allan
AU - Jukema, J. Wouter
AU - Khera, Amit V.
AU - Männikkö, Minna
AU - Jarvelin, Marjo Riitta
AU - Kutalik, Zoltan
AU - Francesco, Cucca
AU - Mook-Kanamori, Dennis O.
AU - van Dijk, Ko Willems
AU - Watkins, Hugh
AU - Strachan, David P.
AU - Grarup, Niels
AU - Sever, Peter
AU - Poulter, Neil
AU - Chuang, Lee Ming
AU - Rotter, Jerome I.
AU - Dantoft, Thomas M.
AU - Karpe, Fredrik
AU - Neville, Matt J.
AU - Timpson, Nicholas J.
AU - Cheng, Ching Yu
AU - Wong, Tien Yin
AU - Khor, Chiea Chuen
AU - Li, Hengtong
AU - Sabanayagam, Charumathi
AU - Peters, Annette
AU - Gieger, Christian
AU - Hattersley, Andrew T.
AU - Pedersen, Nancy L.
AU - Magnusson, Patrik K.E.
AU - Boomsma, Dorret I.
AU - Willemsen, Allegonda H.M.
AU - Cupples, LAdrienne
AU - van Meurs, Joyce B.J.
AU - Ghanbari, Mohsen
AU - Gordon-Larsen, Penny
AU - Huang, Wei
AU - Kim, Young Jin
AU - Tabara, Yasuharu
AU - Wareham, Nicholas J.
AU - Langenberg, Claudia
AU - Zeggini, Eleftheria
AU - Kuusisto, Johanna
AU - Laakso, Markku
AU - Ingelsson, Erik
AU - Abecasis, Goncalo
AU - Chambers, John C.
AU - Kooner, Jaspal S.
AU - de Vries, Paul S.
AU - Morrison, Alanna C.
AU - Hazelhurst, Scott
AU - Ramsay, Michèle
AU - North, Kari E.
AU - Daviglus, Martha
AU - Kraft, Peter
AU - Martin, Nicholas G.
AU - Whitfield, John B.
AU - Abbas, Shahid
AU - Saleheen, Danish
AU - Walters, Robin G.
AU - Holmes, Michael V.
AU - Black, Corri
AU - Smith, Blair H.
AU - Baras, Aris
AU - Justice, Anne E.
AU - Buring, Julie E.
AU - Ridker, Paul M.
AU - Chasman, Daniel I.
AU - Kooperberg, Charles
AU - Tamiya, Gen
AU - Yamamoto, Masayuki
AU - van Heel, David A.
AU - Trembath, Richard C.
AU - Wei, Wei Qi
AU - Jarvik, Gail P.
AU - Namjou, Bahram
AU - Hayes, M. Geoffrey
AU - Ritchie, Marylyn D.
AU - Jousilahti, Pekka
AU - Salomaa, Veikko
AU - Hveem, Kristian
AU - Åsvold, Bjørn Olav
AU - Kubo, Michiaki
AU - Kamatani, Yoichiro
AU - Okada, Yukinori
AU - Murakami, Yoshinori
AU - Kim, Bong Jo
AU - Thorsteinsdottir, Unnur
AU - Stefansson, Kari
AU - Zhang, Jifeng
AU - Chen, YEugene
AU - Ho, Yuk Lam
AU - Lynch, Julie A.
AU - Rader, Daniel J.
AU - Tsao, Philip S.
AU - Chang, Kyong Mi
AU - Cho, Kelly
AU - O'Donnell, Christopher J.
AU - Gaziano, John M.
AU - Wilson, Peter W.F.
AU - Frayling, Timothy M.
AU - Hirschhorn, Joel N.
AU - Kathiresan, Sekar
AU - Mohlke, Karen L.
AU - Sun, Yan V.
AU - Morris, Andrew P.
AU - Boehnke, Michael
AU - Brown, Christopher D.
AU - Natarajan, Pradeep
AU - Deloukas, Panos
AU - Willer, Cristen J.
AU - Assimes, Themistocles L.
AU - Peloso, Gina M.
N1 - Publisher Copyright:
© 2022. The Author(s).
PY - 2022
Y1 - 2022
N2 - BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. RESULTS: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. CONCLUSIONS: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
AB - BACKGROUND: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. RESULTS: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3-5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. CONCLUSIONS: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.
KW - Cholesterol
KW - Genetics
KW - Genome-wide association study
KW - GWAS
KW - Lipids
U2 - 10.1186/s13059-022-02837-1
DO - 10.1186/s13059-022-02837-1
M3 - Journal article
C2 - 36575460
AN - SCOPUS:85144774123
VL - 23
JO - Genome Biology (Online Edition)
JF - Genome Biology (Online Edition)
SN - 1474-7596
IS - 1
M1 - 268
ER -
