Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD

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Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD. / Schnurr, Theresia M; Katz, Sophia Figueroa; Justesen, Johanne M; O'Sullivan, Jack W; Saliba-Gustafsson, Peter; Assimes, Themistocles L.; Carcamo-Orive, Ivan; Ahmed, Aijaz; Ashley, Euan A.; Hansen, Torben; Knowles, Joshua W.

In: Hepatology Communications, Vol. 6, No. 7, 2022, p. 1516-1526.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Schnurr, TM, Katz, SF, Justesen, JM, O'Sullivan, JW, Saliba-Gustafsson, P, Assimes, TL, Carcamo-Orive, I, Ahmed, A, Ashley, EA, Hansen, T & Knowles, JW 2022, 'Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD', Hepatology Communications, vol. 6, no. 7, pp. 1516-1526. https://doi.org/10.1002/hep4.1932

APA

Schnurr, T. M., Katz, S. F., Justesen, J. M., O'Sullivan, J. W., Saliba-Gustafsson, P., Assimes, T. L., Carcamo-Orive, I., Ahmed, A., Ashley, E. A., Hansen, T., & Knowles, J. W. (2022). Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD. Hepatology Communications, 6(7), 1516-1526. https://doi.org/10.1002/hep4.1932

Vancouver

Schnurr TM, Katz SF, Justesen JM, O'Sullivan JW, Saliba-Gustafsson P, Assimes TL et al. Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD. Hepatology Communications. 2022;6(7):1516-1526. https://doi.org/10.1002/hep4.1932

Author

Schnurr, Theresia M ; Katz, Sophia Figueroa ; Justesen, Johanne M ; O'Sullivan, Jack W ; Saliba-Gustafsson, Peter ; Assimes, Themistocles L. ; Carcamo-Orive, Ivan ; Ahmed, Aijaz ; Ashley, Euan A. ; Hansen, Torben ; Knowles, Joshua W. / Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD. In: Hepatology Communications. 2022 ; Vol. 6, No. 7. pp. 1516-1526.

Bibtex

@article{f965dc02c9f247a3aa6152faaefcb2d3,
title = "Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD",
abstract = "Genetic predisposition and unhealthy lifestyle are risk factors for nonalcoholic fatty liver disease (NAFLD). We investigated whether the genetic risk of NAFLD is modified by physical activity, muscular fitness, and/or adiposity. In up to 242,524 UK Biobank participants without excessive alcohol intake or known liver disease, we examined cross-sectional interactions and joint associations of physical activity, muscular fitness, body mass index (BMI), and a genetic risk score (GRS) with alanine aminotransferase (ALT) levels and the proxy definition for suspected NAFLD of ALT levels > 30 U/L in women and >40 U/L in men. Genetic predisposition to NAFLD was quantified using a GRS consisting of 68 loci known to be associated with chronically elevated ALT. Physical activity was assessed using accelerometry, and muscular fitness was estimated by measuring handgrip strength. We found that increased physical activity and grip strength modestly attenuate genetic predisposition to elevation in ALT levels, whereas higher BMI markedly amplifies it (all p values < 0.001). Among those with normal weight and high level of physical activity, the odds of suspected NAFLD were 1.6-fold higher in those with high versus low genetic risk (reference group). In those with high genetic risk, the odds of suspected NAFLD were 12-fold higher in obese participants with low physical activity versus those with normal weight and high physical activity (odds ratio for NAFLD = 19.2 and 1.6, respectively, vs. reference group). Conclusion: In individuals with high genetic predisposition for NAFLD, maintaining a normal body weight and increased physical activity may reduce the risk of NAFLD.",
author = "Schnurr, {Theresia M} and Katz, {Sophia Figueroa} and Justesen, {Johanne M} and O'Sullivan, {Jack W} and Peter Saliba-Gustafsson and Assimes, {Themistocles L.} and Ivan Carcamo-Orive and Aijaz Ahmed and Ashley, {Euan A.} and Torben Hansen and Knowles, {Joshua W.}",
note = "{\textcopyright} 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.",
year = "2022",
doi = "10.1002/hep4.1932",
language = "English",
volume = "6",
pages = "1516--1526",
journal = "Hepatology Communications",
issn = "2471-254X",
publisher = "Wiley-Blackwell",
number = "7",

}

RIS

TY - JOUR

T1 - Interactions of physical activity, muscular fitness, adiposity, and genetic risk for NAFLD

AU - Schnurr, Theresia M

AU - Katz, Sophia Figueroa

AU - Justesen, Johanne M

AU - O'Sullivan, Jack W

AU - Saliba-Gustafsson, Peter

AU - Assimes, Themistocles L.

AU - Carcamo-Orive, Ivan

AU - Ahmed, Aijaz

AU - Ashley, Euan A.

AU - Hansen, Torben

AU - Knowles, Joshua W.

N1 - © 2022 The Authors. Hepatology Communications published by Wiley Periodicals LLC on behalf of American Association for the Study of Liver Diseases.

PY - 2022

Y1 - 2022

N2 - Genetic predisposition and unhealthy lifestyle are risk factors for nonalcoholic fatty liver disease (NAFLD). We investigated whether the genetic risk of NAFLD is modified by physical activity, muscular fitness, and/or adiposity. In up to 242,524 UK Biobank participants without excessive alcohol intake or known liver disease, we examined cross-sectional interactions and joint associations of physical activity, muscular fitness, body mass index (BMI), and a genetic risk score (GRS) with alanine aminotransferase (ALT) levels and the proxy definition for suspected NAFLD of ALT levels > 30 U/L in women and >40 U/L in men. Genetic predisposition to NAFLD was quantified using a GRS consisting of 68 loci known to be associated with chronically elevated ALT. Physical activity was assessed using accelerometry, and muscular fitness was estimated by measuring handgrip strength. We found that increased physical activity and grip strength modestly attenuate genetic predisposition to elevation in ALT levels, whereas higher BMI markedly amplifies it (all p values < 0.001). Among those with normal weight and high level of physical activity, the odds of suspected NAFLD were 1.6-fold higher in those with high versus low genetic risk (reference group). In those with high genetic risk, the odds of suspected NAFLD were 12-fold higher in obese participants with low physical activity versus those with normal weight and high physical activity (odds ratio for NAFLD = 19.2 and 1.6, respectively, vs. reference group). Conclusion: In individuals with high genetic predisposition for NAFLD, maintaining a normal body weight and increased physical activity may reduce the risk of NAFLD.

AB - Genetic predisposition and unhealthy lifestyle are risk factors for nonalcoholic fatty liver disease (NAFLD). We investigated whether the genetic risk of NAFLD is modified by physical activity, muscular fitness, and/or adiposity. In up to 242,524 UK Biobank participants without excessive alcohol intake or known liver disease, we examined cross-sectional interactions and joint associations of physical activity, muscular fitness, body mass index (BMI), and a genetic risk score (GRS) with alanine aminotransferase (ALT) levels and the proxy definition for suspected NAFLD of ALT levels > 30 U/L in women and >40 U/L in men. Genetic predisposition to NAFLD was quantified using a GRS consisting of 68 loci known to be associated with chronically elevated ALT. Physical activity was assessed using accelerometry, and muscular fitness was estimated by measuring handgrip strength. We found that increased physical activity and grip strength modestly attenuate genetic predisposition to elevation in ALT levels, whereas higher BMI markedly amplifies it (all p values < 0.001). Among those with normal weight and high level of physical activity, the odds of suspected NAFLD were 1.6-fold higher in those with high versus low genetic risk (reference group). In those with high genetic risk, the odds of suspected NAFLD were 12-fold higher in obese participants with low physical activity versus those with normal weight and high physical activity (odds ratio for NAFLD = 19.2 and 1.6, respectively, vs. reference group). Conclusion: In individuals with high genetic predisposition for NAFLD, maintaining a normal body weight and increased physical activity may reduce the risk of NAFLD.

U2 - 10.1002/hep4.1932

DO - 10.1002/hep4.1932

M3 - Journal article

C2 - 35293152

VL - 6

SP - 1516

EP - 1526

JO - Hepatology Communications

JF - Hepatology Communications

SN - 2471-254X

IS - 7

ER -

ID: 300670390