Levels and Changes in Childhood Body Mass Index in Relation to Risk of Atrial Fibrillation and Atrial Flutter in Adulthood
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Levels and Changes in Childhood Body Mass Index in Relation to Risk of Atrial Fibrillation and Atrial Flutter in Adulthood. / Adelborg, Kasper; Ängquist, Lars; Ording, Anne; Gjærde, Line K.; Bjerregaard, Lise G; Sørensen, Henrik T.; Sørensen, Thorkild I. A.; Baker, Jennifer L.
In: American Journal of Epidemiology, Vol. 188, No. 4, 2019, p. 684-693.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Levels and Changes in Childhood Body Mass Index in Relation to Risk of Atrial Fibrillation and Atrial Flutter in Adulthood
AU - Adelborg, Kasper
AU - Ängquist, Lars
AU - Ording, Anne
AU - Gjærde, Line K.
AU - Bjerregaard, Lise G
AU - Sørensen, Henrik T.
AU - Sørensen, Thorkild I. A.
AU - Baker, Jennifer L
PY - 2019
Y1 - 2019
N2 - Children with obesity have a cardio-metabolic risk profile that may predispose them to cardiovascular diseases. We examined the associations between childhood body mass index (BMI) levels and changes on the risk of atrial fibrillation and flutter (AFF) in adulthood.We conducted a population-based cohort study of Danish schoolchildren aged 7-13 years born from 1930-1989. Among 314,140 children, 17,594 were diagnosed with AFF as adults. In both men and women, above-average BMIs in childhood were associated with increased risks of AFF. Children who were persistently heavy at ages 7 and 13 years, and children whose BMI increased from the internal 25th-75th percentiles or from the internal 75.1 th-90th percentiles between ages 7 and 13 years had higher risks of AFF in adulthood than children whose BMIs remained in the internal 25th-75th percentiles at both ages. A decrease in BMI percentile categories between 7 and 13 years of age reduced risks of AFF in adulthood, with risks of AFF reverting to levels similar to those in the reference group for women, but not for men.In conclusion, risks of AFF in adulthood increased with higher childhood BMIs. Remission from overweight by age 13 years reduced AFF risks, especially in women.
AB - Children with obesity have a cardio-metabolic risk profile that may predispose them to cardiovascular diseases. We examined the associations between childhood body mass index (BMI) levels and changes on the risk of atrial fibrillation and flutter (AFF) in adulthood.We conducted a population-based cohort study of Danish schoolchildren aged 7-13 years born from 1930-1989. Among 314,140 children, 17,594 were diagnosed with AFF as adults. In both men and women, above-average BMIs in childhood were associated with increased risks of AFF. Children who were persistently heavy at ages 7 and 13 years, and children whose BMI increased from the internal 25th-75th percentiles or from the internal 75.1 th-90th percentiles between ages 7 and 13 years had higher risks of AFF in adulthood than children whose BMIs remained in the internal 25th-75th percentiles at both ages. A decrease in BMI percentile categories between 7 and 13 years of age reduced risks of AFF in adulthood, with risks of AFF reverting to levels similar to those in the reference group for women, but not for men.In conclusion, risks of AFF in adulthood increased with higher childhood BMIs. Remission from overweight by age 13 years reduced AFF risks, especially in women.
U2 - 10.1093/aje/kwz003
DO - 10.1093/aje/kwz003
M3 - Journal article
C2 - 30649157
VL - 188
SP - 684
EP - 693
JO - American Journal of Epidemiology
JF - American Journal of Epidemiology
SN - 0002-9262
IS - 4
ER -
ID: 212499260