Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition. / Wibaek, Rasmus; Andersen, Gregers S.; Linneberg, Allan; Hansen, Torben; Grarup, Niels; Thuesen, Anne Cathrine B.; Jensen, Rasmus T.; Wells, Jonathan C.K.; Pilgaard, Kasper A.; Brøns, Charlotte; Vistisen, Dorte; Vaag, Allan A.

In: Diabetologia, Vol. 66, 2023, p. 1669–1679.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Wibaek, R, Andersen, GS, Linneberg, A, Hansen, T, Grarup, N, Thuesen, ACB, Jensen, RT, Wells, JCK, Pilgaard, KA, Brøns, C, Vistisen, D & Vaag, AA 2023, 'Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition', Diabetologia, vol. 66, pp. 1669–1679. https://doi.org/10.1007/s00125-023-05937-0

APA

Wibaek, R., Andersen, G. S., Linneberg, A., Hansen, T., Grarup, N., Thuesen, A. C. B., Jensen, R. T., Wells, J. C. K., Pilgaard, K. A., Brøns, C., Vistisen, D., & Vaag, A. A. (2023). Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition. Diabetologia, 66, 1669–1679. https://doi.org/10.1007/s00125-023-05937-0

Vancouver

Wibaek R, Andersen GS, Linneberg A, Hansen T, Grarup N, Thuesen ACB et al. Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition. Diabetologia. 2023;66:1669–1679. https://doi.org/10.1007/s00125-023-05937-0

Author

Wibaek, Rasmus ; Andersen, Gregers S. ; Linneberg, Allan ; Hansen, Torben ; Grarup, Niels ; Thuesen, Anne Cathrine B. ; Jensen, Rasmus T. ; Wells, Jonathan C.K. ; Pilgaard, Kasper A. ; Brøns, Charlotte ; Vistisen, Dorte ; Vaag, Allan A. / Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition. In: Diabetologia. 2023 ; Vol. 66. pp. 1669–1679.

Bibtex

@article{52d255c914b04562808764d320376df9,
title = "Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition",
abstract = "Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes. Most previous studies are based on cross-sectional prevalence data, not designed to study the timing of onset of type 2 diabetes in relation to birthweight. We aimed to examine associations of birthweight with age-specific incidence rate of type 2 diabetes in middle-aged to older adults over two decades. Methods: Adults aged 30–60 years enrolled in the Danish Inter99 cohort in 1999–2001 (baseline examination), with information on birthweight from original birth records from 1939–1971 and without diabetes at baseline, were eligible. Birth records were linked with individual-level data on age at diabetes diagnosis and key covariates. Incidence rates of type 2 diabetes as a function of age, sex and birthweight were modelled using Poisson regression, adjusting for prematurity status at birth, parity, polygenic scores for birthweight and type 2 diabetes, maternal and paternal diabetes history, socioeconomic status and adult BMI. Results: In 4590 participants there were 492 incident type 2 diabetes cases during a mean follow-up of 19 years. Type 2 diabetes incidence rate increased with age, was higher in male participants, and decreased with increasing birthweight (incidence rate ratio [95% CI per 1 kg increase in birthweight] 0.60 [0.48, 0.75]). The inverse association of birthweight with type 2 diabetes incidence was statistically significant across all models and in sensitivity analysis. Conclusions/interpretation: A lower birthweight was associated with increased risk of developing type 2 diabetes independent of adult BMI and genetic risk of type 2 diabetes and birthweight. Graphical Abstract: [Figure not available: see fulltext.].",
keywords = "Birthweight, Cohort, Developmental origins, Fetal programming, Genetic susceptibility, Low birthweight, Type 2 diabetes",
author = "Rasmus Wibaek and Andersen, {Gregers S.} and Allan Linneberg and Torben Hansen and Niels Grarup and Thuesen, {Anne Cathrine B.} and Jensen, {Rasmus T.} and Wells, {Jonathan C.K.} and Pilgaard, {Kasper A.} and Charlotte Br{\o}ns and Dorte Vistisen and Vaag, {Allan A.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2023",
doi = "10.1007/s00125-023-05937-0",
language = "English",
volume = "66",
pages = "1669–1679",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Low birthweight is associated with a higher incidence of type 2 diabetes over two decades independent of adult BMI and genetic predisposition

AU - Wibaek, Rasmus

AU - Andersen, Gregers S.

AU - Linneberg, Allan

AU - Hansen, Torben

AU - Grarup, Niels

AU - Thuesen, Anne Cathrine B.

AU - Jensen, Rasmus T.

AU - Wells, Jonathan C.K.

AU - Pilgaard, Kasper A.

AU - Brøns, Charlotte

AU - Vistisen, Dorte

AU - Vaag, Allan A.

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2023

Y1 - 2023

N2 - Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes. Most previous studies are based on cross-sectional prevalence data, not designed to study the timing of onset of type 2 diabetes in relation to birthweight. We aimed to examine associations of birthweight with age-specific incidence rate of type 2 diabetes in middle-aged to older adults over two decades. Methods: Adults aged 30–60 years enrolled in the Danish Inter99 cohort in 1999–2001 (baseline examination), with information on birthweight from original birth records from 1939–1971 and without diabetes at baseline, were eligible. Birth records were linked with individual-level data on age at diabetes diagnosis and key covariates. Incidence rates of type 2 diabetes as a function of age, sex and birthweight were modelled using Poisson regression, adjusting for prematurity status at birth, parity, polygenic scores for birthweight and type 2 diabetes, maternal and paternal diabetes history, socioeconomic status and adult BMI. Results: In 4590 participants there were 492 incident type 2 diabetes cases during a mean follow-up of 19 years. Type 2 diabetes incidence rate increased with age, was higher in male participants, and decreased with increasing birthweight (incidence rate ratio [95% CI per 1 kg increase in birthweight] 0.60 [0.48, 0.75]). The inverse association of birthweight with type 2 diabetes incidence was statistically significant across all models and in sensitivity analysis. Conclusions/interpretation: A lower birthweight was associated with increased risk of developing type 2 diabetes independent of adult BMI and genetic risk of type 2 diabetes and birthweight. Graphical Abstract: [Figure not available: see fulltext.].

AB - Aims/hypothesis: Low birthweight is a risk factor for type 2 diabetes. Most previous studies are based on cross-sectional prevalence data, not designed to study the timing of onset of type 2 diabetes in relation to birthweight. We aimed to examine associations of birthweight with age-specific incidence rate of type 2 diabetes in middle-aged to older adults over two decades. Methods: Adults aged 30–60 years enrolled in the Danish Inter99 cohort in 1999–2001 (baseline examination), with information on birthweight from original birth records from 1939–1971 and without diabetes at baseline, were eligible. Birth records were linked with individual-level data on age at diabetes diagnosis and key covariates. Incidence rates of type 2 diabetes as a function of age, sex and birthweight were modelled using Poisson regression, adjusting for prematurity status at birth, parity, polygenic scores for birthweight and type 2 diabetes, maternal and paternal diabetes history, socioeconomic status and adult BMI. Results: In 4590 participants there were 492 incident type 2 diabetes cases during a mean follow-up of 19 years. Type 2 diabetes incidence rate increased with age, was higher in male participants, and decreased with increasing birthweight (incidence rate ratio [95% CI per 1 kg increase in birthweight] 0.60 [0.48, 0.75]). The inverse association of birthweight with type 2 diabetes incidence was statistically significant across all models and in sensitivity analysis. Conclusions/interpretation: A lower birthweight was associated with increased risk of developing type 2 diabetes independent of adult BMI and genetic risk of type 2 diabetes and birthweight. Graphical Abstract: [Figure not available: see fulltext.].

KW - Birthweight

KW - Cohort

KW - Developmental origins

KW - Fetal programming

KW - Genetic susceptibility

KW - Low birthweight

KW - Type 2 diabetes

U2 - 10.1007/s00125-023-05937-0

DO - 10.1007/s00125-023-05937-0

M3 - Journal article

C2 - 37303008

AN - SCOPUS:85161517431

VL - 66

SP - 1669

EP - 1679

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

ER -

ID: 357280303