Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality. / Molinaro, Antonio; Nemet, Ina; Bel Lassen, Pierre; Chakaroun, Rima; Nielsen, Trine; Aron-Wisnewsky, Judith; Bergh, Per Olof; Li, Lin; Henricsson, Marcus; Køber, Lars; Isnard, Richard; Helft, Gerard; Stumvoll, Michael; Pedersen, Oluf; Smith, J. Gustav; Tang, W. H.Wilson; Clément, Karine; Hazen, Stanley L.; Bäckhed, Fredrik; MetaCardis Consortium.

In: JACC: Heart Failure, Vol. 11, No. 7, 2023, p. 810-821.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Molinaro, A, Nemet, I, Bel Lassen, P, Chakaroun, R, Nielsen, T, Aron-Wisnewsky, J, Bergh, PO, Li, L, Henricsson, M, Køber, L, Isnard, R, Helft, G, Stumvoll, M, Pedersen, O, Smith, JG, Tang, WHW, Clément, K, Hazen, SL, Bäckhed, F & MetaCardis Consortium 2023, 'Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality', JACC: Heart Failure, vol. 11, no. 7, pp. 810-821. https://doi.org/10.1016/j.jchf.2023.03.008

APA

Molinaro, A., Nemet, I., Bel Lassen, P., Chakaroun, R., Nielsen, T., Aron-Wisnewsky, J., Bergh, P. O., Li, L., Henricsson, M., Køber, L., Isnard, R., Helft, G., Stumvoll, M., Pedersen, O., Smith, J. G., Tang, W. H. W., Clément, K., Hazen, S. L., Bäckhed, F., & MetaCardis Consortium (2023). Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality. JACC: Heart Failure, 11(7), 810-821. https://doi.org/10.1016/j.jchf.2023.03.008

Vancouver

Molinaro A, Nemet I, Bel Lassen P, Chakaroun R, Nielsen T, Aron-Wisnewsky J et al. Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality. JACC: Heart Failure. 2023;11(7):810-821. https://doi.org/10.1016/j.jchf.2023.03.008

Author

Molinaro, Antonio ; Nemet, Ina ; Bel Lassen, Pierre ; Chakaroun, Rima ; Nielsen, Trine ; Aron-Wisnewsky, Judith ; Bergh, Per Olof ; Li, Lin ; Henricsson, Marcus ; Køber, Lars ; Isnard, Richard ; Helft, Gerard ; Stumvoll, Michael ; Pedersen, Oluf ; Smith, J. Gustav ; Tang, W. H.Wilson ; Clément, Karine ; Hazen, Stanley L. ; Bäckhed, Fredrik ; MetaCardis Consortium. / Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality. In: JACC: Heart Failure. 2023 ; Vol. 11, No. 7. pp. 810-821.

Bibtex

@article{cdb40483201a495daf767ff9893f3e2a,
title = "Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality",
abstract = "Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated with heart failure. Objectives: The authors aimed to explore whether ImP is associated with heart failure and mortality. Methods: ImP serum measurements in 2 large and independent clinical cohorts of patients (European [n = 1,985] and North American [n = 2,155]) with a range of severity of cardiovascular disease including heart failure. Univariate and multivariate Cox regression analyses were performed to delineate the impact of ImP on 5-year mortality in the North American cohort, independent of other covariates. Results: ImP is independently associated with reduced ejection fraction and heart failure in both cohorts, even after adjusting for traditional risk factors. Elevated ImP was a significant independent predictor of 5-year mortality (for the highest quartile, adjusted HR: 1.85 [95% CI: 1.20-2.88]; P < 0.01). Conclusions: The gut microbial metabolite ImP is increased in individuals with heart failure and is a predictor of overall survival.",
keywords = "heart failure, histidine, imidazole propionate, microbiota",
author = "Antonio Molinaro and Ina Nemet and {Bel Lassen}, Pierre and Rima Chakaroun and Trine Nielsen and Judith Aron-Wisnewsky and Bergh, {Per Olof} and Lin Li and Marcus Henricsson and Lars K{\o}ber and Richard Isnard and Gerard Helft and Michael Stumvoll and Oluf Pedersen and Smith, {J. Gustav} and Tang, {W. H.Wilson} and Karine Cl{\'e}ment and Hazen, {Stanley L.} and Fredrik B{\"a}ckhed and {MetaCardis Consortium}",
note = "Publisher Copyright: {\textcopyright} 2023 The Authors",
year = "2023",
doi = "10.1016/j.jchf.2023.03.008",
language = "English",
volume = "11",
pages = "810--821",
journal = "J A C C: Heart Failure",
issn = "2213-1779",
publisher = "Elsevier",
number = "7",

}

RIS

TY - JOUR

T1 - Microbially Produced Imidazole Propionate Is Associated With Heart Failure and Mortality

AU - Molinaro, Antonio

AU - Nemet, Ina

AU - Bel Lassen, Pierre

AU - Chakaroun, Rima

AU - Nielsen, Trine

AU - Aron-Wisnewsky, Judith

AU - Bergh, Per Olof

AU - Li, Lin

AU - Henricsson, Marcus

AU - Køber, Lars

AU - Isnard, Richard

AU - Helft, Gerard

AU - Stumvoll, Michael

AU - Pedersen, Oluf

AU - Smith, J. Gustav

AU - Tang, W. H.Wilson

AU - Clément, Karine

AU - Hazen, Stanley L.

AU - Bäckhed, Fredrik

AU - MetaCardis Consortium

N1 - Publisher Copyright: © 2023 The Authors

PY - 2023

Y1 - 2023

N2 - Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated with heart failure. Objectives: The authors aimed to explore whether ImP is associated with heart failure and mortality. Methods: ImP serum measurements in 2 large and independent clinical cohorts of patients (European [n = 1,985] and North American [n = 2,155]) with a range of severity of cardiovascular disease including heart failure. Univariate and multivariate Cox regression analyses were performed to delineate the impact of ImP on 5-year mortality in the North American cohort, independent of other covariates. Results: ImP is independently associated with reduced ejection fraction and heart failure in both cohorts, even after adjusting for traditional risk factors. Elevated ImP was a significant independent predictor of 5-year mortality (for the highest quartile, adjusted HR: 1.85 [95% CI: 1.20-2.88]; P < 0.01). Conclusions: The gut microbial metabolite ImP is increased in individuals with heart failure and is a predictor of overall survival.

AB - Background: Over the past years, it has become clear that the microbial ecosystem in the gut has a profound capacity to interact with the host through the production of a wide range of bioactive metabolites. The microbially produced metabolite imidazole propionate (ImP) is clinically and mechanistically linked with insulin resistance and type 2 diabetes, but it is unclear how ImP is associated with heart failure. Objectives: The authors aimed to explore whether ImP is associated with heart failure and mortality. Methods: ImP serum measurements in 2 large and independent clinical cohorts of patients (European [n = 1,985] and North American [n = 2,155]) with a range of severity of cardiovascular disease including heart failure. Univariate and multivariate Cox regression analyses were performed to delineate the impact of ImP on 5-year mortality in the North American cohort, independent of other covariates. Results: ImP is independently associated with reduced ejection fraction and heart failure in both cohorts, even after adjusting for traditional risk factors. Elevated ImP was a significant independent predictor of 5-year mortality (for the highest quartile, adjusted HR: 1.85 [95% CI: 1.20-2.88]; P < 0.01). Conclusions: The gut microbial metabolite ImP is increased in individuals with heart failure and is a predictor of overall survival.

KW - heart failure

KW - histidine

KW - imidazole propionate

KW - microbiota

U2 - 10.1016/j.jchf.2023.03.008

DO - 10.1016/j.jchf.2023.03.008

M3 - Journal article

C2 - 37115134

AN - SCOPUS:85160840012

VL - 11

SP - 810

EP - 821

JO - J A C C: Heart Failure

JF - J A C C: Heart Failure

SN - 2213-1779

IS - 7

ER -

ID: 357581561