Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy

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Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy. / Daggag, Hinda; Gjesing, Anette P.; Mohammad, Alshafi; Ängquist, Lars; Shobi, Bindu; Antony, Suma; Haj, Dalia; Al Tikriti, Alia; Buckley, Adam; Hansen, Torben; Barakat, Maha T.

In: Metabolism open, Vol. 16, 100213, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Daggag, H, Gjesing, AP, Mohammad, A, Ängquist, L, Shobi, B, Antony, S, Haj, D, Al Tikriti, A, Buckley, A, Hansen, T & Barakat, MT 2022, 'Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy', Metabolism open, vol. 16, 100213. https://doi.org/10.1016/j.metop.2022.100213

APA

Daggag, H., Gjesing, A. P., Mohammad, A., Ängquist, L., Shobi, B., Antony, S., Haj, D., Al Tikriti, A., Buckley, A., Hansen, T., & Barakat, M. T. (2022). Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy. Metabolism open, 16, [100213]. https://doi.org/10.1016/j.metop.2022.100213

Vancouver

Daggag H, Gjesing AP, Mohammad A, Ängquist L, Shobi B, Antony S et al. Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy. Metabolism open. 2022;16. 100213. https://doi.org/10.1016/j.metop.2022.100213

Author

Daggag, Hinda ; Gjesing, Anette P. ; Mohammad, Alshafi ; Ängquist, Lars ; Shobi, Bindu ; Antony, Suma ; Haj, Dalia ; Al Tikriti, Alia ; Buckley, Adam ; Hansen, Torben ; Barakat, Maha T. / Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy. In: Metabolism open. 2022 ; Vol. 16.

Bibtex

@article{758a7bdf70994bce9c0e320fe462a482,
title = "Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy",
abstract = "AIMS: To investigate the prevalence of pathogenic variants in monogenic diabetes genes in Emirati women with gestational diabetes (GDM) and examine the risk of developing hyperglycemia during follow-up in carriers and non-carriers.METHODS: Female patients with GDM (n = 370) were identified. Selected monogenic diabetes genes, GCK, HNF1A, HNF4A, HNF1B, INS, ABCC8 and KCNJ1I, were examined by sequencing and identified variants were classified. Anthropometrics and subsequent diagnosis of diabetes were extracted from hospital records. Median follow-up time was 6-years. RESULTS: A total of 34 variants were detected. Seven women (2%) were carriers of pathogenic variants in GCK, HNF1A, INS, ABCC8 or KCNJ11. A significantly larger fraction of women carrying pathogenic variants were diagnosed with any form of hyperglycemia or diabetes postpartum (risk ratio = 1.8 (1.1-2.9), p = 0.02) or 2.5 (1.3-4.8; p = 0.009), respectively) and they had a shorter disease-free period after GDM compared to women without such variants. There were no significant associations between carrying pathogenic variants and anthropometric measures or C-peptide. CONCLUSIONS: Pathogenic variants were found in known monogenic diabetes genes in two percent of Emirati women with GDM, allowing for precision medicine utilisation in these women both during and outside pregnancy. Carriers were at an increased risk of being diagnosed with hyperglycemia or type 2 diabetes mellitus within 5 years after pregnancy.",
author = "Hinda Daggag and Gjesing, {Anette P.} and Alshafi Mohammad and Lars {\"A}ngquist and Bindu Shobi and Suma Antony and Dalia Haj and {Al Tikriti}, Alia and Adam Buckley and Torben Hansen and Barakat, {Maha T}",
note = "{\textcopyright} 2022 The Authors.",
year = "2022",
doi = "10.1016/j.metop.2022.100213",
language = "English",
volume = "16",
journal = "Metabolism open",
issn = "2589-9368",

}

RIS

TY - JOUR

T1 - Monogenic diabetes variants in Emirati women with gestational diabetes are associated with risk of non-autoimmune diabetes within 5 years after pregnancy

AU - Daggag, Hinda

AU - Gjesing, Anette P.

AU - Mohammad, Alshafi

AU - Ängquist, Lars

AU - Shobi, Bindu

AU - Antony, Suma

AU - Haj, Dalia

AU - Al Tikriti, Alia

AU - Buckley, Adam

AU - Hansen, Torben

AU - Barakat, Maha T

N1 - © 2022 The Authors.

PY - 2022

Y1 - 2022

N2 - AIMS: To investigate the prevalence of pathogenic variants in monogenic diabetes genes in Emirati women with gestational diabetes (GDM) and examine the risk of developing hyperglycemia during follow-up in carriers and non-carriers.METHODS: Female patients with GDM (n = 370) were identified. Selected monogenic diabetes genes, GCK, HNF1A, HNF4A, HNF1B, INS, ABCC8 and KCNJ1I, were examined by sequencing and identified variants were classified. Anthropometrics and subsequent diagnosis of diabetes were extracted from hospital records. Median follow-up time was 6-years. RESULTS: A total of 34 variants were detected. Seven women (2%) were carriers of pathogenic variants in GCK, HNF1A, INS, ABCC8 or KCNJ11. A significantly larger fraction of women carrying pathogenic variants were diagnosed with any form of hyperglycemia or diabetes postpartum (risk ratio = 1.8 (1.1-2.9), p = 0.02) or 2.5 (1.3-4.8; p = 0.009), respectively) and they had a shorter disease-free period after GDM compared to women without such variants. There were no significant associations between carrying pathogenic variants and anthropometric measures or C-peptide. CONCLUSIONS: Pathogenic variants were found in known monogenic diabetes genes in two percent of Emirati women with GDM, allowing for precision medicine utilisation in these women both during and outside pregnancy. Carriers were at an increased risk of being diagnosed with hyperglycemia or type 2 diabetes mellitus within 5 years after pregnancy.

AB - AIMS: To investigate the prevalence of pathogenic variants in monogenic diabetes genes in Emirati women with gestational diabetes (GDM) and examine the risk of developing hyperglycemia during follow-up in carriers and non-carriers.METHODS: Female patients with GDM (n = 370) were identified. Selected monogenic diabetes genes, GCK, HNF1A, HNF4A, HNF1B, INS, ABCC8 and KCNJ1I, were examined by sequencing and identified variants were classified. Anthropometrics and subsequent diagnosis of diabetes were extracted from hospital records. Median follow-up time was 6-years. RESULTS: A total of 34 variants were detected. Seven women (2%) were carriers of pathogenic variants in GCK, HNF1A, INS, ABCC8 or KCNJ11. A significantly larger fraction of women carrying pathogenic variants were diagnosed with any form of hyperglycemia or diabetes postpartum (risk ratio = 1.8 (1.1-2.9), p = 0.02) or 2.5 (1.3-4.8; p = 0.009), respectively) and they had a shorter disease-free period after GDM compared to women without such variants. There were no significant associations between carrying pathogenic variants and anthropometric measures or C-peptide. CONCLUSIONS: Pathogenic variants were found in known monogenic diabetes genes in two percent of Emirati women with GDM, allowing for precision medicine utilisation in these women both during and outside pregnancy. Carriers were at an increased risk of being diagnosed with hyperglycemia or type 2 diabetes mellitus within 5 years after pregnancy.

U2 - 10.1016/j.metop.2022.100213

DO - 10.1016/j.metop.2022.100213

M3 - Journal article

C2 - 36407475

VL - 16

JO - Metabolism open

JF - Metabolism open

SN - 2589-9368

M1 - 100213

ER -

ID: 339688413