Standard
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. / Lu, Yingchang; Day, Felix R; Gustafsson, Stefan; Buchkovich, Martin L; Na, Jianbo; Bataille, Veronique; Cousminer, Diana L; Dastani, Zari; Drong, Alexander W; Esko, Tõnu; Evans, David M; Falchi, Mario; Feitosa, Mary F; Ferreira, Teresa; Hedman, Åsa K; Haring, Robin; Hysi, Pirro G; Iles, Mark M; Justice, Anne E; Kanoni, Stavroula; Lagou, Vasiliki; Li, Rui; Li, Xin; Locke, Adam; Lu, Chen; Mägi, Reedik; Perry, John R B; Pers, Tune H; Qi, Qibin; Sanna, Marianna; Schmidt, Ellen M; Scott, William R; Shungin, Dmitry; Teumer, Alexander; Vinkhuyzen, Anna A E; Walker, Ryan W; Westra, Harm-Jan; Zhang, Mingfeng; Zhang, Weihua; Zhao, Jing Hua; Zhu, Zhihong; Afzal, Uzma; Ahluwalia, Tarun Veer Singh; Bakker, Stephan J L; Bellis, Claire; Bonnefond, Amélie; Borodulin, Katja; Buchman, Aron S; Cederholm, Tommy; Choh, Audrey C; Choi, Hyung Jin; Curran, Joanne E; de Groot, Lisette C P G M; De Jager, Philip L; Dhonukshe-Rutten, Rosalie A M; Enneman, Anke W; Eury, Elodie; Evans, Daniel S; Forsen, Tom; Friedrich, Nele; Fumeron, Frédéric; Garcia, Melissa E; Gärtner, Simone; Han, Bok-Ghee; Havulinna, Aki S; Hayward, Caroline; Hernandez, Dena; Hillege, Hans; Ittermann, Till; Kent, Jack W; Kolcic, Ivana; Laatikainen, Tiina; Lahti, Jari; Mateo Leach, Irene; Lee, Christine G; Lee, Jong-Young; Liu, Tian; Liu, Youfang; Lobbens, Stéphane; Loh, Marie; Lyytikäinen, Leo-Pekka; Medina-Gomez, Carolina; Michaëlsson, Karl; Nalls, Mike A; Nielson, Carrie M; Oozageer, Laticia; Pascoe, Laura; Paternoster, Lavinia; Polašek, Ozren; Ripatti, Samuli; Sarzynski, Mark A; Shin, Chan Soo; Narančić, Nina Smolej; Spira, Dominik; Srikanth, Priya; Steinhagen-Thiessen, Elisabeth; Sung, Yun Ju; Swart, Karin M A; Taittonen, Leena; Tanaka, Toshiko; Tikkanen, Emmi; van der Velde, Nathalie; van Schoor, Natasja M; Verweij, Niek; Wright, Alan F; Yu, Lei; Zmuda, Joseph M; Eklund, Niina; Forrester, Terrence; Grarup, Niels; Jackson, Anne U; Kristiansson, Kati; Kuulasmaa, Teemu; Kuusisto, Johanna; Lichtner, Peter; Luan, Jian'an; Mahajan, Anubha; Männistö, Satu; Palmer, Cameron D; Ried, Janina S; Scott, Robert A; Stancáková, Alena; Wagner, Peter J; Demirkan, Ayse; Döring, Angela; Gudnason, Vilmundur; Kiel, Douglas P; Kühnel, Brigitte; Mangino, Massimo; Mcknight, Barbara; Menni, Cristina; O'Connell, Jeffrey R; Oostra, Ben A; Shuldiner, Alan R; Song, Kijoung; Vandenput, Liesbeth; van Duijn, Cornelia M; Vollenweider, Peter; White, Charles C; Boehnke, Michael; Boettcher, Yvonne; Cooper, Richard S; Forouhi, Nita G; Gieger, Christian; Grallert, Harald; Hingorani, Aroon; Jørgensen, Torben; Jousilahti, Pekka; Kivimaki, Mika; Kumari, Meena; Laakso, Markku; Langenberg, Claudia; Linneberg, Allan; Luke, Amy; Mckenzie, Colin A; Palotie, Aarno; Pedersen, Oluf; Peters, Annette; Strauch, Konstantin; Tayo, Bamidele O; Wareham, Nicholas J; Bennett, David A; Bertram, Lars; Blangero, John; Blüher, Matthias; Bouchard, Claude; Campbell, Harry; Cho, Nam H; Cummings, Steven R; Czerwinski, Stefan A; Demuth, Ilja; Eckardt, Rahel; Eriksson, Johan G; Ferrucci, Luigi; Franco, Oscar H; Froguel, Philippe; Gansevoort, Ron T; Hansen, Torben; Harris, Tamara B; Hastie, Nicholas; Heliövaara, Markku; Hofman, Albert; Jordan, Joanne M; Jula, Antti; Kähönen, Mika; Kajantie, Eero; Knekt, Paul B; Koskinen, Seppo; Kovacs, Peter; Lehtimäki, Terho; Lind, Lars; Liu, Yongmei; Orwoll, Eric S; Osmond, Clive; Perola, Markus; Pérusse, Louis; Raitakari, Olli T; Rankinen, Tuomo; Rao, D C; Rice, Treva K; Rivadeneira, Fernando; Rudan, Igor; Salomaa, Veikko; Sørensen, Thorkild I A; Stumvoll, Michael; Tönjes, Anke; Towne, Bradford; Tranah, Gregory J; Tremblay, Angelo; Uitterlinden, André G; van der Harst, Pim; Vartiainen, Erkki; Viikari, Jorma S; Vitart, Veronique; Vohl, Marie-Claude; Völzke, Henry; Walker, Mark; Wallaschofski, Henri; Wild, Sarah; Wilson, James F; Yengo, Loïc; Bishop, D Timothy; Borecki, Ingrid B; Chambers, John C; Cupples, L Adrienne; Dehghan, Abbas; Deloukas, Panos; Fatemifar, Ghazaleh; Fox, Caroline; Furey, Terrence S; Franke, Lude; Han, Jiali; Hunter, David J; Karjalainen, Juha; Karpe, Fredrik; Kaplan, Robert C; Kooner, Jaspal S; McCarthy, Mark I; Murabito, Joanne M; Morris, Andrew P; Bishop, Julia A N; North, Kari E; Ohlsson, Claes; Ong, Ken K; Prokopenko, Inga; Richards, J Brent; Schadt, Eric E; Spector, Tim D; Widén, Elisabeth; Willer, Cristen J; Yang, Jian; Ingelsson, Erik; Mohlke, Karen L; Hirschhorn, Joel N; Pospisilik, John Andrew; Zillikens, M Carola; Lindgren, Cecilia; Kilpeläinen, Tuomas Oskari; Loos, Ruth J F.
In:
Nature Communications, Vol. 7, 10495, 01.02.2016, p. 1-15.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Lu, Y, Day, FR, Gustafsson, S, Buchkovich, ML, Na, J, Bataille, V, Cousminer, DL, Dastani, Z, Drong, AW, Esko, T, Evans, DM, Falchi, M, Feitosa, MF, Ferreira, T, Hedman, ÅK, Haring, R, Hysi, PG, Iles, MM, Justice, AE, Kanoni, S, Lagou, V, Li, R, Li, X, Locke, A, Lu, C, Mägi, R, Perry, JRB
, Pers, TH, Qi, Q, Sanna, M, Schmidt, EM, Scott, WR, Shungin, D, Teumer, A, Vinkhuyzen, AAE, Walker, RW, Westra, H-J, Zhang, M, Zhang, W, Zhao, JH, Zhu, Z, Afzal, U
, Ahluwalia, TVS, Bakker, SJL, Bellis, C, Bonnefond, A, Borodulin, K, Buchman, AS, Cederholm, T, Choh, AC, Choi, HJ, Curran, JE, de Groot, LCPGM, De Jager, PL, Dhonukshe-Rutten, RAM, Enneman, AW, Eury, E, Evans, DS, Forsen, T, Friedrich, N, Fumeron, F, Garcia, ME, Gärtner, S, Han, B-G, Havulinna, AS, Hayward, C, Hernandez, D, Hillege, H, Ittermann, T, Kent, JW, Kolcic, I, Laatikainen, T, Lahti, J, Mateo Leach, I, Lee, CG, Lee, J-Y, Liu, T, Liu, Y, Lobbens, S, Loh, M, Lyytikäinen, L-P, Medina-Gomez, C, Michaëlsson, K, Nalls, MA, Nielson, CM, Oozageer, L, Pascoe, L, Paternoster, L, Polašek, O, Ripatti, S, Sarzynski, MA, Shin, CS, Narančić, NS, Spira, D, Srikanth, P, Steinhagen-Thiessen, E, Sung, YJ, Swart, KMA, Taittonen, L, Tanaka, T, Tikkanen, E, van der Velde, N, van Schoor, NM, Verweij, N, Wright, AF, Yu, L, Zmuda, JM, Eklund, N, Forrester, T
, Grarup, N, Jackson, AU, Kristiansson, K, Kuulasmaa, T, Kuusisto, J, Lichtner, P, Luan, J, Mahajan, A, Männistö, S, Palmer, CD, Ried, JS, Scott, RA, Stancáková, A, Wagner, PJ, Demirkan, A, Döring, A, Gudnason, V, Kiel, DP, Kühnel, B, Mangino, M, Mcknight, B, Menni, C, O'Connell, JR, Oostra, BA, Shuldiner, AR, Song, K, Vandenput, L, van Duijn, CM, Vollenweider, P, White, CC, Boehnke, M, Boettcher, Y, Cooper, RS, Forouhi, NG, Gieger, C, Grallert, H, Hingorani, A, Jørgensen, T, Jousilahti, P, Kivimaki, M, Kumari, M, Laakso, M, Langenberg, C
, Linneberg, A, Luke, A, Mckenzie, CA, Palotie, A
, Pedersen, O, Peters, A, Strauch, K, Tayo, BO, Wareham, NJ, Bennett, DA, Bertram, L, Blangero, J, Blüher, M, Bouchard, C, Campbell, H, Cho, NH, Cummings, SR, Czerwinski, SA, Demuth, I, Eckardt, R, Eriksson, JG, Ferrucci, L, Franco, OH, Froguel, P, Gansevoort, RT
, Hansen, T, Harris, TB, Hastie, N, Heliövaara, M, Hofman, A, Jordan, JM, Jula, A, Kähönen, M, Kajantie, E, Knekt, PB, Koskinen, S, Kovacs, P, Lehtimäki, T, Lind, L, Liu, Y, Orwoll, ES, Osmond, C, Perola, M, Pérusse, L, Raitakari, OT, Rankinen, T, Rao, DC, Rice, TK, Rivadeneira, F, Rudan, I, Salomaa, V
, Sørensen, TIA, Stumvoll, M, Tönjes, A, Towne, B, Tranah, GJ, Tremblay, A, Uitterlinden, AG, van der Harst, P, Vartiainen, E, Viikari, JS, Vitart, V, Vohl, M-C, Völzke, H, Walker, M, Wallaschofski, H, Wild, S, Wilson, JF, Yengo, L, Bishop, DT, Borecki, IB, Chambers, JC, Cupples, LA, Dehghan, A, Deloukas, P, Fatemifar, G, Fox, C, Furey, TS, Franke, L, Han, J, Hunter, DJ, Karjalainen, J, Karpe, F, Kaplan, RC, Kooner, JS, McCarthy, MI, Murabito, JM, Morris, AP, Bishop, JAN, North, KE, Ohlsson, C, Ong, KK, Prokopenko, I, Richards, JB, Schadt, EE, Spector, TD, Widén, E, Willer, CJ, Yang, J, Ingelsson, E, Mohlke, KL, Hirschhorn, JN, Pospisilik, JA, Zillikens, MC, Lindgren, C
, Kilpeläinen, TO & Loos, RJF 2016, '
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk',
Nature Communications, vol. 7, 10495, pp. 1-15.
https://doi.org/10.1038/ncomms10495APA
Lu, Y., Day, F. R., Gustafsson, S., Buchkovich, M. L., Na, J., Bataille, V., Cousminer, D. L., Dastani, Z., Drong, A. W., Esko, T., Evans, D. M., Falchi, M., Feitosa, M. F., Ferreira, T., Hedman, Å. K., Haring, R., Hysi, P. G., Iles, M. M., Justice, A. E.
, ... Loos, R. J. F. (2016).
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Nature Communications,
7, 1-15. [10495].
https://doi.org/10.1038/ncomms10495Vancouver
Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V et al.
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk.
Nature Communications. 2016 Feb 1;7:1-15. 10495.
https://doi.org/10.1038/ncomms10495Author
Lu, Yingchang ; Day, Felix R ; Gustafsson, Stefan ; Buchkovich, Martin L ; Na, Jianbo ; Bataille, Veronique ; Cousminer, Diana L ; Dastani, Zari ; Drong, Alexander W ; Esko, Tõnu ; Evans, David M ; Falchi, Mario ; Feitosa, Mary F ; Ferreira, Teresa ; Hedman, Åsa K ; Haring, Robin ; Hysi, Pirro G ; Iles, Mark M ; Justice, Anne E ; Kanoni, Stavroula ; Lagou, Vasiliki ; Li, Rui ; Li, Xin ; Locke, Adam ; Lu, Chen ; Mägi, Reedik ; Perry, John R B ; Pers, Tune H ; Qi, Qibin ; Sanna, Marianna ; Schmidt, Ellen M ; Scott, William R ; Shungin, Dmitry ; Teumer, Alexander ; Vinkhuyzen, Anna A E ; Walker, Ryan W ; Westra, Harm-Jan ; Zhang, Mingfeng ; Zhang, Weihua ; Zhao, Jing Hua ; Zhu, Zhihong ; Afzal, Uzma ; Ahluwalia, Tarun Veer Singh ; Bakker, Stephan J L ; Bellis, Claire ; Bonnefond, Amélie ; Borodulin, Katja ; Buchman, Aron S ; Cederholm, Tommy ; Choh, Audrey C ; Choi, Hyung Jin ; Curran, Joanne E ; de Groot, Lisette C P G M ; De Jager, Philip L ; Dhonukshe-Rutten, Rosalie A M ; Enneman, Anke W ; Eury, Elodie ; Evans, Daniel S ; Forsen, Tom ; Friedrich, Nele ; Fumeron, Frédéric ; Garcia, Melissa E ; Gärtner, Simone ; Han, Bok-Ghee ; Havulinna, Aki S ; Hayward, Caroline ; Hernandez, Dena ; Hillege, Hans ; Ittermann, Till ; Kent, Jack W ; Kolcic, Ivana ; Laatikainen, Tiina ; Lahti, Jari ; Mateo Leach, Irene ; Lee, Christine G ; Lee, Jong-Young ; Liu, Tian ; Liu, Youfang ; Lobbens, Stéphane ; Loh, Marie ; Lyytikäinen, Leo-Pekka ; Medina-Gomez, Carolina ; Michaëlsson, Karl ; Nalls, Mike A ; Nielson, Carrie M ; Oozageer, Laticia ; Pascoe, Laura ; Paternoster, Lavinia ; Polašek, Ozren ; Ripatti, Samuli ; Sarzynski, Mark A ; Shin, Chan Soo ; Narančić, Nina Smolej ; Spira, Dominik ; Srikanth, Priya ; Steinhagen-Thiessen, Elisabeth ; Sung, Yun Ju ; Swart, Karin M A ; Taittonen, Leena ; Tanaka, Toshiko ; Tikkanen, Emmi ; van der Velde, Nathalie ; van Schoor, Natasja M ; Verweij, Niek ; Wright, Alan F ; Yu, Lei ; Zmuda, Joseph M ; Eklund, Niina ; Forrester, Terrence ; Grarup, Niels ; Jackson, Anne U ; Kristiansson, Kati ; Kuulasmaa, Teemu ; Kuusisto, Johanna ; Lichtner, Peter ; Luan, Jian'an ; Mahajan, Anubha ; Männistö, Satu ; Palmer, Cameron D ; Ried, Janina S ; Scott, Robert A ; Stancáková, Alena ; Wagner, Peter J ; Demirkan, Ayse ; Döring, Angela ; Gudnason, Vilmundur ; Kiel, Douglas P ; Kühnel, Brigitte ; Mangino, Massimo ; Mcknight, Barbara ; Menni, Cristina ; O'Connell, Jeffrey R ; Oostra, Ben A ; Shuldiner, Alan R ; Song, Kijoung ; Vandenput, Liesbeth ; van Duijn, Cornelia M ; Vollenweider, Peter ; White, Charles C ; Boehnke, Michael ; Boettcher, Yvonne ; Cooper, Richard S ; Forouhi, Nita G ; Gieger, Christian ; Grallert, Harald ; Hingorani, Aroon ; Jørgensen, Torben ; Jousilahti, Pekka ; Kivimaki, Mika ; Kumari, Meena ; Laakso, Markku ; Langenberg, Claudia ; Linneberg, Allan ; Luke, Amy ; Mckenzie, Colin A ; Palotie, Aarno ; Pedersen, Oluf ; Peters, Annette ; Strauch, Konstantin ; Tayo, Bamidele O ; Wareham, Nicholas J ; Bennett, David A ; Bertram, Lars ; Blangero, John ; Blüher, Matthias ; Bouchard, Claude ; Campbell, Harry ; Cho, Nam H ; Cummings, Steven R ; Czerwinski, Stefan A ; Demuth, Ilja ; Eckardt, Rahel ; Eriksson, Johan G ; Ferrucci, Luigi ; Franco, Oscar H ; Froguel, Philippe ; Gansevoort, Ron T ; Hansen, Torben ; Harris, Tamara B ; Hastie, Nicholas ; Heliövaara, Markku ; Hofman, Albert ; Jordan, Joanne M ; Jula, Antti ; Kähönen, Mika ; Kajantie, Eero ; Knekt, Paul B ; Koskinen, Seppo ; Kovacs, Peter ; Lehtimäki, Terho ; Lind, Lars ; Liu, Yongmei ; Orwoll, Eric S ; Osmond, Clive ; Perola, Markus ; Pérusse, Louis ; Raitakari, Olli T ; Rankinen, Tuomo ; Rao, D C ; Rice, Treva K ; Rivadeneira, Fernando ; Rudan, Igor ; Salomaa, Veikko ; Sørensen, Thorkild I A ; Stumvoll, Michael ; Tönjes, Anke ; Towne, Bradford ; Tranah, Gregory J ; Tremblay, Angelo ; Uitterlinden, André G ; van der Harst, Pim ; Vartiainen, Erkki ; Viikari, Jorma S ; Vitart, Veronique ; Vohl, Marie-Claude ; Völzke, Henry ; Walker, Mark ; Wallaschofski, Henri ; Wild, Sarah ; Wilson, James F ; Yengo, Loïc ; Bishop, D Timothy ; Borecki, Ingrid B ; Chambers, John C ; Cupples, L Adrienne ; Dehghan, Abbas ; Deloukas, Panos ; Fatemifar, Ghazaleh ; Fox, Caroline ; Furey, Terrence S ; Franke, Lude ; Han, Jiali ; Hunter, David J ; Karjalainen, Juha ; Karpe, Fredrik ; Kaplan, Robert C ; Kooner, Jaspal S ; McCarthy, Mark I ; Murabito, Joanne M ; Morris, Andrew P ; Bishop, Julia A N ; North, Kari E ; Ohlsson, Claes ; Ong, Ken K ; Prokopenko, Inga ; Richards, J Brent ; Schadt, Eric E ; Spector, Tim D ; Widén, Elisabeth ; Willer, Cristen J ; Yang, Jian ; Ingelsson, Erik ; Mohlke, Karen L ; Hirschhorn, Joel N ; Pospisilik, John Andrew ; Zillikens, M Carola ; Lindgren, Cecilia ; Kilpeläinen, Tuomas Oskari ; Loos, Ruth J F. / New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk. In: Nature Communications. 2016 ; Vol. 7. pp. 1-15.
Bibtex
@article{3c0858b47c0e4aeabde5ee47c324bb07,
title = "New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk",
abstract = "To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.",
author = "Yingchang Lu and Day, {Felix R} and Stefan Gustafsson and Buchkovich, {Martin L} and Jianbo Na and Veronique Bataille and Cousminer, {Diana L} and Zari Dastani and Drong, {Alexander W} and T{\~o}nu Esko and Evans, {David M} and Mario Falchi and Feitosa, {Mary F} and Teresa Ferreira and Hedman, {{\AA}sa K} and Robin Haring and Hysi, {Pirro G} and Iles, {Mark M} and Justice, {Anne E} and Stavroula Kanoni and Vasiliki Lagou and Rui Li and Xin Li and Adam Locke and Chen Lu and Reedik M{\"a}gi and Perry, {John R B} and Pers, {Tune H} and Qibin Qi and Marianna Sanna and Schmidt, {Ellen M} and Scott, {William R} and Dmitry Shungin and Alexander Teumer and Vinkhuyzen, {Anna A E} and Walker, {Ryan W} and Harm-Jan Westra and Mingfeng Zhang and Weihua Zhang and Zhao, {Jing Hua} and Zhihong Zhu and Uzma Afzal and Ahluwalia, {Tarun Veer Singh} and Bakker, {Stephan J L} and Claire Bellis and Am{\'e}lie Bonnefond and Katja Borodulin and Buchman, {Aron S} and Tommy Cederholm and Choh, {Audrey C} and Choi, {Hyung Jin} and Curran, {Joanne E} and {de Groot}, {Lisette C P G M} and {De Jager}, {Philip L} and Dhonukshe-Rutten, {Rosalie A M} and Enneman, {Anke W} and Elodie Eury and Evans, {Daniel S} and Tom Forsen and Nele Friedrich and Fr{\'e}d{\'e}ric Fumeron and Garcia, {Melissa E} and Simone G{\"a}rtner and Bok-Ghee Han and Havulinna, {Aki S} and Caroline Hayward and Dena Hernandez and Hans Hillege and Till Ittermann and Kent, {Jack W} and Ivana Kolcic and Tiina Laatikainen and Jari Lahti and {Mateo Leach}, Irene and Lee, {Christine G} and Jong-Young Lee and Tian Liu and Youfang Liu and St{\'e}phane Lobbens and Marie Loh and Leo-Pekka Lyytik{\"a}inen and Carolina Medina-Gomez and Karl Micha{\"e}lsson and Nalls, {Mike A} and Nielson, {Carrie M} and Laticia Oozageer and Laura Pascoe and Lavinia Paternoster and Ozren Pola{\v s}ek and Samuli Ripatti and Sarzynski, {Mark A} and Shin, {Chan Soo} and Naran{\v c}i{\'c}, {Nina Smolej} and Dominik Spira and Priya Srikanth and Elisabeth Steinhagen-Thiessen and Sung, {Yun Ju} and Swart, {Karin M A} and Leena Taittonen and Toshiko Tanaka and Emmi Tikkanen and {van der Velde}, Nathalie and {van Schoor}, {Natasja M} and Niek Verweij and Wright, {Alan F} and Lei Yu and Zmuda, {Joseph M} and Niina Eklund and Terrence Forrester and Niels Grarup and Jackson, {Anne U} and Kati Kristiansson and Teemu Kuulasmaa and Johanna Kuusisto and Peter Lichtner and Jian'an Luan and Anubha Mahajan and Satu M{\"a}nnist{\"o} and Palmer, {Cameron D} and Ried, {Janina S} and Scott, {Robert A} and Alena Stanc{\'a}kov{\'a} and Wagner, {Peter J} and Ayse Demirkan and Angela D{\"o}ring and Vilmundur Gudnason and Kiel, {Douglas P} and Brigitte K{\"u}hnel and Massimo Mangino and Barbara Mcknight and Cristina Menni and O'Connell, {Jeffrey R} and Oostra, {Ben A} and Shuldiner, {Alan R} and Kijoung Song and Liesbeth Vandenput and {van Duijn}, {Cornelia M} and Peter Vollenweider and White, {Charles C} and Michael Boehnke and Yvonne Boettcher and Cooper, {Richard S} and Forouhi, {Nita G} and Christian Gieger and Harald Grallert and Aroon Hingorani and Torben J{\o}rgensen and Pekka Jousilahti and Mika Kivimaki and Meena Kumari and Markku Laakso and Claudia Langenberg and Allan Linneberg and Amy Luke and Mckenzie, {Colin A} and Aarno Palotie and Oluf Pedersen and Annette Peters and Konstantin Strauch and Tayo, {Bamidele O} and Wareham, {Nicholas J} and Bennett, {David A} and Lars Bertram and John Blangero and Matthias Bl{\"u}her and Claude Bouchard and Harry Campbell and Cho, {Nam H} and Cummings, {Steven R} and Czerwinski, {Stefan A} and Ilja Demuth and Rahel Eckardt and Eriksson, {Johan G} and Luigi Ferrucci and Franco, {Oscar H} and Philippe Froguel and Gansevoort, {Ron T} and Torben Hansen and Harris, {Tamara B} and Nicholas Hastie and Markku Heli{\"o}vaara and Albert Hofman and Jordan, {Joanne M} and Antti Jula and Mika K{\"a}h{\"o}nen and Eero Kajantie and Knekt, {Paul B} and Seppo Koskinen and Peter Kovacs and Terho Lehtim{\"a}ki and Lars Lind and Yongmei Liu and Orwoll, {Eric S} and Clive Osmond and Markus Perola and Louis P{\'e}russe and Raitakari, {Olli T} and Tuomo Rankinen and Rao, {D C} and Rice, {Treva K} and Fernando Rivadeneira and Igor Rudan and Veikko Salomaa and S{\o}rensen, {Thorkild I A} and Michael Stumvoll and Anke T{\"o}njes and Bradford Towne and Tranah, {Gregory J} and Angelo Tremblay and Uitterlinden, {Andr{\'e} G} and {van der Harst}, Pim and Erkki Vartiainen and Viikari, {Jorma S} and Veronique Vitart and Marie-Claude Vohl and Henry V{\"o}lzke and Mark Walker and Henri Wallaschofski and Sarah Wild and Wilson, {James F} and Lo{\"i}c Yengo and Bishop, {D Timothy} and Borecki, {Ingrid B} and Chambers, {John C} and Cupples, {L Adrienne} and Abbas Dehghan and Panos Deloukas and Ghazaleh Fatemifar and Caroline Fox and Furey, {Terrence S} and Lude Franke and Jiali Han and Hunter, {David J} and Juha Karjalainen and Fredrik Karpe and Kaplan, {Robert C} and Kooner, {Jaspal S} and McCarthy, {Mark I} and Murabito, {Joanne M} and Morris, {Andrew P} and Bishop, {Julia A N} and North, {Kari E} and Claes Ohlsson and Ong, {Ken K} and Inga Prokopenko and Richards, {J Brent} and Schadt, {Eric E} and Spector, {Tim D} and Elisabeth Wid{\'e}n and Willer, {Cristen J} and Jian Yang and Erik Ingelsson and Mohlke, {Karen L} and Hirschhorn, {Joel N} and Pospisilik, {John Andrew} and Zillikens, {M Carola} and Cecilia Lindgren and Kilpel{\"a}inen, {Tuomas Oskari} and Loos, {Ruth J F}",
year = "2016",
month = feb,
day = "1",
doi = "10.1038/ncomms10495",
language = "English",
volume = "7",
pages = "1--15",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
AU - Lu, Yingchang
AU - Day, Felix R
AU - Gustafsson, Stefan
AU - Buchkovich, Martin L
AU - Na, Jianbo
AU - Bataille, Veronique
AU - Cousminer, Diana L
AU - Dastani, Zari
AU - Drong, Alexander W
AU - Esko, Tõnu
AU - Evans, David M
AU - Falchi, Mario
AU - Feitosa, Mary F
AU - Ferreira, Teresa
AU - Hedman, Åsa K
AU - Haring, Robin
AU - Hysi, Pirro G
AU - Iles, Mark M
AU - Justice, Anne E
AU - Kanoni, Stavroula
AU - Lagou, Vasiliki
AU - Li, Rui
AU - Li, Xin
AU - Locke, Adam
AU - Lu, Chen
AU - Mägi, Reedik
AU - Perry, John R B
AU - Pers, Tune H
AU - Qi, Qibin
AU - Sanna, Marianna
AU - Schmidt, Ellen M
AU - Scott, William R
AU - Shungin, Dmitry
AU - Teumer, Alexander
AU - Vinkhuyzen, Anna A E
AU - Walker, Ryan W
AU - Westra, Harm-Jan
AU - Zhang, Mingfeng
AU - Zhang, Weihua
AU - Zhao, Jing Hua
AU - Zhu, Zhihong
AU - Afzal, Uzma
AU - Ahluwalia, Tarun Veer Singh
AU - Bakker, Stephan J L
AU - Bellis, Claire
AU - Bonnefond, Amélie
AU - Borodulin, Katja
AU - Buchman, Aron S
AU - Cederholm, Tommy
AU - Choh, Audrey C
AU - Choi, Hyung Jin
AU - Curran, Joanne E
AU - de Groot, Lisette C P G M
AU - De Jager, Philip L
AU - Dhonukshe-Rutten, Rosalie A M
AU - Enneman, Anke W
AU - Eury, Elodie
AU - Evans, Daniel S
AU - Forsen, Tom
AU - Friedrich, Nele
AU - Fumeron, Frédéric
AU - Garcia, Melissa E
AU - Gärtner, Simone
AU - Han, Bok-Ghee
AU - Havulinna, Aki S
AU - Hayward, Caroline
AU - Hernandez, Dena
AU - Hillege, Hans
AU - Ittermann, Till
AU - Kent, Jack W
AU - Kolcic, Ivana
AU - Laatikainen, Tiina
AU - Lahti, Jari
AU - Mateo Leach, Irene
AU - Lee, Christine G
AU - Lee, Jong-Young
AU - Liu, Tian
AU - Liu, Youfang
AU - Lobbens, Stéphane
AU - Loh, Marie
AU - Lyytikäinen, Leo-Pekka
AU - Medina-Gomez, Carolina
AU - Michaëlsson, Karl
AU - Nalls, Mike A
AU - Nielson, Carrie M
AU - Oozageer, Laticia
AU - Pascoe, Laura
AU - Paternoster, Lavinia
AU - Polašek, Ozren
AU - Ripatti, Samuli
AU - Sarzynski, Mark A
AU - Shin, Chan Soo
AU - Narančić, Nina Smolej
AU - Spira, Dominik
AU - Srikanth, Priya
AU - Steinhagen-Thiessen, Elisabeth
AU - Sung, Yun Ju
AU - Swart, Karin M A
AU - Taittonen, Leena
AU - Tanaka, Toshiko
AU - Tikkanen, Emmi
AU - van der Velde, Nathalie
AU - van Schoor, Natasja M
AU - Verweij, Niek
AU - Wright, Alan F
AU - Yu, Lei
AU - Zmuda, Joseph M
AU - Eklund, Niina
AU - Forrester, Terrence
AU - Grarup, Niels
AU - Jackson, Anne U
AU - Kristiansson, Kati
AU - Kuulasmaa, Teemu
AU - Kuusisto, Johanna
AU - Lichtner, Peter
AU - Luan, Jian'an
AU - Mahajan, Anubha
AU - Männistö, Satu
AU - Palmer, Cameron D
AU - Ried, Janina S
AU - Scott, Robert A
AU - Stancáková, Alena
AU - Wagner, Peter J
AU - Demirkan, Ayse
AU - Döring, Angela
AU - Gudnason, Vilmundur
AU - Kiel, Douglas P
AU - Kühnel, Brigitte
AU - Mangino, Massimo
AU - Mcknight, Barbara
AU - Menni, Cristina
AU - O'Connell, Jeffrey R
AU - Oostra, Ben A
AU - Shuldiner, Alan R
AU - Song, Kijoung
AU - Vandenput, Liesbeth
AU - van Duijn, Cornelia M
AU - Vollenweider, Peter
AU - White, Charles C
AU - Boehnke, Michael
AU - Boettcher, Yvonne
AU - Cooper, Richard S
AU - Forouhi, Nita G
AU - Gieger, Christian
AU - Grallert, Harald
AU - Hingorani, Aroon
AU - Jørgensen, Torben
AU - Jousilahti, Pekka
AU - Kivimaki, Mika
AU - Kumari, Meena
AU - Laakso, Markku
AU - Langenberg, Claudia
AU - Linneberg, Allan
AU - Luke, Amy
AU - Mckenzie, Colin A
AU - Palotie, Aarno
AU - Pedersen, Oluf
AU - Peters, Annette
AU - Strauch, Konstantin
AU - Tayo, Bamidele O
AU - Wareham, Nicholas J
AU - Bennett, David A
AU - Bertram, Lars
AU - Blangero, John
AU - Blüher, Matthias
AU - Bouchard, Claude
AU - Campbell, Harry
AU - Cho, Nam H
AU - Cummings, Steven R
AU - Czerwinski, Stefan A
AU - Demuth, Ilja
AU - Eckardt, Rahel
AU - Eriksson, Johan G
AU - Ferrucci, Luigi
AU - Franco, Oscar H
AU - Froguel, Philippe
AU - Gansevoort, Ron T
AU - Hansen, Torben
AU - Harris, Tamara B
AU - Hastie, Nicholas
AU - Heliövaara, Markku
AU - Hofman, Albert
AU - Jordan, Joanne M
AU - Jula, Antti
AU - Kähönen, Mika
AU - Kajantie, Eero
AU - Knekt, Paul B
AU - Koskinen, Seppo
AU - Kovacs, Peter
AU - Lehtimäki, Terho
AU - Lind, Lars
AU - Liu, Yongmei
AU - Orwoll, Eric S
AU - Osmond, Clive
AU - Perola, Markus
AU - Pérusse, Louis
AU - Raitakari, Olli T
AU - Rankinen, Tuomo
AU - Rao, D C
AU - Rice, Treva K
AU - Rivadeneira, Fernando
AU - Rudan, Igor
AU - Salomaa, Veikko
AU - Sørensen, Thorkild I A
AU - Stumvoll, Michael
AU - Tönjes, Anke
AU - Towne, Bradford
AU - Tranah, Gregory J
AU - Tremblay, Angelo
AU - Uitterlinden, André G
AU - van der Harst, Pim
AU - Vartiainen, Erkki
AU - Viikari, Jorma S
AU - Vitart, Veronique
AU - Vohl, Marie-Claude
AU - Völzke, Henry
AU - Walker, Mark
AU - Wallaschofski, Henri
AU - Wild, Sarah
AU - Wilson, James F
AU - Yengo, Loïc
AU - Bishop, D Timothy
AU - Borecki, Ingrid B
AU - Chambers, John C
AU - Cupples, L Adrienne
AU - Dehghan, Abbas
AU - Deloukas, Panos
AU - Fatemifar, Ghazaleh
AU - Fox, Caroline
AU - Furey, Terrence S
AU - Franke, Lude
AU - Han, Jiali
AU - Hunter, David J
AU - Karjalainen, Juha
AU - Karpe, Fredrik
AU - Kaplan, Robert C
AU - Kooner, Jaspal S
AU - McCarthy, Mark I
AU - Murabito, Joanne M
AU - Morris, Andrew P
AU - Bishop, Julia A N
AU - North, Kari E
AU - Ohlsson, Claes
AU - Ong, Ken K
AU - Prokopenko, Inga
AU - Richards, J Brent
AU - Schadt, Eric E
AU - Spector, Tim D
AU - Widén, Elisabeth
AU - Willer, Cristen J
AU - Yang, Jian
AU - Ingelsson, Erik
AU - Mohlke, Karen L
AU - Hirschhorn, Joel N
AU - Pospisilik, John Andrew
AU - Zillikens, M Carola
AU - Lindgren, Cecilia
AU - Kilpeläinen, Tuomas Oskari
AU - Loos, Ruth J F
PY - 2016/2/1
Y1 - 2016/2/1
N2 - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
AB - To increase our understanding of the genetic basis of adiposity and its links to cardiometabolic disease risk, we conducted a genome-wide association meta-analysis of body fat percentage (BF%) in up to 100,716 individuals. Twelve loci reached genome-wide significance (P<5 × 10(-8)), of which eight were previously associated with increased overall adiposity (BMI, BF%) and four (in or near COBLL1/GRB14, IGF2BP1, PLA2G6, CRTC1) were novel associations with BF%. Seven loci showed a larger effect on BF% than on BMI, suggestive of a primary association with adiposity, while five loci showed larger effects on BMI than on BF%, suggesting association with both fat and lean mass. In particular, the loci more strongly associated with BF% showed distinct cross-phenotype association signatures with a range of cardiometabolic traits revealing new insights in the link between adiposity and disease risk.
U2 - 10.1038/ncomms10495
DO - 10.1038/ncomms10495
M3 - Journal article
C2 - 26833246
VL - 7
SP - 1
EP - 15
JO - Nature Communications
JF - Nature Communications
SN - 2041-1723
M1 - 10495
ER -
