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Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits : a multi-ethnic meta-analysis of 45,891 individuals. / Dastani, Zari; Hivert, Marie-France; Timpson, Nicholas; Perry, John R B; Yuan, Xin; Scott, Robert A; Henneman, Peter; Heid, Iris M; Kizer, Jorge R; Lyytikäinen, Leo-Pekka; Fuchsberger, Christian; Tanaka, Toshiko; Morris, Andrew P; Small, Kerrin; Isaacs, Aaron; Beekman, Marian; Coassin, Stefan; Lohman, Kurt; Qi, Lu; Kanoni, Stavroula; Pankow, James S; Uh, Hae-Won; Wu, Ying; Bidulescu, Aurelian; Rasmussen-Torvik, Laura J; Greenwood, Celia M T; Ladouceur, Martin; Grimsby, Jonna; Manning, Alisa K; Liu, Ching-Ti; Kooner, Jaspal; Mooser, Vincent E; Vollenweider, Peter; Kapur, Karen A; Chambers, John; Wareham, Nicholas J; Langenberg, Claudia; Frants, Rune; Willems-Vandijk, Ko; Oostra, Ben A; Willems, Sara M; Lamina, Claudia; Winkler, Thomas W; Grarup, Niels; Jørgensen, Torben; Sparsø, Thomas; Hansen, Torben; Pedersen, Oluf; Karpe, Fredrik; Kyvik, Kirsten O; DIAGRAM+ Consortium.
In:
P L o S Genetics (Online), Vol. 8, No. 3, 2012, p. e1002607.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Dastani, Z, Hivert, M-F, Timpson, N, Perry, JRB, Yuan, X, Scott, RA, Henneman, P, Heid, IM, Kizer, JR, Lyytikäinen, L-P, Fuchsberger, C, Tanaka, T, Morris, AP, Small, K, Isaacs, A, Beekman, M, Coassin, S, Lohman, K, Qi, L, Kanoni, S, Pankow, JS, Uh, H-W, Wu, Y, Bidulescu, A, Rasmussen-Torvik, LJ, Greenwood, CMT, Ladouceur, M, Grimsby, J, Manning, AK, Liu, C-T, Kooner, J, Mooser, VE, Vollenweider, P, Kapur, KA, Chambers, J, Wareham, NJ, Langenberg, C, Frants, R, Willems-Vandijk, K, Oostra, BA, Willems, SM, Lamina, C, Winkler, TW
, Grarup, N, Jørgensen, T, Sparsø, T
, Hansen, T, Pedersen, O, Karpe, F, Kyvik, KO & DIAGRAM+ Consortium 2012, '
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals',
P L o S Genetics (Online), vol. 8, no. 3, pp. e1002607.
https://doi.org/10.1371/journal.pgen.1002607APA
Dastani, Z., Hivert, M-F., Timpson, N., Perry, J. R. B., Yuan, X., Scott, R. A., Henneman, P., Heid, I. M., Kizer, J. R., Lyytikäinen, L-P., Fuchsberger, C., Tanaka, T., Morris, A. P., Small, K., Isaacs, A., Beekman, M., Coassin, S., Lohman, K., Qi, L., ... DIAGRAM+ Consortium (2012).
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
P L o S Genetics (Online),
8(3), e1002607.
https://doi.org/10.1371/journal.pgen.1002607Vancouver
Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA et al.
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.
P L o S Genetics (Online). 2012;8(3):e1002607.
https://doi.org/10.1371/journal.pgen.1002607Author
Dastani, Zari ; Hivert, Marie-France ; Timpson, Nicholas ; Perry, John R B ; Yuan, Xin ; Scott, Robert A ; Henneman, Peter ; Heid, Iris M ; Kizer, Jorge R ; Lyytikäinen, Leo-Pekka ; Fuchsberger, Christian ; Tanaka, Toshiko ; Morris, Andrew P ; Small, Kerrin ; Isaacs, Aaron ; Beekman, Marian ; Coassin, Stefan ; Lohman, Kurt ; Qi, Lu ; Kanoni, Stavroula ; Pankow, James S ; Uh, Hae-Won ; Wu, Ying ; Bidulescu, Aurelian ; Rasmussen-Torvik, Laura J ; Greenwood, Celia M T ; Ladouceur, Martin ; Grimsby, Jonna ; Manning, Alisa K ; Liu, Ching-Ti ; Kooner, Jaspal ; Mooser, Vincent E ; Vollenweider, Peter ; Kapur, Karen A ; Chambers, John ; Wareham, Nicholas J ; Langenberg, Claudia ; Frants, Rune ; Willems-Vandijk, Ko ; Oostra, Ben A ; Willems, Sara M ; Lamina, Claudia ; Winkler, Thomas W ; Grarup, Niels ; Jørgensen, Torben ; Sparsø, Thomas ; Hansen, Torben ; Pedersen, Oluf ; Karpe, Fredrik ; Kyvik, Kirsten O ; DIAGRAM+ Consortium. / Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits : a multi-ethnic meta-analysis of 45,891 individuals. In: P L o S Genetics (Online). 2012 ; Vol. 8, No. 3. pp. e1002607.
Bibtex
@article{bd32e392852749ff8cd73d6a32652ae5,
title = "Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals",
abstract = "Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P¿=¿4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N¿=¿4,232 African Americans, N¿=¿1,776 Asians, and N¿=¿29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p",
author = "Zari Dastani and Marie-France Hivert and Nicholas Timpson and Perry, {John R B} and Xin Yuan and Scott, {Robert A} and Peter Henneman and Heid, {Iris M} and Kizer, {Jorge R} and Leo-Pekka Lyytik{\"a}inen and Christian Fuchsberger and Toshiko Tanaka and Morris, {Andrew P} and Kerrin Small and Aaron Isaacs and Marian Beekman and Stefan Coassin and Kurt Lohman and Lu Qi and Stavroula Kanoni and Pankow, {James S} and Hae-Won Uh and Ying Wu and Aurelian Bidulescu and Rasmussen-Torvik, {Laura J} and Greenwood, {Celia M T} and Martin Ladouceur and Jonna Grimsby and Manning, {Alisa K} and Ching-Ti Liu and Jaspal Kooner and Mooser, {Vincent E} and Peter Vollenweider and Kapur, {Karen A} and John Chambers and Wareham, {Nicholas J} and Claudia Langenberg and Rune Frants and Ko Willems-Vandijk and Oostra, {Ben A} and Willems, {Sara M} and Claudia Lamina and Winkler, {Thomas W} and Niels Grarup and Torben J{\o}rgensen and Thomas Spars{\o} and Torben Hansen and Oluf Pedersen and Fredrik Karpe and Kyvik, {Kirsten O} and {DIAGRAM+ Consortium}",
year = "2012",
doi = "10.1371/journal.pgen.1002607",
language = "English",
volume = "8",
pages = "e1002607",
journal = "P L o S Genetics",
issn = "1553-7390",
publisher = "Public Library of Science",
number = "3",
}
RIS
TY - JOUR
T1 - Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits
T2 - a multi-ethnic meta-analysis of 45,891 individuals
AU - Dastani, Zari
AU - Hivert, Marie-France
AU - Timpson, Nicholas
AU - Perry, John R B
AU - Yuan, Xin
AU - Scott, Robert A
AU - Henneman, Peter
AU - Heid, Iris M
AU - Kizer, Jorge R
AU - Lyytikäinen, Leo-Pekka
AU - Fuchsberger, Christian
AU - Tanaka, Toshiko
AU - Morris, Andrew P
AU - Small, Kerrin
AU - Isaacs, Aaron
AU - Beekman, Marian
AU - Coassin, Stefan
AU - Lohman, Kurt
AU - Qi, Lu
AU - Kanoni, Stavroula
AU - Pankow, James S
AU - Uh, Hae-Won
AU - Wu, Ying
AU - Bidulescu, Aurelian
AU - Rasmussen-Torvik, Laura J
AU - Greenwood, Celia M T
AU - Ladouceur, Martin
AU - Grimsby, Jonna
AU - Manning, Alisa K
AU - Liu, Ching-Ti
AU - Kooner, Jaspal
AU - Mooser, Vincent E
AU - Vollenweider, Peter
AU - Kapur, Karen A
AU - Chambers, John
AU - Wareham, Nicholas J
AU - Langenberg, Claudia
AU - Frants, Rune
AU - Willems-Vandijk, Ko
AU - Oostra, Ben A
AU - Willems, Sara M
AU - Lamina, Claudia
AU - Winkler, Thomas W
AU - Grarup, Niels
AU - Jørgensen, Torben
AU - Sparsø, Thomas
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Karpe, Fredrik
AU - Kyvik, Kirsten O
AU - DIAGRAM+ Consortium
PY - 2012
Y1 - 2012
N2 - Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P¿=¿4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N¿=¿4,232 African Americans, N¿=¿1,776 Asians, and N¿=¿29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p
AB - Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P¿=¿4.5×10(-8)-1.2×10(-43)). Using a novel method to combine data across ethnicities (N¿=¿4,232 African Americans, N¿=¿1,776 Asians, and N¿=¿29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidate regions were associated with adiponectin concentrations after accounting for multiple testing (p
U2 - 10.1371/journal.pgen.1002607
DO - 10.1371/journal.pgen.1002607
M3 - Journal article
C2 - 22479202
VL - 8
SP - e1002607
JO - P L o S Genetics
JF - P L o S Genetics
SN - 1553-7390
IS - 3
ER -
