Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. / Donkin, Ida; Versteyhe, Soetkin; Ingerslev, Lars R; Qian, Kui; Mechta, Mie; Nordkap, Loa; Mortensen, Brynjulf; Appel, Emil Vincent R; Jørgensen, Niels; Kristiansen, Viggo B; Hansen, Torben; Workman, Christopher T.; Zierath, Juleen R; Barrès, Romain.

In: Cell Metabolism, Vol. 23, No. 2, 09.02.2016, p. 369-78.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Donkin, I, Versteyhe, S, Ingerslev, LR, Qian, K, Mechta, M, Nordkap, L, Mortensen, B, Appel, EVR, Jørgensen, N, Kristiansen, VB, Hansen, T, Workman, CT, Zierath, JR & Barrès, R 2016, 'Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans', Cell Metabolism, vol. 23, no. 2, pp. 369-78. https://doi.org/10.1016/j.cmet.2015.11.004

APA

Donkin, I., Versteyhe, S., Ingerslev, L. R., Qian, K., Mechta, M., Nordkap, L., Mortensen, B., Appel, E. V. R., Jørgensen, N., Kristiansen, V. B., Hansen, T., Workman, C. T., Zierath, J. R., & Barrès, R. (2016). Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metabolism, 23(2), 369-78. https://doi.org/10.1016/j.cmet.2015.11.004

Vancouver

Donkin I, Versteyhe S, Ingerslev LR, Qian K, Mechta M, Nordkap L et al. Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. Cell Metabolism. 2016 Feb 9;23(2):369-78. https://doi.org/10.1016/j.cmet.2015.11.004

Author

Donkin, Ida ; Versteyhe, Soetkin ; Ingerslev, Lars R ; Qian, Kui ; Mechta, Mie ; Nordkap, Loa ; Mortensen, Brynjulf ; Appel, Emil Vincent R ; Jørgensen, Niels ; Kristiansen, Viggo B ; Hansen, Torben ; Workman, Christopher T. ; Zierath, Juleen R ; Barrès, Romain. / Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans. In: Cell Metabolism. 2016 ; Vol. 23, No. 2. pp. 369-78.

Bibtex

@article{3c980689be4143ba8272eeeadfe456b3,
title = "Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans",
abstract = "Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss remodels the epigenetic signature of spermatozoa in human obesity. Comprehensive profiling of the epigenome of sperm from lean and obese men showed similar histone positioning, but small non-coding RNA expression and DNA methylation patterns were markedly different. In a separate cohort of morbidly obese men, surgery-induced weight loss was associated with a dramatic remodeling of sperm DNA methylation, notably at genetic locations implicated in the central control of appetite. Our data provide evidence that the epigenome of human spermatozoa dynamically changes under environmental pressure and offers insight into how obesity may propagate metabolic dysfunction to the next generation.",
author = "Ida Donkin and Soetkin Versteyhe and Ingerslev, {Lars R} and Kui Qian and Mie Mechta and Loa Nordkap and Brynjulf Mortensen and Appel, {Emil Vincent R} and Niels J{\o}rgensen and Kristiansen, {Viggo B} and Torben Hansen and Workman, {Christopher T.} and Zierath, {Juleen R} and Romain Barr{\`e}s",
note = "Copyright {\textcopyright} 2016 Elsevier Inc. All rights reserved.",
year = "2016",
month = feb,
day = "9",
doi = "10.1016/j.cmet.2015.11.004",
language = "English",
volume = "23",
pages = "369--78",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "2",

}

RIS

TY - JOUR

T1 - Obesity and Bariatric Surgery Drive Epigenetic Variation of Spermatozoa in Humans

AU - Donkin, Ida

AU - Versteyhe, Soetkin

AU - Ingerslev, Lars R

AU - Qian, Kui

AU - Mechta, Mie

AU - Nordkap, Loa

AU - Mortensen, Brynjulf

AU - Appel, Emil Vincent R

AU - Jørgensen, Niels

AU - Kristiansen, Viggo B

AU - Hansen, Torben

AU - Workman, Christopher T.

AU - Zierath, Juleen R

AU - Barrès, Romain

N1 - Copyright © 2016 Elsevier Inc. All rights reserved.

PY - 2016/2/9

Y1 - 2016/2/9

N2 - Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss remodels the epigenetic signature of spermatozoa in human obesity. Comprehensive profiling of the epigenome of sperm from lean and obese men showed similar histone positioning, but small non-coding RNA expression and DNA methylation patterns were markedly different. In a separate cohort of morbidly obese men, surgery-induced weight loss was associated with a dramatic remodeling of sperm DNA methylation, notably at genetic locations implicated in the central control of appetite. Our data provide evidence that the epigenome of human spermatozoa dynamically changes under environmental pressure and offers insight into how obesity may propagate metabolic dysfunction to the next generation.

AB - Obesity is a heritable disorder, with children of obese fathers at higher risk of developing obesity. Environmental factors epigenetically influence somatic tissues, but the contribution of these factors to the establishment of epigenetic patterns in human gametes is unknown. Here, we hypothesized that weight loss remodels the epigenetic signature of spermatozoa in human obesity. Comprehensive profiling of the epigenome of sperm from lean and obese men showed similar histone positioning, but small non-coding RNA expression and DNA methylation patterns were markedly different. In a separate cohort of morbidly obese men, surgery-induced weight loss was associated with a dramatic remodeling of sperm DNA methylation, notably at genetic locations implicated in the central control of appetite. Our data provide evidence that the epigenome of human spermatozoa dynamically changes under environmental pressure and offers insight into how obesity may propagate metabolic dysfunction to the next generation.

U2 - 10.1016/j.cmet.2015.11.004

DO - 10.1016/j.cmet.2015.11.004

M3 - Journal article

C2 - 26669700

VL - 23

SP - 369

EP - 378

JO - Cell Metabolism

JF - Cell Metabolism

SN - 1550-4131

IS - 2

ER -

ID: 156086772