Protein intake, metabolic status and the gut microbiota in different ethnicities: Results from two independent cohorts
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Protein intake, metabolic status and the gut microbiota in different ethnicities : Results from two independent cohorts. / Bel Lassen, Pierre; Attaye, Ilias; Adriouch, Solia; Nicolaou, Mary; Aron-Wisnewsky, Judith; Nielsen, Trine; Chakaroun, Rima; Le Chatelier, Emmanuelle; Forslund, Sofia; Belda, Eugeni; Bork, Peer; Bäckhed, Fredrik; Stumvoll, Michael; Pedersen, Oluf; Herrema, Hilde; Groen, Albert K.; Pinto-Sietsma, Sara Joan; Zwinderman, Aeilko H.; Nieuwdorp, Max; Clement, Karine; MetaCardis Consortium.
In: Nutrients, Vol. 13, No. 9, 3159, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Protein intake, metabolic status and the gut microbiota in different ethnicities
T2 - Results from two independent cohorts
AU - Bel Lassen, Pierre
AU - Attaye, Ilias
AU - Adriouch, Solia
AU - Nicolaou, Mary
AU - Aron-Wisnewsky, Judith
AU - Nielsen, Trine
AU - Chakaroun, Rima
AU - Le Chatelier, Emmanuelle
AU - Forslund, Sofia
AU - Belda, Eugeni
AU - Bork, Peer
AU - Bäckhed, Fredrik
AU - Stumvoll, Michael
AU - Pedersen, Oluf
AU - Herrema, Hilde
AU - Groen, Albert K.
AU - Pinto-Sietsma, Sara Joan
AU - Zwinderman, Aeilko H.
AU - Nieuwdorp, Max
AU - Clement, Karine
AU - MetaCardis Consortium
N1 - Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2021
Y1 - 2021
N2 - Background: Protein intake has been associated with the development of pre-diabetes (pre-T2D) and type 2 diabetes (T2D). The gut microbiota has the capacity to produce harmful metabolites derived from dietary protein. Furthermore, both the gut microbiota composition and metabolic status (e.g., insulin resistance) can be modulated by diet and ethnicity. However, to date most studies have predominantly focused on carbohydrate and fiber intake with regards to metabolic status and gut microbiota composition. Objectives: To determine the associations between dietary protein intake, gut microbiota composition, and metabolic status in different ethnicities. Methods: Separate cross-sectional analysis of two European cohorts (MetaCardis, n = 1759; HELIUS, n = 1528) including controls, patients with pre-T2D, and patients with T2D of Caucasian/non-Caucasian origin with nutritional data obtained from Food Frequency Questionnaires and gut microbiota composition. Results: In both cohorts, animal (but not plant) protein intake was associated with pre-T2D status and T2D status after adjustment for confounders. There was no significant association between protein intake (total, animal, or plant) with either gut microbiota alpha diversity or beta diversity, regardless of ethnicity. At the species level, we identified taxonomical signatures associated with animal protein intake that overlapped in both cohorts with different abundances according to metabolic status and ethnicity. Conclusions: Animal protein intake is associated with pre-T2D and T2D status but not with gut microbiota beta or alpha diversity, regardless of ethnicity. Gut microbial taxonomical signatures were identified, which could function as potential modulators in the association between dietary protein intake and metabolic status.
AB - Background: Protein intake has been associated with the development of pre-diabetes (pre-T2D) and type 2 diabetes (T2D). The gut microbiota has the capacity to produce harmful metabolites derived from dietary protein. Furthermore, both the gut microbiota composition and metabolic status (e.g., insulin resistance) can be modulated by diet and ethnicity. However, to date most studies have predominantly focused on carbohydrate and fiber intake with regards to metabolic status and gut microbiota composition. Objectives: To determine the associations between dietary protein intake, gut microbiota composition, and metabolic status in different ethnicities. Methods: Separate cross-sectional analysis of two European cohorts (MetaCardis, n = 1759; HELIUS, n = 1528) including controls, patients with pre-T2D, and patients with T2D of Caucasian/non-Caucasian origin with nutritional data obtained from Food Frequency Questionnaires and gut microbiota composition. Results: In both cohorts, animal (but not plant) protein intake was associated with pre-T2D status and T2D status after adjustment for confounders. There was no significant association between protein intake (total, animal, or plant) with either gut microbiota alpha diversity or beta diversity, regardless of ethnicity. At the species level, we identified taxonomical signatures associated with animal protein intake that overlapped in both cohorts with different abundances according to metabolic status and ethnicity. Conclusions: Animal protein intake is associated with pre-T2D and T2D status but not with gut microbiota beta or alpha diversity, regardless of ethnicity. Gut microbial taxonomical signatures were identified, which could function as potential modulators in the association between dietary protein intake and metabolic status.
KW - Diabetes
KW - Ethnicity
KW - Gut microbiota
KW - HELIUS study
KW - Protein diet
U2 - 10.3390/nu13093159
DO - 10.3390/nu13093159
M3 - Journal article
C2 - 34579043
AN - SCOPUS:85114507628
VL - 13
JO - Nutrients
JF - Nutrients
SN - 2072-6643
IS - 9
M1 - 3159
ER -
ID: 281598433