Reference values for serum total adiponectin in healthy non-obese children and adolescents

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Reference values for serum total adiponectin in healthy non-obese children and adolescents. / Lausten-Thomsen, Ulrik; Christiansen, Michael; Fonvig, Cilius Esmann; Trier, Cæcilie; Pedersen, Oluf; Hansen, Torben; Holm, Jens-Christian.

In: Clinica Chimica Acta, Vol. 450, 23.10.2015, p. 11-4.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lausten-Thomsen, U, Christiansen, M, Fonvig, CE, Trier, C, Pedersen, O, Hansen, T & Holm, J-C 2015, 'Reference values for serum total adiponectin in healthy non-obese children and adolescents', Clinica Chimica Acta, vol. 450, pp. 11-4. https://doi.org/10.1016/j.cca.2015.07.012

APA

Lausten-Thomsen, U., Christiansen, M., Fonvig, C. E., Trier, C., Pedersen, O., Hansen, T., & Holm, J-C. (2015). Reference values for serum total adiponectin in healthy non-obese children and adolescents. Clinica Chimica Acta, 450, 11-4. https://doi.org/10.1016/j.cca.2015.07.012

Vancouver

Lausten-Thomsen U, Christiansen M, Fonvig CE, Trier C, Pedersen O, Hansen T et al. Reference values for serum total adiponectin in healthy non-obese children and adolescents. Clinica Chimica Acta. 2015 Oct 23;450:11-4. https://doi.org/10.1016/j.cca.2015.07.012

Author

Lausten-Thomsen, Ulrik ; Christiansen, Michael ; Fonvig, Cilius Esmann ; Trier, Cæcilie ; Pedersen, Oluf ; Hansen, Torben ; Holm, Jens-Christian. / Reference values for serum total adiponectin in healthy non-obese children and adolescents. In: Clinica Chimica Acta. 2015 ; Vol. 450. pp. 11-4.

Bibtex

@article{f6de59ce94d248458e4c58d17a412adf,
title = "Reference values for serum total adiponectin in healthy non-obese children and adolescents",
abstract = "BACKGROUND: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels.METHODS: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet{\textregistered} ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization.RESULTS: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p<0.0001) and boys (p=<0.0001) and for both sexes combined (p<0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y=-0.1478∗X+6.046; 2.5th percentile: Y=-0.06256∗X+2.34; 97.5th percentile: Y=-0.4086∗X+22.39, where Y=adiponectin in μg/mL and X=years of age (from 6 to 18years).CONCLUSION: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.",
author = "Ulrik Lausten-Thomsen and Michael Christiansen and Fonvig, {Cilius Esmann} and C{\ae}cilie Trier and Oluf Pedersen and Torben Hansen and Jens-Christian Holm",
note = "Copyright {\textcopyright} 2015. Published by Elsevier B.V.",
year = "2015",
month = oct,
day = "23",
doi = "10.1016/j.cca.2015.07.012",
language = "English",
volume = "450",
pages = "11--4",
journal = "Clinica Chimica Acta",
issn = "0009-8981",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Reference values for serum total adiponectin in healthy non-obese children and adolescents

AU - Lausten-Thomsen, Ulrik

AU - Christiansen, Michael

AU - Fonvig, Cilius Esmann

AU - Trier, Cæcilie

AU - Pedersen, Oluf

AU - Hansen, Torben

AU - Holm, Jens-Christian

N1 - Copyright © 2015. Published by Elsevier B.V.

PY - 2015/10/23

Y1 - 2015/10/23

N2 - BACKGROUND: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels.METHODS: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet® ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization.RESULTS: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p<0.0001) and boys (p=<0.0001) and for both sexes combined (p<0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y=-0.1478∗X+6.046; 2.5th percentile: Y=-0.06256∗X+2.34; 97.5th percentile: Y=-0.4086∗X+22.39, where Y=adiponectin in μg/mL and X=years of age (from 6 to 18years).CONCLUSION: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.

AB - BACKGROUND: Adiponectin is an abundant adipocyte-secreted hormone that modulates a number of metabolic processes and is correlated to various metabolic disorders. Pediatric reference levels are needed for the risk stratification and interpretation of individual serum adiponectin levels.METHODS: A total of 1193 healthy, non-obese Danish schoolchildren (730 girls, 463 boys) aged 6-18years (median 11.9) were examined by trained medical staff. Total serum adiponectin concentrations in venous fasting blood samples were quantitated by a DuoSet® ELISA human Adiponectin/Acrp30 (R&D Systems) following optimization.RESULTS: In a generalized linear model adjusted for BMI SDS, total serum adiponectin concentrations were correlated to age in girls (p<0.0001) and boys (p=<0.0001) and for both sexes combined (p<0.0001). No significant difference between sexes was found. Reference intervals were calculated using age as a continuous variable. The best fitted reference curve for both sexes was: 50th percentile: Y=-0.1478∗X+6.046; 2.5th percentile: Y=-0.06256∗X+2.34; 97.5th percentile: Y=-0.4086∗X+22.39, where Y=adiponectin in μg/mL and X=years of age (from 6 to 18years).CONCLUSION: We developed a pediatric reference levels for total serum adiponectin in a sample of 1193 Danish children and adolescents aged 6-18years. A correlation with age was demonstrated in children, but no significant difference was seen between the sexes.

U2 - 10.1016/j.cca.2015.07.012

DO - 10.1016/j.cca.2015.07.012

M3 - Journal article

C2 - 26169157

VL - 450

SP - 11

EP - 14

JO - Clinica Chimica Acta

JF - Clinica Chimica Acta

SN - 0009-8981

ER -

ID: 150709195