Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

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Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts. / Silventoinen, Karri; Piirtola, Maarit; Jelenkovic, Aline; Sund, Reijo; Tarnoki, Adam D.; Tarnoki, David L.; Medda, Emanuela; Nisticò, Lorenza; Toccaceli, Virgilia; Honda, Chika; Inui, Fujio; Tomizawa, Rie; Watanabe, Mikio; Sakai, Norio; Gatz, Margaret; Butler, David A.; Lee, Jooyeon; Lee, Soo Ji; Sung, Joohon; Franz, Carol E.; Kremen, William S.; Lyons, Michael J.; Derom, Catherine A.; Vlietinck, Robert F.; Loos, Ruth J.F.; Tynelius, Per; Rasmussen, Finn; Martin, Nicholas G.; Medland, Sarah E.; Montgomery, Grant W.; Brandt, Ingunn; Nilsen, Thomas S.; Harris, Jennifer R.; Tyler, Jessica; Hopper, John L.; Magnusson, Patrik K.E.; Pedersen, Nancy L.; Dahl Aslan, Anna K.; Ordoñana, Juan R.; Sánchez-Romera, Juan F.; Colodro-Conde, Lucia; Rebato, Esther; Zhang, Dongfeng; Pang, Zengchang; Tan, Qihua; Silberg, Judy L.; Maes, Hermine H.; Boomsma, Dorret I.; Sørensen, Thorkild I.A.; Korhonen, Tellervo; Kaprio, Jaakko.

In: Scientific Reports, Vol. 12, No. 1, 13148, 2022.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Silventoinen, K, Piirtola, M, Jelenkovic, A, Sund, R, Tarnoki, AD, Tarnoki, DL, Medda, E, Nisticò, L, Toccaceli, V, Honda, C, Inui, F, Tomizawa, R, Watanabe, M, Sakai, N, Gatz, M, Butler, DA, Lee, J, Lee, SJ, Sung, J, Franz, CE, Kremen, WS, Lyons, MJ, Derom, CA, Vlietinck, RF, Loos, RJF, Tynelius, P, Rasmussen, F, Martin, NG, Medland, SE, Montgomery, GW, Brandt, I, Nilsen, TS, Harris, JR, Tyler, J, Hopper, JL, Magnusson, PKE, Pedersen, NL, Dahl Aslan, AK, Ordoñana, JR, Sánchez-Romera, JF, Colodro-Conde, L, Rebato, E, Zhang, D, Pang, Z, Tan, Q, Silberg, JL, Maes, HH, Boomsma, DI, Sørensen, TIA, Korhonen, T & Kaprio, J 2022, 'Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts', Scientific Reports, vol. 12, no. 1, 13148. https://doi.org/10.1038/s41598-022-17536-x

APA

Silventoinen, K., Piirtola, M., Jelenkovic, A., Sund, R., Tarnoki, A. D., Tarnoki, D. L., Medda, E., Nisticò, L., Toccaceli, V., Honda, C., Inui, F., Tomizawa, R., Watanabe, M., Sakai, N., Gatz, M., Butler, D. A., Lee, J., Lee, S. J., Sung, J., ... Kaprio, J. (2022). Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts. Scientific Reports, 12(1), [13148]. https://doi.org/10.1038/s41598-022-17536-x

Vancouver

Silventoinen K, Piirtola M, Jelenkovic A, Sund R, Tarnoki AD, Tarnoki DL et al. Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts. Scientific Reports. 2022;12(1). 13148. https://doi.org/10.1038/s41598-022-17536-x

Author

Silventoinen, Karri ; Piirtola, Maarit ; Jelenkovic, Aline ; Sund, Reijo ; Tarnoki, Adam D. ; Tarnoki, David L. ; Medda, Emanuela ; Nisticò, Lorenza ; Toccaceli, Virgilia ; Honda, Chika ; Inui, Fujio ; Tomizawa, Rie ; Watanabe, Mikio ; Sakai, Norio ; Gatz, Margaret ; Butler, David A. ; Lee, Jooyeon ; Lee, Soo Ji ; Sung, Joohon ; Franz, Carol E. ; Kremen, William S. ; Lyons, Michael J. ; Derom, Catherine A. ; Vlietinck, Robert F. ; Loos, Ruth J.F. ; Tynelius, Per ; Rasmussen, Finn ; Martin, Nicholas G. ; Medland, Sarah E. ; Montgomery, Grant W. ; Brandt, Ingunn ; Nilsen, Thomas S. ; Harris, Jennifer R. ; Tyler, Jessica ; Hopper, John L. ; Magnusson, Patrik K.E. ; Pedersen, Nancy L. ; Dahl Aslan, Anna K. ; Ordoñana, Juan R. ; Sánchez-Romera, Juan F. ; Colodro-Conde, Lucia ; Rebato, Esther ; Zhang, Dongfeng ; Pang, Zengchang ; Tan, Qihua ; Silberg, Judy L. ; Maes, Hermine H. ; Boomsma, Dorret I. ; Sørensen, Thorkild I.A. ; Korhonen, Tellervo ; Kaprio, Jaakko. / Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts. In: Scientific Reports. 2022 ; Vol. 12, No. 1.

Bibtex

@article{532db1d0dbb74fbba17cd1fbc1496d50,
title = "Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts",
abstract = "We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.",
author = "Karri Silventoinen and Maarit Piirtola and Aline Jelenkovic and Reijo Sund and Tarnoki, {Adam D.} and Tarnoki, {David L.} and Emanuela Medda and Lorenza Nistic{\`o} and Virgilia Toccaceli and Chika Honda and Fujio Inui and Rie Tomizawa and Mikio Watanabe and Norio Sakai and Margaret Gatz and Butler, {David A.} and Jooyeon Lee and Lee, {Soo Ji} and Joohon Sung and Franz, {Carol E.} and Kremen, {William S.} and Lyons, {Michael J.} and Derom, {Catherine A.} and Vlietinck, {Robert F.} and Loos, {Ruth J.F.} and Per Tynelius and Finn Rasmussen and Martin, {Nicholas G.} and Medland, {Sarah E.} and Montgomery, {Grant W.} and Ingunn Brandt and Nilsen, {Thomas S.} and Harris, {Jennifer R.} and Jessica Tyler and Hopper, {John L.} and Magnusson, {Patrik K.E.} and Pedersen, {Nancy L.} and {Dahl Aslan}, {Anna K.} and Ordo{\~n}ana, {Juan R.} and S{\'a}nchez-Romera, {Juan F.} and Lucia Colodro-Conde and Esther Rebato and Dongfeng Zhang and Zengchang Pang and Qihua Tan and Silberg, {Judy L.} and Maes, {Hermine H.} and Boomsma, {Dorret I.} and S{\o}rensen, {Thorkild I.A.} and Tellervo Korhonen and Jaakko Kaprio",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s).",
year = "2022",
doi = "10.1038/s41598-022-17536-x",
language = "English",
volume = "12",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Smoking remains associated with education after controlling for social background and genetic factors in a study of 18 twin cohorts

AU - Silventoinen, Karri

AU - Piirtola, Maarit

AU - Jelenkovic, Aline

AU - Sund, Reijo

AU - Tarnoki, Adam D.

AU - Tarnoki, David L.

AU - Medda, Emanuela

AU - Nisticò, Lorenza

AU - Toccaceli, Virgilia

AU - Honda, Chika

AU - Inui, Fujio

AU - Tomizawa, Rie

AU - Watanabe, Mikio

AU - Sakai, Norio

AU - Gatz, Margaret

AU - Butler, David A.

AU - Lee, Jooyeon

AU - Lee, Soo Ji

AU - Sung, Joohon

AU - Franz, Carol E.

AU - Kremen, William S.

AU - Lyons, Michael J.

AU - Derom, Catherine A.

AU - Vlietinck, Robert F.

AU - Loos, Ruth J.F.

AU - Tynelius, Per

AU - Rasmussen, Finn

AU - Martin, Nicholas G.

AU - Medland, Sarah E.

AU - Montgomery, Grant W.

AU - Brandt, Ingunn

AU - Nilsen, Thomas S.

AU - Harris, Jennifer R.

AU - Tyler, Jessica

AU - Hopper, John L.

AU - Magnusson, Patrik K.E.

AU - Pedersen, Nancy L.

AU - Dahl Aslan, Anna K.

AU - Ordoñana, Juan R.

AU - Sánchez-Romera, Juan F.

AU - Colodro-Conde, Lucia

AU - Rebato, Esther

AU - Zhang, Dongfeng

AU - Pang, Zengchang

AU - Tan, Qihua

AU - Silberg, Judy L.

AU - Maes, Hermine H.

AU - Boomsma, Dorret I.

AU - Sørensen, Thorkild I.A.

AU - Korhonen, Tellervo

AU - Kaprio, Jaakko

N1 - Publisher Copyright: © 2022, The Author(s).

PY - 2022

Y1 - 2022

N2 - We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.

AB - We tested the causality between education and smoking using the natural experiment of discordant twin pairs allowing to optimally control for background genetic and childhood social factors. Data from 18 cohorts including 10,527 monozygotic (MZ) and same-sex dizygotic (DZ) twin pairs discordant for education and smoking were analyzed by linear fixed effects regression models. Within twin pairs, education levels were lower among the currently smoking than among the never smoking co-twins and this education difference was larger within DZ than MZ pairs. Similarly, education levels were higher among former smoking than among currently smoking co-twins, and this difference was larger within DZ pairs. Our results support the hypothesis of a causal effect of education on both current smoking status and smoking cessation. However, the even greater intra-pair differences within DZ pairs, who share only 50% of their segregating genes, provide evidence that shared genetic factors also contribute to these associations.

U2 - 10.1038/s41598-022-17536-x

DO - 10.1038/s41598-022-17536-x

M3 - Journal article

C2 - 35909142

AN - SCOPUS:85135182674

VL - 12

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 13148

ER -

ID: 315979189