Studies of metabolic phenotypic correlates of 15 obesity associated gene variants

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Studies of metabolic phenotypic correlates of 15 obesity associated gene variants. / Sandholt, Camilla Helene; Vestmar, Marie Aare; Bille, Dorthe Sadowa; Borglykke, Anders; Almind, Katrine; Hansen, Lars; Sandbæk, Annelli; Lauritzen, Torsten; Witte, Daniel; Jørgensen, Torben; Pedersen, Oluf; Hansen, Torben.

In: P L o S One, Vol. 6, No. 9, 01.01.2011, p. e23531.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sandholt, CH, Vestmar, MA, Bille, DS, Borglykke, A, Almind, K, Hansen, L, Sandbæk, A, Lauritzen, T, Witte, D, Jørgensen, T, Pedersen, O & Hansen, T 2011, 'Studies of metabolic phenotypic correlates of 15 obesity associated gene variants', P L o S One, vol. 6, no. 9, pp. e23531. https://doi.org/10.1371/journal.pone.0023531

APA

Sandholt, C. H., Vestmar, M. A., Bille, D. S., Borglykke, A., Almind, K., Hansen, L., Sandbæk, A., Lauritzen, T., Witte, D., Jørgensen, T., Pedersen, O., & Hansen, T. (2011). Studies of metabolic phenotypic correlates of 15 obesity associated gene variants. P L o S One, 6(9), e23531. https://doi.org/10.1371/journal.pone.0023531

Vancouver

Sandholt CH, Vestmar MA, Bille DS, Borglykke A, Almind K, Hansen L et al. Studies of metabolic phenotypic correlates of 15 obesity associated gene variants. P L o S One. 2011 Jan 1;6(9):e23531. https://doi.org/10.1371/journal.pone.0023531

Author

Sandholt, Camilla Helene ; Vestmar, Marie Aare ; Bille, Dorthe Sadowa ; Borglykke, Anders ; Almind, Katrine ; Hansen, Lars ; Sandbæk, Annelli ; Lauritzen, Torsten ; Witte, Daniel ; Jørgensen, Torben ; Pedersen, Oluf ; Hansen, Torben. / Studies of metabolic phenotypic correlates of 15 obesity associated gene variants. In: P L o S One. 2011 ; Vol. 6, No. 9. pp. e23531.

Bibtex

@article{f4b7c7ed0d2145d0abf613dc59bd5d3e,
title = "Studies of metabolic phenotypic correlates of 15 obesity associated gene variants",
abstract = "Aims: Genome-wide association studies have identified novel BMI/obesity associated susceptibility loci. The purpose of this study is to determine associations with overweight, obesity, morbid obesity and/or general adiposity in a Danish population. Moreover, we want to investigate if these loci associate with type 2 diabetes and to elucidate potential underlying metabolic mechanisms. Methods: 15 gene variants in 14 loci including TMEM18 (rs7561317), SH2B1 (rs7498665), KCTD15 (rs29941), NEGR1 (rs2568958), ETV5 (rs7647305), BDNF (rs4923461, rs925946), SEC16B (rs10913469), FAIM2 (rs7138803), GNPDA2 (rs10938397), MTCH2 (rs10838738), BAT2 (rs2260000), NPC1 (rs1805081), MAF (rs1424233), and PTER (rs10508503) were genotyped in 18,014 middle-aged Danes. Results: Five of the 15 gene variants associated with overweight, obesity and/or morbid obesity. Per allele ORs ranged from 1.15–1.20 for overweight, 1.10–1.25 for obesity, and 1.41–1.46 for morbid obesity. Five of the 15 variants moreover associated with increased measures of adiposity. BDNF rs4923461 displayed a borderline BMI-dependent protective effect on type 2 diabetes (0.87 (0.78–0.96, p = 0.008)), whereas SH2B1 rs7498665 associated with nominally BMI-independent increased risk of type 2 diabetes (1.16 (1.07–1.27, p = 7.861024)). Conclusions: Associations with overweight and/or obesity and measures of obesity were confirmed for seven out of the 15 gene variants. The obesity risk allele of BDNF rs4923461 protected against type 2 diabetes, which could suggest neuronal and peripheral distinctive ways of actions for the protein. SH2B1 rs7498665 associated with type 2 diabetes independently of BMI.",
author = "Sandholt, {Camilla Helene} and Vestmar, {Marie Aare} and Bille, {Dorthe Sadowa} and Anders Borglykke and Katrine Almind and Lars Hansen and Annelli Sandb{\ae}k and Torsten Lauritzen and Daniel Witte and Torben J{\o}rgensen and Oluf Pedersen and Torben Hansen",
year = "2011",
month = jan,
day = "1",
doi = "10.1371/journal.pone.0023531",
language = "English",
volume = "6",
pages = "e23531",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "9",

}

RIS

TY - JOUR

T1 - Studies of metabolic phenotypic correlates of 15 obesity associated gene variants

AU - Sandholt, Camilla Helene

AU - Vestmar, Marie Aare

AU - Bille, Dorthe Sadowa

AU - Borglykke, Anders

AU - Almind, Katrine

AU - Hansen, Lars

AU - Sandbæk, Annelli

AU - Lauritzen, Torsten

AU - Witte, Daniel

AU - Jørgensen, Torben

AU - Pedersen, Oluf

AU - Hansen, Torben

PY - 2011/1/1

Y1 - 2011/1/1

N2 - Aims: Genome-wide association studies have identified novel BMI/obesity associated susceptibility loci. The purpose of this study is to determine associations with overweight, obesity, morbid obesity and/or general adiposity in a Danish population. Moreover, we want to investigate if these loci associate with type 2 diabetes and to elucidate potential underlying metabolic mechanisms. Methods: 15 gene variants in 14 loci including TMEM18 (rs7561317), SH2B1 (rs7498665), KCTD15 (rs29941), NEGR1 (rs2568958), ETV5 (rs7647305), BDNF (rs4923461, rs925946), SEC16B (rs10913469), FAIM2 (rs7138803), GNPDA2 (rs10938397), MTCH2 (rs10838738), BAT2 (rs2260000), NPC1 (rs1805081), MAF (rs1424233), and PTER (rs10508503) were genotyped in 18,014 middle-aged Danes. Results: Five of the 15 gene variants associated with overweight, obesity and/or morbid obesity. Per allele ORs ranged from 1.15–1.20 for overweight, 1.10–1.25 for obesity, and 1.41–1.46 for morbid obesity. Five of the 15 variants moreover associated with increased measures of adiposity. BDNF rs4923461 displayed a borderline BMI-dependent protective effect on type 2 diabetes (0.87 (0.78–0.96, p = 0.008)), whereas SH2B1 rs7498665 associated with nominally BMI-independent increased risk of type 2 diabetes (1.16 (1.07–1.27, p = 7.861024)). Conclusions: Associations with overweight and/or obesity and measures of obesity were confirmed for seven out of the 15 gene variants. The obesity risk allele of BDNF rs4923461 protected against type 2 diabetes, which could suggest neuronal and peripheral distinctive ways of actions for the protein. SH2B1 rs7498665 associated with type 2 diabetes independently of BMI.

AB - Aims: Genome-wide association studies have identified novel BMI/obesity associated susceptibility loci. The purpose of this study is to determine associations with overweight, obesity, morbid obesity and/or general adiposity in a Danish population. Moreover, we want to investigate if these loci associate with type 2 diabetes and to elucidate potential underlying metabolic mechanisms. Methods: 15 gene variants in 14 loci including TMEM18 (rs7561317), SH2B1 (rs7498665), KCTD15 (rs29941), NEGR1 (rs2568958), ETV5 (rs7647305), BDNF (rs4923461, rs925946), SEC16B (rs10913469), FAIM2 (rs7138803), GNPDA2 (rs10938397), MTCH2 (rs10838738), BAT2 (rs2260000), NPC1 (rs1805081), MAF (rs1424233), and PTER (rs10508503) were genotyped in 18,014 middle-aged Danes. Results: Five of the 15 gene variants associated with overweight, obesity and/or morbid obesity. Per allele ORs ranged from 1.15–1.20 for overweight, 1.10–1.25 for obesity, and 1.41–1.46 for morbid obesity. Five of the 15 variants moreover associated with increased measures of adiposity. BDNF rs4923461 displayed a borderline BMI-dependent protective effect on type 2 diabetes (0.87 (0.78–0.96, p = 0.008)), whereas SH2B1 rs7498665 associated with nominally BMI-independent increased risk of type 2 diabetes (1.16 (1.07–1.27, p = 7.861024)). Conclusions: Associations with overweight and/or obesity and measures of obesity were confirmed for seven out of the 15 gene variants. The obesity risk allele of BDNF rs4923461 protected against type 2 diabetes, which could suggest neuronal and peripheral distinctive ways of actions for the protein. SH2B1 rs7498665 associated with type 2 diabetes independently of BMI.

U2 - 10.1371/journal.pone.0023531

DO - 10.1371/journal.pone.0023531

M3 - Journal article

C2 - 21912638

VL - 6

SP - e23531

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 9

ER -

ID: 35313684