Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans. / Burgdorf, Kristoffer Sølvsten; Grarup, Niels; Justesen, Johanne Marie; Harder, Marie Neergaard; Witte, Daniel Rinse; Jørgensen, Torben; Sandbæk, Annelli; Lauritzen, Torsten; Madsbad, Sten; Hansen, Torben; DIAGRAM Consortium ; Pedersen, Oluf.

In: P L o S One, Vol. 6, No. 1, 2011, p. e15813.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Burgdorf, KS, Grarup, N, Justesen, JM, Harder, MN, Witte, DR, Jørgensen, T, Sandbæk, A, Lauritzen, T, Madsbad, S, Hansen, T, DIAGRAM Consortium & Pedersen, O 2011, 'Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans', P L o S One, vol. 6, no. 1, pp. e15813. https://doi.org/10.1371/journal.pone.0015813

APA

Burgdorf, K. S., Grarup, N., Justesen, J. M., Harder, M. N., Witte, D. R., Jørgensen, T., Sandbæk, A., Lauritzen, T., Madsbad, S., Hansen, T., DIAGRAM Consortium, & Pedersen, O. (2011). Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans. P L o S One, 6(1), e15813. https://doi.org/10.1371/journal.pone.0015813

Vancouver

Burgdorf KS, Grarup N, Justesen JM, Harder MN, Witte DR, Jørgensen T et al. Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans. P L o S One. 2011;6(1):e15813. https://doi.org/10.1371/journal.pone.0015813

Author

Burgdorf, Kristoffer Sølvsten ; Grarup, Niels ; Justesen, Johanne Marie ; Harder, Marie Neergaard ; Witte, Daniel Rinse ; Jørgensen, Torben ; Sandbæk, Annelli ; Lauritzen, Torsten ; Madsbad, Sten ; Hansen, Torben ; DIAGRAM Consortium ; Pedersen, Oluf. / Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans. In: P L o S One. 2011 ; Vol. 6, No. 1. pp. e15813.

Bibtex

@article{b552bd0054b94c3abdee22884a9d0667,
title = "Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans",
abstract = "Aims: A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 Finnish individuals. We aimed to replicate these associations in a Danish case-control study and to substantiate any replicated associations in meta-analyses. Furthermore, we evaluated the impact on diabetes-related intermediate traits in a population-based sample of middle-aged Danes. Methods: We genotyped nine lead variants in the seven genes in 4,973 glucose-tolerant and 3,612 type 2 diabetes Danish individuals. In meta-analyses we combined case-control data from the DIAGRAM+ Consortium (n = 47,117) and the present genotyping results. The quantitative trait studies involved 5,882 treatment-naive individuals from the Danish Inter99 study. Results: None of the nine investigated variants were significantly associated with type 2 diabetes in the Danish samples. However, for all nine variants the estimate of increase in type 2 diabetes risk was observed for the same allele as previously reported. In a meta-analysis of published and online data including 55,521 Europeans the G-allele of rs1042522 in TP53 showed significant association with type 2 diabetes (OR = 1.06 95% CI 1.02–1.11, p = 0.0032). No substantial associations with diabetes-related intermediary phenotypes were found. Conclusion: The G-allele of TP53 rs1042522 is associated with an increased prevalence of type 2 diabetes in a combined analysis of 55,521 Europeans.",
keywords = "Case-Control Studies, Diabetes Mellitus, Type 2, Europe, European Continental Ancestry Group, Genome-Wide Association Study, Genotype, Humans, Tumor Suppressor Protein p53",
author = "Burgdorf, {Kristoffer S{\o}lvsten} and Niels Grarup and Justesen, {Johanne Marie} and Harder, {Marie Neergaard} and Witte, {Daniel Rinse} and Torben J{\o}rgensen and Annelli Sandb{\ae}k and Torsten Lauritzen and Sten Madsbad and Torben Hansen and {DIAGRAM Consortium} and Oluf Pedersen",
year = "2011",
doi = "10.1371/journal.pone.0015813",
language = "English",
volume = "6",
pages = "e15813",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1",

}

RIS

TY - JOUR

T1 - Studies of the Association of Arg72Pro of Tumor Suppressor Protein p53 with Type 2 Diabetes in a Combined Analysis of 55,521 Europeans

AU - Burgdorf, Kristoffer Sølvsten

AU - Grarup, Niels

AU - Justesen, Johanne Marie

AU - Harder, Marie Neergaard

AU - Witte, Daniel Rinse

AU - Jørgensen, Torben

AU - Sandbæk, Annelli

AU - Lauritzen, Torsten

AU - Madsbad, Sten

AU - Hansen, Torben

AU - DIAGRAM Consortium

AU - Pedersen, Oluf

PY - 2011

Y1 - 2011

N2 - Aims: A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 Finnish individuals. We aimed to replicate these associations in a Danish case-control study and to substantiate any replicated associations in meta-analyses. Furthermore, we evaluated the impact on diabetes-related intermediate traits in a population-based sample of middle-aged Danes. Methods: We genotyped nine lead variants in the seven genes in 4,973 glucose-tolerant and 3,612 type 2 diabetes Danish individuals. In meta-analyses we combined case-control data from the DIAGRAM+ Consortium (n = 47,117) and the present genotyping results. The quantitative trait studies involved 5,882 treatment-naive individuals from the Danish Inter99 study. Results: None of the nine investigated variants were significantly associated with type 2 diabetes in the Danish samples. However, for all nine variants the estimate of increase in type 2 diabetes risk was observed for the same allele as previously reported. In a meta-analysis of published and online data including 55,521 Europeans the G-allele of rs1042522 in TP53 showed significant association with type 2 diabetes (OR = 1.06 95% CI 1.02–1.11, p = 0.0032). No substantial associations with diabetes-related intermediary phenotypes were found. Conclusion: The G-allele of TP53 rs1042522 is associated with an increased prevalence of type 2 diabetes in a combined analysis of 55,521 Europeans.

AB - Aims: A study of 222 candidate genes in type 2 diabetes reported association of variants in RAPGEF1, ENPP1, TP53, NRF1, SLC2A2, SLC2A4 and FOXC2 with type 2 diabetes in 4,805 Finnish individuals. We aimed to replicate these associations in a Danish case-control study and to substantiate any replicated associations in meta-analyses. Furthermore, we evaluated the impact on diabetes-related intermediate traits in a population-based sample of middle-aged Danes. Methods: We genotyped nine lead variants in the seven genes in 4,973 glucose-tolerant and 3,612 type 2 diabetes Danish individuals. In meta-analyses we combined case-control data from the DIAGRAM+ Consortium (n = 47,117) and the present genotyping results. The quantitative trait studies involved 5,882 treatment-naive individuals from the Danish Inter99 study. Results: None of the nine investigated variants were significantly associated with type 2 diabetes in the Danish samples. However, for all nine variants the estimate of increase in type 2 diabetes risk was observed for the same allele as previously reported. In a meta-analysis of published and online data including 55,521 Europeans the G-allele of rs1042522 in TP53 showed significant association with type 2 diabetes (OR = 1.06 95% CI 1.02–1.11, p = 0.0032). No substantial associations with diabetes-related intermediary phenotypes were found. Conclusion: The G-allele of TP53 rs1042522 is associated with an increased prevalence of type 2 diabetes in a combined analysis of 55,521 Europeans.

KW - Case-Control Studies

KW - Diabetes Mellitus, Type 2

KW - Europe

KW - European Continental Ancestry Group

KW - Genome-Wide Association Study

KW - Genotype

KW - Humans

KW - Tumor Suppressor Protein p53

U2 - 10.1371/journal.pone.0015813

DO - 10.1371/journal.pone.0015813

M3 - Journal article

C2 - 21283750

VL - 6

SP - e15813

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 1

ER -

ID: 35314794