The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland. / Overvad, Maria; Díaz, Lars Jorge; Bjerregaard, Peter; Pedersen, Michael Lynge; Larsen, Christina Viskum Lytken; Grarup, Niels; Hansen, Torben; Rossing, Peter; Jørgensen, Marit Eika.

In: International Journal of Circumpolar Health, Vol. 82, 2191406, 2023.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Overvad, M, Díaz, LJ, Bjerregaard, P, Pedersen, ML, Larsen, CVL, Grarup, N, Hansen, T, Rossing, P & Jørgensen, ME 2023, 'The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland', International Journal of Circumpolar Health, vol. 82, 2191406. https://doi.org/10.1080/22423982.2023.2191406

APA

Overvad, M., Díaz, L. J., Bjerregaard, P., Pedersen, M. L., Larsen, C. V. L., Grarup, N., Hansen, T., Rossing, P., & Jørgensen, M. E. (2023). The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland. International Journal of Circumpolar Health, 82, [2191406]. https://doi.org/10.1080/22423982.2023.2191406

Vancouver

Overvad M, Díaz LJ, Bjerregaard P, Pedersen ML, Larsen CVL, Grarup N et al. The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland. International Journal of Circumpolar Health. 2023;82. 2191406. https://doi.org/10.1080/22423982.2023.2191406

Author

Overvad, Maria ; Díaz, Lars Jorge ; Bjerregaard, Peter ; Pedersen, Michael Lynge ; Larsen, Christina Viskum Lytken ; Grarup, Niels ; Hansen, Torben ; Rossing, Peter ; Jørgensen, Marit Eika. / The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland. In: International Journal of Circumpolar Health. 2023 ; Vol. 82.

Bibtex

@article{54863bd2c9e74c32b44d22b1e1a0cd20,
title = "The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland",
abstract = "The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR <60 ml/min/1.73m2), comparing individuals with and without diabetes, including the effect of TBC1D4 variant. Of the 3,909 participants with complete data, 9.3% had diabetes. Albuminuria was found in 27.6% and 9.5% and CKD was found in 10.8% and 6.3% among those with and without diabetes, respectively. Diabetes was cross-sectionally associated with an increased risk of albuminuria (OR (95% CI) = 2.37 (1.69,3.33); p < 0.001) and the TBC1D4 variant protected against albuminuria (OR (95% CI) = 0.44 (0.22,0.90); p = 0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. Diabetes conferred an increased risk of albuminuria, and the TBC1D4 variant was associated with a decreased risk of albuminuria, but neither was associated with CKD. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies.",
keywords = "CKD, complications, diabetes, genetics, Greenland",
author = "Maria Overvad and D{\'i}az, {Lars Jorge} and Peter Bjerregaard and Pedersen, {Michael Lynge} and Larsen, {Christina Viskum Lytken} and Niels Grarup and Torben Hansen and Peter Rossing and J{\o}rgensen, {Marit Eika}",
note = "Publisher Copyright: {\textcopyright} 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.",
year = "2023",
doi = "10.1080/22423982.2023.2191406",
language = "English",
volume = "82",
journal = "International Journal of Circumpolar Health",
issn = "1239-9736",
publisher = "International Association of Circumpolar Health Publishers",

}

RIS

TY - JOUR

T1 - The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland

AU - Overvad, Maria

AU - Díaz, Lars Jorge

AU - Bjerregaard, Peter

AU - Pedersen, Michael Lynge

AU - Larsen, Christina Viskum Lytken

AU - Grarup, Niels

AU - Hansen, Torben

AU - Rossing, Peter

AU - Jørgensen, Marit Eika

N1 - Publisher Copyright: © 2023 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.

PY - 2023

Y1 - 2023

N2 - The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR <60 ml/min/1.73m2), comparing individuals with and without diabetes, including the effect of TBC1D4 variant. Of the 3,909 participants with complete data, 9.3% had diabetes. Albuminuria was found in 27.6% and 9.5% and CKD was found in 10.8% and 6.3% among those with and without diabetes, respectively. Diabetes was cross-sectionally associated with an increased risk of albuminuria (OR (95% CI) = 2.37 (1.69,3.33); p < 0.001) and the TBC1D4 variant protected against albuminuria (OR (95% CI) = 0.44 (0.22,0.90); p = 0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. Diabetes conferred an increased risk of albuminuria, and the TBC1D4 variant was associated with a decreased risk of albuminuria, but neither was associated with CKD. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies.

AB - The aim of this study was to examine the effect of diabetes and the diabetogenic TBC1D4 variant on kidney function in Greenland in a population-based setting. Health survey data and TBC1D4 genotypes from 5,336 Greenlanders were used to estimate odds ratios (ORs) of albuminuria (>30 mg/g creatinine) and chronic kidney disease (CKD, eGFR <60 ml/min/1.73m2), comparing individuals with and without diabetes, including the effect of TBC1D4 variant. Of the 3,909 participants with complete data, 9.3% had diabetes. Albuminuria was found in 27.6% and 9.5% and CKD was found in 10.8% and 6.3% among those with and without diabetes, respectively. Diabetes was cross-sectionally associated with an increased risk of albuminuria (OR (95% CI) = 2.37 (1.69,3.33); p < 0.001) and the TBC1D4 variant protected against albuminuria (OR (95% CI) = 0.44 (0.22,0.90); p = 0.02) in a multivariable model. Neither diabetes nor the TBC1D4 variant significantly associated with CKD. The presence/absence of diabetes did not predict changes in eGFR and UACR in longitudinal analyses. Diabetes conferred an increased risk of albuminuria, and the TBC1D4 variant was associated with a decreased risk of albuminuria, but neither was associated with CKD. The potential renoprotective association of the TBC1D4 variant on albuminuria calls for further studies.

KW - CKD

KW - complications

KW - diabetes

KW - genetics

KW - Greenland

U2 - 10.1080/22423982.2023.2191406

DO - 10.1080/22423982.2023.2191406

M3 - Journal article

C2 - 36944026

AN - SCOPUS:85150673209

VL - 82

JO - International Journal of Circumpolar Health

JF - International Journal of Circumpolar Health

SN - 1239-9736

M1 - 2191406

ER -

ID: 342506493