The effect of ferritin-guided iron supplementation among Danish female first-time blood donors
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The effect of ferritin-guided iron supplementation among Danish female first-time blood donors. / Drechsler, Louise Ørnskov; Boldsen, Jens Kjærgaard; Hindhede, Lotte; Aagaard, Bitten; Harritshøj, Lene Holm; Mikkelsen, Christina; Brodersen, Thorsten; Brøns, Nanna; Schwinn, Michael; Hjalgrim, Henrik; Rostgaard, Klaus; Topholm Bruun, Mie; Ostrowski, Sisse Rye; Pedersen, Ole Birger; Mikkelsen, Susan; Erikstrup, Christian.
In: Transfusion, Vol. 63, No. 9, 2023, p. 1710-1718.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The effect of ferritin-guided iron supplementation among Danish female first-time blood donors
AU - Drechsler, Louise Ørnskov
AU - Boldsen, Jens Kjærgaard
AU - Hindhede, Lotte
AU - Aagaard, Bitten
AU - Harritshøj, Lene Holm
AU - Mikkelsen, Christina
AU - Brodersen, Thorsten
AU - Brøns, Nanna
AU - Schwinn, Michael
AU - Hjalgrim, Henrik
AU - Rostgaard, Klaus
AU - Topholm Bruun, Mie
AU - Ostrowski, Sisse Rye
AU - Pedersen, Ole Birger
AU - Mikkelsen, Susan
AU - Erikstrup, Christian
N1 - Publisher Copyright: © 2023 The Authors. Transfusion published by Wiley Periodicals LLC on behalf of AABB.
PY - 2023
Y1 - 2023
N2 - Background The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark. Study Design and Methods We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L ~ 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period. Results We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71–0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95% CI: 1.02–1.08. Discussion Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor.
AB - Background The identification of blood donors at risk of developing low hemoglobin (Hb) and subsequent intervention is expected to reduce donation-induced iron deficiency and low Hb among blood donors. This study explores the effects of ferritin-guided iron supplementation for female first-time donors implemented in four of five administrative regions in Denmark. Study Design and Methods We included 45,919 female first-time donors in this study. Hb values were determined in donations of included donors during a 2-year follow-up period. For each region, an intervention group (after implementation) and a control group (before implementation) were defined. The primary outcome was Hb below the donation threshold (7.8 mmol/L ~ 12.5 g/dL) at the time of donation, in the control group, and the intervention group, using logistic regression. The secondary outcome was the number of donations per donor given during the follow-up period. Results We observed a statistically significant decrease in the risk of female first-time donors experiencing a donation with low Hb after ferritin-guided iron supplementation was introduced: Odds ratio, 0.82; 95% confidence interval (CI), 0.71–0.95. We found a statistically significant increase in the number of donations per donor during the follow-up period after intervention; rate ratio: 1.05, 95% CI: 1.02–1.08. Discussion Ferritin-guided iron supplementation led to a significant reduction in the occurrence of low hemoglobin (Hb) levels among Danish female first-time blood donors. The intervention was additionally associated with an increase in the number of donations per donor.
KW - blood donation
KW - ferritin
KW - hemoglobin
KW - iron supplementation
U2 - 10.1111/trf.17484
DO - 10.1111/trf.17484
M3 - Journal article
C2 - 37452554
AN - SCOPUS:85165303551
VL - 63
SP - 1710
EP - 1718
JO - Transfusion
JF - Transfusion
SN - 0041-1132
IS - 9
ER -
ID: 360861062