The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

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Standard

The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. / Sparsø, T; Andersen, G; Nielsen, T; Burgdorf, K S; Gjesing, Anette Marianne Prior; Nielsen, A L; Albrechtsen, Anders; Rasmussen, S S; Jørgensen, Torben; Borch-Johnsen, K; Sandbaek, A; Lauritzen, T; Madsbad, S; Hansen, T; Pedersen, Oluf.

In: Diabetologia, Vol. 51, No. 1, 2007, p. 70-5.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Sparsø, T, Andersen, G, Nielsen, T, Burgdorf, KS, Gjesing, AMP, Nielsen, AL, Albrechtsen, A, Rasmussen, SS, Jørgensen, T, Borch-Johnsen, K, Sandbaek, A, Lauritzen, T, Madsbad, S, Hansen, T & Pedersen, O 2007, 'The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes', Diabetologia, vol. 51, no. 1, pp. 70-5. https://doi.org/10.1007/s00125-007-0865-z

APA

Sparsø, T., Andersen, G., Nielsen, T., Burgdorf, K. S., Gjesing, A. M. P., Nielsen, A. L., Albrechtsen, A., Rasmussen, S. S., Jørgensen, T., Borch-Johnsen, K., Sandbaek, A., Lauritzen, T., Madsbad, S., Hansen, T., & Pedersen, O. (2007). The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia, 51(1), 70-5. https://doi.org/10.1007/s00125-007-0865-z

Vancouver

Sparsø T, Andersen G, Nielsen T, Burgdorf KS, Gjesing AMP, Nielsen AL et al. The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. Diabetologia. 2007;51(1):70-5. https://doi.org/10.1007/s00125-007-0865-z

Author

Sparsø, T ; Andersen, G ; Nielsen, T ; Burgdorf, K S ; Gjesing, Anette Marianne Prior ; Nielsen, A L ; Albrechtsen, Anders ; Rasmussen, S S ; Jørgensen, Torben ; Borch-Johnsen, K ; Sandbaek, A ; Lauritzen, T ; Madsbad, S ; Hansen, T ; Pedersen, Oluf. / The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes. In: Diabetologia. 2007 ; Vol. 51, No. 1. pp. 70-5.

Bibtex

@article{1b4f38b0eede11ddbf70000ea68e967b,
title = "The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes",
abstract = "AIMS/HYPOTHESIS: Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly fasting hypertriacylglycerolaemia) and traits related to pancreatic beta cell function. METHODS: The polymorphism was genotyped in 16,853 Danes using Taqman allelic discrimination. Association was analysed in case-control studies and quantitative trait analyses. We also analysed the possible interactive effect between the GCK -30G>A polymorphism and the GCKR rs780094 variant on metabolic traits. RESULTS: The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01). Significantly increased fasting serum insulin concentrations were demonstrated when analysing the GCK -30A and GCKR rs780094 G-alleles in an additive model. CONCLUSIONS/INTERPRETATION: The GCKR rs780094 polymorphism, or another variant with which it is in tight linkage disequilibrium, is likely to increase glucokinase regulatory protein activity to induce improved glycaemic regulation at the expense of hypertriacylglycerolaemia as reflected in the present study of 16,853 Danes. We also suggest an additive effect of GCK and GCKR risk alleles on plasma glucose and serum insulin release.",
author = "T Spars{\o} and G Andersen and T Nielsen and Burgdorf, {K S} and Gjesing, {Anette Marianne Prior} and Nielsen, {A L} and Anders Albrechtsen and Rasmussen, {S S} and Torben J{\o}rgensen and K Borch-Johnsen and A Sandbaek and T Lauritzen and S Madsbad and T Hansen and Oluf Pedersen",
note = "Keywords: Adult; Diabetes Mellitus, Type 2; Female; Glucokinase; Glucose; Glucose Tolerance Test; Humans; Insulin; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Receptors, Cytoplasmic and Nuclear; Risk; Triglycerides Erratum DOI: 10.1007/s00125-007-0900-0",
year = "2007",
doi = "10.1007/s00125-007-0865-z",
language = "English",
volume = "51",
pages = "70--5",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",
number = "1",

}

RIS

TY - JOUR

T1 - The GCKR rs780094 polymorphism is associated with elevated fasting serum triacylglycerol, reduced fasting and OGTT-related insulinaemia, and reduced risk of type 2 diabetes

AU - Sparsø, T

AU - Andersen, G

AU - Nielsen, T

AU - Burgdorf, K S

AU - Gjesing, Anette Marianne Prior

AU - Nielsen, A L

AU - Albrechtsen, Anders

AU - Rasmussen, S S

AU - Jørgensen, Torben

AU - Borch-Johnsen, K

AU - Sandbaek, A

AU - Lauritzen, T

AU - Madsbad, S

AU - Hansen, T

AU - Pedersen, Oluf

N1 - Keywords: Adult; Diabetes Mellitus, Type 2; Female; Glucokinase; Glucose; Glucose Tolerance Test; Humans; Insulin; Male; Middle Aged; Phenotype; Polymorphism, Genetic; Receptors, Cytoplasmic and Nuclear; Risk; Triglycerides Erratum DOI: 10.1007/s00125-007-0900-0

PY - 2007

Y1 - 2007

N2 - AIMS/HYPOTHESIS: Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly fasting hypertriacylglycerolaemia) and traits related to pancreatic beta cell function. METHODS: The polymorphism was genotyped in 16,853 Danes using Taqman allelic discrimination. Association was analysed in case-control studies and quantitative trait analyses. We also analysed the possible interactive effect between the GCK -30G>A polymorphism and the GCKR rs780094 variant on metabolic traits. RESULTS: The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01). Significantly increased fasting serum insulin concentrations were demonstrated when analysing the GCK -30A and GCKR rs780094 G-alleles in an additive model. CONCLUSIONS/INTERPRETATION: The GCKR rs780094 polymorphism, or another variant with which it is in tight linkage disequilibrium, is likely to increase glucokinase regulatory protein activity to induce improved glycaemic regulation at the expense of hypertriacylglycerolaemia as reflected in the present study of 16,853 Danes. We also suggest an additive effect of GCK and GCKR risk alleles on plasma glucose and serum insulin release.

AB - AIMS/HYPOTHESIS: Recent genome-wide association studies have suggested that a polymorphism in GCKR, the gene encoding the glucokinase regulatory protein, is involved in triacylglycerol regulation. Our aim was to examine in large-scale studies the common GCKR rs780094 polymorphism in relation to metabolic traits (mainly fasting hypertriacylglycerolaemia) and traits related to pancreatic beta cell function. METHODS: The polymorphism was genotyped in 16,853 Danes using Taqman allelic discrimination. Association was analysed in case-control studies and quantitative trait analyses. We also analysed the possible interactive effect between the GCK -30G>A polymorphism and the GCKR rs780094 variant on metabolic traits. RESULTS: The minor GCKR A-allele of rs780094 is associated with an increased level of fasting serum triacylglycerol (p = 6 x 10(-14)), impaired fasting (p = 0.001) and OGTT-related insulin release (p = 3 x 10(-6)), reduced homeostasis model assessment of insulin resistance (p = 0.0004), WHO-defined dyslipidaemia (p = 6 x 10(-9)) and a modestly decreased risk of type 2 diabetes (p = 0.01). Significantly increased fasting serum insulin concentrations were demonstrated when analysing the GCK -30A and GCKR rs780094 G-alleles in an additive model. CONCLUSIONS/INTERPRETATION: The GCKR rs780094 polymorphism, or another variant with which it is in tight linkage disequilibrium, is likely to increase glucokinase regulatory protein activity to induce improved glycaemic regulation at the expense of hypertriacylglycerolaemia as reflected in the present study of 16,853 Danes. We also suggest an additive effect of GCK and GCKR risk alleles on plasma glucose and serum insulin release.

UR - https://doi.org/10.1007/s00125-007-0900-0

U2 - 10.1007/s00125-007-0865-z

DO - 10.1007/s00125-007-0865-z

M3 - Journal article

C2 - 18008060

VL - 51

SP - 70

EP - 75

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

IS - 1

ER -

ID: 10027035