Standard
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. / Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P; Manning, Alisa K; Grarup, Niels; Sim, Xueling; Barnes, Daniel R; Witkowska, Kate; Staley, James R; Tragante, Vinicius; Tukiainen, Taru; Yaghootkar, Hanieh; Masca, Nicholas; Freitag, Daniel F; Ferreira, Teresa; Giannakopoulou, Olga; Tinker, Andrew; Harakalova, Magdalena; Mihailov, Evelin; Liu, Chunyu; Kraja, Aldi T; Nielsen, Sune Fallgaard; Rasheed, Asif; Samuel, Maria; Zhao, Wei; Bonnycastle, Lori L; Jackson, Anne U; Narisu, Narisu; Swift, Amy J; Southam, Lorraine; Marten, Jonathan; Huyghe, Jeroen R; Stančáková, Alena; Fava, Cristiano; Ohlsson, Therese; Matchan, Angela; Stirrups, Kathleen E; Bork-Jensen, Jette; Gjesing, Anette P; Kontto, Jukka; Perola, Markus; Shaw-Hawkins, Susan; Havulinna, Aki S; Husemoen, Lise L; Linneberg, Allan; Hansen, Torben; Pedersen, Oluf; Nordestgaard, Børge Grønne; CHARGE-Heart Failure Consortium ; V Varga, Tibor.
In:
Nature Genetics, Vol. 48, No. 10, 12.09.2016, p. 1151-1161.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Surendran, P, Drenos, F, Young, R, Warren, H, Cook, JP, Manning, AK
, Grarup, N, Sim, X, Barnes, DR, Witkowska, K, Staley, JR, Tragante, V, Tukiainen, T, Yaghootkar, H, Masca, N, Freitag, DF, Ferreira, T, Giannakopoulou, O, Tinker, A, Harakalova, M, Mihailov, E, Liu, C, Kraja, AT, Nielsen, SF, Rasheed, A, Samuel, M, Zhao, W, Bonnycastle, LL, Jackson, AU, Narisu, N, Swift, AJ, Southam, L, Marten, J, Huyghe, JR, Stančáková, A, Fava, C, Ohlsson, T, Matchan, A, Stirrups, KE, Bork-Jensen, J, Gjesing, AP, Kontto, J, Perola, M, Shaw-Hawkins, S, Havulinna, AS, Husemoen, LL
, Linneberg, A, Hansen, T, Pedersen, O, Nordestgaard, BG, CHARGE-Heart Failure Consortium
& V Varga, T 2016, '
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension',
Nature Genetics, vol. 48, no. 10, pp. 1151-1161.
https://doi.org/10.1038/ng.3654APA
Surendran, P., Drenos, F., Young, R., Warren, H., Cook, J. P., Manning, A. K.
, Grarup, N., Sim, X., Barnes, D. R., Witkowska, K., Staley, J. R., Tragante, V., Tukiainen, T., Yaghootkar, H., Masca, N., Freitag, D. F., Ferreira, T., Giannakopoulou, O., Tinker, A.
, ... V Varga, T. (2016).
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Nature Genetics,
48(10), 1151-1161.
https://doi.org/10.1038/ng.3654Vancouver
Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK et al.
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.
Nature Genetics. 2016 Sep 12;48(10):1151-1161.
https://doi.org/10.1038/ng.3654Author
Surendran, Praveen ; Drenos, Fotios ; Young, Robin ; Warren, Helen ; Cook, James P ; Manning, Alisa K ; Grarup, Niels ; Sim, Xueling ; Barnes, Daniel R ; Witkowska, Kate ; Staley, James R ; Tragante, Vinicius ; Tukiainen, Taru ; Yaghootkar, Hanieh ; Masca, Nicholas ; Freitag, Daniel F ; Ferreira, Teresa ; Giannakopoulou, Olga ; Tinker, Andrew ; Harakalova, Magdalena ; Mihailov, Evelin ; Liu, Chunyu ; Kraja, Aldi T ; Nielsen, Sune Fallgaard ; Rasheed, Asif ; Samuel, Maria ; Zhao, Wei ; Bonnycastle, Lori L ; Jackson, Anne U ; Narisu, Narisu ; Swift, Amy J ; Southam, Lorraine ; Marten, Jonathan ; Huyghe, Jeroen R ; Stančáková, Alena ; Fava, Cristiano ; Ohlsson, Therese ; Matchan, Angela ; Stirrups, Kathleen E ; Bork-Jensen, Jette ; Gjesing, Anette P ; Kontto, Jukka ; Perola, Markus ; Shaw-Hawkins, Susan ; Havulinna, Aki S ; Husemoen, Lise L ; Linneberg, Allan ; Hansen, Torben ; Pedersen, Oluf ; Nordestgaard, Børge Grønne ; CHARGE-Heart Failure Consortium ; V Varga, Tibor. / Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. In: Nature Genetics. 2016 ; Vol. 48, No. 10. pp. 1151-1161.
Bibtex
@article{f4c600e443454ca394e4f185bf0c03a7,
title = "Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension",
abstract = "High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.",
author = "Praveen Surendran and Fotios Drenos and Robin Young and Helen Warren and Cook, {James P} and Manning, {Alisa K} and Niels Grarup and Xueling Sim and Barnes, {Daniel R} and Kate Witkowska and Staley, {James R} and Vinicius Tragante and Taru Tukiainen and Hanieh Yaghootkar and Nicholas Masca and Freitag, {Daniel F} and Teresa Ferreira and Olga Giannakopoulou and Andrew Tinker and Magdalena Harakalova and Evelin Mihailov and Chunyu Liu and Kraja, {Aldi T} and Nielsen, {Sune Fallgaard} and Asif Rasheed and Maria Samuel and Wei Zhao and Bonnycastle, {Lori L} and Jackson, {Anne U} and Narisu Narisu and Swift, {Amy J} and Lorraine Southam and Jonathan Marten and Huyghe, {Jeroen R} and Alena Stan{\v c}{\'a}kov{\'a} and Cristiano Fava and Therese Ohlsson and Angela Matchan and Stirrups, {Kathleen E} and Jette Bork-Jensen and Gjesing, {Anette P} and Jukka Kontto and Markus Perola and Susan Shaw-Hawkins and Havulinna, {Aki S} and Husemoen, {Lise L} and Allan Linneberg and Torben Hansen and Oluf Pedersen and Nordestgaard, {B{\o}rge Gr{\o}nne} and {CHARGE-Heart Failure Consortium} and {V Varga}, Tibor",
year = "2016",
month = sep,
day = "12",
doi = "10.1038/ng.3654",
language = "English",
volume = "48",
pages = "1151--1161",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "10",
}
RIS
TY - JOUR
T1 - Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
AU - Surendran, Praveen
AU - Drenos, Fotios
AU - Young, Robin
AU - Warren, Helen
AU - Cook, James P
AU - Manning, Alisa K
AU - Grarup, Niels
AU - Sim, Xueling
AU - Barnes, Daniel R
AU - Witkowska, Kate
AU - Staley, James R
AU - Tragante, Vinicius
AU - Tukiainen, Taru
AU - Yaghootkar, Hanieh
AU - Masca, Nicholas
AU - Freitag, Daniel F
AU - Ferreira, Teresa
AU - Giannakopoulou, Olga
AU - Tinker, Andrew
AU - Harakalova, Magdalena
AU - Mihailov, Evelin
AU - Liu, Chunyu
AU - Kraja, Aldi T
AU - Nielsen, Sune Fallgaard
AU - Rasheed, Asif
AU - Samuel, Maria
AU - Zhao, Wei
AU - Bonnycastle, Lori L
AU - Jackson, Anne U
AU - Narisu, Narisu
AU - Swift, Amy J
AU - Southam, Lorraine
AU - Marten, Jonathan
AU - Huyghe, Jeroen R
AU - Stančáková, Alena
AU - Fava, Cristiano
AU - Ohlsson, Therese
AU - Matchan, Angela
AU - Stirrups, Kathleen E
AU - Bork-Jensen, Jette
AU - Gjesing, Anette P
AU - Kontto, Jukka
AU - Perola, Markus
AU - Shaw-Hawkins, Susan
AU - Havulinna, Aki S
AU - Husemoen, Lise L
AU - Linneberg, Allan
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - Nordestgaard, Børge Grønne
AU - CHARGE-Heart Failure Consortium
AU - V Varga, Tibor
PY - 2016/9/12
Y1 - 2016/9/12
N2 - High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
AB - High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we genotyped 242,296 rare, low-frequency and common genetic variants in up to 192,763 individuals and used ∼155,063 samples for independent replication. We identified 30 new blood pressure- or hypertension-associated genetic regions in the general population, including 3 rare missense variants in RBM47, COL21A1 and RRAS with larger effects (>1.5 mm Hg/allele) than common variants. Multiple rare nonsense and missense variant associations were found in A2ML1, and a low-frequency nonsense variant in ENPEP was identified. Our data extend the spectrum of allelic variation underlying blood pressure traits and hypertension, provide new insights into the pathophysiology of hypertension and indicate new targets for clinical intervention.
U2 - 10.1038/ng.3654
DO - 10.1038/ng.3654
M3 - Journal article
C2 - 27618447
VL - 48
SP - 1151
EP - 1161
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 10
ER -
