Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures?

Research output: Contribution to journal › Journal article › Research › peer-review

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Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures? / Guimarães, Marta; Pereira, Sofia S.; Holst, Jens J.; Nora, Mário; Monteiro, Mariana P.

In: Obesity Surgery, Vol. 31, 2021, p. 2174-2179.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Guimarães, M, Pereira, SS, Holst, JJ, Nora, M & Monteiro, MP 2021, 'Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures?', Obesity Surgery, vol. 31, pp. 2174-2179. https://doi.org/10.1007/s11695-021-05246-8

APA

Guimarães, M., Pereira, S. S., Holst, J. J., Nora, M., & Monteiro, M. P. (2021). Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures? Obesity Surgery, 31, 2174-2179. https://doi.org/10.1007/s11695-021-05246-8

Vancouver

Guimarães M, Pereira SS, Holst JJ, Nora M, Monteiro MP. Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures? Obesity Surgery. 2021;31:2174-2179. https://doi.org/10.1007/s11695-021-05246-8

Author

Guimarães, Marta ; Pereira, Sofia S. ; Holst, Jens J. ; Nora, Mário ; Monteiro, Mariana P. / Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures?. In: Obesity Surgery. 2021 ; Vol. 31. pp. 2174-2179.

Bibtex

@article{c59c3933cfb54c44a45b99299c344650,
title = "Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures?",
abstract = "Purpose: There are no formal guidelines for choosing among different bariatric surgery procedures for obesity treatment. So, our aim was to evaluate whether post-absorptive metabolite and hormone profiles could aid the surgeon decision when considering bariatric surgery interventions. Materials and Methods: Subjects (N=38) previously submitted to biliopancreatic diversion with duodenal switch (BPD-DS, n=9), single anastomosis duodenal–ileum bypass with sleeve gastrectomy (SADI-S, n= 9), long biliopancreatic limb Roux-en-Y gastric bypass (RYGB-M, n= 11), and classic RYGB (RYGB-C, n= 9) underwent a mixed meal test to evaluate post-absorptive glucose, total amino acid (AA), insulin, and GLP-1 profiles. Results: Glucose, AA, insulin, and GLP-1 excursions were lower after BPD-DS when compared to other surgeries. SADI-S resulted in lower glucose but similar AA and insulin excursions when compared to RYGB-M. The highest GLP-1 excursion was observed after RYGB-M. There were no significant differences in glucose or AA post-prandial excursions between RYGB procedures, yet insulin excursion was higher after RYGB-C when compared to RYGB-M. Conclusion: Post-prandial metabolite excursions diverge across bariatric procedures being lowest after BPD-DS, intermediate after SADI-S, and highest after RYGB, in parallel with the anti-diabetic efficacy and malabsorption risk reported for each type of intervention. SADI-S and RYGB-M seem to elicit similar post-prandial hormonal profiles, with potentially lower risk of protein malnutrition when compared to BPD-DS. Post-absorptive metabolite and hormone profiles could provide a rationale as decision-aid when choosing among bariatric surgery interventions, as long as these findings are validated in future trials.",
keywords = "Bariatric surgery, biliopancreatic diversion with duodenal switch, obesity, Roux-en-Y Gastric Bypass, singleanastomosis duodeno-ileal bypass with sleeve gastrectomy",
author = "Marta Guimar{\~a}es and Pereira, {Sofia S.} and Holst, {Jens J.} and M{\'a}rio Nora and Monteiro, {Mariana P.}",
year = "2021",
doi = "10.1007/s11695-021-05246-8",
language = "English",
volume = "31",
pages = "2174--2179",
journal = "Obesity Surgery",
issn = "0960-8923",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Can Metabolite and Hormone Profiles Provide a Rationale for Choosing Between Bariatric Procedures?

AU - Guimarães, Marta

AU - Pereira, Sofia S.

AU - Holst, Jens J.

AU - Nora, Mário

AU - Monteiro, Mariana P.

PY - 2021

Y1 - 2021

N2 - Purpose: There are no formal guidelines for choosing among different bariatric surgery procedures for obesity treatment. So, our aim was to evaluate whether post-absorptive metabolite and hormone profiles could aid the surgeon decision when considering bariatric surgery interventions. Materials and Methods: Subjects (N=38) previously submitted to biliopancreatic diversion with duodenal switch (BPD-DS, n=9), single anastomosis duodenal–ileum bypass with sleeve gastrectomy (SADI-S, n= 9), long biliopancreatic limb Roux-en-Y gastric bypass (RYGB-M, n= 11), and classic RYGB (RYGB-C, n= 9) underwent a mixed meal test to evaluate post-absorptive glucose, total amino acid (AA), insulin, and GLP-1 profiles. Results: Glucose, AA, insulin, and GLP-1 excursions were lower after BPD-DS when compared to other surgeries. SADI-S resulted in lower glucose but similar AA and insulin excursions when compared to RYGB-M. The highest GLP-1 excursion was observed after RYGB-M. There were no significant differences in glucose or AA post-prandial excursions between RYGB procedures, yet insulin excursion was higher after RYGB-C when compared to RYGB-M. Conclusion: Post-prandial metabolite excursions diverge across bariatric procedures being lowest after BPD-DS, intermediate after SADI-S, and highest after RYGB, in parallel with the anti-diabetic efficacy and malabsorption risk reported for each type of intervention. SADI-S and RYGB-M seem to elicit similar post-prandial hormonal profiles, with potentially lower risk of protein malnutrition when compared to BPD-DS. Post-absorptive metabolite and hormone profiles could provide a rationale as decision-aid when choosing among bariatric surgery interventions, as long as these findings are validated in future trials.

AB - Purpose: There are no formal guidelines for choosing among different bariatric surgery procedures for obesity treatment. So, our aim was to evaluate whether post-absorptive metabolite and hormone profiles could aid the surgeon decision when considering bariatric surgery interventions. Materials and Methods: Subjects (N=38) previously submitted to biliopancreatic diversion with duodenal switch (BPD-DS, n=9), single anastomosis duodenal–ileum bypass with sleeve gastrectomy (SADI-S, n= 9), long biliopancreatic limb Roux-en-Y gastric bypass (RYGB-M, n= 11), and classic RYGB (RYGB-C, n= 9) underwent a mixed meal test to evaluate post-absorptive glucose, total amino acid (AA), insulin, and GLP-1 profiles. Results: Glucose, AA, insulin, and GLP-1 excursions were lower after BPD-DS when compared to other surgeries. SADI-S resulted in lower glucose but similar AA and insulin excursions when compared to RYGB-M. The highest GLP-1 excursion was observed after RYGB-M. There were no significant differences in glucose or AA post-prandial excursions between RYGB procedures, yet insulin excursion was higher after RYGB-C when compared to RYGB-M. Conclusion: Post-prandial metabolite excursions diverge across bariatric procedures being lowest after BPD-DS, intermediate after SADI-S, and highest after RYGB, in parallel with the anti-diabetic efficacy and malabsorption risk reported for each type of intervention. SADI-S and RYGB-M seem to elicit similar post-prandial hormonal profiles, with potentially lower risk of protein malnutrition when compared to BPD-DS. Post-absorptive metabolite and hormone profiles could provide a rationale as decision-aid when choosing among bariatric surgery interventions, as long as these findings are validated in future trials.

KW - Bariatric surgery

KW - biliopancreatic diversion with duodenal switch

KW - obesity

KW - Roux-en-Y Gastric Bypass

KW - singleanastomosis duodeno-ileal bypass with sleeve gastrectomy

U2 - 10.1007/s11695-021-05246-8

DO - 10.1007/s11695-021-05246-8

M3 - Journal article

C2 - 33511559

AN - SCOPUS:85099989982

VL - 31

SP - 2174

EP - 2179

JO - Obesity Surgery

JF - Obesity Surgery

SN - 0960-8923

ER -

ID: 256938427