Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight. / DeBenedictis, Julia Nicole; Nymo, Siren; Ollestad, Karoline Haagensli; Boyesen, Guro Akersveen; Rehfeld, Jens Frederik; Holst, Jens Juul; Truby, Helen; Kulseng, Bard; Martins, Catia.

In: Journal of Clinical Endocrinology & Metabolism, Vol. 105, No. 7, 2020, p. e2538-e2546.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

DeBenedictis, JN, Nymo, S, Ollestad, KH, Boyesen, GA, Rehfeld, JF, Holst, JJ, Truby, H, Kulseng, B & Martins, C 2020, 'Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight', Journal of Clinical Endocrinology & Metabolism, vol. 105, no. 7, pp. e2538-e2546. https://doi.org/10.1210/clinem/dgaa202

APA

DeBenedictis, J. N., Nymo, S., Ollestad, K. H., Boyesen, G. A., Rehfeld, J. F., Holst, J. J., Truby, H., Kulseng, B., & Martins, C. (2020). Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight. Journal of Clinical Endocrinology & Metabolism, 105(7), e2538-e2546. https://doi.org/10.1210/clinem/dgaa202

Vancouver

DeBenedictis JN, Nymo S, Ollestad KH, Boyesen GA, Rehfeld JF, Holst JJ et al. Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight. Journal of Clinical Endocrinology & Metabolism. 2020;105(7):e2538-e2546. https://doi.org/10.1210/clinem/dgaa202

Author

DeBenedictis, Julia Nicole ; Nymo, Siren ; Ollestad, Karoline Haagensli ; Boyesen, Guro Akersveen ; Rehfeld, Jens Frederik ; Holst, Jens Juul ; Truby, Helen ; Kulseng, Bard ; Martins, Catia. / Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight. In: Journal of Clinical Endocrinology & Metabolism. 2020 ; Vol. 105, No. 7. pp. e2538-e2546.

Bibtex

@article{080ed81f803b4724a5fbb987a197d188,
title = "Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight",
abstract = "Objective: To compare appetite markers in reduced-obese individuals with a nonobese control group.Methods: A total of 34 adults with obesity who lost 17% body weight at week 13 and maintained this weight loss (WL) at 1 year were compared with 33 nonobese controls matched for body composition. Basal and postprandial subjective appetite ratings and appetite-related hormone concentrations (ghrelin, total peptide YY, peptide YY3-36, total and active glucagon-like peptide 1, and cholecystokinin) were measured in all participants and repeated at week 13 and 1 year in the weight-reduced group.Results: WL led to a reduction in prospective food consumption and an increase in feelings of hunger, fullness, and ghrelin secretion (basal and postprandial), but these new ratings were no different from those seen in controls. Postprandial concentrations of active glucagon-like peptide 1, total peptide YY, and cholecystokinin were lower in individuals with obesity at all time points compared with controls.Conclusion: The increased drive to eat (both subjective feelings of hunger and ghrelin concentrations) seen in reduced-obese individuals, both after acute and sustained WL, reflects a normalization toward a lower body weight. Overall, WL does not have a sustained negative impact on satiety peptide secretion, despite a blunted secretion in individuals with obesity compared with nonobese controls.",
keywords = "weight loss, normalization, compensation, ghrelin, hunger, GLUCAGON-LIKE PEPTIDE-1, ENERGY-INTAKE, LOSS MAINTENANCE, OBESE, TERM, CHOLECYSTOKININ, GHRELIN, INSULIN, ADULTS, REGAIN",
author = "DeBenedictis, {Julia Nicole} and Siren Nymo and Ollestad, {Karoline Haagensli} and Boyesen, {Guro Akersveen} and Rehfeld, {Jens Frederik} and Holst, {Jens Juul} and Helen Truby and Bard Kulseng and Catia Martins",
year = "2020",
doi = "10.1210/clinem/dgaa202",
language = "English",
volume = "105",
pages = "e2538--e2546",
journal = "Journal of Clinical Endocrinology and Metabolism",
issn = "0021-972X",
publisher = "Oxford University Press",
number = "7",

}

RIS

TY - JOUR

T1 - Changes in the Homeostatic Appetite System After Weight Loss Reflect a Normalization Toward a Lower Body Weight

AU - DeBenedictis, Julia Nicole

AU - Nymo, Siren

AU - Ollestad, Karoline Haagensli

AU - Boyesen, Guro Akersveen

AU - Rehfeld, Jens Frederik

AU - Holst, Jens Juul

AU - Truby, Helen

AU - Kulseng, Bard

AU - Martins, Catia

PY - 2020

Y1 - 2020

N2 - Objective: To compare appetite markers in reduced-obese individuals with a nonobese control group.Methods: A total of 34 adults with obesity who lost 17% body weight at week 13 and maintained this weight loss (WL) at 1 year were compared with 33 nonobese controls matched for body composition. Basal and postprandial subjective appetite ratings and appetite-related hormone concentrations (ghrelin, total peptide YY, peptide YY3-36, total and active glucagon-like peptide 1, and cholecystokinin) were measured in all participants and repeated at week 13 and 1 year in the weight-reduced group.Results: WL led to a reduction in prospective food consumption and an increase in feelings of hunger, fullness, and ghrelin secretion (basal and postprandial), but these new ratings were no different from those seen in controls. Postprandial concentrations of active glucagon-like peptide 1, total peptide YY, and cholecystokinin were lower in individuals with obesity at all time points compared with controls.Conclusion: The increased drive to eat (both subjective feelings of hunger and ghrelin concentrations) seen in reduced-obese individuals, both after acute and sustained WL, reflects a normalization toward a lower body weight. Overall, WL does not have a sustained negative impact on satiety peptide secretion, despite a blunted secretion in individuals with obesity compared with nonobese controls.

AB - Objective: To compare appetite markers in reduced-obese individuals with a nonobese control group.Methods: A total of 34 adults with obesity who lost 17% body weight at week 13 and maintained this weight loss (WL) at 1 year were compared with 33 nonobese controls matched for body composition. Basal and postprandial subjective appetite ratings and appetite-related hormone concentrations (ghrelin, total peptide YY, peptide YY3-36, total and active glucagon-like peptide 1, and cholecystokinin) were measured in all participants and repeated at week 13 and 1 year in the weight-reduced group.Results: WL led to a reduction in prospective food consumption and an increase in feelings of hunger, fullness, and ghrelin secretion (basal and postprandial), but these new ratings were no different from those seen in controls. Postprandial concentrations of active glucagon-like peptide 1, total peptide YY, and cholecystokinin were lower in individuals with obesity at all time points compared with controls.Conclusion: The increased drive to eat (both subjective feelings of hunger and ghrelin concentrations) seen in reduced-obese individuals, both after acute and sustained WL, reflects a normalization toward a lower body weight. Overall, WL does not have a sustained negative impact on satiety peptide secretion, despite a blunted secretion in individuals with obesity compared with nonobese controls.

KW - weight loss

KW - normalization

KW - compensation

KW - ghrelin

KW - hunger

KW - GLUCAGON-LIKE PEPTIDE-1

KW - ENERGY-INTAKE

KW - LOSS MAINTENANCE

KW - OBESE

KW - TERM

KW - CHOLECYSTOKININ

KW - GHRELIN

KW - INSULIN

KW - ADULTS

KW - REGAIN

U2 - 10.1210/clinem/dgaa202

DO - 10.1210/clinem/dgaa202

M3 - Journal article

C2 - 32301981

VL - 105

SP - e2538-e2546

JO - Journal of Clinical Endocrinology and Metabolism

JF - Journal of Clinical Endocrinology and Metabolism

SN - 0021-972X

IS - 7

ER -

ID: 250120352