Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans. / Muller, Mattea; Hernandez, Manuel A. Gonzalez; Goossens, Gijs H.; Reijnders, Dorien; Holst, Jens J.; Jocken, Johan W. E.; van Eijk, Hans; Canfora, Emanuel E.; Blaak, Ellen E.

In: Scientific Reports, Vol. 9, 12515, 2019.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Muller, M, Hernandez, MAG, Goossens, GH, Reijnders, D, Holst, JJ, Jocken, JWE, van Eijk, H, Canfora, EE & Blaak, EE 2019, 'Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans', Scientific Reports, vol. 9, 12515. https://doi.org/10.1038/s41598-019-48775-0

APA

Muller, M., Hernandez, M. A. G., Goossens, G. H., Reijnders, D., Holst, J. J., Jocken, J. W. E., van Eijk, H., Canfora, E. E., & Blaak, E. E. (2019). Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans. Scientific Reports, 9, [12515]. https://doi.org/10.1038/s41598-019-48775-0

Vancouver

Muller M, Hernandez MAG, Goossens GH, Reijnders D, Holst JJ, Jocken JWE et al. Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans. Scientific Reports. 2019;9. 12515. https://doi.org/10.1038/s41598-019-48775-0

Author

Muller, Mattea ; Hernandez, Manuel A. Gonzalez ; Goossens, Gijs H. ; Reijnders, Dorien ; Holst, Jens J. ; Jocken, Johan W. E. ; van Eijk, Hans ; Canfora, Emanuel E. ; Blaak, Ellen E. / Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans. In: Scientific Reports. 2019 ; Vol. 9.

Bibtex

@article{c511ced2ba114082a87a24fc2f938b0d,
title = "Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans",
abstract = "Microbial-derived short-chain fatty acids (SCFA) acetate, propionate and butyrate may provide a link between gut microbiota and whole-body insulin sensitivity (IS). In this cross-sectional study (160 participants, 64% male, BMI: 19.2-41.0kg/m(2), normal or impaired glucose metabolism), associations between SCFA (faecal and fasting circulating) and circulating metabolites, substrate oxidation and IS were investigated. In a subgroup (n = 93), IS was determined using a hyperinsulinemic-euglycemic clamp. Data were analyzed using multiple linear regression analysis adjusted for sex, age and BMI. Fasting circulating acetate, propionate and butyrate concentrations were positively associated with fasting GLP-1 concentrations. Additionally, circulating SCFA were negatively related to whole-body lipolysis (glycerol), triacylglycerols and free fatty acids levels (standardized (std) beta adjusted (adj) - 0.190, P = 0.023; std beta adj - 0.202, P = 0.010; std beta adj - 0.306, P = 0.001, respectively). Circulating acetate and propionate were, respectively, negatively and positively correlated with IS (M-value: std beta adj - 0.294, P < 0.001; std beta adj 0.161, P = 0.033, respectively). We show that circulating rather than faecal SCFA were associated with GLP-1 concentrations, whole-body lipolysis and peripheral IS in humans. Therefore, circulating SCFA are more directly linked to metabolic health, which indicates the need to measure circulating SCFA in human prebiotic/probiotic intervention studies as a biomarker/mediator of effects on host metabolism.",
author = "Mattea Muller and Hernandez, {Manuel A. Gonzalez} and Goossens, {Gijs H.} and Dorien Reijnders and Holst, {Jens J.} and Jocken, {Johan W. E.} and {van Eijk}, Hans and Canfora, {Emanuel E.} and Blaak, {Ellen E.}",
year = "2019",
doi = "10.1038/s41598-019-48775-0",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - Circulating but not faecal short-chain fatty acids are related to insulin sensitivity, lipolysis and GLP-1 concentrations in humans

AU - Muller, Mattea

AU - Hernandez, Manuel A. Gonzalez

AU - Goossens, Gijs H.

AU - Reijnders, Dorien

AU - Holst, Jens J.

AU - Jocken, Johan W. E.

AU - van Eijk, Hans

AU - Canfora, Emanuel E.

AU - Blaak, Ellen E.

PY - 2019

Y1 - 2019

N2 - Microbial-derived short-chain fatty acids (SCFA) acetate, propionate and butyrate may provide a link between gut microbiota and whole-body insulin sensitivity (IS). In this cross-sectional study (160 participants, 64% male, BMI: 19.2-41.0kg/m(2), normal or impaired glucose metabolism), associations between SCFA (faecal and fasting circulating) and circulating metabolites, substrate oxidation and IS were investigated. In a subgroup (n = 93), IS was determined using a hyperinsulinemic-euglycemic clamp. Data were analyzed using multiple linear regression analysis adjusted for sex, age and BMI. Fasting circulating acetate, propionate and butyrate concentrations were positively associated with fasting GLP-1 concentrations. Additionally, circulating SCFA were negatively related to whole-body lipolysis (glycerol), triacylglycerols and free fatty acids levels (standardized (std) beta adjusted (adj) - 0.190, P = 0.023; std beta adj - 0.202, P = 0.010; std beta adj - 0.306, P = 0.001, respectively). Circulating acetate and propionate were, respectively, negatively and positively correlated with IS (M-value: std beta adj - 0.294, P < 0.001; std beta adj 0.161, P = 0.033, respectively). We show that circulating rather than faecal SCFA were associated with GLP-1 concentrations, whole-body lipolysis and peripheral IS in humans. Therefore, circulating SCFA are more directly linked to metabolic health, which indicates the need to measure circulating SCFA in human prebiotic/probiotic intervention studies as a biomarker/mediator of effects on host metabolism.

AB - Microbial-derived short-chain fatty acids (SCFA) acetate, propionate and butyrate may provide a link between gut microbiota and whole-body insulin sensitivity (IS). In this cross-sectional study (160 participants, 64% male, BMI: 19.2-41.0kg/m(2), normal or impaired glucose metabolism), associations between SCFA (faecal and fasting circulating) and circulating metabolites, substrate oxidation and IS were investigated. In a subgroup (n = 93), IS was determined using a hyperinsulinemic-euglycemic clamp. Data were analyzed using multiple linear regression analysis adjusted for sex, age and BMI. Fasting circulating acetate, propionate and butyrate concentrations were positively associated with fasting GLP-1 concentrations. Additionally, circulating SCFA were negatively related to whole-body lipolysis (glycerol), triacylglycerols and free fatty acids levels (standardized (std) beta adjusted (adj) - 0.190, P = 0.023; std beta adj - 0.202, P = 0.010; std beta adj - 0.306, P = 0.001, respectively). Circulating acetate and propionate were, respectively, negatively and positively correlated with IS (M-value: std beta adj - 0.294, P < 0.001; std beta adj 0.161, P = 0.033, respectively). We show that circulating rather than faecal SCFA were associated with GLP-1 concentrations, whole-body lipolysis and peripheral IS in humans. Therefore, circulating SCFA are more directly linked to metabolic health, which indicates the need to measure circulating SCFA in human prebiotic/probiotic intervention studies as a biomarker/mediator of effects on host metabolism.

U2 - 10.1038/s41598-019-48775-0

DO - 10.1038/s41598-019-48775-0

M3 - Journal article

C2 - 31467327

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 12515

ER -

ID: 227566959