Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial
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Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial. / Lehrskov, Louise Lang; Christensen, Regitse Hojgaard; Wedell-Neergaard, Anne-Sophie; Legaard, Grit Elster; Dorph, Emma; Larsen, Monica Korsager; Henneberg, Marie; Launbo, Natja; Fagerlind, Sabrina Ravn; Seide, Sidsel Kofoed; Nymand, Stine; Ball, Maria; Vinum, Nicole; Dahl, Camilla; Albrechtsen, Nicolai Jacob Wewer; Holst, Jens Juul; Ried-Larsen, Mathias; Rosenmeier, Jaya Birgitte; Krogh-Madsen, Rikke; Karstoft, Kristian; Pedersen, Bente Klarlund; Ellingsgaard, Helga.
In: Frontiers in Physiology, Vol. 10, 1249 , 2019.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Effects of Exercise Training and IL-6 Receptor Blockade on Gastric Emptying and GLP-1 Secretion in Obese Humans: Secondary Analyses From a Double Blind Randomized Clinical Trial
AU - Lehrskov, Louise Lang
AU - Christensen, Regitse Hojgaard
AU - Wedell-Neergaard, Anne-Sophie
AU - Legaard, Grit Elster
AU - Dorph, Emma
AU - Larsen, Monica Korsager
AU - Henneberg, Marie
AU - Launbo, Natja
AU - Fagerlind, Sabrina Ravn
AU - Seide, Sidsel Kofoed
AU - Nymand, Stine
AU - Ball, Maria
AU - Vinum, Nicole
AU - Dahl, Camilla
AU - Albrechtsen, Nicolai Jacob Wewer
AU - Holst, Jens Juul
AU - Ried-Larsen, Mathias
AU - Rosenmeier, Jaya Birgitte
AU - Krogh-Madsen, Rikke
AU - Karstoft, Kristian
AU - Pedersen, Bente Klarlund
AU - Ellingsgaard, Helga
PY - 2019
Y1 - 2019
N2 - Background: Interleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise. We recently showed that an acute increase in IL-6 delayed gastric emptying rate and improved postprandial glycemia. Here we investigate whether repeated increases in IL-6, induced by exercise training, influence gastric emptying rate and moreover if IL-6 is required for exercise-induced adaptations in glycemic control including secretion of glucagon and glucagon-like peptide-1 (GLP-1). Methods: A total of 52 abdominally obese non-diabetic men and women were randomly assigned into four groups performing 12 weeks of endurance exercise or no exercise with or without IL-6 receptor blockade (tocilizumab). The primary endpoint was change in gastric emptying rate in response to the intervention and other endpoints included changes in glycemic control, glucagon, and GLP-1 secretion. Results: There was no change in gastric emptying rate in any of the four groups following the intervention and comparing differences in change between groups also revealed no difference. Postprandial glucose remained unchanged in all groups but the exercise + tocilizumab group, which improved postprandial glucose in response to the intervention. The area under the curve for meal-stimulated glucagon, active and total GLP-1 increased in response to IL-6 receptor blockade, this effect was independent of exercise. Conclusion: Exercise training and long-term IL-6 receptor blockade did not change gastric emptying rates in obese humans. IL-6 receptor blockade increased glucagon and GLP-1 secretion and implicate IL-6 in the regulation of the human alpha and L cells.
AB - Background: Interleukin-6 (IL-6) is released from skeletal muscle during exercise and systemic IL-6 levels therefore increase acutely in response to a single bout of exercise. We recently showed that an acute increase in IL-6 delayed gastric emptying rate and improved postprandial glycemia. Here we investigate whether repeated increases in IL-6, induced by exercise training, influence gastric emptying rate and moreover if IL-6 is required for exercise-induced adaptations in glycemic control including secretion of glucagon and glucagon-like peptide-1 (GLP-1). Methods: A total of 52 abdominally obese non-diabetic men and women were randomly assigned into four groups performing 12 weeks of endurance exercise or no exercise with or without IL-6 receptor blockade (tocilizumab). The primary endpoint was change in gastric emptying rate in response to the intervention and other endpoints included changes in glycemic control, glucagon, and GLP-1 secretion. Results: There was no change in gastric emptying rate in any of the four groups following the intervention and comparing differences in change between groups also revealed no difference. Postprandial glucose remained unchanged in all groups but the exercise + tocilizumab group, which improved postprandial glucose in response to the intervention. The area under the curve for meal-stimulated glucagon, active and total GLP-1 increased in response to IL-6 receptor blockade, this effect was independent of exercise. Conclusion: Exercise training and long-term IL-6 receptor blockade did not change gastric emptying rates in obese humans. IL-6 receptor blockade increased glucagon and GLP-1 secretion and implicate IL-6 in the regulation of the human alpha and L cells.
KW - interleukin-6
KW - gastric emptying
KW - exercise
KW - tocilizumab
KW - glucagon
KW - GLP-1
U2 - 10.3389/fphys.2019.01249
DO - 10.3389/fphys.2019.01249
M3 - Journal article
C2 - 31636570
VL - 10
JO - Frontiers in Physiology
JF - Frontiers in Physiology
SN - 1664-042X
M1 - 1249
ER -
ID: 231904065