Endocrine and Metabolic Insights from Pancreatic Surgery

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Endocrine and Metabolic Insights from Pancreatic Surgery. / Mezza, Teresa; Cefalo, Chiara M. A.; Cinti, Francesca; Quero, Giuseppe; Pontecorvi, Alfredo; Alfieri, Sergio; Holst, Jens J.; Giaccari, Andrea.

In: Trends in Endocrinology and Metabolism, Vol. 31, No. 10, 10.2020, p. 760-772.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Mezza, T, Cefalo, CMA, Cinti, F, Quero, G, Pontecorvi, A, Alfieri, S, Holst, JJ & Giaccari, A 2020, 'Endocrine and Metabolic Insights from Pancreatic Surgery', Trends in Endocrinology and Metabolism, vol. 31, no. 10, pp. 760-772. https://doi.org/10.1016/j.tem.2020.07.003

APA

Mezza, T., Cefalo, C. M. A., Cinti, F., Quero, G., Pontecorvi, A., Alfieri, S., Holst, J. J., & Giaccari, A. (2020). Endocrine and Metabolic Insights from Pancreatic Surgery. Trends in Endocrinology and Metabolism, 31(10), 760-772. https://doi.org/10.1016/j.tem.2020.07.003

Vancouver

Mezza T, Cefalo CMA, Cinti F, Quero G, Pontecorvi A, Alfieri S et al. Endocrine and Metabolic Insights from Pancreatic Surgery. Trends in Endocrinology and Metabolism. 2020 Oct;31(10):760-772. https://doi.org/10.1016/j.tem.2020.07.003

Author

Mezza, Teresa ; Cefalo, Chiara M. A. ; Cinti, Francesca ; Quero, Giuseppe ; Pontecorvi, Alfredo ; Alfieri, Sergio ; Holst, Jens J. ; Giaccari, Andrea. / Endocrine and Metabolic Insights from Pancreatic Surgery. In: Trends in Endocrinology and Metabolism. 2020 ; Vol. 31, No. 10. pp. 760-772.

Bibtex

@article{9b4c7165bc1d47eaaf9ba37a339a7e9d,
title = "Endocrine and Metabolic Insights from Pancreatic Surgery",
abstract = "Although it is well established that diabetes can also develop as a result of diseases or maneuvers on the exocrine pancreas, the complex relationship between glucose disorders and underlying pancreatic disease is still debated. There is evidence that several features linked to pancreatic diseases can modify endocrine and metabolic conditions before and after surgery. However, pancreatic surgery provides a rare opportunity to correlate in vivo endocrine and metabolic pathways with ex vivo pancreatic samples, to examine the endocrine and metabolic effects of acute islet removal, and finally to clarify the pathogenesis of diabetes. This approach could therefore represent a unique method to shed light on the molecular mechanisms, predicting factors, and metabolic consequences of insulin resistance, islet plasticity, 13 cell failure, and type 2 diabetes.",
keywords = "DIABETES-MELLITUS SECONDARY, GLUCAGON-LIKE PEPTIDE-1, INSULIN-RESISTANCE, DISTAL PANCREATECTOMY, GLUCOSE-METABOLISM, FASTING GLUCOSE, C-PEPTIDE, CANCER, SECRETION, CELLS",
author = "Teresa Mezza and Cefalo, {Chiara M. A.} and Francesca Cinti and Giuseppe Quero and Alfredo Pontecorvi and Sergio Alfieri and Holst, {Jens J.} and Andrea Giaccari",
year = "2020",
month = oct,
doi = "10.1016/j.tem.2020.07.003",
language = "English",
volume = "31",
pages = "760--772",
journal = "Trends in Endocrinology and Metabolism",
issn = "1043-2760",
publisher = "Elsevier Ltd. * Trends Journals",
number = "10",

}

RIS

TY - JOUR

T1 - Endocrine and Metabolic Insights from Pancreatic Surgery

AU - Mezza, Teresa

AU - Cefalo, Chiara M. A.

AU - Cinti, Francesca

AU - Quero, Giuseppe

AU - Pontecorvi, Alfredo

AU - Alfieri, Sergio

AU - Holst, Jens J.

AU - Giaccari, Andrea

PY - 2020/10

Y1 - 2020/10

N2 - Although it is well established that diabetes can also develop as a result of diseases or maneuvers on the exocrine pancreas, the complex relationship between glucose disorders and underlying pancreatic disease is still debated. There is evidence that several features linked to pancreatic diseases can modify endocrine and metabolic conditions before and after surgery. However, pancreatic surgery provides a rare opportunity to correlate in vivo endocrine and metabolic pathways with ex vivo pancreatic samples, to examine the endocrine and metabolic effects of acute islet removal, and finally to clarify the pathogenesis of diabetes. This approach could therefore represent a unique method to shed light on the molecular mechanisms, predicting factors, and metabolic consequences of insulin resistance, islet plasticity, 13 cell failure, and type 2 diabetes.

AB - Although it is well established that diabetes can also develop as a result of diseases or maneuvers on the exocrine pancreas, the complex relationship between glucose disorders and underlying pancreatic disease is still debated. There is evidence that several features linked to pancreatic diseases can modify endocrine and metabolic conditions before and after surgery. However, pancreatic surgery provides a rare opportunity to correlate in vivo endocrine and metabolic pathways with ex vivo pancreatic samples, to examine the endocrine and metabolic effects of acute islet removal, and finally to clarify the pathogenesis of diabetes. This approach could therefore represent a unique method to shed light on the molecular mechanisms, predicting factors, and metabolic consequences of insulin resistance, islet plasticity, 13 cell failure, and type 2 diabetes.

KW - DIABETES-MELLITUS SECONDARY

KW - GLUCAGON-LIKE PEPTIDE-1

KW - INSULIN-RESISTANCE

KW - DISTAL PANCREATECTOMY

KW - GLUCOSE-METABOLISM

KW - FASTING GLUCOSE

KW - C-PEPTIDE

KW - CANCER

KW - SECRETION

KW - CELLS

U2 - 10.1016/j.tem.2020.07.003

DO - 10.1016/j.tem.2020.07.003

M3 - Review

C2 - 32830029

VL - 31

SP - 760

EP - 772

JO - Trends in Endocrinology and Metabolism

JF - Trends in Endocrinology and Metabolism

SN - 1043-2760

IS - 10

ER -

ID: 250213946