Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake. / Gether, Ida M.; Jensen, Marie M.; Nexøe-Larsen, Christina C.; Jorsal, Tina; Gasbjerg, Lærke S.; Naver, Lars; Rehfeld, Jens F.; Holst, Jens J.; Vilsbøll, Tina; Knop, Filip K.

In: Obesity Surgery, Vol. 32, 2022, p. 1385–1390.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Gether, IM, Jensen, MM, Nexøe-Larsen, CC, Jorsal, T, Gasbjerg, LS, Naver, L, Rehfeld, JF, Holst, JJ, Vilsbøll, T & Knop, FK 2022, 'Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake', Obesity Surgery, vol. 32, pp. 1385–1390. https://doi.org/10.1007/s11695-021-05839-3

APA

Gether, I. M., Jensen, M. M., Nexøe-Larsen, C. C., Jorsal, T., Gasbjerg, L. S., Naver, L., Rehfeld, J. F., Holst, J. J., Vilsbøll, T., & Knop, F. K. (2022). Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake. Obesity Surgery, 32, 1385–1390. https://doi.org/10.1007/s11695-021-05839-3

Vancouver

Gether IM, Jensen MM, Nexøe-Larsen CC, Jorsal T, Gasbjerg LS, Naver L et al. Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake. Obesity Surgery. 2022;32:1385–1390. https://doi.org/10.1007/s11695-021-05839-3

Author

Gether, Ida M. ; Jensen, Marie M. ; Nexøe-Larsen, Christina C. ; Jorsal, Tina ; Gasbjerg, Lærke S. ; Naver, Lars ; Rehfeld, Jens F. ; Holst, Jens J. ; Vilsbøll, Tina ; Knop, Filip K. / Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake. In: Obesity Surgery. 2022 ; Vol. 32. pp. 1385–1390.

Bibtex

@article{85ece0928ca24763896dccb571c7012a,
title = "Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake",
abstract = "Introduction: AspireAssist{\textregistered} allows aspiration of ~30% of an ingested meal through a percutaneous gastrostomy tube, reducing caloric uptake. We evaluated the acute effects of gastric aspiration on postprandial glucose tolerance, responses of gluco-regulatory and appetite-regulating hormones, appetite sensations, and food intake. Methods: Seven AspireAssist{\textregistered}-treated individuals underwent two separate experimental days each involving a mixed meal test (MMT) with double-blinded aspiration and sham aspiration, respectively. Seven age and body mass index (BMI)-matched controls underwent one MMT.MMTs were followed by an ad libitum meal. Results: Postprandial glucose tolerance was improved during aspiration vs. sham visits(median [interquartile range] baseline-subtracted area under the curve (bsAUC) 170 [88.4;356] vs. 388 [239;456] mmol/L × min, p = 0.025). Reduced responses (bsAUCs) of C-peptide (113 [28.4;224] vs. 302 [215;433] nmol/L × min, p = 0.014), cholecystokinin (223 [59.4;402] vs. 467 [416;546] pmol/L × min, p = 0.005), glucose-dependent insulinotropic polypeptide (4.63 [1.49;9.04] vs. 15.4 [9.59;18.9] nmol/L × min, p = 0.025), and glucagon-like peptide 1 (532.8 [274.5;1,278] vs. 1,296 [746.2;1,618] pmol/L × min, p = 0.032) were observed during aspiration vs. sham visits. Responses of glucagon, gastrin, ghrelin and peptide YY, appetite sensations, and ad libitum food intake were unaffected by aspiration. Responses of plasma glucose,gut hormones, appetite sensations, and food intake were similar during sham and control visits. Conclusion: Gastric aspiration improved postprandial glucose tolerance without causingcompensatory increases in appetite or food intake, pointing to acute beneficial metabolic effects of aspiration therapy together with previously reported body weight-lowering effects.",
keywords = "Aspiration therapy, AspireAssist{\textregistered}, Gastric aspiration, Obesity treatment",
author = "Gether, {Ida M.} and Jensen, {Marie M.} and Nex{\o}e-Larsen, {Christina C.} and Tina Jorsal and Gasbjerg, {L{\ae}rke S.} and Lars Naver and Rehfeld, {Jens F.} and Holst, {Jens J.} and Tina Vilsb{\o}ll and Knop, {Filip K.}",
note = "Publisher Copyright: {\textcopyright} 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2022",
doi = "10.1007/s11695-021-05839-3",
language = "English",
volume = "32",
pages = "1385–1390",
journal = "Obesity Surgery",
issn = "0960-8923",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Gastric Aspiration Improves Postprandial Glucose Tolerance Without Causing a Compensatory Increase in Appetite and Food Intake

AU - Gether, Ida M.

AU - Jensen, Marie M.

AU - Nexøe-Larsen, Christina C.

AU - Jorsal, Tina

AU - Gasbjerg, Lærke S.

AU - Naver, Lars

AU - Rehfeld, Jens F.

AU - Holst, Jens J.

AU - Vilsbøll, Tina

AU - Knop, Filip K.

N1 - Publisher Copyright: © 2022, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

PY - 2022

Y1 - 2022

N2 - Introduction: AspireAssist® allows aspiration of ~30% of an ingested meal through a percutaneous gastrostomy tube, reducing caloric uptake. We evaluated the acute effects of gastric aspiration on postprandial glucose tolerance, responses of gluco-regulatory and appetite-regulating hormones, appetite sensations, and food intake. Methods: Seven AspireAssist®-treated individuals underwent two separate experimental days each involving a mixed meal test (MMT) with double-blinded aspiration and sham aspiration, respectively. Seven age and body mass index (BMI)-matched controls underwent one MMT.MMTs were followed by an ad libitum meal. Results: Postprandial glucose tolerance was improved during aspiration vs. sham visits(median [interquartile range] baseline-subtracted area under the curve (bsAUC) 170 [88.4;356] vs. 388 [239;456] mmol/L × min, p = 0.025). Reduced responses (bsAUCs) of C-peptide (113 [28.4;224] vs. 302 [215;433] nmol/L × min, p = 0.014), cholecystokinin (223 [59.4;402] vs. 467 [416;546] pmol/L × min, p = 0.005), glucose-dependent insulinotropic polypeptide (4.63 [1.49;9.04] vs. 15.4 [9.59;18.9] nmol/L × min, p = 0.025), and glucagon-like peptide 1 (532.8 [274.5;1,278] vs. 1,296 [746.2;1,618] pmol/L × min, p = 0.032) were observed during aspiration vs. sham visits. Responses of glucagon, gastrin, ghrelin and peptide YY, appetite sensations, and ad libitum food intake were unaffected by aspiration. Responses of plasma glucose,gut hormones, appetite sensations, and food intake were similar during sham and control visits. Conclusion: Gastric aspiration improved postprandial glucose tolerance without causingcompensatory increases in appetite or food intake, pointing to acute beneficial metabolic effects of aspiration therapy together with previously reported body weight-lowering effects.

AB - Introduction: AspireAssist® allows aspiration of ~30% of an ingested meal through a percutaneous gastrostomy tube, reducing caloric uptake. We evaluated the acute effects of gastric aspiration on postprandial glucose tolerance, responses of gluco-regulatory and appetite-regulating hormones, appetite sensations, and food intake. Methods: Seven AspireAssist®-treated individuals underwent two separate experimental days each involving a mixed meal test (MMT) with double-blinded aspiration and sham aspiration, respectively. Seven age and body mass index (BMI)-matched controls underwent one MMT.MMTs were followed by an ad libitum meal. Results: Postprandial glucose tolerance was improved during aspiration vs. sham visits(median [interquartile range] baseline-subtracted area under the curve (bsAUC) 170 [88.4;356] vs. 388 [239;456] mmol/L × min, p = 0.025). Reduced responses (bsAUCs) of C-peptide (113 [28.4;224] vs. 302 [215;433] nmol/L × min, p = 0.014), cholecystokinin (223 [59.4;402] vs. 467 [416;546] pmol/L × min, p = 0.005), glucose-dependent insulinotropic polypeptide (4.63 [1.49;9.04] vs. 15.4 [9.59;18.9] nmol/L × min, p = 0.025), and glucagon-like peptide 1 (532.8 [274.5;1,278] vs. 1,296 [746.2;1,618] pmol/L × min, p = 0.032) were observed during aspiration vs. sham visits. Responses of glucagon, gastrin, ghrelin and peptide YY, appetite sensations, and ad libitum food intake were unaffected by aspiration. Responses of plasma glucose,gut hormones, appetite sensations, and food intake were similar during sham and control visits. Conclusion: Gastric aspiration improved postprandial glucose tolerance without causingcompensatory increases in appetite or food intake, pointing to acute beneficial metabolic effects of aspiration therapy together with previously reported body weight-lowering effects.

KW - Aspiration therapy

KW - AspireAssist®

KW - Gastric aspiration

KW - Obesity treatment

U2 - 10.1007/s11695-021-05839-3

DO - 10.1007/s11695-021-05839-3

M3 - Journal article

C2 - 35064866

AN - SCOPUS:85123491419

VL - 32

SP - 1385

EP - 1390

JO - Obesity Surgery

JF - Obesity Surgery

SN - 0960-8923

ER -

ID: 291357940