Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis. / Broberg, Bo; Madsen, Jan L.; Fuglsang, Stefan; Holst, Jens J.; Christensen, Karl Bang; Rydahl, Casper; Idorn, Thomas; Feldt-Rasmussen, Bo; Hornum, Mads.
In: Neurogastroenterology and Motility, Vol. 31, No. 4, e13554, 2019.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Gastrointestinal motility in patients with end-stage renal disease on chronic hemodialysis
AU - Broberg, Bo
AU - Madsen, Jan L.
AU - Fuglsang, Stefan
AU - Holst, Jens J.
AU - Christensen, Karl Bang
AU - Rydahl, Casper
AU - Idorn, Thomas
AU - Feldt-Rasmussen, Bo
AU - Hornum, Mads
PY - 2019
Y1 - 2019
N2 - Background: Previous studies indicated delayed gastric emptying in patients with end-stage renal disease (ESRD) using indirect methods. The objective of the current study was to examine gastrointestinal motility using a direct method as well as the role of the incretin hormones and glucagon. Methods: Patients on chronic hemodialysis and with either normal glucose tolerance, impaired glucose tolerance or type 2 diabetes, and healthy control subjects (N = 8, respectively) were studied. Gastric emptying time was measured by repeated gamma camera imaging for 6 hours after intake of a radioactive labeled standardized mixed solid and liquid meal. Glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) levels were measured. Key Results: Patients were age, gender and BMI matched with controls. We found significantly higher gastric retention at 15 minutes, prolonged gastric mean emptying time, and gastric half-emptying time of the solid marker in all three groups of ESRD patients compared to controls. Significant differences in mean total area under the concentration curve (AUC) values across the four groups for GIP (P = 0.001), but not for GLP-1 and glucagon. The ESRD group had significant higher total AUC of GIP and glucagon compared to controls (P < 0.001 and P < 0.04) but not for GLP-1 (P = 0.4). No difference in incremental AUC was found. Conclusions and Inferences: We found altered gastrointestinal motility in dialysis patients, with higher gastric retention and prolonged gastric emptying, and higher total AUC of GIP and glucagon independent of the presence of diabetes or prediabetes.
AB - Background: Previous studies indicated delayed gastric emptying in patients with end-stage renal disease (ESRD) using indirect methods. The objective of the current study was to examine gastrointestinal motility using a direct method as well as the role of the incretin hormones and glucagon. Methods: Patients on chronic hemodialysis and with either normal glucose tolerance, impaired glucose tolerance or type 2 diabetes, and healthy control subjects (N = 8, respectively) were studied. Gastric emptying time was measured by repeated gamma camera imaging for 6 hours after intake of a radioactive labeled standardized mixed solid and liquid meal. Glucagon, glucagon-like peptide-1 (GLP-1), and glucose-dependent insulinotropic polypeptide (GIP) levels were measured. Key Results: Patients were age, gender and BMI matched with controls. We found significantly higher gastric retention at 15 minutes, prolonged gastric mean emptying time, and gastric half-emptying time of the solid marker in all three groups of ESRD patients compared to controls. Significant differences in mean total area under the concentration curve (AUC) values across the four groups for GIP (P = 0.001), but not for GLP-1 and glucagon. The ESRD group had significant higher total AUC of GIP and glucagon compared to controls (P < 0.001 and P < 0.04) but not for GLP-1 (P = 0.4). No difference in incremental AUC was found. Conclusions and Inferences: We found altered gastrointestinal motility in dialysis patients, with higher gastric retention and prolonged gastric emptying, and higher total AUC of GIP and glucagon independent of the presence of diabetes or prediabetes.
KW - diabetes mellitus
KW - gastrointestinal motility
KW - hemodialysis
KW - intestinal hormones
U2 - 10.1111/nmo.13554
DO - 10.1111/nmo.13554
M3 - Journal article
C2 - 30667131
AN - SCOPUS:85060342563
VL - 31
JO - Neurogastroenterology and Motility
JF - Neurogastroenterology and Motility
SN - 1350-1925
IS - 4
M1 - e13554
ER -
ID: 214749566