Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals

Research output: Contribution to journal › Journal article › Research › peer-review

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Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals. / Kliim-Hansen, Vivian; Gether, Ida M.; Juel, Caroline T.-B.; Ellegaard, Anne-Marie; Pedersen, Miriam G.; Hartmann, Bolette; Albrechtsen, Nicolai J. Wewer; Holst, Jens J.; Lund, Asger B.; Gasbjerg, Lærke S.; Knop, Filip K.

In: Peptides, Vol. 179, 171242, 2024.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Kliim-Hansen, V, Gether, IM, Juel, CT-B, Ellegaard, A-M, Pedersen, MG, Hartmann, B, Albrechtsen, NJW, Holst, JJ, Lund, AB, Gasbjerg, LS & Knop, FK 2024, 'Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals', Peptides, vol. 179, 171242. https://doi.org/10.1016/j.peptides.2024.171242

APA

Kliim-Hansen, V., Gether, I. M., Juel, C. T-B., Ellegaard, A-M., Pedersen, M. G., Hartmann, B., Albrechtsen, N. J. W., Holst, J. J., Lund, A. B., Gasbjerg, L. S., & Knop, F. K. (2024). Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals. Peptides, 179, [171242]. https://doi.org/10.1016/j.peptides.2024.171242

Vancouver

Kliim-Hansen V, Gether IM, Juel CT-B, Ellegaard A-M, Pedersen MG, Hartmann B et al. Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals. Peptides. 2024;179. 171242. https://doi.org/10.1016/j.peptides.2024.171242

Author

Kliim-Hansen, Vivian ; Gether, Ida M. ; Juel, Caroline T.-B. ; Ellegaard, Anne-Marie ; Pedersen, Miriam G. ; Hartmann, Bolette ; Albrechtsen, Nicolai J. Wewer ; Holst, Jens J. ; Lund, Asger B. ; Gasbjerg, Lærke S. ; Knop, Filip K. / Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals. In: Peptides. 2024 ; Vol. 179.

Bibtex

@article{8ce6c2f452cb449da53e1af68e017b38,
title = "Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals",
abstract = "Oxytocin has been proposed to possess glucose-stabilizing effects through the release of insulin and glucagon from the pancreas. Also, exogenous oxytocin has been shown to stimulate extrapancreatic glucagon secretion in depancreatized dogs. Here, we investigated the effect of exogenous oxytocin on circulating levels of pancreatic and gut-derived glucose-stabilizing hormones (insulin [measured as C-peptide], glucagon, glucagon-like peptide 1 [GLP-1], and glucose-dependent insulinotropic polypeptide). We studied nine pancreatectomized (PX) patients and nine healthy controls (CTRLs) (matched on age and body mass index) before, during, and after an intravenous infusion of 10 IU of oxytocin administered over 12minutes. Oxytocin did not increase plasma glucagon levels, nor induce any changes in plasma glucose, C-peptide, or GIP in any of the groups. Oxytocin decreased plasma glucagon levels by 19 ± 10% in CTRLs (from 2.0 ± 0.5 [mean ± SEM] to 1.3 ± 0.2 pmol/l, P = 0.0025) and increased GLP-1 by 42 ± 22% in PX patients (from 9.0 ± 1.0 to 12.7 ± 1.0 pmol/l, P = 0.0003). Fasting plasma glucose levels were higher in PX patients compared with CTRLs (13.1 ± 1.1 vs. 5.1 ± 0.1mmol/l, P < 0.0001). In conclusion, the present findings do not support pancreas-mediated glucose-stabilizing effects of acute oxytocin administration in humans and warrant further investigation of oxytocin's gluco-metabolic effects. Trial registration ClinicalTrials.gov NCT02944110.",
author = "Vivian Kliim-Hansen and Gether, {Ida M.} and Juel, {Caroline T.-B.} and Anne-Marie Ellegaard and Pedersen, {Miriam G.} and Bolette Hartmann and Albrechtsen, {Nicolai J. Wewer} and Holst, {Jens J.} and Lund, {Asger B.} and Gasbjerg, {L{\ae}rke S.} and Knop, {Filip K.}",
note = "Copyright {\textcopyright} 2024. Published by Elsevier Inc.",
year = "2024",
doi = "10.1016/j.peptides.2024.171242",
language = "English",
volume = "179",
journal = "Peptides",
issn = "0196-9781",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Gluco-metabolic response to exogenous oxytocin in totally pancreatectomized patients and healthy individuals

AU - Kliim-Hansen, Vivian

AU - Gether, Ida M.

AU - Juel, Caroline T.-B.

AU - Ellegaard, Anne-Marie

AU - Pedersen, Miriam G.

AU - Hartmann, Bolette

AU - Albrechtsen, Nicolai J. Wewer

AU - Holst, Jens J.

AU - Lund, Asger B.

AU - Gasbjerg, Lærke S.

AU - Knop, Filip K.

N1 - Copyright © 2024. Published by Elsevier Inc.

PY - 2024

Y1 - 2024

N2 - Oxytocin has been proposed to possess glucose-stabilizing effects through the release of insulin and glucagon from the pancreas. Also, exogenous oxytocin has been shown to stimulate extrapancreatic glucagon secretion in depancreatized dogs. Here, we investigated the effect of exogenous oxytocin on circulating levels of pancreatic and gut-derived glucose-stabilizing hormones (insulin [measured as C-peptide], glucagon, glucagon-like peptide 1 [GLP-1], and glucose-dependent insulinotropic polypeptide). We studied nine pancreatectomized (PX) patients and nine healthy controls (CTRLs) (matched on age and body mass index) before, during, and after an intravenous infusion of 10 IU of oxytocin administered over 12minutes. Oxytocin did not increase plasma glucagon levels, nor induce any changes in plasma glucose, C-peptide, or GIP in any of the groups. Oxytocin decreased plasma glucagon levels by 19 ± 10% in CTRLs (from 2.0 ± 0.5 [mean ± SEM] to 1.3 ± 0.2 pmol/l, P = 0.0025) and increased GLP-1 by 42 ± 22% in PX patients (from 9.0 ± 1.0 to 12.7 ± 1.0 pmol/l, P = 0.0003). Fasting plasma glucose levels were higher in PX patients compared with CTRLs (13.1 ± 1.1 vs. 5.1 ± 0.1mmol/l, P < 0.0001). In conclusion, the present findings do not support pancreas-mediated glucose-stabilizing effects of acute oxytocin administration in humans and warrant further investigation of oxytocin's gluco-metabolic effects. Trial registration ClinicalTrials.gov NCT02944110.

AB - Oxytocin has been proposed to possess glucose-stabilizing effects through the release of insulin and glucagon from the pancreas. Also, exogenous oxytocin has been shown to stimulate extrapancreatic glucagon secretion in depancreatized dogs. Here, we investigated the effect of exogenous oxytocin on circulating levels of pancreatic and gut-derived glucose-stabilizing hormones (insulin [measured as C-peptide], glucagon, glucagon-like peptide 1 [GLP-1], and glucose-dependent insulinotropic polypeptide). We studied nine pancreatectomized (PX) patients and nine healthy controls (CTRLs) (matched on age and body mass index) before, during, and after an intravenous infusion of 10 IU of oxytocin administered over 12minutes. Oxytocin did not increase plasma glucagon levels, nor induce any changes in plasma glucose, C-peptide, or GIP in any of the groups. Oxytocin decreased plasma glucagon levels by 19 ± 10% in CTRLs (from 2.0 ± 0.5 [mean ± SEM] to 1.3 ± 0.2 pmol/l, P = 0.0025) and increased GLP-1 by 42 ± 22% in PX patients (from 9.0 ± 1.0 to 12.7 ± 1.0 pmol/l, P = 0.0003). Fasting plasma glucose levels were higher in PX patients compared with CTRLs (13.1 ± 1.1 vs. 5.1 ± 0.1mmol/l, P < 0.0001). In conclusion, the present findings do not support pancreas-mediated glucose-stabilizing effects of acute oxytocin administration in humans and warrant further investigation of oxytocin's gluco-metabolic effects. Trial registration ClinicalTrials.gov NCT02944110.

U2 - 10.1016/j.peptides.2024.171242

DO - 10.1016/j.peptides.2024.171242

M3 - Journal article

C2 - 38782050

VL - 179

JO - Peptides

JF - Peptides

SN - 0196-9781

M1 - 171242

ER -

ID: 392976797