Incretin-based therapy of metabolic disease
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Incretin-based therapy of metabolic disease. / Holst, Jens Juul.
In: Danish Medical Journal, Vol. 70, No. 1, A10220597, 2023.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Incretin-based therapy of metabolic disease
AU - Holst, Jens Juul
N1 - Publisher Copyright: © 2023, Almindelige Danske Laegeforening. All rights reserved.
PY - 2023
Y1 - 2023
N2 - Recent studies show that incretin hormone analogues effectively control blood glucose while producing major weight losses and reducing the risk of all-cause mortality, myocardial infarction, stroke and kidney function impairment. Furthermore, the risk of dementia and cognitive impairment is reduced. A monomolecular coagonist (tirzepatide) of receptors for both incretin hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide) produced HbA1c values below 5.7% in 50% of the treated patients and weight losses exceeding 20% in obese individuals. These new agents will radically change our approach to the treatment of T2DM and obesity alike.
AB - Recent studies show that incretin hormone analogues effectively control blood glucose while producing major weight losses and reducing the risk of all-cause mortality, myocardial infarction, stroke and kidney function impairment. Furthermore, the risk of dementia and cognitive impairment is reduced. A monomolecular coagonist (tirzepatide) of receptors for both incretin hormones (glucagon-like peptide-1 and glucose-dependent insulinotropic polypeptide) produced HbA1c values below 5.7% in 50% of the treated patients and weight losses exceeding 20% in obese individuals. These new agents will radically change our approach to the treatment of T2DM and obesity alike.
UR - http://www.scopus.com/inward/record.url?scp=85148425752&partnerID=8YFLogxK
M3 - Journal article
AN - SCOPUS:85148425752
VL - 70
JO - Danish Medical Journal
JF - Danish Medical Journal
SN - 2245-1919
IS - 1
M1 - A10220597
ER -
ID: 340118796