The effect of preceding glucose decline rate on low-dose glucagon efficacy in individuals with type 1 diabetes: A randomized crossover trial
Research output: Contribution to journal › Journal article › Research › peer-review
Identifying determinants of low-dose glucagon efficacy is important to optimise its utilization for prevention and treatment of hypoglycaemia in individuals with type 1 diabetes. The study objective was to investigate whether the preceding glucose decline rate affects glucose response to low-dose glucagon administration. Ten adults with insulin pump-treated type 1 diabetes were included in this randomized, single-blind, two-way crossover study. Using a hyperinsulinaemic clamp technique, plasma glucose levels were reduced with either a rapid or slow decline rate while maintaining fixed insulin levels. When the plasma glucose level reached 3.9 mmoL/L, insulin and glucose infusions were discontinued and 150 mu g subcutaneous glucagon was administered, followed by 120 minutes of plasma glucose monitoring. The positive incremental area under the glucose curve after administration of low-dose glucagon did not differ between the rapid-decline and slow-decline visits (mean +/- SEM: 220 +/- 49 vs. 174 +/- 31 mmoL/L x min; P = 0.21). Similarly, no differences in total area under the glucose curve, peak plasma glucose, incremental peak plasma glucose, time-to-peak plasma glucose or end plasma glucose were observed. Thus, preceding glucose decline rate did not significantly affect the glucose response to low-dose glucagon.
Original language | English |
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Journal | Diabetes, Obesity and Metabolism |
Volume | 23 |
Issue number | 4 |
Pages (from-to) | 1057-1062 |
Number of pages | 6 |
ISSN | 1462-8902 |
DOIs | |
Publication status | Published - 2021 |
- glucagon, hypoglycaemia, pharmacodynamics, type 1 diabetes, INDUCED MILD HYPOGLYCEMIA
Research areas
ID: 255212674