The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies

Research output: Contribution to journal › Review › Research › peer-review

Standard

The role of GLP-1 in postprandial glucose metabolism after bariatric surgery : a narrative review of human GLP-1 receptor antagonist studies. / Hindsø, Morten; Svane, Maria S; Hedbäck, Nora; Holst, Jens J; Madsbad, Sten; Bojsen-Møller, Kirstine N.

In: Surgery for Obesity and Related Diseases, Vol. 17, No. 7, 2021, p. 1383-1391.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Hindsø, M, Svane, MS, Hedbäck, N, Holst, JJ, Madsbad, S & Bojsen-Møller, KN 2021, 'The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies', Surgery for Obesity and Related Diseases, vol. 17, no. 7, pp. 1383-1391. https://doi.org/10.1016/j.soard.2021.01.041

APA

Hindsø, M., Svane, M. S., Hedbäck, N., Holst, J. J., Madsbad, S., & Bojsen-Møller, K. N. (2021). The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies. Surgery for Obesity and Related Diseases, 17(7), 1383-1391. https://doi.org/10.1016/j.soard.2021.01.041

Vancouver

Hindsø M, Svane MS, Hedbäck N, Holst JJ, Madsbad S, Bojsen-Møller KN. The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies. Surgery for Obesity and Related Diseases. 2021;17(7):1383-1391. https://doi.org/10.1016/j.soard.2021.01.041

Author

Hindsø, Morten ; Svane, Maria S ; Hedbäck, Nora ; Holst, Jens J ; Madsbad, Sten ; Bojsen-Møller, Kirstine N. / The role of GLP-1 in postprandial glucose metabolism after bariatric surgery : a narrative review of human GLP-1 receptor antagonist studies. In: Surgery for Obesity and Related Diseases. 2021 ; Vol. 17, No. 7. pp. 1383-1391.

Bibtex

@article{6855131136fc4275a844fe6ed25452c7,
title = "The role of GLP-1 in postprandial glucose metabolism after bariatric surgery: a narrative review of human GLP-1 receptor antagonist studies",
abstract = "The Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric procedures lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiologic importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated. The effect of GLP-1 receptor blockade after RYGB has been investigated in 12 studies. The studies indicate a shift toward a more prominent role for GLP-1 in postprandial β-cell function after RYGB. The effect of GLP-1 receptor antagonism on glucose tolerance after RYGB is more complex and is associated with important methodological challenges. The postprandial GLP-1 response is less enhanced after SG compared with RYGB. However, the effect of GLP-1 receptor blockade after SG has been examined in 1 study only and needs further investigation.",
author = "Morten Hinds{\o} and Svane, {Maria S} and Nora Hedb{\"a}ck and Holst, {Jens J} and Sten Madsbad and Bojsen-M{\o}ller, {Kirstine N.}",
note = "Copyright {\textcopyright} 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.",
year = "2021",
doi = "10.1016/j.soard.2021.01.041",
language = "English",
volume = "17",
pages = "1383--1391",
journal = "Surgery for Obesity and Related Diseases",
issn = "1550-7289",
publisher = "Elsevier",
number = "7",

}

RIS

TY - JOUR

T1 - The role of GLP-1 in postprandial glucose metabolism after bariatric surgery

T2 - a narrative review of human GLP-1 receptor antagonist studies

AU - Hindsø, Morten

AU - Svane, Maria S

AU - Hedbäck, Nora

AU - Holst, Jens J

AU - Madsbad, Sten

AU - Bojsen-Møller, Kirstine N.

N1 - Copyright © 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved.

PY - 2021

Y1 - 2021

N2 - The Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric procedures lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiologic importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated. The effect of GLP-1 receptor blockade after RYGB has been investigated in 12 studies. The studies indicate a shift toward a more prominent role for GLP-1 in postprandial β-cell function after RYGB. The effect of GLP-1 receptor antagonism on glucose tolerance after RYGB is more complex and is associated with important methodological challenges. The postprandial GLP-1 response is less enhanced after SG compared with RYGB. However, the effect of GLP-1 receptor blockade after SG has been examined in 1 study only and needs further investigation.

AB - The Roux-en-Y gastric bypass (RYGB) and sleeve gastrectomy (SG) bariatric procedures lead to remission or improvement of type 2 diabetes. A weight loss-independent augmentation of postprandial insulin secretion contributes to the improvement in glycemic control after RYGB and is associated with a ∼10-fold increase in plasma concentrations of the incretin hormone glucagon-like peptide-1 (GLP-1). However, the physiologic importance of the markedly increased postprandial GLP-1 secretion after RYGB has been much debated. The effect of GLP-1 receptor blockade after RYGB has been investigated in 12 studies. The studies indicate a shift toward a more prominent role for GLP-1 in postprandial β-cell function after RYGB. The effect of GLP-1 receptor antagonism on glucose tolerance after RYGB is more complex and is associated with important methodological challenges. The postprandial GLP-1 response is less enhanced after SG compared with RYGB. However, the effect of GLP-1 receptor blockade after SG has been examined in 1 study only and needs further investigation.

U2 - 10.1016/j.soard.2021.01.041

DO - 10.1016/j.soard.2021.01.041

M3 - Review

C2 - 33771461

VL - 17

SP - 1383

EP - 1391

JO - Surgery for Obesity and Related Diseases

JF - Surgery for Obesity and Related Diseases

SN - 1550-7289

IS - 7

ER -

ID: 260351452