Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss. / Christiansen, Malene Revsbech; Kilpelöainen, Tuomas O.; McCaffery, Jeanne M.

In: Diabetes, Vol. 72, No. 10, 2023, p. 1424-1432.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christiansen, MR, Kilpelöainen, TO & McCaffery, JM 2023, 'Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss', Diabetes, vol. 72, no. 10, pp. 1424-1432. https://doi.org/10.2337/db23-0131

APA

Christiansen, M. R., Kilpelöainen, T. O., & McCaffery, J. M. (2023). Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss. Diabetes, 72(10), 1424-1432. https://doi.org/10.2337/db23-0131

Vancouver

Christiansen MR, Kilpelöainen TO, McCaffery JM. Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss. Diabetes. 2023;72(10):1424-1432. https://doi.org/10.2337/db23-0131

Author

Christiansen, Malene Revsbech ; Kilpelöainen, Tuomas O. ; McCaffery, Jeanne M. / Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss. In: Diabetes. 2023 ; Vol. 72, No. 10. pp. 1424-1432.

Bibtex

@article{f6185027dbfd4b0e9f75ecd80c3e3c17,
title = "Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss",
abstract = "Although many individuals are able to achieve weight loss, maintaining this loss over time is challenging. We aimed to study whether genetic predisposition to general or abdominal obesity predicts weight regain after weight loss. We examined the associations between genetic risk scores for higher BMI and higher waist-to-hip ratio adjusted for BMI (WHRadjBMI) with changes in weight and waist circumference up to 3 years after a 1-year weight loss program in participants (n = 822 women, n = 593 men) from the Look AHEAD (Action for Health in Diabe-tes) study who had lost ≥3% of their initial weight. Genetic predisposition to higher BMI or WHRadjBMI was not associated with weight regain after weight loss. How-ever, the WHRadjBMI genetic score did predict an increase in waist circumference independent of weight change. To conclude, a genetic predisposition to higher WHRadjBMI predicts an increase in abdominal obesity after weight loss, whereas genetic predisposition to higher BMI is not predictive of weight regain. These results suggest that genetic effects on abdominal obesity may be more pronounced than those on general obesity during weight regain.",
author = "Christiansen, {Malene Revsbech} and Kilpel{\"o}ainen, {Tuomas O.} and McCaffery, {Jeanne M.}",
note = "Publisher Copyright: {\textcopyright} 2023 by the American Diabetes Association.",
year = "2023",
doi = "10.2337/db23-0131",
language = "English",
volume = "72",
pages = "1424--1432",
journal = "Diabetes",
issn = "0012-1797",
publisher = "American Diabetes Association",
number = "10",

}

RIS

TY - JOUR

T1 - Abdominal Obesity Genetic Variants Predict Waist Circumference Regain After Weight Loss

AU - Christiansen, Malene Revsbech

AU - Kilpelöainen, Tuomas O.

AU - McCaffery, Jeanne M.

N1 - Publisher Copyright: © 2023 by the American Diabetes Association.

PY - 2023

Y1 - 2023

N2 - Although many individuals are able to achieve weight loss, maintaining this loss over time is challenging. We aimed to study whether genetic predisposition to general or abdominal obesity predicts weight regain after weight loss. We examined the associations between genetic risk scores for higher BMI and higher waist-to-hip ratio adjusted for BMI (WHRadjBMI) with changes in weight and waist circumference up to 3 years after a 1-year weight loss program in participants (n = 822 women, n = 593 men) from the Look AHEAD (Action for Health in Diabe-tes) study who had lost ≥3% of their initial weight. Genetic predisposition to higher BMI or WHRadjBMI was not associated with weight regain after weight loss. How-ever, the WHRadjBMI genetic score did predict an increase in waist circumference independent of weight change. To conclude, a genetic predisposition to higher WHRadjBMI predicts an increase in abdominal obesity after weight loss, whereas genetic predisposition to higher BMI is not predictive of weight regain. These results suggest that genetic effects on abdominal obesity may be more pronounced than those on general obesity during weight regain.

AB - Although many individuals are able to achieve weight loss, maintaining this loss over time is challenging. We aimed to study whether genetic predisposition to general or abdominal obesity predicts weight regain after weight loss. We examined the associations between genetic risk scores for higher BMI and higher waist-to-hip ratio adjusted for BMI (WHRadjBMI) with changes in weight and waist circumference up to 3 years after a 1-year weight loss program in participants (n = 822 women, n = 593 men) from the Look AHEAD (Action for Health in Diabe-tes) study who had lost ≥3% of their initial weight. Genetic predisposition to higher BMI or WHRadjBMI was not associated with weight regain after weight loss. How-ever, the WHRadjBMI genetic score did predict an increase in waist circumference independent of weight change. To conclude, a genetic predisposition to higher WHRadjBMI predicts an increase in abdominal obesity after weight loss, whereas genetic predisposition to higher BMI is not predictive of weight regain. These results suggest that genetic effects on abdominal obesity may be more pronounced than those on general obesity during weight regain.

U2 - 10.2337/db23-0131

DO - 10.2337/db23-0131

M3 - Journal article

C2 - 37494631

AN - SCOPUS:85171901479

VL - 72

SP - 1424

EP - 1432

JO - Diabetes

JF - Diabetes

SN - 0012-1797

IS - 10

ER -

ID: 369122016