Standard
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. / Speliotes, Elizabeth K; Willer, Cristen J; Berndt, Sonja I; Monda, Keri L; Thorleifsson, Gudmar; Jackson, Anne U; Allen, Hana Lango; Lindgren, Cecilia M; Luan, Jian'an; Mägi, Reedik; Randall, Joshua C; Vedantam, Sailaja; Winkler, Thomas W; Lu, Qi; Workalemahu, Tsegaselassie; Heid, Iris M; Steinthorsdottir, Valgerdur; Stringham, Heather M; Weedon, Michael N; Wheeler, Eleanor; Wood, Andrew R; Ferreira, Teresa; Weyant, Robert J; Segrè, Ayellet V; Estrada, Karol; Liang, Liming; Nemesh, James; Park, Ju-Hyun; Gustafsson, Stefan; Oskari Kilpeläinen, Tuomas; Yang, Jian; Bouatia-Naji, Nabila; Esko, Tõnu; Feitosa, Mary F; Kutalik, Zoltán; Mangino, Massimo; Raychaudhuri, Soumya; Scherag, Andre; Smith, Albert Vernon; Welch, Ryan; Zhao, Jing Hua; Aben, Katja K; Absher, Devin M; Amin, Najaf; Dixon, Anna L; Gjesing, Anette P; Jørgensen, Torben; Witte, Daniel R; Hansen, Torben; Pedersen, Oluf; MAGIC.
In:
Nature Genetics, Vol. 42, No. 11, 01.11.2010, p. 937-48.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Speliotes, EK, Willer, CJ, Berndt, SI, Monda, KL, Thorleifsson, G, Jackson, AU, Allen, HL, Lindgren, CM, Luan, J, Mägi, R, Randall, JC, Vedantam, S, Winkler, TW, Lu, Q, Workalemahu, T, Heid, IM, Steinthorsdottir, V, Stringham, HM, Weedon, MN, Wheeler, E, Wood, AR, Ferreira, T, Weyant, RJ, Segrè, AV, Estrada, K, Liang, L, Nemesh, J, Park, J-H, Gustafsson, S
, Oskari Kilpeläinen, T, Yang, J, Bouatia-Naji, N, Esko, T, Feitosa, MF, Kutalik, Z, Mangino, M, Raychaudhuri, S, Scherag, A, Smith, AV, Welch, R, Zhao, JH, Aben, KK, Absher, DM, Amin, N, Dixon, AL, Gjesing, AP, Jørgensen, T, Witte, DR
, Hansen, T, Pedersen, O & MAGIC 2010, '
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index',
Nature Genetics, vol. 42, no. 11, pp. 937-48.
https://doi.org/10.1038/ng.686APA
Speliotes, E. K., Willer, C. J., Berndt, S. I., Monda, K. L., Thorleifsson, G., Jackson, A. U., Allen, H. L., Lindgren, C. M., Luan, J., Mägi, R., Randall, J. C., Vedantam, S., Winkler, T. W., Lu, Q., Workalemahu, T., Heid, I. M., Steinthorsdottir, V., Stringham, H. M., Weedon, M. N., ... MAGIC (2010).
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Nature Genetics,
42(11), 937-48.
https://doi.org/10.1038/ng.686Vancouver
Speliotes EK, Willer CJ, Berndt SI, Monda KL, Thorleifsson G, Jackson AU et al.
Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.
Nature Genetics. 2010 Nov 1;42(11):937-48.
https://doi.org/10.1038/ng.686Author
Speliotes, Elizabeth K ; Willer, Cristen J ; Berndt, Sonja I ; Monda, Keri L ; Thorleifsson, Gudmar ; Jackson, Anne U ; Allen, Hana Lango ; Lindgren, Cecilia M ; Luan, Jian'an ; Mägi, Reedik ; Randall, Joshua C ; Vedantam, Sailaja ; Winkler, Thomas W ; Lu, Qi ; Workalemahu, Tsegaselassie ; Heid, Iris M ; Steinthorsdottir, Valgerdur ; Stringham, Heather M ; Weedon, Michael N ; Wheeler, Eleanor ; Wood, Andrew R ; Ferreira, Teresa ; Weyant, Robert J ; Segrè, Ayellet V ; Estrada, Karol ; Liang, Liming ; Nemesh, James ; Park, Ju-Hyun ; Gustafsson, Stefan ; Oskari Kilpeläinen, Tuomas ; Yang, Jian ; Bouatia-Naji, Nabila ; Esko, Tõnu ; Feitosa, Mary F ; Kutalik, Zoltán ; Mangino, Massimo ; Raychaudhuri, Soumya ; Scherag, Andre ; Smith, Albert Vernon ; Welch, Ryan ; Zhao, Jing Hua ; Aben, Katja K ; Absher, Devin M ; Amin, Najaf ; Dixon, Anna L ; Gjesing, Anette P ; Jørgensen, Torben ; Witte, Daniel R ; Hansen, Torben ; Pedersen, Oluf ; MAGIC. / Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. In: Nature Genetics. 2010 ; Vol. 42, No. 11. pp. 937-48.
Bibtex
@article{763f5efa71a247c1bc2d4f9bacc8e527,
title = "Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index",
abstract = "Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P <5 × 10¿8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.",
keywords = "Body Height, Body Mass Index, Body Size, Body Weight, Chromosome Mapping, European Continental Ancestry Group, Genetic Predisposition to Disease, Genome-Wide Association Study, Humans, Obesity, Polymorphism, Single Nucleotide",
author = "Speliotes, {Elizabeth K} and Willer, {Cristen J} and Berndt, {Sonja I} and Monda, {Keri L} and Gudmar Thorleifsson and Jackson, {Anne U} and Allen, {Hana Lango} and Lindgren, {Cecilia M} and Jian'an Luan and Reedik M{\"a}gi and Randall, {Joshua C} and Sailaja Vedantam and Winkler, {Thomas W} and Qi Lu and Tsegaselassie Workalemahu and Heid, {Iris M} and Valgerdur Steinthorsdottir and Stringham, {Heather M} and Weedon, {Michael N} and Eleanor Wheeler and Wood, {Andrew R} and Teresa Ferreira and Weyant, {Robert J} and Segr{\`e}, {Ayellet V} and Karol Estrada and Liming Liang and James Nemesh and Ju-Hyun Park and Stefan Gustafsson and {Oskari Kilpel{\"a}inen}, Tuomas and Jian Yang and Nabila Bouatia-Naji and T{\~o}nu Esko and Feitosa, {Mary F} and Zolt{\'a}n Kutalik and Massimo Mangino and Soumya Raychaudhuri and Andre Scherag and Smith, {Albert Vernon} and Ryan Welch and Zhao, {Jing Hua} and Aben, {Katja K} and Absher, {Devin M} and Najaf Amin and Dixon, {Anna L} and Gjesing, {Anette P} and Torben J{\o}rgensen and Witte, {Daniel R} and Torben Hansen and Oluf Pedersen and MAGIC",
year = "2010",
month = nov,
day = "1",
doi = "10.1038/ng.686",
language = "English",
volume = "42",
pages = "937--48",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "11",
}
RIS
TY - JOUR
T1 - Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index
AU - Speliotes, Elizabeth K
AU - Willer, Cristen J
AU - Berndt, Sonja I
AU - Monda, Keri L
AU - Thorleifsson, Gudmar
AU - Jackson, Anne U
AU - Allen, Hana Lango
AU - Lindgren, Cecilia M
AU - Luan, Jian'an
AU - Mägi, Reedik
AU - Randall, Joshua C
AU - Vedantam, Sailaja
AU - Winkler, Thomas W
AU - Lu, Qi
AU - Workalemahu, Tsegaselassie
AU - Heid, Iris M
AU - Steinthorsdottir, Valgerdur
AU - Stringham, Heather M
AU - Weedon, Michael N
AU - Wheeler, Eleanor
AU - Wood, Andrew R
AU - Ferreira, Teresa
AU - Weyant, Robert J
AU - Segrè, Ayellet V
AU - Estrada, Karol
AU - Liang, Liming
AU - Nemesh, James
AU - Park, Ju-Hyun
AU - Gustafsson, Stefan
AU - Oskari Kilpeläinen, Tuomas
AU - Yang, Jian
AU - Bouatia-Naji, Nabila
AU - Esko, Tõnu
AU - Feitosa, Mary F
AU - Kutalik, Zoltán
AU - Mangino, Massimo
AU - Raychaudhuri, Soumya
AU - Scherag, Andre
AU - Smith, Albert Vernon
AU - Welch, Ryan
AU - Zhao, Jing Hua
AU - Aben, Katja K
AU - Absher, Devin M
AU - Amin, Najaf
AU - Dixon, Anna L
AU - Gjesing, Anette P
AU - Jørgensen, Torben
AU - Witte, Daniel R
AU - Hansen, Torben
AU - Pedersen, Oluf
AU - MAGIC
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P <5 × 10¿8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
AB - Obesity is globally prevalent and highly heritable, but its underlying genetic factors remain largely elusive. To identify genetic loci for obesity susceptibility, we examined associations between body mass index and ~ 2.8 million SNPs in up to 123,865 individuals with targeted follow up of 42 SNPs in up to 125,931 additional individuals. We confirmed 14 known obesity susceptibility loci and identified 18 new loci associated with body mass index (P <5 × 10¿8), one of which includes a copy number variant near GPRC5B. Some loci (at MC4R, POMC, SH2B1 and BDNF) map near key hypothalamic regulators of energy balance, and one of these loci is near GIPR, an incretin receptor. Furthermore, genes in other newly associated loci may provide new insights into human body weight regulation.
KW - Body Height
KW - Body Mass Index
KW - Body Size
KW - Body Weight
KW - Chromosome Mapping
KW - European Continental Ancestry Group
KW - Genetic Predisposition to Disease
KW - Genome-Wide Association Study
KW - Humans
KW - Obesity
KW - Polymorphism, Single Nucleotide
U2 - 10.1038/ng.686
DO - 10.1038/ng.686
M3 - Journal article
C2 - 20935630
VL - 42
SP - 937
EP - 948
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -
