Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease

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Standard

Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease. / Carrasquilla, Germán D.; Ängquist, Lars; Sørensen, Thorkild I.A.; Kilpeläinen, Tuomas O.; Loos, Ruth J.F.

In: Diabetologia, Vol. 67, 2024, p. 864–873.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Carrasquilla, GD, Ängquist, L, Sørensen, TIA, Kilpeläinen, TO & Loos, RJF 2024, 'Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease', Diabetologia, vol. 67, pp. 864–873. https://doi.org/10.1007/s00125-023-06058-4

APA

Carrasquilla, G. D., Ängquist, L., Sørensen, T. I. A., Kilpeläinen, T. O., & Loos, R. J. F. (2024). Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease. Diabetologia, 67, 864–873. https://doi.org/10.1007/s00125-023-06058-4

Vancouver

Carrasquilla GD, Ängquist L, Sørensen TIA, Kilpeläinen TO, Loos RJF. Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease. Diabetologia. 2024;67:864–873. https://doi.org/10.1007/s00125-023-06058-4

Author

Carrasquilla, Germán D. ; Ängquist, Lars ; Sørensen, Thorkild I.A. ; Kilpeläinen, Tuomas O. ; Loos, Ruth J.F. / Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease. In: Diabetologia. 2024 ; Vol. 67. pp. 864–873.

Bibtex

@article{6479c91e5e2a4d52b70291e61040cf5c,
title = "Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease",
abstract = "Aims/hypothesis: Childhood overweight increases the risk of type 2 diabetes and cardiovascular disease in adulthood. However, the impact of childhood leanness on adult obesity and disease risk has been overlooked. We examined the independent and combined influences of child and adult body size on the risk of type 2 diabetes and cardiovascular disease. Methods: Data from the UK Biobank on 364,695 individuals of European ancestry and free of type 2 diabetes and cardiovascular disease were divided into nine categories based on their self-reported body size at age 10 and measured BMI in adulthood. After a median follow-up of 12.8 years, 33,460 individuals had developed type 2 diabetes and/or cardiovascular disease. We used Cox regression models to assess the associations of body size categories with disease incidence. Results: Individuals with low body size in childhood and high body size in adulthood had the highest risk of type 2 diabetes (HR 4.73; 95% CI 4.50, 4.99), compared to those with average body size in both childhood and adulthood. This was significantly higher than the risk in those with high body size in both childhood and adulthood (HR 4.05; 95% CI 3.84, 4.26). By contrast, cardiovascular disease risk was determined by adult body size, irrespective of childhood body size. Conclusions/interpretation: Low body size in childhood exacerbates the risk of type 2 diabetes associated with adult obesity but not the risk of cardiovascular disease. Thus, promoting healthy weight management from childhood to adulthood, among lean children, is crucial. Graphical Abstract: [Figure not available: see fulltext.].",
keywords = "Cardiovascular diseases, Follow-up studies, Obesity, Paediatric obesity, Preventive medicine, Public health, Type 2 diabetes, Weight gain",
author = "Carrasquilla, {Germ{\'a}n D.} and Lars {\"A}ngquist and S{\o}rensen, {Thorkild I.A.} and Kilpel{\"a}inen, {Tuomas O.} and Loos, {Ruth J.F.}",
note = "Publisher Copyright: {\textcopyright} 2023, The Author(s).",
year = "2024",
doi = "10.1007/s00125-023-06058-4",
language = "English",
volume = "67",
pages = "864–873",
journal = "Diabetologia",
issn = "0012-186X",
publisher = "Springer",

}

RIS

TY - JOUR

T1 - Child-to-adult body size change and risk of type 2 diabetes and cardiovascular disease

AU - Carrasquilla, Germán D.

AU - Ängquist, Lars

AU - Sørensen, Thorkild I.A.

AU - Kilpeläinen, Tuomas O.

AU - Loos, Ruth J.F.

N1 - Publisher Copyright: © 2023, The Author(s).

PY - 2024

Y1 - 2024

N2 - Aims/hypothesis: Childhood overweight increases the risk of type 2 diabetes and cardiovascular disease in adulthood. However, the impact of childhood leanness on adult obesity and disease risk has been overlooked. We examined the independent and combined influences of child and adult body size on the risk of type 2 diabetes and cardiovascular disease. Methods: Data from the UK Biobank on 364,695 individuals of European ancestry and free of type 2 diabetes and cardiovascular disease were divided into nine categories based on their self-reported body size at age 10 and measured BMI in adulthood. After a median follow-up of 12.8 years, 33,460 individuals had developed type 2 diabetes and/or cardiovascular disease. We used Cox regression models to assess the associations of body size categories with disease incidence. Results: Individuals with low body size in childhood and high body size in adulthood had the highest risk of type 2 diabetes (HR 4.73; 95% CI 4.50, 4.99), compared to those with average body size in both childhood and adulthood. This was significantly higher than the risk in those with high body size in both childhood and adulthood (HR 4.05; 95% CI 3.84, 4.26). By contrast, cardiovascular disease risk was determined by adult body size, irrespective of childhood body size. Conclusions/interpretation: Low body size in childhood exacerbates the risk of type 2 diabetes associated with adult obesity but not the risk of cardiovascular disease. Thus, promoting healthy weight management from childhood to adulthood, among lean children, is crucial. Graphical Abstract: [Figure not available: see fulltext.].

AB - Aims/hypothesis: Childhood overweight increases the risk of type 2 diabetes and cardiovascular disease in adulthood. However, the impact of childhood leanness on adult obesity and disease risk has been overlooked. We examined the independent and combined influences of child and adult body size on the risk of type 2 diabetes and cardiovascular disease. Methods: Data from the UK Biobank on 364,695 individuals of European ancestry and free of type 2 diabetes and cardiovascular disease were divided into nine categories based on their self-reported body size at age 10 and measured BMI in adulthood. After a median follow-up of 12.8 years, 33,460 individuals had developed type 2 diabetes and/or cardiovascular disease. We used Cox regression models to assess the associations of body size categories with disease incidence. Results: Individuals with low body size in childhood and high body size in adulthood had the highest risk of type 2 diabetes (HR 4.73; 95% CI 4.50, 4.99), compared to those with average body size in both childhood and adulthood. This was significantly higher than the risk in those with high body size in both childhood and adulthood (HR 4.05; 95% CI 3.84, 4.26). By contrast, cardiovascular disease risk was determined by adult body size, irrespective of childhood body size. Conclusions/interpretation: Low body size in childhood exacerbates the risk of type 2 diabetes associated with adult obesity but not the risk of cardiovascular disease. Thus, promoting healthy weight management from childhood to adulthood, among lean children, is crucial. Graphical Abstract: [Figure not available: see fulltext.].

KW - Cardiovascular diseases

KW - Follow-up studies

KW - Obesity

KW - Paediatric obesity

KW - Preventive medicine

KW - Public health

KW - Type 2 diabetes

KW - Weight gain

U2 - 10.1007/s00125-023-06058-4

DO - 10.1007/s00125-023-06058-4

M3 - Journal article

C2 - 38085289

AN - SCOPUS:85179357236

VL - 67

SP - 864

EP - 873

JO - Diabetologia

JF - Diabetologia

SN - 0012-186X

ER -

ID: 378127441