Dietary Fat and the Genetic Risk of Type 2 Diabetes

Research output: Contribution to journal › Review › Research › peer-review

Standard

Dietary Fat and the Genetic Risk of Type 2 Diabetes. / Carrasquilla, Germán D.; Jakupović, Hermina; Kilpeläinen, Tuomas O.

In: Current Diabetes Reports, Vol. 19, 109, 2019.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Carrasquilla, GD, Jakupović, H & Kilpeläinen, TO 2019, 'Dietary Fat and the Genetic Risk of Type 2 Diabetes', Current Diabetes Reports, vol. 19, 109. https://doi.org/10.1007/s11892-019-1251-1

APA

Carrasquilla, G. D., Jakupović, H., & Kilpeläinen, T. O. (2019). Dietary Fat and the Genetic Risk of Type 2 Diabetes. Current Diabetes Reports, 19, [109]. https://doi.org/10.1007/s11892-019-1251-1

Vancouver

Carrasquilla GD, Jakupović H, Kilpeläinen TO. Dietary Fat and the Genetic Risk of Type 2 Diabetes. Current Diabetes Reports. 2019;19. 109. https://doi.org/10.1007/s11892-019-1251-1

Author

Carrasquilla, Germán D. ; Jakupović, Hermina ; Kilpeläinen, Tuomas O. / Dietary Fat and the Genetic Risk of Type 2 Diabetes. In: Current Diabetes Reports. 2019 ; Vol. 19.

Bibtex

@article{09a70d1d35df42f18de4bb6e2a95129f,
title = "Dietary Fat and the Genetic Risk of Type 2 Diabetes",
abstract = "Purpose of Review: We review recent evidence of the relationship between dietary fat intake and risk of type 2 diabetes (T2D), the role of epigenetic alterations as a mediator of this relationship, and the impact of gene-dietary fat interactions in the development of the disease. Based on the observations made, we will discuss whether there is evidence to support genetic personalization of fat intake recommendations in T2D prevention. Recent Findings: Strong evidence suggests that polyunsaturated fatty acids (PUFA) have a protective effect on T2D risk, whereas the roles of saturated and monounsaturated fatty acids (SFA and MUFA) remain unclear. Diets enriched with PUFA vs SFA lead to distinct epigenetic alterations that may mediate their effects on T2D risk by changing gene function. However, it is not currently known which of the epigenetic alterations, if any, are causal for T2D. The current literature shows no replicated evidence of genetic variants modifying the effect of dietary fat intake on T2D risk. Summary: There is consistent evidence of a protective role of PUFA in T2D prevention. No evidence supports genetic personalization of dietary recommendations in T2D prevention.",
keywords = "Dietary fat, Epigenetics, Fatty acid composition, Gene, Genetic risk, Type 2 diabetes",
author = "Carrasquilla, {Germ{\'a}n D.} and Hermina Jakupovi{\'c} and Kilpel{\"a}inen, {Tuomas O.}",
year = "2019",
doi = "10.1007/s11892-019-1251-1",
language = "English",
volume = "19",
journal = "Current Diabetes Reports",
issn = "1534-4827",
publisher = "Springer Healthcare",

}

RIS

TY - JOUR

T1 - Dietary Fat and the Genetic Risk of Type 2 Diabetes

AU - Carrasquilla, Germán D.

AU - Jakupović, Hermina

AU - Kilpeläinen, Tuomas O.

PY - 2019

Y1 - 2019

N2 - Purpose of Review: We review recent evidence of the relationship between dietary fat intake and risk of type 2 diabetes (T2D), the role of epigenetic alterations as a mediator of this relationship, and the impact of gene-dietary fat interactions in the development of the disease. Based on the observations made, we will discuss whether there is evidence to support genetic personalization of fat intake recommendations in T2D prevention. Recent Findings: Strong evidence suggests that polyunsaturated fatty acids (PUFA) have a protective effect on T2D risk, whereas the roles of saturated and monounsaturated fatty acids (SFA and MUFA) remain unclear. Diets enriched with PUFA vs SFA lead to distinct epigenetic alterations that may mediate their effects on T2D risk by changing gene function. However, it is not currently known which of the epigenetic alterations, if any, are causal for T2D. The current literature shows no replicated evidence of genetic variants modifying the effect of dietary fat intake on T2D risk. Summary: There is consistent evidence of a protective role of PUFA in T2D prevention. No evidence supports genetic personalization of dietary recommendations in T2D prevention.

AB - Purpose of Review: We review recent evidence of the relationship between dietary fat intake and risk of type 2 diabetes (T2D), the role of epigenetic alterations as a mediator of this relationship, and the impact of gene-dietary fat interactions in the development of the disease. Based on the observations made, we will discuss whether there is evidence to support genetic personalization of fat intake recommendations in T2D prevention. Recent Findings: Strong evidence suggests that polyunsaturated fatty acids (PUFA) have a protective effect on T2D risk, whereas the roles of saturated and monounsaturated fatty acids (SFA and MUFA) remain unclear. Diets enriched with PUFA vs SFA lead to distinct epigenetic alterations that may mediate their effects on T2D risk by changing gene function. However, it is not currently known which of the epigenetic alterations, if any, are causal for T2D. The current literature shows no replicated evidence of genetic variants modifying the effect of dietary fat intake on T2D risk. Summary: There is consistent evidence of a protective role of PUFA in T2D prevention. No evidence supports genetic personalization of dietary recommendations in T2D prevention.

KW - Dietary fat

KW - Epigenetics

KW - Fatty acid composition

KW - Gene

KW - Genetic risk

KW - Type 2 diabetes

U2 - 10.1007/s11892-019-1251-1

DO - 10.1007/s11892-019-1251-1

M3 - Review

C2 - 31686257

AN - SCOPUS:85074324248

VL - 19

JO - Current Diabetes Reports

JF - Current Diabetes Reports

SN - 1534-4827

M1 - 109

ER -

ID: 229957499