Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology: [incl. correction]

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Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology : [incl. correction]. / Spracklen, Cassandra N.; Karaderi, Tugce; Yaghootkar, Hanieh; Schurmann, Claudia; Fine, Rebecca S.; Kutalik, Zoltan; Preuss, Michael H.; Lu, Yingchang; Wittemans, Laura B.L.; Adair, Linda S.; Allison, Matthew; Amin, Najaf; Auer, Paul L.; Bartz, Traci M.; Blüher, Matthias; Boehnke, Michael; Borja, Judith B.; Bork-Jensen, Jette; Broer, Linda; Chasman, Daniel I.; Chen, Yii Der Ida; Chirstofidou, Paraskevi; Demirkan, Ayse; van Duijn, Cornelia M.; Feitosa, Mary F.; Garcia, Melissa E.; Graff, Mariaelisa; Grallert, Harald; Grarup, Niels; Guo, Xiuqing; Haesser, Jeffrey; Hansen, Torben; Harris, Tamara B.; Highland, Heather M.; Hong, Jaeyoung; Ikram, M. Arfan; Ingelsson, Erik; Jackson, Rebecca; Jousilahti, Pekka; Kähönen, Mika; Kizer, Jorge R.; Kovacs, Peter; Kriebel, Jennifer; Laakso, Markku; Lange, Leslie A.; Lehtimäki, Terho; Li, Jin; Lind, Lars; Kilpeläinen, Tuomas O.; Loos, Ruth J.F.; Mohlke, Karen L.

In: American Journal of Human Genetics, Vol. 105, No. 1, 2019, p. 15-28.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Spracklen, CN, Karaderi, T, Yaghootkar, H, Schurmann, C, Fine, RS, Kutalik, Z, Preuss, MH, Lu, Y, Wittemans, LBL, Adair, LS, Allison, M, Amin, N, Auer, PL, Bartz, TM, Blüher, M, Boehnke, M, Borja, JB, Bork-Jensen, J, Broer, L, Chasman, DI, Chen, YDI, Chirstofidou, P, Demirkan, A, van Duijn, CM, Feitosa, MF, Garcia, ME, Graff, M, Grallert, H, Grarup, N, Guo, X, Haesser, J, Hansen, T, Harris, TB, Highland, HM, Hong, J, Ikram, MA, Ingelsson, E, Jackson, R, Jousilahti, P, Kähönen, M, Kizer, JR, Kovacs, P, Kriebel, J, Laakso, M, Lange, LA, Lehtimäki, T, Li, J, Lind, L, Kilpeläinen, TO, Loos, RJF & Mohlke, KL 2019, 'Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology: [incl. correction]', American Journal of Human Genetics, vol. 105, no. 1, pp. 15-28. https://doi.org/10.1016/j.ajhg.2019.05.002

APA

Spracklen, C. N., Karaderi, T., Yaghootkar, H., Schurmann, C., Fine, R. S., Kutalik, Z., Preuss, M. H., Lu, Y., Wittemans, L. B. L., Adair, L. S., Allison, M., Amin, N., Auer, P. L., Bartz, T. M., Blüher, M., Boehnke, M., Borja, J. B., Bork-Jensen, J., Broer, L., ... Mohlke, K. L. (2019). Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology: [incl. correction]. American Journal of Human Genetics, 105(1), 15-28. https://doi.org/10.1016/j.ajhg.2019.05.002

Vancouver

Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z et al. Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology: [incl. correction]. American Journal of Human Genetics. 2019;105(1):15-28. https://doi.org/10.1016/j.ajhg.2019.05.002

Author

Spracklen, Cassandra N. ; Karaderi, Tugce ; Yaghootkar, Hanieh ; Schurmann, Claudia ; Fine, Rebecca S. ; Kutalik, Zoltan ; Preuss, Michael H. ; Lu, Yingchang ; Wittemans, Laura B.L. ; Adair, Linda S. ; Allison, Matthew ; Amin, Najaf ; Auer, Paul L. ; Bartz, Traci M. ; Blüher, Matthias ; Boehnke, Michael ; Borja, Judith B. ; Bork-Jensen, Jette ; Broer, Linda ; Chasman, Daniel I. ; Chen, Yii Der Ida ; Chirstofidou, Paraskevi ; Demirkan, Ayse ; van Duijn, Cornelia M. ; Feitosa, Mary F. ; Garcia, Melissa E. ; Graff, Mariaelisa ; Grallert, Harald ; Grarup, Niels ; Guo, Xiuqing ; Haesser, Jeffrey ; Hansen, Torben ; Harris, Tamara B. ; Highland, Heather M. ; Hong, Jaeyoung ; Ikram, M. Arfan ; Ingelsson, Erik ; Jackson, Rebecca ; Jousilahti, Pekka ; Kähönen, Mika ; Kizer, Jorge R. ; Kovacs, Peter ; Kriebel, Jennifer ; Laakso, Markku ; Lange, Leslie A. ; Lehtimäki, Terho ; Li, Jin ; Lind, Lars ; Kilpeläinen, Tuomas O. ; Loos, Ruth J.F. ; Mohlke, Karen L. / Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology : [incl. correction]. In: American Journal of Human Genetics. 2019 ; Vol. 105, No. 1. pp. 15-28.

Bibtex

@article{00b0ccd0a38f4bfe96146e43d0dac62b,
title = "Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology: [incl. correction]",
abstract = "Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. We identified 20 loci associated with adiponectin, including 11 that had been reported previously (p < 2 × 10−7). Comparison of exome array variants to regional linkage disequilibrium (LD) patterns and prior genome-wide association study (GWAS) results detected candidate variants (r2 > .60) spanning as much as 900 kb. To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. Eight of the nine loci were also associated (p < 1 × 10−4) with at least one obesity or lipid trait. Candidate genes include PRKAR2A, PTH1R, and HDAC9, which have been suggested to play roles in adipocyte differentiation or bone marrow adipose tissue. Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels.",
keywords = "adiponectin, cardio metabolic traits, exome, genetics, genome-wide association study, lipids, obesity",
author = "Spracklen, {Cassandra N.} and Tugce Karaderi and Hanieh Yaghootkar and Claudia Schurmann and Fine, {Rebecca S.} and Zoltan Kutalik and Preuss, {Michael H.} and Yingchang Lu and Wittemans, {Laura B.L.} and Adair, {Linda S.} and Matthew Allison and Najaf Amin and Auer, {Paul L.} and Bartz, {Traci M.} and Matthias Bl{\"u}her and Michael Boehnke and Borja, {Judith B.} and Jette Bork-Jensen and Linda Broer and Chasman, {Daniel I.} and Chen, {Yii Der Ida} and Paraskevi Chirstofidou and Ayse Demirkan and {van Duijn}, {Cornelia M.} and Feitosa, {Mary F.} and Garcia, {Melissa E.} and Mariaelisa Graff and Harald Grallert and Niels Grarup and Xiuqing Guo and Jeffrey Haesser and Torben Hansen and Harris, {Tamara B.} and Highland, {Heather M.} and Jaeyoung Hong and Ikram, {M. Arfan} and Erik Ingelsson and Rebecca Jackson and Pekka Jousilahti and Mika K{\"a}h{\"o}nen and Kizer, {Jorge R.} and Peter Kovacs and Jennifer Kriebel and Markku Laakso and Lange, {Leslie A.} and Terho Lehtim{\"a}ki and Jin Li and Lars Lind and Kilpel{\"a}inen, {Tuomas O.} and Loos, {Ruth J.F.} and Mohlke, {Karen L}",
note = "Corretion to: Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology DOI: 10.1016/j.ajhg.2019.08.001",
year = "2019",
doi = "10.1016/j.ajhg.2019.05.002",
language = "English",
volume = "105",
pages = "15--28",
journal = "American Journal of Human Genetics",
issn = "0002-9297",
publisher = "Cell Press",
number = "1",

}

RIS

TY - JOUR

T1 - Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology

T2 - [incl. correction]

AU - Spracklen, Cassandra N.

AU - Karaderi, Tugce

AU - Yaghootkar, Hanieh

AU - Schurmann, Claudia

AU - Fine, Rebecca S.

AU - Kutalik, Zoltan

AU - Preuss, Michael H.

AU - Lu, Yingchang

AU - Wittemans, Laura B.L.

AU - Adair, Linda S.

AU - Allison, Matthew

AU - Amin, Najaf

AU - Auer, Paul L.

AU - Bartz, Traci M.

AU - Blüher, Matthias

AU - Boehnke, Michael

AU - Borja, Judith B.

AU - Bork-Jensen, Jette

AU - Broer, Linda

AU - Chasman, Daniel I.

AU - Chen, Yii Der Ida

AU - Chirstofidou, Paraskevi

AU - Demirkan, Ayse

AU - van Duijn, Cornelia M.

AU - Feitosa, Mary F.

AU - Garcia, Melissa E.

AU - Graff, Mariaelisa

AU - Grallert, Harald

AU - Grarup, Niels

AU - Guo, Xiuqing

AU - Haesser, Jeffrey

AU - Hansen, Torben

AU - Harris, Tamara B.

AU - Highland, Heather M.

AU - Hong, Jaeyoung

AU - Ikram, M. Arfan

AU - Ingelsson, Erik

AU - Jackson, Rebecca

AU - Jousilahti, Pekka

AU - Kähönen, Mika

AU - Kizer, Jorge R.

AU - Kovacs, Peter

AU - Kriebel, Jennifer

AU - Laakso, Markku

AU - Lange, Leslie A.

AU - Lehtimäki, Terho

AU - Li, Jin

AU - Lind, Lars

AU - Kilpeläinen, Tuomas O.

AU - Loos, Ruth J.F.

AU - Mohlke, Karen L

N1 - Corretion to: Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology DOI: 10.1016/j.ajhg.2019.08.001

PY - 2019

Y1 - 2019

N2 - Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. We identified 20 loci associated with adiponectin, including 11 that had been reported previously (p < 2 × 10−7). Comparison of exome array variants to regional linkage disequilibrium (LD) patterns and prior genome-wide association study (GWAS) results detected candidate variants (r2 > .60) spanning as much as 900 kb. To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. Eight of the nine loci were also associated (p < 1 × 10−4) with at least one obesity or lipid trait. Candidate genes include PRKAR2A, PTH1R, and HDAC9, which have been suggested to play roles in adipocyte differentiation or bone marrow adipose tissue. Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels.

AB - Circulating levels of adiponectin, an adipocyte-secreted protein associated with cardiovascular and metabolic risk, are highly heritable. To gain insights into the biology that regulates adiponectin levels, we performed an exome array meta-analysis of 265,780 genetic variants in 67,739 individuals of European, Hispanic, African American, and East Asian ancestry. We identified 20 loci associated with adiponectin, including 11 that had been reported previously (p < 2 × 10−7). Comparison of exome array variants to regional linkage disequilibrium (LD) patterns and prior genome-wide association study (GWAS) results detected candidate variants (r2 > .60) spanning as much as 900 kb. To identify potential genes and mechanisms through which the previously unreported association signals act to affect adiponectin levels, we assessed cross-trait associations, expression quantitative trait loci in subcutaneous adipose, and biological pathways of nearby genes. Eight of the nine loci were also associated (p < 1 × 10−4) with at least one obesity or lipid trait. Candidate genes include PRKAR2A, PTH1R, and HDAC9, which have been suggested to play roles in adipocyte differentiation or bone marrow adipose tissue. Taken together, these findings provide further insights into the processes that influence circulating adiponectin levels.

KW - adiponectin

KW - cardio metabolic traits

KW - exome

KW - genetics

KW - genome-wide association study

KW - lipids

KW - obesity

UR - https://doi.org/10.1016/j.ajhg.2019.08.001

U2 - 10.1016/j.ajhg.2019.05.002

DO - 10.1016/j.ajhg.2019.05.002

M3 - Journal article

C2 - 31178129

AN - SCOPUS:85068057969

VL - 105

SP - 15

EP - 28

JO - American Journal of Human Genetics

JF - American Journal of Human Genetics

SN - 0002-9297

IS - 1

ER -

ID: 226394821