Standard
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci. / de las Fuentes, Lisa; Schwander, Karen L.; Brown, Michael R.; Bentley, Amy R.; Winkler, Thomas W.; Sung, Yun Ju; Munroe, Patricia B.; Miller, Clint L.; Aschard, Hugo; Aslibekyan, Stella; Bartz, Traci M.; Bielak, Lawrence F.; Chai, Jin Fang; Cheng, Ching Yu; Dorajoo, Rajkumar; Feitosa, Mary F.; Guo, Xiuqing; Hartwig, Fernando P.; Horimoto, Andrea; Kolčić, Ivana; Lim, Elise; Liu, Yongmei; Manning, Alisa K.; Marten, Jonathan; Musani, Solomon K.; Noordam, Raymond; Padmanabhan, Sandosh; Rankinen, Tuomo; Richard, Melissa A.; Ridker, Paul M.; Smith, Albert V.; Vojinovic, Dina; Zonderman, Alan B.; Alver, Maris; Boissel, Mathilde; Christensen, Kaare; Freedman, Barry I.; Gao, Chuan; Giulianini, Franco; Harris, Sarah E.; He, Meian; Hsu, Fang Chi; Kühnel, Brigitte; Laguzzi, Federica; Li, Xiaoyin; Lyytikäinen, Leo Pekka; Nolte, Ilja M.; Poveda, Alaitz; Rauramaa, Rainer; Riaz, Muhammad; Robino, Antonietta; Sofer, Tamar; Takeuchi, Fumihiko; Tayo, Bamidele O.; van der Most, Peter J.; Verweij, Niek; Ware, Erin B.; Weiss, Stefan; Wen, Wanqing; Yanek, Lisa R.; Zhan, Yiqiang; Amin, Najaf; Arking, Dan E.; Ballantyne, Christie; Boerwinkle, Eric; Brody, Jennifer A.; Broeckel, Ulrich; Campbell, Archie; Canouil, Mickaël; Chai, Xiaoran; Chen, Yii Der Ida; Chen, Xu; Chitrala, Kumaraswamy Naidu; Concas, Maria Pina; de Faire, Ulf; de Mutsert, Renée; de Silva, H. Janaka; de Vries, Paul S.; Do, Ahn; Faul, Jessica D.; Fisher, Virginia; Floyd, James S.; Forrester, Terrence; Friedlander, Yechiel; Girotto, Giorgia; Gu, C. Charles; Hallmans, Göran; Heikkinen, Sami; Heng, Chew Kiat; Homuth, Georg; Hunt, Steven; Ikram, M. Arfan; Jacobs, David R.; Kavousi, Maryam; Khor, Chiea Chuen; Kilpeläinen, Tuomas O.; Koh, Woon Puay; Komulainen, Pirjo; Langefeld, Carl D.; Liang, Jingjing; Liu, Kiang; Liu, Jianjun; Lohman, Kurt; Mägi, Reedik; Manichaikul, Ani W.; McKenzie, Colin A.; Meitinger, Thomas; Milaneschi, Yuri; Nauck, Matthias; Nelson, Christopher P.; O’Connell, Jeffrey R.; Palmer, Nicholette D.; Pereira, Alexandre C.; Perls, Thomas; Peters, Annette; Polašek, Ozren; Raitakari, Olli T.; Rice, Kenneth; Rice, Treva K.; Rich, Stephen S.; Sabanayagam, Charumathi; Schreiner, Pamela J.; Shu, Xiao Ou; Sidney, Stephen; Sims, Mario; Smith, Jennifer A.; Starr, John M.; Strauch, Konstantin; Tai, E. Shyong; Taylor, Kent D.; Tsai, Michael Y.; Uitterlinden, André G.; van Heemst, Diana; Waldenberger, Melanie; Wang, Ya Xing; Wei, Wen Bin; Wilson, Gregory; Xuan, Deng; Yao, Jie; Yu, Caizheng; Yuan, Jian Min; Zhao, Wei; Becker, Diane M.; Bonnefond, Amélie; Bowden, Donald W.; Cooper, Richard S.; Deary, Ian J.; Divers, Jasmin; Esko, Tõnu; Franks, Paul W.; Froguel, Philippe; Gieger, Christian; Jonas, Jost B.; Kato, Norihiro; Lakka, Timo A.; Leander, Karin; Lehtimäki, Terho; Magnusson, Patrik K.E.; North, Kari E.; Ntalla, Ioanna; Penninx, Brenda; Samani, Nilesh J.; Snieder, Harold; Spedicati, Beatrice; van der Harst, Pim; Völzke, Henry; Wagenknecht, Lynne E.; Weir, David R.; Wojczynski, Mary K.; Wu, Tangchun; Zheng, Wei; Zhu, Xiaofeng; Bouchard, Claude; Chasman, Daniel I.; Evans, Michele K.; Fox, Ervin R.; Gudnason, Vilmundur; Hayward, Caroline; Horta, Bernardo L.; Kardia, Sharon L.R.; Krieger, Jose Eduardo; Mook-Kanamori, Dennis O.; Peyser, Patricia A.; Province, Michael M.; Psaty, Bruce M.; Rudan, Igor; Sim, Xueling; Smith, Blair H.; van Dam, Rob M.; van Duijn, Cornelia M.; Wong, Tien Yin; Arnett, Donna K.; Rao, Dabeeru C.; Gauderman, James; Liu, Ching Ti; Morrison, Alanna C.; Rotter, Jerome I.; Fornage, Myriam.
In:
Frontiers in Genetics, Vol. 14, 1235337, 2023.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
de las Fuentes, L, Schwander, KL, Brown, MR, Bentley, AR, Winkler, TW, Sung, YJ, Munroe, PB, Miller, CL, Aschard, H, Aslibekyan, S, Bartz, TM, Bielak, LF, Chai, JF, Cheng, CY, Dorajoo, R, Feitosa, MF, Guo, X, Hartwig, FP, Horimoto, A, Kolčić, I, Lim, E, Liu, Y, Manning, AK, Marten, J, Musani, SK, Noordam, R, Padmanabhan, S, Rankinen, T, Richard, MA, Ridker, PM, Smith, AV, Vojinovic, D, Zonderman, AB, Alver, M, Boissel, M, Christensen, K, Freedman, BI, Gao, C, Giulianini, F, Harris, SE, He, M, Hsu, FC, Kühnel, B, Laguzzi, F, Li, X, Lyytikäinen, LP, Nolte, IM, Poveda, A, Rauramaa, R, Riaz, M, Robino, A, Sofer, T, Takeuchi, F, Tayo, BO, van der Most, PJ, Verweij, N, Ware, EB, Weiss, S, Wen, W, Yanek, LR, Zhan, Y, Amin, N, Arking, DE, Ballantyne, C, Boerwinkle, E, Brody, JA, Broeckel, U, Campbell, A, Canouil, M, Chai, X, Chen, YDI, Chen, X, Chitrala, KN, Concas, MP, de Faire, U, de Mutsert, R, de Silva, HJ, de Vries, PS, Do, A, Faul, JD, Fisher, V, Floyd, JS, Forrester, T, Friedlander, Y, Girotto, G, Gu, CC, Hallmans, G, Heikkinen, S, Heng, CK, Homuth, G, Hunt, S, Ikram, MA, Jacobs, DR, Kavousi, M, Khor, CC
, Kilpeläinen, TO, Koh, WP, Komulainen, P, Langefeld, CD, Liang, J, Liu, K, Liu, J, Lohman, K, Mägi, R, Manichaikul, AW, McKenzie, CA, Meitinger, T, Milaneschi, Y, Nauck, M, Nelson, CP, O’Connell, JR, Palmer, ND, Pereira, AC, Perls, T, Peters, A, Polašek, O, Raitakari, OT, Rice, K, Rice, TK, Rich, SS, Sabanayagam, C, Schreiner, PJ, Shu, XO, Sidney, S, Sims, M, Smith, JA, Starr, JM, Strauch, K, Tai, ES, Taylor, KD, Tsai, MY, Uitterlinden, AG, van Heemst, D, Waldenberger, M, Wang, YX, Wei, WB, Wilson, G, Xuan, D, Yao, J, Yu, C, Yuan, JM, Zhao, W, Becker, DM, Bonnefond, A, Bowden, DW, Cooper, RS, Deary, IJ, Divers, J, Esko, T, Franks, PW, Froguel, P, Gieger, C, Jonas, JB, Kato, N, Lakka, TA, Leander, K, Lehtimäki, T, Magnusson, PKE, North, KE, Ntalla, I, Penninx, B, Samani, NJ, Snieder, H, Spedicati, B, van der Harst, P, Völzke, H, Wagenknecht, LE, Weir, DR, Wojczynski, MK, Wu, T, Zheng, W, Zhu, X, Bouchard, C, Chasman, DI, Evans, MK, Fox, ER, Gudnason, V, Hayward, C, Horta, BL, Kardia, SLR, Krieger, JE, Mook-Kanamori, DO, Peyser, PA, Province, MM, Psaty, BM, Rudan, I, Sim, X, Smith, BH, van Dam, RM, van Duijn, CM, Wong, TY, Arnett, DK, Rao, DC, Gauderman, J, Liu, CT, Morrison, AC, Rotter, JI & Fornage, M 2023, '
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci',
Frontiers in Genetics, vol. 14, 1235337.
https://doi.org/10.3389/fgene.2023.1235337APA
de las Fuentes, L., Schwander, K. L., Brown, M. R., Bentley, A. R., Winkler, T. W., Sung, Y. J., Munroe, P. B., Miller, C. L., Aschard, H., Aslibekyan, S., Bartz, T. M., Bielak, L. F., Chai, J. F., Cheng, C. Y., Dorajoo, R., Feitosa, M. F., Guo, X., Hartwig, F. P., Horimoto, A., ... Fornage, M. (2023).
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
Frontiers in Genetics,
14, [1235337].
https://doi.org/10.3389/fgene.2023.1235337Vancouver
de las Fuentes L, Schwander KL, Brown MR, Bentley AR, Winkler TW, Sung YJ et al.
Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci.
Frontiers in Genetics. 2023;14. 1235337.
https://doi.org/10.3389/fgene.2023.1235337Author
de las Fuentes, Lisa ; Schwander, Karen L. ; Brown, Michael R. ; Bentley, Amy R. ; Winkler, Thomas W. ; Sung, Yun Ju ; Munroe, Patricia B. ; Miller, Clint L. ; Aschard, Hugo ; Aslibekyan, Stella ; Bartz, Traci M. ; Bielak, Lawrence F. ; Chai, Jin Fang ; Cheng, Ching Yu ; Dorajoo, Rajkumar ; Feitosa, Mary F. ; Guo, Xiuqing ; Hartwig, Fernando P. ; Horimoto, Andrea ; Kolčić, Ivana ; Lim, Elise ; Liu, Yongmei ; Manning, Alisa K. ; Marten, Jonathan ; Musani, Solomon K. ; Noordam, Raymond ; Padmanabhan, Sandosh ; Rankinen, Tuomo ; Richard, Melissa A. ; Ridker, Paul M. ; Smith, Albert V. ; Vojinovic, Dina ; Zonderman, Alan B. ; Alver, Maris ; Boissel, Mathilde ; Christensen, Kaare ; Freedman, Barry I. ; Gao, Chuan ; Giulianini, Franco ; Harris, Sarah E. ; He, Meian ; Hsu, Fang Chi ; Kühnel, Brigitte ; Laguzzi, Federica ; Li, Xiaoyin ; Lyytikäinen, Leo Pekka ; Nolte, Ilja M. ; Poveda, Alaitz ; Rauramaa, Rainer ; Riaz, Muhammad ; Robino, Antonietta ; Sofer, Tamar ; Takeuchi, Fumihiko ; Tayo, Bamidele O. ; van der Most, Peter J. ; Verweij, Niek ; Ware, Erin B. ; Weiss, Stefan ; Wen, Wanqing ; Yanek, Lisa R. ; Zhan, Yiqiang ; Amin, Najaf ; Arking, Dan E. ; Ballantyne, Christie ; Boerwinkle, Eric ; Brody, Jennifer A. ; Broeckel, Ulrich ; Campbell, Archie ; Canouil, Mickaël ; Chai, Xiaoran ; Chen, Yii Der Ida ; Chen, Xu ; Chitrala, Kumaraswamy Naidu ; Concas, Maria Pina ; de Faire, Ulf ; de Mutsert, Renée ; de Silva, H. Janaka ; de Vries, Paul S. ; Do, Ahn ; Faul, Jessica D. ; Fisher, Virginia ; Floyd, James S. ; Forrester, Terrence ; Friedlander, Yechiel ; Girotto, Giorgia ; Gu, C. Charles ; Hallmans, Göran ; Heikkinen, Sami ; Heng, Chew Kiat ; Homuth, Georg ; Hunt, Steven ; Ikram, M. Arfan ; Jacobs, David R. ; Kavousi, Maryam ; Khor, Chiea Chuen ; Kilpeläinen, Tuomas O. ; Koh, Woon Puay ; Komulainen, Pirjo ; Langefeld, Carl D. ; Liang, Jingjing ; Liu, Kiang ; Liu, Jianjun ; Lohman, Kurt ; Mägi, Reedik ; Manichaikul, Ani W. ; McKenzie, Colin A. ; Meitinger, Thomas ; Milaneschi, Yuri ; Nauck, Matthias ; Nelson, Christopher P. ; O’Connell, Jeffrey R. ; Palmer, Nicholette D. ; Pereira, Alexandre C. ; Perls, Thomas ; Peters, Annette ; Polašek, Ozren ; Raitakari, Olli T. ; Rice, Kenneth ; Rice, Treva K. ; Rich, Stephen S. ; Sabanayagam, Charumathi ; Schreiner, Pamela J. ; Shu, Xiao Ou ; Sidney, Stephen ; Sims, Mario ; Smith, Jennifer A. ; Starr, John M. ; Strauch, Konstantin ; Tai, E. Shyong ; Taylor, Kent D. ; Tsai, Michael Y. ; Uitterlinden, André G. ; van Heemst, Diana ; Waldenberger, Melanie ; Wang, Ya Xing ; Wei, Wen Bin ; Wilson, Gregory ; Xuan, Deng ; Yao, Jie ; Yu, Caizheng ; Yuan, Jian Min ; Zhao, Wei ; Becker, Diane M. ; Bonnefond, Amélie ; Bowden, Donald W. ; Cooper, Richard S. ; Deary, Ian J. ; Divers, Jasmin ; Esko, Tõnu ; Franks, Paul W. ; Froguel, Philippe ; Gieger, Christian ; Jonas, Jost B. ; Kato, Norihiro ; Lakka, Timo A. ; Leander, Karin ; Lehtimäki, Terho ; Magnusson, Patrik K.E. ; North, Kari E. ; Ntalla, Ioanna ; Penninx, Brenda ; Samani, Nilesh J. ; Snieder, Harold ; Spedicati, Beatrice ; van der Harst, Pim ; Völzke, Henry ; Wagenknecht, Lynne E. ; Weir, David R. ; Wojczynski, Mary K. ; Wu, Tangchun ; Zheng, Wei ; Zhu, Xiaofeng ; Bouchard, Claude ; Chasman, Daniel I. ; Evans, Michele K. ; Fox, Ervin R. ; Gudnason, Vilmundur ; Hayward, Caroline ; Horta, Bernardo L. ; Kardia, Sharon L.R. ; Krieger, Jose Eduardo ; Mook-Kanamori, Dennis O. ; Peyser, Patricia A. ; Province, Michael M. ; Psaty, Bruce M. ; Rudan, Igor ; Sim, Xueling ; Smith, Blair H. ; van Dam, Rob M. ; van Duijn, Cornelia M. ; Wong, Tien Yin ; Arnett, Donna K. ; Rao, Dabeeru C. ; Gauderman, James ; Liu, Ching Ti ; Morrison, Alanna C. ; Rotter, Jerome I. ; Fornage, Myriam. / Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci. In: Frontiers in Genetics. 2023 ; Vol. 14.
Bibtex
@article{8c0e25a33c2c40dcb7df1453e013d03f,
title = "Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci",
abstract = "Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.",
keywords = "cholesterol, educational attainment, genome-wide association study, lipids, meta-analysis, triglycerides",
author = "{de las Fuentes}, Lisa and Schwander, {Karen L.} and Brown, {Michael R.} and Bentley, {Amy R.} and Winkler, {Thomas W.} and Sung, {Yun Ju} and Munroe, {Patricia B.} and Miller, {Clint L.} and Hugo Aschard and Stella Aslibekyan and Bartz, {Traci M.} and Bielak, {Lawrence F.} and Chai, {Jin Fang} and Cheng, {Ching Yu} and Rajkumar Dorajoo and Feitosa, {Mary F.} and Xiuqing Guo and Hartwig, {Fernando P.} and Andrea Horimoto and Ivana Kol{\v c}i{\'c} and Elise Lim and Yongmei Liu and Manning, {Alisa K.} and Jonathan Marten and Musani, {Solomon K.} and Raymond Noordam and Sandosh Padmanabhan and Tuomo Rankinen and Richard, {Melissa A.} and Ridker, {Paul M.} and Smith, {Albert V.} and Dina Vojinovic and Zonderman, {Alan B.} and Maris Alver and Mathilde Boissel and Kaare Christensen and Freedman, {Barry I.} and Chuan Gao and Franco Giulianini and Harris, {Sarah E.} and Meian He and Hsu, {Fang Chi} and Brigitte K{\"u}hnel and Federica Laguzzi and Xiaoyin Li and Lyytik{\"a}inen, {Leo Pekka} and Nolte, {Ilja M.} and Alaitz Poveda and Rainer Rauramaa and Muhammad Riaz and Antonietta Robino and Tamar Sofer and Fumihiko Takeuchi and Tayo, {Bamidele O.} and {van der Most}, {Peter J.} and Niek Verweij and Ware, {Erin B.} and Stefan Weiss and Wanqing Wen and Yanek, {Lisa R.} and Yiqiang Zhan and Najaf Amin and Arking, {Dan E.} and Christie Ballantyne and Eric Boerwinkle and Brody, {Jennifer A.} and Ulrich Broeckel and Archie Campbell and Micka{\"e}l Canouil and Xiaoran Chai and Chen, {Yii Der Ida} and Xu Chen and Chitrala, {Kumaraswamy Naidu} and Concas, {Maria Pina} and {de Faire}, Ulf and {de Mutsert}, Ren{\'e}e and {de Silva}, {H. Janaka} and {de Vries}, {Paul S.} and Ahn Do and Faul, {Jessica D.} and Virginia Fisher and Floyd, {James S.} and Terrence Forrester and Yechiel Friedlander and Giorgia Girotto and Gu, {C. Charles} and G{\"o}ran Hallmans and Sami Heikkinen and Heng, {Chew Kiat} and Georg Homuth and Steven Hunt and Ikram, {M. Arfan} and Jacobs, {David R.} and Maryam Kavousi and Khor, {Chiea Chuen} and Kilpel{\"a}inen, {Tuomas O.} and Koh, {Woon Puay} and Pirjo Komulainen and Langefeld, {Carl D.} and Jingjing Liang and Kiang Liu and Jianjun Liu and Kurt Lohman and Reedik M{\"a}gi and Manichaikul, {Ani W.} and McKenzie, {Colin A.} and Thomas Meitinger and Yuri Milaneschi and Matthias Nauck and Nelson, {Christopher P.} and O{\textquoteright}Connell, {Jeffrey R.} and Palmer, {Nicholette D.} and Pereira, {Alexandre C.} and Thomas Perls and Annette Peters and Ozren Pola{\v s}ek and Raitakari, {Olli T.} and Kenneth Rice and Rice, {Treva K.} and Rich, {Stephen S.} and Charumathi Sabanayagam and Schreiner, {Pamela J.} and Shu, {Xiao Ou} and Stephen Sidney and Mario Sims and Smith, {Jennifer A.} and Starr, {John M.} and Konstantin Strauch and Tai, {E. Shyong} and Taylor, {Kent D.} and Tsai, {Michael Y.} and Uitterlinden, {Andr{\'e} G.} and {van Heemst}, Diana and Melanie Waldenberger and Wang, {Ya Xing} and Wei, {Wen Bin} and Gregory Wilson and Deng Xuan and Jie Yao and Caizheng Yu and Yuan, {Jian Min} and Wei Zhao and Becker, {Diane M.} and Am{\'e}lie Bonnefond and Bowden, {Donald W.} and Cooper, {Richard S.} and Deary, {Ian J.} and Jasmin Divers and T{\~o}nu Esko and Franks, {Paul W.} and Philippe Froguel and Christian Gieger and Jonas, {Jost B.} and Norihiro Kato and Lakka, {Timo A.} and Karin Leander and Terho Lehtim{\"a}ki and Magnusson, {Patrik K.E.} and North, {Kari E.} and Ioanna Ntalla and Brenda Penninx and Samani, {Nilesh J.} and Harold Snieder and Beatrice Spedicati and {van der Harst}, Pim and Henry V{\"o}lzke and Wagenknecht, {Lynne E.} and Weir, {David R.} and Wojczynski, {Mary K.} and Tangchun Wu and Wei Zheng and Xiaofeng Zhu and Claude Bouchard and Chasman, {Daniel I.} and Evans, {Michele K.} and Fox, {Ervin R.} and Vilmundur Gudnason and Caroline Hayward and Horta, {Bernardo L.} and Kardia, {Sharon L.R.} and Krieger, {Jose Eduardo} and Mook-Kanamori, {Dennis O.} and Peyser, {Patricia A.} and Province, {Michael M.} and Psaty, {Bruce M.} and Igor Rudan and Xueling Sim and Smith, {Blair H.} and {van Dam}, {Rob M.} and {van Duijn}, {Cornelia M.} and Wong, {Tien Yin} and Arnett, {Donna K.} and Rao, {Dabeeru C.} and James Gauderman and Liu, {Ching Ti} and Morrison, {Alanna C.} and Rotter, {Jerome I.} and Myriam Fornage",
note = "Publisher Copyright: Copyright {\textcopyright} 2023 de las Fuentes",
year = "2023",
doi = "10.3389/fgene.2023.1235337",
language = "English",
volume = "14",
journal = "Frontiers in Genetics",
issn = "1664-8021",
publisher = "Frontiers Media S.A.",
}
RIS
TY - JOUR
T1 - Gene-educational attainment interactions in a multi-population genome-wide meta-analysis identify novel lipid loci
AU - de las Fuentes, Lisa
AU - Schwander, Karen L.
AU - Brown, Michael R.
AU - Bentley, Amy R.
AU - Winkler, Thomas W.
AU - Sung, Yun Ju
AU - Munroe, Patricia B.
AU - Miller, Clint L.
AU - Aschard, Hugo
AU - Aslibekyan, Stella
AU - Bartz, Traci M.
AU - Bielak, Lawrence F.
AU - Chai, Jin Fang
AU - Cheng, Ching Yu
AU - Dorajoo, Rajkumar
AU - Feitosa, Mary F.
AU - Guo, Xiuqing
AU - Hartwig, Fernando P.
AU - Horimoto, Andrea
AU - Kolčić, Ivana
AU - Lim, Elise
AU - Liu, Yongmei
AU - Manning, Alisa K.
AU - Marten, Jonathan
AU - Musani, Solomon K.
AU - Noordam, Raymond
AU - Padmanabhan, Sandosh
AU - Rankinen, Tuomo
AU - Richard, Melissa A.
AU - Ridker, Paul M.
AU - Smith, Albert V.
AU - Vojinovic, Dina
AU - Zonderman, Alan B.
AU - Alver, Maris
AU - Boissel, Mathilde
AU - Christensen, Kaare
AU - Freedman, Barry I.
AU - Gao, Chuan
AU - Giulianini, Franco
AU - Harris, Sarah E.
AU - He, Meian
AU - Hsu, Fang Chi
AU - Kühnel, Brigitte
AU - Laguzzi, Federica
AU - Li, Xiaoyin
AU - Lyytikäinen, Leo Pekka
AU - Nolte, Ilja M.
AU - Poveda, Alaitz
AU - Rauramaa, Rainer
AU - Riaz, Muhammad
AU - Robino, Antonietta
AU - Sofer, Tamar
AU - Takeuchi, Fumihiko
AU - Tayo, Bamidele O.
AU - van der Most, Peter J.
AU - Verweij, Niek
AU - Ware, Erin B.
AU - Weiss, Stefan
AU - Wen, Wanqing
AU - Yanek, Lisa R.
AU - Zhan, Yiqiang
AU - Amin, Najaf
AU - Arking, Dan E.
AU - Ballantyne, Christie
AU - Boerwinkle, Eric
AU - Brody, Jennifer A.
AU - Broeckel, Ulrich
AU - Campbell, Archie
AU - Canouil, Mickaël
AU - Chai, Xiaoran
AU - Chen, Yii Der Ida
AU - Chen, Xu
AU - Chitrala, Kumaraswamy Naidu
AU - Concas, Maria Pina
AU - de Faire, Ulf
AU - de Mutsert, Renée
AU - de Silva, H. Janaka
AU - de Vries, Paul S.
AU - Do, Ahn
AU - Faul, Jessica D.
AU - Fisher, Virginia
AU - Floyd, James S.
AU - Forrester, Terrence
AU - Friedlander, Yechiel
AU - Girotto, Giorgia
AU - Gu, C. Charles
AU - Hallmans, Göran
AU - Heikkinen, Sami
AU - Heng, Chew Kiat
AU - Homuth, Georg
AU - Hunt, Steven
AU - Ikram, M. Arfan
AU - Jacobs, David R.
AU - Kavousi, Maryam
AU - Khor, Chiea Chuen
AU - Kilpeläinen, Tuomas O.
AU - Koh, Woon Puay
AU - Komulainen, Pirjo
AU - Langefeld, Carl D.
AU - Liang, Jingjing
AU - Liu, Kiang
AU - Liu, Jianjun
AU - Lohman, Kurt
AU - Mägi, Reedik
AU - Manichaikul, Ani W.
AU - McKenzie, Colin A.
AU - Meitinger, Thomas
AU - Milaneschi, Yuri
AU - Nauck, Matthias
AU - Nelson, Christopher P.
AU - O’Connell, Jeffrey R.
AU - Palmer, Nicholette D.
AU - Pereira, Alexandre C.
AU - Perls, Thomas
AU - Peters, Annette
AU - Polašek, Ozren
AU - Raitakari, Olli T.
AU - Rice, Kenneth
AU - Rice, Treva K.
AU - Rich, Stephen S.
AU - Sabanayagam, Charumathi
AU - Schreiner, Pamela J.
AU - Shu, Xiao Ou
AU - Sidney, Stephen
AU - Sims, Mario
AU - Smith, Jennifer A.
AU - Starr, John M.
AU - Strauch, Konstantin
AU - Tai, E. Shyong
AU - Taylor, Kent D.
AU - Tsai, Michael Y.
AU - Uitterlinden, André G.
AU - van Heemst, Diana
AU - Waldenberger, Melanie
AU - Wang, Ya Xing
AU - Wei, Wen Bin
AU - Wilson, Gregory
AU - Xuan, Deng
AU - Yao, Jie
AU - Yu, Caizheng
AU - Yuan, Jian Min
AU - Zhao, Wei
AU - Becker, Diane M.
AU - Bonnefond, Amélie
AU - Bowden, Donald W.
AU - Cooper, Richard S.
AU - Deary, Ian J.
AU - Divers, Jasmin
AU - Esko, Tõnu
AU - Franks, Paul W.
AU - Froguel, Philippe
AU - Gieger, Christian
AU - Jonas, Jost B.
AU - Kato, Norihiro
AU - Lakka, Timo A.
AU - Leander, Karin
AU - Lehtimäki, Terho
AU - Magnusson, Patrik K.E.
AU - North, Kari E.
AU - Ntalla, Ioanna
AU - Penninx, Brenda
AU - Samani, Nilesh J.
AU - Snieder, Harold
AU - Spedicati, Beatrice
AU - van der Harst, Pim
AU - Völzke, Henry
AU - Wagenknecht, Lynne E.
AU - Weir, David R.
AU - Wojczynski, Mary K.
AU - Wu, Tangchun
AU - Zheng, Wei
AU - Zhu, Xiaofeng
AU - Bouchard, Claude
AU - Chasman, Daniel I.
AU - Evans, Michele K.
AU - Fox, Ervin R.
AU - Gudnason, Vilmundur
AU - Hayward, Caroline
AU - Horta, Bernardo L.
AU - Kardia, Sharon L.R.
AU - Krieger, Jose Eduardo
AU - Mook-Kanamori, Dennis O.
AU - Peyser, Patricia A.
AU - Province, Michael M.
AU - Psaty, Bruce M.
AU - Rudan, Igor
AU - Sim, Xueling
AU - Smith, Blair H.
AU - van Dam, Rob M.
AU - van Duijn, Cornelia M.
AU - Wong, Tien Yin
AU - Arnett, Donna K.
AU - Rao, Dabeeru C.
AU - Gauderman, James
AU - Liu, Ching Ti
AU - Morrison, Alanna C.
AU - Rotter, Jerome I.
AU - Fornage, Myriam
N1 - Publisher Copyright:
Copyright © 2023 de las Fuentes
PY - 2023
Y1 - 2023
N2 - Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.
AB - Introduction: Educational attainment, widely used in epidemiologic studies as a surrogate for socioeconomic status, is a predictor of cardiovascular health outcomes. Methods: A two-stage genome-wide meta-analysis of low-density lipoprotein cholesterol (LDL), high-density lipoprotein cholesterol (HDL), and triglyceride (TG) levels was performed while accounting for gene-educational attainment interactions in up to 226,315 individuals from five population groups. We considered two educational attainment variables: “Some College” (yes/no, for any education beyond high school) and “Graduated College” (yes/no, for completing a 4-year college degree). Genome-wide significant (p < 5 × 10−8) and suggestive (p < 1 × 10−6) variants were identified in Stage 1 (in up to 108,784 individuals) through genome-wide analysis, and those variants were followed up in Stage 2 studies (in up to 117,531 individuals). Results: In combined analysis of Stages 1 and 2, we identified 18 novel lipid loci (nine for LDL, seven for HDL, and two for TG) by two degree-of-freedom (2 DF) joint tests of main and interaction effects. Four loci showed significant interaction with educational attainment. Two loci were significant only in cross-population analyses. Several loci include genes with known or suggested roles in adipose (FOXP1, MBOAT4, SKP2, STIM1, STX4), brain (BRI3, FILIP1, FOXP1, LINC00290, LMTK2, MBOAT4, MYO6, SENP6, SRGAP3, STIM1, TMEM167A, TMEM30A), and liver (BRI3, FOXP1) biology, highlighting the potential importance of brain-adipose-liver communication in the regulation of lipid metabolism. An investigation of the potential druggability of genes in identified loci resulted in five gene targets shown to interact with drugs approved by the Food and Drug Administration, including genes with roles in adipose and brain tissue. Discussion: Genome-wide interaction analysis of educational attainment identified novel lipid loci not previously detected by analyses limited to main genetic effects.
KW - cholesterol
KW - educational attainment
KW - genome-wide association study
KW - lipids
KW - meta-analysis
KW - triglycerides
U2 - 10.3389/fgene.2023.1235337
DO - 10.3389/fgene.2023.1235337
M3 - Journal article
C2 - 38028628
AN - SCOPUS:85177065494
VL - 14
JO - Frontiers in Genetics
JF - Frontiers in Genetics
SN - 1664-8021
M1 - 1235337
ER -
