Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. / Smith, Caren E; Follis, Jack L; Dashti, Hassan S; Tanaka, Toshiko; Graff, Mariaelisa; Fretts, Amanda M; Kilpeläinen, Tuomas O.; Wojczynski, Mary K; Richardson, Kris; Nalls, Mike A; Schulz, Christina-Alexandra; Liu, Yongmei; Frazier-Wood, Alexis C; van Eekelen, Esther; Wang, Carol; de Vries, Paul S; Mikkilä, Vera; Rohde, Rebecca; Psaty, Bruce M; Hansen, Torben; Feitosa, Mary F; Lai, Chao-Qiang; Houston, Denise K; Ferruci, Luigi; Ericson, Ulrika; Wang, Zhe; de Mutsert, Renée; Oddy, Wendy H; de Jonge, Ester A L; Seppälä, Ilkka; Justice, Anne E; Lemaitre, Rozenn N; Sørensen, Thorkild I.A.; Province, Michael A; Parnell, Laurence D; Garcia, Melissa E; Bandinelli, Stefania; Orho-Melander, Marju; Rich, Stephen S; Rosendaal, Frits R; Pennell, Craig E; Kiefte-de Jong, Jessica C; Kähönen, Mika; Young, Kristin L; Pedersen, Oluf; Aslibekyan, Stella; Rotter, Jerome I; Mook-Kanamori, Dennis O; Zillikens, M Carola; Raitakari, Olli T; North, Kari E; Overvad, Kim; Arnett, Donna K; Hofman, Albert; Lehtimäki, Terho; Tjønneland, Anne; Uitterlinden, André G; Rivadeneira, Fernando; Franco, Oscar H; German, J Bruce; Siscovick, David S; Cupples, L Adrienne; Ordovás, José M.

In: Molecular Nutrition & Food Research, Vol. 62, No. 3, 1700347, 2018, p. 1-12.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Smith, CE, Follis, JL, Dashti, HS, Tanaka, T, Graff, M, Fretts, AM, Kilpeläinen, TO, Wojczynski, MK, Richardson, K, Nalls, MA, Schulz, C-A, Liu, Y, Frazier-Wood, AC, van Eekelen, E, Wang, C, de Vries, PS, Mikkilä, V, Rohde, R, Psaty, BM, Hansen, T, Feitosa, MF, Lai, C-Q, Houston, DK, Ferruci, L, Ericson, U, Wang, Z, de Mutsert, R, Oddy, WH, de Jonge, EAL, Seppälä, I, Justice, AE, Lemaitre, RN, Sørensen, TIA, Province, MA, Parnell, LD, Garcia, ME, Bandinelli, S, Orho-Melander, M, Rich, SS, Rosendaal, FR, Pennell, CE, Kiefte-de Jong, JC, Kähönen, M, Young, KL, Pedersen, O, Aslibekyan, S, Rotter, JI, Mook-Kanamori, DO, Zillikens, MC, Raitakari, OT, North, KE, Overvad, K, Arnett, DK, Hofman, A, Lehtimäki, T, Tjønneland, A, Uitterlinden, AG, Rivadeneira, F, Franco, OH, German, JB, Siscovick, DS, Cupples, LA & Ordovás, JM 2018, 'Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent', Molecular Nutrition & Food Research, vol. 62, no. 3, 1700347, pp. 1-12. https://doi.org/10.1002/mnfr.201700347

APA

Smith, C. E., Follis, J. L., Dashti, H. S., Tanaka, T., Graff, M., Fretts, A. M., Kilpeläinen, T. O., Wojczynski, M. K., Richardson, K., Nalls, M. A., Schulz, C-A., Liu, Y., Frazier-Wood, A. C., van Eekelen, E., Wang, C., de Vries, P. S., Mikkilä, V., Rohde, R., Psaty, B. M., ... Ordovás, J. M. (2018). Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. Molecular Nutrition & Food Research, 62(3), 1-12. [1700347]. https://doi.org/10.1002/mnfr.201700347

Vancouver

Smith CE, Follis JL, Dashti HS, Tanaka T, Graff M, Fretts AM et al. Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. Molecular Nutrition & Food Research. 2018;62(3):1-12. 1700347. https://doi.org/10.1002/mnfr.201700347

Author

Smith, Caren E ; Follis, Jack L ; Dashti, Hassan S ; Tanaka, Toshiko ; Graff, Mariaelisa ; Fretts, Amanda M ; Kilpeläinen, Tuomas O. ; Wojczynski, Mary K ; Richardson, Kris ; Nalls, Mike A ; Schulz, Christina-Alexandra ; Liu, Yongmei ; Frazier-Wood, Alexis C ; van Eekelen, Esther ; Wang, Carol ; de Vries, Paul S ; Mikkilä, Vera ; Rohde, Rebecca ; Psaty, Bruce M ; Hansen, Torben ; Feitosa, Mary F ; Lai, Chao-Qiang ; Houston, Denise K ; Ferruci, Luigi ; Ericson, Ulrika ; Wang, Zhe ; de Mutsert, Renée ; Oddy, Wendy H ; de Jonge, Ester A L ; Seppälä, Ilkka ; Justice, Anne E ; Lemaitre, Rozenn N ; Sørensen, Thorkild I.A. ; Province, Michael A ; Parnell, Laurence D ; Garcia, Melissa E ; Bandinelli, Stefania ; Orho-Melander, Marju ; Rich, Stephen S ; Rosendaal, Frits R ; Pennell, Craig E ; Kiefte-de Jong, Jessica C ; Kähönen, Mika ; Young, Kristin L ; Pedersen, Oluf ; Aslibekyan, Stella ; Rotter, Jerome I ; Mook-Kanamori, Dennis O ; Zillikens, M Carola ; Raitakari, Olli T ; North, Kari E ; Overvad, Kim ; Arnett, Donna K ; Hofman, Albert ; Lehtimäki, Terho ; Tjønneland, Anne ; Uitterlinden, André G ; Rivadeneira, Fernando ; Franco, Oscar H ; German, J Bruce ; Siscovick, David S ; Cupples, L Adrienne ; Ordovás, José M. / Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent. In: Molecular Nutrition & Food Research. 2018 ; Vol. 62, No. 3. pp. 1-12.

Bibtex

@article{49267cdcd7334bc1bb1647261a2cee4a,
title = "Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent",
abstract = "SCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.METHODS AND RESULTS: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10-7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3' of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10-8)such that each serving of low-fat dairy was associated with 0.225 kg m-2lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure.CONCLUSION: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.",
keywords = "Journal Article, genome-wide interaction study, dairy intake, body mass index, meta-analysis, CHARGE consortium",
author = "Smith, {Caren E} and Follis, {Jack L} and Dashti, {Hassan S} and Toshiko Tanaka and Mariaelisa Graff and Fretts, {Amanda M} and Kilpel{\"a}inen, {Tuomas O.} and Wojczynski, {Mary K} and Kris Richardson and Nalls, {Mike A} and Christina-Alexandra Schulz and Yongmei Liu and Frazier-Wood, {Alexis C} and {van Eekelen}, Esther and Carol Wang and {de Vries}, {Paul S} and Vera Mikkil{\"a} and Rebecca Rohde and Psaty, {Bruce M} and Torben Hansen and Feitosa, {Mary F} and Chao-Qiang Lai and Houston, {Denise K} and Luigi Ferruci and Ulrika Ericson and Zhe Wang and {de Mutsert}, Ren{\'e}e and Oddy, {Wendy H} and {de Jonge}, {Ester A L} and Ilkka Sepp{\"a}l{\"a} and Justice, {Anne E} and Lemaitre, {Rozenn N} and S{\o}rensen, {Thorkild I.A.} and Province, {Michael A} and Parnell, {Laurence D} and Garcia, {Melissa E} and Stefania Bandinelli and Marju Orho-Melander and Rich, {Stephen S} and Rosendaal, {Frits R} and Pennell, {Craig E} and {Kiefte-de Jong}, {Jessica C} and Mika K{\"a}h{\"o}nen and Young, {Kristin L} and Oluf Pedersen and Stella Aslibekyan and Rotter, {Jerome I} and Mook-Kanamori, {Dennis O} and Zillikens, {M Carola} and Raitakari, {Olli T} and North, {Kari E} and Kim Overvad and Arnett, {Donna K} and Albert Hofman and Terho Lehtim{\"a}ki and Anne Tj{\o}nneland and Uitterlinden, {Andr{\'e} G} and Fernando Rivadeneira and Franco, {Oscar H} and German, {J Bruce} and Siscovick, {David S} and Cupples, {L Adrienne} and Ordov{\'a}s, {Jos{\'e} M}",
note = "{\textcopyright} 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2018",
doi = "10.1002/mnfr.201700347",
language = "English",
volume = "62",
pages = "1--12",
journal = "Molecular Nutrition & Food Research",
issn = "1613-4125",
publisher = "Wiley-VCH",
number = "3",

}

RIS

TY - JOUR

T1 - Genome-Wide Interactions with Dairy Intake for Body Mass Index in Adults of European Descent

AU - Smith, Caren E

AU - Follis, Jack L

AU - Dashti, Hassan S

AU - Tanaka, Toshiko

AU - Graff, Mariaelisa

AU - Fretts, Amanda M

AU - Kilpeläinen, Tuomas O.

AU - Wojczynski, Mary K

AU - Richardson, Kris

AU - Nalls, Mike A

AU - Schulz, Christina-Alexandra

AU - Liu, Yongmei

AU - Frazier-Wood, Alexis C

AU - van Eekelen, Esther

AU - Wang, Carol

AU - de Vries, Paul S

AU - Mikkilä, Vera

AU - Rohde, Rebecca

AU - Psaty, Bruce M

AU - Hansen, Torben

AU - Feitosa, Mary F

AU - Lai, Chao-Qiang

AU - Houston, Denise K

AU - Ferruci, Luigi

AU - Ericson, Ulrika

AU - Wang, Zhe

AU - de Mutsert, Renée

AU - Oddy, Wendy H

AU - de Jonge, Ester A L

AU - Seppälä, Ilkka

AU - Justice, Anne E

AU - Lemaitre, Rozenn N

AU - Sørensen, Thorkild I.A.

AU - Province, Michael A

AU - Parnell, Laurence D

AU - Garcia, Melissa E

AU - Bandinelli, Stefania

AU - Orho-Melander, Marju

AU - Rich, Stephen S

AU - Rosendaal, Frits R

AU - Pennell, Craig E

AU - Kiefte-de Jong, Jessica C

AU - Kähönen, Mika

AU - Young, Kristin L

AU - Pedersen, Oluf

AU - Aslibekyan, Stella

AU - Rotter, Jerome I

AU - Mook-Kanamori, Dennis O

AU - Zillikens, M Carola

AU - Raitakari, Olli T

AU - North, Kari E

AU - Overvad, Kim

AU - Arnett, Donna K

AU - Hofman, Albert

AU - Lehtimäki, Terho

AU - Tjønneland, Anne

AU - Uitterlinden, André G

AU - Rivadeneira, Fernando

AU - Franco, Oscar H

AU - German, J Bruce

AU - Siscovick, David S

AU - Cupples, L Adrienne

AU - Ordovás, José M

N1 - © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2018

Y1 - 2018

N2 - SCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.METHODS AND RESULTS: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10-7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3' of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10-8)such that each serving of low-fat dairy was associated with 0.225 kg m-2lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure.CONCLUSION: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.

AB - SCOPE: Body weight responds variably to the intake of dairy foods. Genetic variation may contribute to inter-individual variability in associations between body weight and dairy consumption.METHODS AND RESULTS: A genome-wide interaction study to discover genetic variants that account for variation in BMI in the context of low-fat, high-fat and total dairy intake in cross-sectional analysis was conducted. Data from nine discovery studies (up to 25 513 European descent individuals) were meta-analyzed. Twenty-six genetic variants reached the selected significance threshold (p-interaction <10-7), and six independent variants (LINC01512-rs7751666, PALM2/AKAP2-rs914359, ACTA2-rs1388, PPP1R12A-rs7961195, LINC00333-rs9635058, AC098847.1-rs1791355) were evaluated meta-analytically for replication of interaction in up to 17 675 individuals. Variant rs9635058 (128 kb 3' of LINC00333) was replicated (p-interaction = 0.004). In the discovery cohorts, rs9635058 interacted with dairy (p-interaction = 7.36 × 10-8)such that each serving of low-fat dairy was associated with 0.225 kg m-2lower BMI per each additional copy of the effect allele (A). A second genetic variant (ACTA2-rs1388) approached interaction replication significance for low-fat dairy exposure.CONCLUSION: Body weight responses to dairy intake may be modified by genotype, in that greater dairy intake may protect a genetic subgroup from higher body weight.

KW - Journal Article

KW - genome-wide interaction study

KW - dairy intake

KW - body mass index

KW - meta-analysis

KW - CHARGE consortium

U2 - 10.1002/mnfr.201700347

DO - 10.1002/mnfr.201700347

M3 - Journal article

C2 - 28941034

VL - 62

SP - 1

EP - 12

JO - Molecular Nutrition & Food Research

JF - Molecular Nutrition & Food Research

SN - 1613-4125

IS - 3

M1 - 1700347

ER -

ID: 189863224