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Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. / Heid, Iris M; Jackson, Anne U; Randall, Joshua C; Winkler, Thomas W; Qi, Lu; Steinthorsdottir, Valgerdur; Thorleifsson, Gudmar; Zillikens, M Carola; Speliotes, Elizabeth K; Mägi, Reedik; Workalemahu, Tsegaselassie; White, Charles C; Bouatia-Naji, Nabila; Harris, Tamara B; Berndt, Sonja I; Ingelsson, Erik; Willer, Cristen J; Weedon, Michael N; Luan, Jian'an; Vedantam, Sailaja; Esko, Tõnu; Oskari Kilpeläinen, Tuomas; Kutalik, Zoltán; Li, Shengxu; Monda, Keri L; Dixon, Anna L; Holmes, Christopher C; Kaplan, Lee M; Liang, Liming; Min, Josine L; Moffatt, Miriam F; Molony, Cliona; Nicholson, George; Schadt, Eric E; Zondervan, Krina T; Feitosa, Mary F; Ferreira, Teresa; Allen, Hana Lango; Weyant, Robert J; Wheeler, Eleanor; Wood, Andrew R; Estrada, Karol; Goddard, Michael E; Lettre, Guillaume; Mangino, Massimo; Gjesing, Anette P; Witte, Daniel R; Hansen, Torben; Jørgensen, Torben; Pedersen, Oluf; MAGIC.
In:
Nature Genetics, Vol. 42, No. 11, 01.11.2010, p. 949-60.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Heid, IM, Jackson, AU, Randall, JC, Winkler, TW, Qi, L, Steinthorsdottir, V, Thorleifsson, G, Zillikens, MC, Speliotes, EK, Mägi, R, Workalemahu, T, White, CC, Bouatia-Naji, N, Harris, TB, Berndt, SI, Ingelsson, E, Willer, CJ, Weedon, MN, Luan, J, Vedantam, S, Esko, T
, Oskari Kilpeläinen, T, Kutalik, Z, Li, S, Monda, KL, Dixon, AL, Holmes, CC, Kaplan, LM, Liang, L, Min, JL, Moffatt, MF, Molony, C, Nicholson, G, Schadt, EE, Zondervan, KT, Feitosa, MF, Ferreira, T, Allen, HL, Weyant, RJ, Wheeler, E, Wood, AR, Estrada, K, Goddard, ME, Lettre, G, Mangino, M, Gjesing, AP, Witte, DR
, Hansen, T, Jørgensen, T
, Pedersen, O & MAGIC 2010, '
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution',
Nature Genetics, vol. 42, no. 11, pp. 949-60.
https://doi.org/10.1038/ng.685APA
Heid, I. M., Jackson, A. U., Randall, J. C., Winkler, T. W., Qi, L., Steinthorsdottir, V., Thorleifsson, G., Zillikens, M. C., Speliotes, E. K., Mägi, R., Workalemahu, T., White, C. C., Bouatia-Naji, N., Harris, T. B., Berndt, S. I., Ingelsson, E., Willer, C. J., Weedon, M. N., Luan, J., ... MAGIC (2010).
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Nature Genetics,
42(11), 949-60.
https://doi.org/10.1038/ng.685Vancouver
Heid IM, Jackson AU, Randall JC, Winkler TW, Qi L, Steinthorsdottir V et al.
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.
Nature Genetics. 2010 Nov 1;42(11):949-60.
https://doi.org/10.1038/ng.685Author
Heid, Iris M ; Jackson, Anne U ; Randall, Joshua C ; Winkler, Thomas W ; Qi, Lu ; Steinthorsdottir, Valgerdur ; Thorleifsson, Gudmar ; Zillikens, M Carola ; Speliotes, Elizabeth K ; Mägi, Reedik ; Workalemahu, Tsegaselassie ; White, Charles C ; Bouatia-Naji, Nabila ; Harris, Tamara B ; Berndt, Sonja I ; Ingelsson, Erik ; Willer, Cristen J ; Weedon, Michael N ; Luan, Jian'an ; Vedantam, Sailaja ; Esko, Tõnu ; Oskari Kilpeläinen, Tuomas ; Kutalik, Zoltán ; Li, Shengxu ; Monda, Keri L ; Dixon, Anna L ; Holmes, Christopher C ; Kaplan, Lee M ; Liang, Liming ; Min, Josine L ; Moffatt, Miriam F ; Molony, Cliona ; Nicholson, George ; Schadt, Eric E ; Zondervan, Krina T ; Feitosa, Mary F ; Ferreira, Teresa ; Allen, Hana Lango ; Weyant, Robert J ; Wheeler, Eleanor ; Wood, Andrew R ; Estrada, Karol ; Goddard, Michael E ; Lettre, Guillaume ; Mangino, Massimo ; Gjesing, Anette P ; Witte, Daniel R ; Hansen, Torben ; Jørgensen, Torben ; Pedersen, Oluf ; MAGIC. / Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. In: Nature Genetics. 2010 ; Vol. 42, No. 11. pp. 949-60.
Bibtex
@article{f80fd0b43dd3401bb287e976597934ce,
title = "Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution",
abstract = "Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10¿¿ to P = 1.8 × 10¿4°) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10¿³ to P = 1.2 × 10¿¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.",
keywords = "Adipose Tissue, Age Factors, Chromosome Mapping, Female, Genome, Human, Genome-Wide Association Study, Humans, Male, Meta-Analysis as Topic, Polymorphism, Single Nucleotide, Sex Characteristics, Waist-Hip Ratio",
author = "Heid, {Iris M} and Jackson, {Anne U} and Randall, {Joshua C} and Winkler, {Thomas W} and Lu Qi and Valgerdur Steinthorsdottir and Gudmar Thorleifsson and Zillikens, {M Carola} and Speliotes, {Elizabeth K} and Reedik M{\"a}gi and Tsegaselassie Workalemahu and White, {Charles C} and Nabila Bouatia-Naji and Harris, {Tamara B} and Berndt, {Sonja I} and Erik Ingelsson and Willer, {Cristen J} and Weedon, {Michael N} and Jian'an Luan and Sailaja Vedantam and T{\~o}nu Esko and {Oskari Kilpel{\"a}inen}, Tuomas and Zolt{\'a}n Kutalik and Shengxu Li and Monda, {Keri L} and Dixon, {Anna L} and Holmes, {Christopher C} and Kaplan, {Lee M} and Liming Liang and Min, {Josine L} and Moffatt, {Miriam F} and Cliona Molony and George Nicholson and Schadt, {Eric E} and Zondervan, {Krina T} and Feitosa, {Mary F} and Teresa Ferreira and Allen, {Hana Lango} and Weyant, {Robert J} and Eleanor Wheeler and Wood, {Andrew R} and Karol Estrada and Goddard, {Michael E} and Guillaume Lettre and Massimo Mangino and Gjesing, {Anette P} and Witte, {Daniel R} and Torben Hansen and Torben J{\o}rgensen and Oluf Pedersen and MAGIC",
year = "2010",
month = nov,
day = "1",
doi = "10.1038/ng.685",
language = "English",
volume = "42",
pages = "949--60",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "11",
}
RIS
TY - JOUR
T1 - Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution
AU - Heid, Iris M
AU - Jackson, Anne U
AU - Randall, Joshua C
AU - Winkler, Thomas W
AU - Qi, Lu
AU - Steinthorsdottir, Valgerdur
AU - Thorleifsson, Gudmar
AU - Zillikens, M Carola
AU - Speliotes, Elizabeth K
AU - Mägi, Reedik
AU - Workalemahu, Tsegaselassie
AU - White, Charles C
AU - Bouatia-Naji, Nabila
AU - Harris, Tamara B
AU - Berndt, Sonja I
AU - Ingelsson, Erik
AU - Willer, Cristen J
AU - Weedon, Michael N
AU - Luan, Jian'an
AU - Vedantam, Sailaja
AU - Esko, Tõnu
AU - Oskari Kilpeläinen, Tuomas
AU - Kutalik, Zoltán
AU - Li, Shengxu
AU - Monda, Keri L
AU - Dixon, Anna L
AU - Holmes, Christopher C
AU - Kaplan, Lee M
AU - Liang, Liming
AU - Min, Josine L
AU - Moffatt, Miriam F
AU - Molony, Cliona
AU - Nicholson, George
AU - Schadt, Eric E
AU - Zondervan, Krina T
AU - Feitosa, Mary F
AU - Ferreira, Teresa
AU - Allen, Hana Lango
AU - Weyant, Robert J
AU - Wheeler, Eleanor
AU - Wood, Andrew R
AU - Estrada, Karol
AU - Goddard, Michael E
AU - Lettre, Guillaume
AU - Mangino, Massimo
AU - Gjesing, Anette P
AU - Witte, Daniel R
AU - Hansen, Torben
AU - Jørgensen, Torben
AU - Pedersen, Oluf
AU - MAGIC
PY - 2010/11/1
Y1 - 2010/11/1
N2 - Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10¿¿ to P = 1.8 × 10¿4°) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10¿³ to P = 1.2 × 10¿¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
AB - Waist-hip ratio (WHR) is a measure of body fat distribution and a predictor of metabolic consequences independent of overall adiposity. WHR is heritable, but few genetic variants influencing this trait have been identified. We conducted a meta-analysis of 32 genome-wide association studies for WHR adjusted for body mass index (comprising up to 77,167 participants), following up 16 loci in an additional 29 studies (comprising up to 113,636 subjects). We identified 13 new loci in or near RSPO3, VEGFA, TBX15-WARS2, NFE2L3, GRB14, DNM3-PIGC, ITPR2-SSPN, LY86, HOXC13, ADAMTS9, ZNRF3-KREMEN1, NISCH-STAB1 and CPEB4 (P = 1.9 × 10¿¿ to P = 1.8 × 10¿4°) and the known signal at LYPLAL1. Seven of these loci exhibited marked sexual dimorphism, all with a stronger effect on WHR in women than men (P for sex difference = 1.9 × 10¿³ to P = 1.2 × 10¿¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions.
KW - Adipose Tissue
KW - Age Factors
KW - Chromosome Mapping
KW - Female
KW - Genome, Human
KW - Genome-Wide Association Study
KW - Humans
KW - Male
KW - Meta-Analysis as Topic
KW - Polymorphism, Single Nucleotide
KW - Sex Characteristics
KW - Waist-Hip Ratio
U2 - 10.1038/ng.685
DO - 10.1038/ng.685
M3 - Journal article
C2 - 20935629
VL - 42
SP - 949
EP - 960
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 11
ER -
