Standard
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. / Wang, Heming; Noordam, Raymond; Cade, Brian E; Schwander, Karen; Winkler, Thomas W; Lee, Jiwon; Sung, Yun Ju; Bentley, Amy R; Manning, Alisa K; Aschard, Hugues; Kilpeläinen, Tuomas O; Ilkov, Marjan; Brown, Michael R; Horimoto, Andrea R; Richard, Melissa; Bartz, Traci M; Vojinovic, Dina; Lim, Elise; Nierenberg, Jovia L; Liu, Yongmei; Chitrala, Kumaraswamynaidu; Rankinen, Tuomo; Musani, Solomon K; Franceschini, Nora; Rauramaa, Rainer; Alver, Maris; Zee, Phyllis C; Harris, Sarah E; van der Most, Peter J; Nolte, Ilja M; Munroe, Patricia B; Palmer, Nicholette D; Kühnel, Brigitte; Weiss, Stefan; Wen, Wanqing; Hall, Kelly A; Lyytikäinen, Leo-Pekka; O'Connell, Jeff; Eiriksdottir, Gudny; Launer, Lenore J; de Vries, Paul S; Arking, Dan E; Chen, Han; Boerwinkle, Eric; Krieger, Jose E; Schreiner, Pamela J; Sidney, Stephen; Shikany, James M; Rice, Kenneth; Chen, Yii-Der Ida; Gharib, Sina A; Bis, Joshua C; Luik, Annemarie I; Ikram, M Arfan; Uitterlinden, André G; Amin, Najaf; Xu, Hanfei; Levy, Daniel; He, Jiang; Lohman, Kurt K; Zonderman, Alan B; Rice, Treva K; Sims, Mario; Wilson, Gregory; Sofer, Tamar; Rich, Stephen S; Palmas, Walter; Yao, Jie; Guo, Xiuqing; Rotter, Jerome I; Biermasz, Nienke R; Mook-Kanamori, Dennis O; Martin, Lisa W; Barac, Ana; Wallace, Robert B; Gottlieb, Daniel J; Komulainen, Pirjo; Heikkinen, Sami; Mägi, Reedik; Milani, Lili; Metspalu, Andres; Starr, John M; Milaneschi, Yuri; Waken, R J; Gao, Chuan; Waldenberger, Melanie; Peters, Annette; Strauch, Konstantin; Meitinger, Thomas; Roenneberg, Till; Völker, Uwe; Dörr, Marcus; Shu, Xiao-Ou; Mukherjee, Sutapa; Hillman, David R; Kähönen, Mika; Wagenknecht, Lynne E; Gieger, Christian; Grabe, Hans J; Zheng, Wei; Palmer, Lyle J; Lehtimäki, Terho; Gudnason, Vilmundur; Morrison, Alanna C; Pereira, Alexandre C; Fornage, Myriam; Psaty, Bruce M; van Duijn, Cornelia M; Liu, Ching-Ti; Kelly, Tanika N; Evans, Michele K; Bouchard, Claude; Fox, Ervin R; Kooperberg, Charles; Zhu, Xiaofeng; Lakka, Timo A; Esko, Tõnu; North, Kari E; Deary, Ian J; Snieder, Harold; Penninx, Brenda W J H; Gauderman, W James; Rao, Dabeeru C; Redline, Susan; van Heemst, Diana.
In:
Molecular Psychiatry, Vol. 26, 2021, p. 6293-6304.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Wang, H, Noordam, R, Cade, BE, Schwander, K, Winkler, TW, Lee, J, Sung, YJ, Bentley, AR, Manning, AK, Aschard, H
, Kilpeläinen, TO, Ilkov, M, Brown, MR, Horimoto, AR, Richard, M, Bartz, TM, Vojinovic, D, Lim, E, Nierenberg, JL, Liu, Y, Chitrala, K, Rankinen, T, Musani, SK, Franceschini, N, Rauramaa, R, Alver, M, Zee, PC, Harris, SE, van der Most, PJ, Nolte, IM, Munroe, PB, Palmer, ND, Kühnel, B, Weiss, S, Wen, W, Hall, KA, Lyytikäinen, L-P, O'Connell, J, Eiriksdottir, G, Launer, LJ, de Vries, PS, Arking, DE, Chen, H, Boerwinkle, E, Krieger, JE, Schreiner, PJ, Sidney, S, Shikany, JM, Rice, K, Chen, Y-DI, Gharib, SA, Bis, JC, Luik, AI, Ikram, MA, Uitterlinden, AG, Amin, N, Xu, H, Levy, D, He, J, Lohman, KK, Zonderman, AB, Rice, TK, Sims, M, Wilson, G, Sofer, T, Rich, SS, Palmas, W, Yao, J, Guo, X, Rotter, JI, Biermasz, NR, Mook-Kanamori, DO, Martin, LW, Barac, A, Wallace, RB, Gottlieb, DJ, Komulainen, P, Heikkinen, S, Mägi, R, Milani, L, Metspalu, A, Starr, JM, Milaneschi, Y, Waken, RJ, Gao, C, Waldenberger, M, Peters, A, Strauch, K, Meitinger, T, Roenneberg, T, Völker, U, Dörr, M, Shu, X-O, Mukherjee, S, Hillman, DR, Kähönen, M, Wagenknecht, LE, Gieger, C, Grabe, HJ, Zheng, W, Palmer, LJ, Lehtimäki, T, Gudnason, V, Morrison, AC, Pereira, AC, Fornage, M, Psaty, BM, van Duijn, CM, Liu, C-T, Kelly, TN, Evans, MK, Bouchard, C, Fox, ER, Kooperberg, C, Zhu, X, Lakka, TA, Esko, T, North, KE, Deary, IJ, Snieder, H, Penninx, BWJH, Gauderman, WJ, Rao, DC, Redline, S & van Heemst, D 2021, '
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure',
Molecular Psychiatry, vol. 26, pp. 6293-6304.
https://doi.org/10.1038/s41380-021-01087-0APA
Wang, H., Noordam, R., Cade, B. E., Schwander, K., Winkler, T. W., Lee, J., Sung, Y. J., Bentley, A. R., Manning, A. K., Aschard, H.
, Kilpeläinen, T. O., Ilkov, M., Brown, M. R., Horimoto, A. R., Richard, M., Bartz, T. M., Vojinovic, D., Lim, E., Nierenberg, J. L., ... van Heemst, D. (2021).
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
Molecular Psychiatry,
26, 6293-6304.
https://doi.org/10.1038/s41380-021-01087-0Vancouver
Wang H, Noordam R, Cade BE, Schwander K, Winkler TW, Lee J et al.
Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure.
Molecular Psychiatry. 2021;26:6293-6304.
https://doi.org/10.1038/s41380-021-01087-0Author
Wang, Heming ; Noordam, Raymond ; Cade, Brian E ; Schwander, Karen ; Winkler, Thomas W ; Lee, Jiwon ; Sung, Yun Ju ; Bentley, Amy R ; Manning, Alisa K ; Aschard, Hugues ; Kilpeläinen, Tuomas O ; Ilkov, Marjan ; Brown, Michael R ; Horimoto, Andrea R ; Richard, Melissa ; Bartz, Traci M ; Vojinovic, Dina ; Lim, Elise ; Nierenberg, Jovia L ; Liu, Yongmei ; Chitrala, Kumaraswamynaidu ; Rankinen, Tuomo ; Musani, Solomon K ; Franceschini, Nora ; Rauramaa, Rainer ; Alver, Maris ; Zee, Phyllis C ; Harris, Sarah E ; van der Most, Peter J ; Nolte, Ilja M ; Munroe, Patricia B ; Palmer, Nicholette D ; Kühnel, Brigitte ; Weiss, Stefan ; Wen, Wanqing ; Hall, Kelly A ; Lyytikäinen, Leo-Pekka ; O'Connell, Jeff ; Eiriksdottir, Gudny ; Launer, Lenore J ; de Vries, Paul S ; Arking, Dan E ; Chen, Han ; Boerwinkle, Eric ; Krieger, Jose E ; Schreiner, Pamela J ; Sidney, Stephen ; Shikany, James M ; Rice, Kenneth ; Chen, Yii-Der Ida ; Gharib, Sina A ; Bis, Joshua C ; Luik, Annemarie I ; Ikram, M Arfan ; Uitterlinden, André G ; Amin, Najaf ; Xu, Hanfei ; Levy, Daniel ; He, Jiang ; Lohman, Kurt K ; Zonderman, Alan B ; Rice, Treva K ; Sims, Mario ; Wilson, Gregory ; Sofer, Tamar ; Rich, Stephen S ; Palmas, Walter ; Yao, Jie ; Guo, Xiuqing ; Rotter, Jerome I ; Biermasz, Nienke R ; Mook-Kanamori, Dennis O ; Martin, Lisa W ; Barac, Ana ; Wallace, Robert B ; Gottlieb, Daniel J ; Komulainen, Pirjo ; Heikkinen, Sami ; Mägi, Reedik ; Milani, Lili ; Metspalu, Andres ; Starr, John M ; Milaneschi, Yuri ; Waken, R J ; Gao, Chuan ; Waldenberger, Melanie ; Peters, Annette ; Strauch, Konstantin ; Meitinger, Thomas ; Roenneberg, Till ; Völker, Uwe ; Dörr, Marcus ; Shu, Xiao-Ou ; Mukherjee, Sutapa ; Hillman, David R ; Kähönen, Mika ; Wagenknecht, Lynne E ; Gieger, Christian ; Grabe, Hans J ; Zheng, Wei ; Palmer, Lyle J ; Lehtimäki, Terho ; Gudnason, Vilmundur ; Morrison, Alanna C ; Pereira, Alexandre C ; Fornage, Myriam ; Psaty, Bruce M ; van Duijn, Cornelia M ; Liu, Ching-Ti ; Kelly, Tanika N ; Evans, Michele K ; Bouchard, Claude ; Fox, Ervin R ; Kooperberg, Charles ; Zhu, Xiaofeng ; Lakka, Timo A ; Esko, Tõnu ; North, Kari E ; Deary, Ian J ; Snieder, Harold ; Penninx, Brenda W J H ; Gauderman, W James ; Rao, Dabeeru C ; Redline, Susan ; van Heemst, Diana. / Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure. In: Molecular Psychiatry. 2021 ; Vol. 26. pp. 6293-6304.
Bibtex
@article{87bf00a026c74e8a9c460155101801db,
title = "Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure",
abstract = "Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 Pjoint < 5 × 10-8), including rs7955964 (FIGNL2/ANKRD33) that increases BP among long sleepers, and rs73493041 (SNORA26/C9orf170) and rs10406644 (KCTD15/LSM14A) that increase BP among short sleepers (Pint < 5 × 10-8). Secondary ancestry-specific analysis identified another novel gene by long sleep interaction at rs111887471 (TRPC3/KIAA1109) in individuals of African ancestry (Pint = 2 × 10-6). Combined stage 1 and 2 analyses additionally identified significant gene by long sleep interactions at 10 loci including MKLN1 and RGL3/ELAVL3 previously associated with BP, and significant gene by short sleep interactions at 10 loci including C2orf43 previously associated with BP (Pint < 10-3). 2df test also identified novel loci for BP after modeling sleep that has known functions in sleep-wake regulation, nervous and cardiometabolic systems. This study indicates that sleep and primary mechanisms regulating BP may interact to elevate BP level, suggesting novel insights into sleep-related BP regulation.",
author = "Heming Wang and Raymond Noordam and Cade, {Brian E} and Karen Schwander and Winkler, {Thomas W} and Jiwon Lee and Sung, {Yun Ju} and Bentley, {Amy R} and Manning, {Alisa K} and Hugues Aschard and Kilpel{\"a}inen, {Tuomas O} and Marjan Ilkov and Brown, {Michael R} and Horimoto, {Andrea R} and Melissa Richard and Bartz, {Traci M} and Dina Vojinovic and Elise Lim and Nierenberg, {Jovia L} and Yongmei Liu and Kumaraswamynaidu Chitrala and Tuomo Rankinen and Musani, {Solomon K} and Nora Franceschini and Rainer Rauramaa and Maris Alver and Zee, {Phyllis C} and Harris, {Sarah E} and {van der Most}, {Peter J} and Nolte, {Ilja M} and Munroe, {Patricia B} and Palmer, {Nicholette D} and Brigitte K{\"u}hnel and Stefan Weiss and Wanqing Wen and Hall, {Kelly A} and Leo-Pekka Lyytik{\"a}inen and Jeff O'Connell and Gudny Eiriksdottir and Launer, {Lenore J} and {de Vries}, {Paul S} and Arking, {Dan E} and Han Chen and Eric Boerwinkle and Krieger, {Jose E} and Schreiner, {Pamela J} and Stephen Sidney and Shikany, {James M} and Kenneth Rice and Chen, {Yii-Der Ida} and Gharib, {Sina A} and Bis, {Joshua C} and Luik, {Annemarie I} and Ikram, {M Arfan} and Uitterlinden, {Andr{\'e} G} and Najaf Amin and Hanfei Xu and Daniel Levy and Jiang He and Lohman, {Kurt K} and Zonderman, {Alan B} and Rice, {Treva K} and Mario Sims and Gregory Wilson and Tamar Sofer and Rich, {Stephen S} and Walter Palmas and Jie Yao and Xiuqing Guo and Rotter, {Jerome I} and Biermasz, {Nienke R} and Mook-Kanamori, {Dennis O} and Martin, {Lisa W} and Ana Barac and Wallace, {Robert B} and Gottlieb, {Daniel J} and Pirjo Komulainen and Sami Heikkinen and Reedik M{\"a}gi and Lili Milani and Andres Metspalu and Starr, {John M} and Yuri Milaneschi and Waken, {R J} and Chuan Gao and Melanie Waldenberger and Annette Peters and Konstantin Strauch and Thomas Meitinger and Till Roenneberg and Uwe V{\"o}lker and Marcus D{\"o}rr and Xiao-Ou Shu and Sutapa Mukherjee and Hillman, {David R} and Mika K{\"a}h{\"o}nen and Wagenknecht, {Lynne E} and Christian Gieger and Grabe, {Hans J} and Wei Zheng and Palmer, {Lyle J} and Terho Lehtim{\"a}ki and Vilmundur Gudnason and Morrison, {Alanna C} and Pereira, {Alexandre C} and Myriam Fornage and Psaty, {Bruce M} and {van Duijn}, {Cornelia M} and Ching-Ti Liu and Kelly, {Tanika N} and Evans, {Michele K} and Claude Bouchard and Fox, {Ervin R} and Charles Kooperberg and Xiaofeng Zhu and Lakka, {Timo A} and T{\~o}nu Esko and North, {Kari E} and Deary, {Ian J} and Harold Snieder and Penninx, {Brenda W J H} and Gauderman, {W James} and Rao, {Dabeeru C} and Susan Redline and {van Heemst}, Diana",
year = "2021",
doi = "10.1038/s41380-021-01087-0",
language = "English",
volume = "26",
pages = "6293--6304",
journal = "Molecular Psychiatry",
issn = "1359-4184",
publisher = "nature publishing group",
}
RIS
TY - JOUR
T1 - Multi-ancestry genome-wide gene-sleep interactions identify novel loci for blood pressure
AU - Wang, Heming
AU - Noordam, Raymond
AU - Cade, Brian E
AU - Schwander, Karen
AU - Winkler, Thomas W
AU - Lee, Jiwon
AU - Sung, Yun Ju
AU - Bentley, Amy R
AU - Manning, Alisa K
AU - Aschard, Hugues
AU - Kilpeläinen, Tuomas O
AU - Ilkov, Marjan
AU - Brown, Michael R
AU - Horimoto, Andrea R
AU - Richard, Melissa
AU - Bartz, Traci M
AU - Vojinovic, Dina
AU - Lim, Elise
AU - Nierenberg, Jovia L
AU - Liu, Yongmei
AU - Chitrala, Kumaraswamynaidu
AU - Rankinen, Tuomo
AU - Musani, Solomon K
AU - Franceschini, Nora
AU - Rauramaa, Rainer
AU - Alver, Maris
AU - Zee, Phyllis C
AU - Harris, Sarah E
AU - van der Most, Peter J
AU - Nolte, Ilja M
AU - Munroe, Patricia B
AU - Palmer, Nicholette D
AU - Kühnel, Brigitte
AU - Weiss, Stefan
AU - Wen, Wanqing
AU - Hall, Kelly A
AU - Lyytikäinen, Leo-Pekka
AU - O'Connell, Jeff
AU - Eiriksdottir, Gudny
AU - Launer, Lenore J
AU - de Vries, Paul S
AU - Arking, Dan E
AU - Chen, Han
AU - Boerwinkle, Eric
AU - Krieger, Jose E
AU - Schreiner, Pamela J
AU - Sidney, Stephen
AU - Shikany, James M
AU - Rice, Kenneth
AU - Chen, Yii-Der Ida
AU - Gharib, Sina A
AU - Bis, Joshua C
AU - Luik, Annemarie I
AU - Ikram, M Arfan
AU - Uitterlinden, André G
AU - Amin, Najaf
AU - Xu, Hanfei
AU - Levy, Daniel
AU - He, Jiang
AU - Lohman, Kurt K
AU - Zonderman, Alan B
AU - Rice, Treva K
AU - Sims, Mario
AU - Wilson, Gregory
AU - Sofer, Tamar
AU - Rich, Stephen S
AU - Palmas, Walter
AU - Yao, Jie
AU - Guo, Xiuqing
AU - Rotter, Jerome I
AU - Biermasz, Nienke R
AU - Mook-Kanamori, Dennis O
AU - Martin, Lisa W
AU - Barac, Ana
AU - Wallace, Robert B
AU - Gottlieb, Daniel J
AU - Komulainen, Pirjo
AU - Heikkinen, Sami
AU - Mägi, Reedik
AU - Milani, Lili
AU - Metspalu, Andres
AU - Starr, John M
AU - Milaneschi, Yuri
AU - Waken, R J
AU - Gao, Chuan
AU - Waldenberger, Melanie
AU - Peters, Annette
AU - Strauch, Konstantin
AU - Meitinger, Thomas
AU - Roenneberg, Till
AU - Völker, Uwe
AU - Dörr, Marcus
AU - Shu, Xiao-Ou
AU - Mukherjee, Sutapa
AU - Hillman, David R
AU - Kähönen, Mika
AU - Wagenknecht, Lynne E
AU - Gieger, Christian
AU - Grabe, Hans J
AU - Zheng, Wei
AU - Palmer, Lyle J
AU - Lehtimäki, Terho
AU - Gudnason, Vilmundur
AU - Morrison, Alanna C
AU - Pereira, Alexandre C
AU - Fornage, Myriam
AU - Psaty, Bruce M
AU - van Duijn, Cornelia M
AU - Liu, Ching-Ti
AU - Kelly, Tanika N
AU - Evans, Michele K
AU - Bouchard, Claude
AU - Fox, Ervin R
AU - Kooperberg, Charles
AU - Zhu, Xiaofeng
AU - Lakka, Timo A
AU - Esko, Tõnu
AU - North, Kari E
AU - Deary, Ian J
AU - Snieder, Harold
AU - Penninx, Brenda W J H
AU - Gauderman, W James
AU - Rao, Dabeeru C
AU - Redline, Susan
AU - van Heemst, Diana
PY - 2021
Y1 - 2021
N2 - Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 Pjoint < 5 × 10-8), including rs7955964 (FIGNL2/ANKRD33) that increases BP among long sleepers, and rs73493041 (SNORA26/C9orf170) and rs10406644 (KCTD15/LSM14A) that increase BP among short sleepers (Pint < 5 × 10-8). Secondary ancestry-specific analysis identified another novel gene by long sleep interaction at rs111887471 (TRPC3/KIAA1109) in individuals of African ancestry (Pint = 2 × 10-6). Combined stage 1 and 2 analyses additionally identified significant gene by long sleep interactions at 10 loci including MKLN1 and RGL3/ELAVL3 previously associated with BP, and significant gene by short sleep interactions at 10 loci including C2orf43 previously associated with BP (Pint < 10-3). 2df test also identified novel loci for BP after modeling sleep that has known functions in sleep-wake regulation, nervous and cardiometabolic systems. This study indicates that sleep and primary mechanisms regulating BP may interact to elevate BP level, suggesting novel insights into sleep-related BP regulation.
AB - Long and short sleep duration are associated with elevated blood pressure (BP), possibly through effects on molecular pathways that influence neuroendocrine and vascular systems. To gain new insights into the genetic basis of sleep-related BP variation, we performed genome-wide gene by short or long sleep duration interaction analyses on four BP traits (systolic BP, diastolic BP, mean arterial pressure, and pulse pressure) across five ancestry groups in two stages using 2 degree of freedom (df) joint test followed by 1df test of interaction effects. Primary multi-ancestry analysis in 62,969 individuals in stage 1 identified three novel gene by sleep interactions that were replicated in an additional 59,296 individuals in stage 2 (stage 1 + 2 Pjoint < 5 × 10-8), including rs7955964 (FIGNL2/ANKRD33) that increases BP among long sleepers, and rs73493041 (SNORA26/C9orf170) and rs10406644 (KCTD15/LSM14A) that increase BP among short sleepers (Pint < 5 × 10-8). Secondary ancestry-specific analysis identified another novel gene by long sleep interaction at rs111887471 (TRPC3/KIAA1109) in individuals of African ancestry (Pint = 2 × 10-6). Combined stage 1 and 2 analyses additionally identified significant gene by long sleep interactions at 10 loci including MKLN1 and RGL3/ELAVL3 previously associated with BP, and significant gene by short sleep interactions at 10 loci including C2orf43 previously associated with BP (Pint < 10-3). 2df test also identified novel loci for BP after modeling sleep that has known functions in sleep-wake regulation, nervous and cardiometabolic systems. This study indicates that sleep and primary mechanisms regulating BP may interact to elevate BP level, suggesting novel insights into sleep-related BP regulation.
U2 - 10.1038/s41380-021-01087-0
DO - 10.1038/s41380-021-01087-0
M3 - Journal article
C2 - 33859359
VL - 26
SP - 6293
EP - 6304
JO - Molecular Psychiatry
JF - Molecular Psychiatry
SN - 1359-4184
ER -
