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Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. / Bentley, Amy R; Sung, Yun J; Brown, Michael R; Winkler, Thomas W; Kraja, Aldi T; Ntalla, Ioanna; Schwander, Karen; Chasman, Daniel I; Lim, Elise; Deng, Xuan; Guo, Xiuqing; Liu, Jingmin; Lu, Yingchang; Cheng, Ching-Yu; Sim, Xueling; Vojinovic, Dina; Huffman, Jennifer E; Musani, Solomon K; Li, Changwei; Feitosa, Mary F; Richard, Melissa A; Noordam, Raymond; Baker, Jenna; Chen, Guanjie; Aschard, Hugues; Bartz, Traci M; Ding, Jingzhong; Dorajoo, Rajkumar; Manning, Alisa K; Rankinen, Tuomo; Smith, Albert V; Tajuddin, Salman M; Zhao, Wei; Graff, Mariaelisa; Alver, Maris; Boissel, Mathilde; Chai, Jin Fang; Chen, Xu; Divers, Jasmin; Evangelou, Evangelos; Gao, Chuan; Goel, Anuj; Hagemeijer, Yanick; Harris, Sarah E; Hartwig, Fernando P; Zhao, Jing Hua; Christensen, Kaare; Kilpeläinen, Tuomas O; Wang, Jun-Sing; Loos, Ruth J F; COGENT-Kidney Consortium ; V Varga, Tibor.
In:
Nature Genetics, Vol. 51, No. 4, 04.2019, p. 636-648.
Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
Bentley, AR, Sung, YJ, Brown, MR, Winkler, TW, Kraja, AT, Ntalla, I, Schwander, K, Chasman, DI, Lim, E, Deng, X, Guo, X, Liu, J, Lu, Y, Cheng, C-Y, Sim, X, Vojinovic, D, Huffman, JE, Musani, SK, Li, C, Feitosa, MF, Richard, MA, Noordam, R, Baker, J, Chen, G, Aschard, H, Bartz, TM, Ding, J, Dorajoo, R, Manning, AK, Rankinen, T, Smith, AV, Tajuddin, SM, Zhao, W, Graff, M, Alver, M, Boissel, M, Chai, JF, Chen, X, Divers, J, Evangelou, E, Gao, C, Goel, A, Hagemeijer, Y, Harris, SE, Hartwig, FP, Zhao, JH, Christensen, K
, Kilpeläinen, TO, Wang, J-S
, Loos, RJF, COGENT-Kidney Consortium
& V Varga, T 2019, '
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids',
Nature Genetics, vol. 51, no. 4, pp. 636-648.
https://doi.org/10.1038/s41588-019-0378-yAPA
Bentley, A. R., Sung, Y. J., Brown, M. R., Winkler, T. W., Kraja, A. T., Ntalla, I., Schwander, K., Chasman, D. I., Lim, E., Deng, X., Guo, X., Liu, J., Lu, Y., Cheng, C-Y., Sim, X., Vojinovic, D., Huffman, J. E., Musani, S. K., Li, C.
, ... V Varga, T. (2019).
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Nature Genetics,
51(4), 636-648.
https://doi.org/10.1038/s41588-019-0378-yVancouver
Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I et al.
Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids.
Nature Genetics. 2019 Apr;51(4):636-648.
https://doi.org/10.1038/s41588-019-0378-yAuthor
Bentley, Amy R ; Sung, Yun J ; Brown, Michael R ; Winkler, Thomas W ; Kraja, Aldi T ; Ntalla, Ioanna ; Schwander, Karen ; Chasman, Daniel I ; Lim, Elise ; Deng, Xuan ; Guo, Xiuqing ; Liu, Jingmin ; Lu, Yingchang ; Cheng, Ching-Yu ; Sim, Xueling ; Vojinovic, Dina ; Huffman, Jennifer E ; Musani, Solomon K ; Li, Changwei ; Feitosa, Mary F ; Richard, Melissa A ; Noordam, Raymond ; Baker, Jenna ; Chen, Guanjie ; Aschard, Hugues ; Bartz, Traci M ; Ding, Jingzhong ; Dorajoo, Rajkumar ; Manning, Alisa K ; Rankinen, Tuomo ; Smith, Albert V ; Tajuddin, Salman M ; Zhao, Wei ; Graff, Mariaelisa ; Alver, Maris ; Boissel, Mathilde ; Chai, Jin Fang ; Chen, Xu ; Divers, Jasmin ; Evangelou, Evangelos ; Gao, Chuan ; Goel, Anuj ; Hagemeijer, Yanick ; Harris, Sarah E ; Hartwig, Fernando P ; Zhao, Jing Hua ; Christensen, Kaare ; Kilpeläinen, Tuomas O ; Wang, Jun-Sing ; Loos, Ruth J F ; COGENT-Kidney Consortium ; V Varga, Tibor. / Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids. In: Nature Genetics. 2019 ; Vol. 51, No. 4. pp. 636-648.
Bibtex
@article{50ba04f033034eb0b4f5f1d93c582fa4,
title = "Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids",
abstract = "The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.",
keywords = "Adolescent, Adult, Aged, Aged, 80 and over, Female, Genome-Wide Association Study/methods, Genotype, Humans, Life Style, Linkage Disequilibrium/genetics, Lipids/blood, Male, Middle Aged, Smoking/blood, Young Adult",
author = "Bentley, {Amy R} and Sung, {Yun J} and Brown, {Michael R} and Winkler, {Thomas W} and Kraja, {Aldi T} and Ioanna Ntalla and Karen Schwander and Chasman, {Daniel I} and Elise Lim and Xuan Deng and Xiuqing Guo and Jingmin Liu and Yingchang Lu and Ching-Yu Cheng and Xueling Sim and Dina Vojinovic and Huffman, {Jennifer E} and Musani, {Solomon K} and Changwei Li and Feitosa, {Mary F} and Richard, {Melissa A} and Raymond Noordam and Jenna Baker and Guanjie Chen and Hugues Aschard and Bartz, {Traci M} and Jingzhong Ding and Rajkumar Dorajoo and Manning, {Alisa K} and Tuomo Rankinen and Smith, {Albert V} and Tajuddin, {Salman M} and Wei Zhao and Mariaelisa Graff and Maris Alver and Mathilde Boissel and Chai, {Jin Fang} and Xu Chen and Jasmin Divers and Evangelos Evangelou and Chuan Gao and Anuj Goel and Yanick Hagemeijer and Harris, {Sarah E} and Hartwig, {Fernando P} and Zhao, {Jing Hua} and Kaare Christensen and Kilpel{\"a}inen, {Tuomas O} and Jun-Sing Wang and Loos, {Ruth J F} and {COGENT-Kidney Consortium} and {V Varga}, Tibor",
year = "2019",
month = apr,
doi = "10.1038/s41588-019-0378-y",
language = "English",
volume = "51",
pages = "636--648",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "nature publishing group",
number = "4",
}
RIS
TY - JOUR
T1 - Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
AU - Bentley, Amy R
AU - Sung, Yun J
AU - Brown, Michael R
AU - Winkler, Thomas W
AU - Kraja, Aldi T
AU - Ntalla, Ioanna
AU - Schwander, Karen
AU - Chasman, Daniel I
AU - Lim, Elise
AU - Deng, Xuan
AU - Guo, Xiuqing
AU - Liu, Jingmin
AU - Lu, Yingchang
AU - Cheng, Ching-Yu
AU - Sim, Xueling
AU - Vojinovic, Dina
AU - Huffman, Jennifer E
AU - Musani, Solomon K
AU - Li, Changwei
AU - Feitosa, Mary F
AU - Richard, Melissa A
AU - Noordam, Raymond
AU - Baker, Jenna
AU - Chen, Guanjie
AU - Aschard, Hugues
AU - Bartz, Traci M
AU - Ding, Jingzhong
AU - Dorajoo, Rajkumar
AU - Manning, Alisa K
AU - Rankinen, Tuomo
AU - Smith, Albert V
AU - Tajuddin, Salman M
AU - Zhao, Wei
AU - Graff, Mariaelisa
AU - Alver, Maris
AU - Boissel, Mathilde
AU - Chai, Jin Fang
AU - Chen, Xu
AU - Divers, Jasmin
AU - Evangelou, Evangelos
AU - Gao, Chuan
AU - Goel, Anuj
AU - Hagemeijer, Yanick
AU - Harris, Sarah E
AU - Hartwig, Fernando P
AU - Zhao, Jing Hua
AU - Christensen, Kaare
AU - Kilpeläinen, Tuomas O
AU - Wang, Jun-Sing
AU - Loos, Ruth J F
AU - COGENT-Kidney Consortium
AU - V Varga, Tibor
PY - 2019/4
Y1 - 2019/4
N2 - The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
AB - The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Female
KW - Genome-Wide Association Study/methods
KW - Genotype
KW - Humans
KW - Life Style
KW - Linkage Disequilibrium/genetics
KW - Lipids/blood
KW - Male
KW - Middle Aged
KW - Smoking/blood
KW - Young Adult
U2 - 10.1038/s41588-019-0378-y
DO - 10.1038/s41588-019-0378-y
M3 - Journal article
C2 - 30926973
VL - 51
SP - 636
EP - 648
JO - Nature Genetics
JF - Nature Genetics
SN - 1061-4036
IS - 4
ER -
