Novo Nordisk Foundation Center for Basic Metabolic Research

  1. 2017
  2. Published

    Treatment with liraglutide may improve markers of CVD reflected by reduced levels of apoB

    pjx571, pjx571, Lundgren, Jens, Albrechtsen, Nicolai Jacob Wewer, Mahendran, Y., Iepsen, E. P. W., Finocchietto, P., Jonsson, Anna Elisabet, Madsbad, Sten, Holst, Jens Juul, drb459, drb459, Hansen, Torben & Torekov, Signe Sørensen, 2017, In: Obesity Science & Practice. 3, 4, p. 425-433 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  3. Published

    Causal relationship between obesity and serum testosterone status in men: A bi-directional mendelian randomization analysis

    Eriksson, J., Haring, R., Grarup, N., Vandenput, L., Wallaschofski, H., Lorentzen, E., Hansen, Torben, Mellström, D., Pedersen, Oluf Borbye, Nauck, M., Lorentzon, M., Nystrup Husemoen, L. L., Völzke, H., Karlsson, M., Baumeister, S. E., Linneberg, Allan René & Ohlsson, C., 2017, In: PloS one. 12, 4, 15 p., e0176277.

    Research output: Contribution to journalJournal articleResearchpeer-review

  4. Published

    Interdependency of EGF and GLP-2 Signaling in Attenuating Mucosal Atrophy in a Mouse Model of Parenteral Nutrition

    Feng, Y., Demehri, F. R., Xiao, W., Tsai, Y., Jones, J. C., Brindley, C. D., Threadgill, D. W., Holst, Jens Juul, Hartmann, Bolette, Barrett, T. A., Teitelbaum, D. H. & Dempsey, P. J., May 2017, In: Cellular and Molecular Gastroenterology and Hepatology. 3, 3, p. 447-468 22 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  5. Published

    Data Descriptor: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls

    Flannick, J., Fuchsberger, C., Mahajan, A., Teslovich, T. M., Agarwala, V., Gaulton, K. J., Caulkins, L., Koesterer, R., Ma, C., Moutsianas, L., McCarthy, D. J., Rivas, M. A., Perry, J. R. B., Sim, X., Blackwell, T. W., Robertson, N. R., Rayner, N. W., Cingolani, P., Locke, A. E., Tajes, J. F. & 281 others, Highland, H. M., Dupuis, J., Chines, P. S., Lindgren, C. M., Hartl, C., Jackson, A. U., Chen, H., Huyghe, J. R., Van De Bunt, M., Pearson, R. D., Kumar, A., Müller-Nurasyid, M., Grarup, N., Stringham, H. M., Gamazon, E. R., Lee, J., Chen, Y., Scott, R. A., Below, J. E., Chen, P., Huang, J., Go, M. J., Stitzel, M. L., Pasko, D., Parker, S. C. J., V Varga, Tibor, Green, T., Beer, N. L., Day-Williams, A. G., Ferreira, T., Fingerlin, T., Horikoshi, M., Hu, C., Huh, I., Ikram, M. K., Kim, B. J., Kim, Y., Kim, Y. J., Kwon, M. S., Lee, J., Lee, S., Lin, K. H., Maxwell, T. J., Nagai, Y., Wang, X., Welch, R. P., Yoon, J., Zhang, W., Barzilai, N., Voight, B. F., Han, B. G., Jenkinson, C. P., Kuulasmaa, T., Kuusisto, J., Manning, A., Ng, M. C. Y., Palmer, N. D., Balkau, B., Stančáková, A., Abboud, H. E., Boeing, H., Giedraitis, V., Prabhakaran, D., Gottesman, O., Scott, J., Carey, J., Kwan, P., Grant, G., Smith, J. D., Neale, B. M., Purcell, S., Butterworth, A. S., Howson, J. M. M., Lee, H. M., Lu, Y., Kwak, S. H., Zhao, W., Danesh, J., Lam, V. K. L., Park, K. S., Saleheen, D., So, W. Y., Tam, C. H. T., Afzal, U., Aguilar, D., Arya, R., Aung, T., Chan, E., Navarro, C., Cheng, C. Y., Palli, D., Correa, A., Curran, J. E., Rybin, D., Farook, V. S., Fowler, S. P., Freedman, B. I., Griswold, M., Hale, D. E., Hicks, P. J., Khor, C. C., Kumar, S., Lehne, B., Thuillier, D., Lim, W. Y., Liu, J., Loh, M., Musani, S. K., Puppala, S., Scott, W. R., Yengo, L., Tan, S. T., Taylor, H. A., Thameem, F., Wilson, G., Wong, T. Y., Njølstad, P. R., Levy, J. C., Mangino, M., Bonnycastle, L. L., Schwarzmayr, T., Fadista, J., Surdulescu, G. L., Herder, C., Groves, C. J., Wieland, T., Bork-Jensen, J., Brandslund, I., Christensen, C., Koistinen, H. A., Doney, A. S. F., Kinnunen, L., Esko, T., Farmer, A. J., Hakaste, L., Hodgkiss, D., Kravic, J., Lyssenko, V., Hollensted, M., Jørgensen, M. E., Jørgensen, T., Ladenvall, C., Justesen, Johanne Marie, Käräjämäki, A., Kriebel, J., Rathmann, W., Lannfelt, L., Lauritzen, T., Narisu, N., Linneberg, Allan René, Melander, O., Milani, L., Neville, M., Orho-Melander, M., Qi, L., Qi, Q., Roden, M., Rolandsson, O., Swift, A., Rosengren, A. H., Stirrups, K., Wood, A. R., Mihailov, E., Blancher, C., Carneiro, M. O., Maguire, J., Poplin, R., Shakir, K., Fennell, T., DePristo, M., De Angelis, M. H., Deloukas, P., Gjesing, A. P., Jun, G., Nilsson, P. M., Murphy, J., Onofrio, R., Thorand, B., Hansen, Torben, Meisinger, C., Hu, F. B., Isomaa, B., Karpe, F., Liang, L., Peters, A., Huth, C., O'Rahilly, S. P., Palmer, C. N. A., Pedersen, Oluf Borbye, Rauramaa, R., Tuomilehto, J., Salomaa, V., Watanabe, R. M., Syvänen, A. C., Bergman, R. N., Bharadwaj, D., Bottinger, E. P., Cho, Y. S., Chandak, G. R., Chan, J. C. N., Chia, K. S., Daly, M. J., Ebrahim, S. B., Langenberg, C., Elliott, P., Jablonski, K. A., Lehman, D. M., Jia, W., Ma, R. C. W., Pollin, T. I., Sandhu, M., Tandon, N., Froguel, P., Barroso, I., Teo, Y. Y., Zeggini, E., Loos, Ruth, Small, K. S., Ried, J. S., DeFronzo, R. A., Grallert, H., Glaser, B., Metspalu, A., Wareham, N. J., Walker, M., Banks, E., Gieger, C., Ingelsson, E., Im, H. K., Illig, T., Franks, P. W., Buck, G., Trakalo, J., Buck, D., Prokopenko, I., Mägi, R., Lind, L., Farjoun, Y., Owen, K. R., Gloyn, A. L., Strauch, K., Tuomi, T., Kooner, J. S., Lee, J. Y., Park, T., Donnelly, P., Morris, A. D., Hattersley, A. T., Bowden, D. W., Collins, F. S., Atzmon, G., Chambers, J. C., Spector, T. D., Laakso, M., Strom, T. M., Bell, G. I., Blangero, J., Duggirala, R., Tai, E., McVean, G., Hanis, C. L., Wilson, J. G., Seielstad, M., Frayling, T. M., Meigs, J. B., Cox, N. J., Sladek, R., Lander, E. S., Gabriel, S., Mohlke, K. L., Meitinger, T., Groop, L., Abecasis, G., Scott, L. J., Morris, A. P., Kang, H. M., Altshuler, D., Burtt, N. P., Florez, J. C., Boehnke, M. & McCarthy, M. I., 19 Dec 2017, In: Scientific Data. 4, p. 1-20 20 p., 170179.

    Research output: Contribution to journalJournal articleResearchpeer-review

  6. Published

    Impact of gain-of-function mutations in the low-density lipoprotein receptor-related protein 5 (LRP5) on glucose and lipid homeostasis

    Foer, D., Zhu, M., Cardone, R. L., Simpson, C., Sullivan, R., Nemiroff, S., Lee, G., Kibbey, R. G., Petersen, K. M. F. & Insogna, K. L., 10 Mar 2017, In: Osteoporosis International. 28, 6, p. 2011-17 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  7. Published

    Nonalcoholic Fatty Liver Disease Is Prevalent in Women With Prior Gestational Diabetes Mellitus and Independently Associated With Insulin Resistance and Waist Circumference

    Foghsgaard, S., Andreasen, C., Vedtofte, L., Andersen, E. S., Bahne, E., Strandberg, C., Buhl, T., Holst, Jens Juul, Svare, J. A., Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Damm, Peter, Gluud, Lise Lotte, Knop, Filip Krag & Vilsbøll, Tina, Jan 2017, In: Diabetes Care. 40, 1, p. 109-116 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  8. Published

    Women with prior gestational diabetes mellitus and prediabetes are characterised by a decreased incretin effect

    Foghsgaard, S., Vedtofte, L., Andreasen, C., Andersen, E. S., Bahne, E., Bagger, J. I., Svare, J. A., Holst, Jens Juul, Clausen, Tine Dalsgaard, Mathiesen, Elisabeth, Damm, Peter, Knop, Filip Krag & Vilsbøll, Tina, Jul 2017, In: Diabetologia. 60, 7, p. 1344-1353 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  9. Published

    Subjective evaluation of psychosocial well-being in children and youths with overweight or obesity: the impact of multidisciplinary obesity treatment

    Fonvig, Cilius Esmann, Hamann, S. A., Nielsen, T. R. H., Johansen, M. Ø., Grønbæk, H. N., Mollerup, P. M. & Holm, Jens-Christian, Dec 2017, In: Quality of Life Research. 26, 12, p. 3279-3288 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  10. Published

    Corrigendum: Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota

    Forslund, K., Hildebrand, F., Nielsen, T., Falony, G., Le Chatelier, E., Sunagawa, S., Prifti, E., Vieira-Silva, S., Gudmundsdottir, V., Pedersen, H. K., Arumugam, M., Kristiansen, K., Voigt, A. Y., Vestergaard, H., Hercog, R., Costea, P. I., Kultima, J. R., Li, J., Jørgensen, T., Levenez, F. & 10 others, Doré, J., Nielsen, H. B., Brunak, Søren, Raes, J., Hansen, Torben, Wang, J., Ehrlich, S. D., Bork, P., Pedersen, Oluf Borbye & MetaHIT consortium, M. C., 3 May 2017, In: Nature. 545, 116, 1 p., 22318.

    Research output: Contribution to journalComment/debateResearch

  11. Published

    Three-phase bone scintigraphy for diagnosis of Charcot neuropathic osteoarthropathy in the diabetic foot – does quantitative data improve diagnostic value?

    Fosbol, M., Reving, S., Petersen, E. H., Rossing, Peter, Lajer, M. & Zerahn, B., Jan 2017, In: Clinical Physiology and Functional Imaging. 37, 1, p. 30-36

    Research output: Contribution to journalJournal articleResearchpeer-review

  12. Published

    Liraglutide as adjunct to insulin treatment in type 1 diabetes does not interfere with glycaemic recovery or gastric emptying rate during hypoglycaemia: a randomised, placebo-controlled, double-blind, parallel-group study

    Frandsen, C. S., Dejgaard, T. F., Andersen, H. U., Holst, Jens Juul, Hartmann, Bolette, Thorsteinsson, B. & Madsbad, Sten, 17 Mar 2017, In: Diabetes, Obesity and Metabolism. 19, 6, p. 773-782 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  13. Published

    Urinary metabolomics reveals glycemic and coffee associated signatures of thyroid function in two population-based cohorts

    Friedrich, N., Pietzner, M., Cannet, C., Thuesen, B. H., Hansen, Torben, Wallaschofski, H., Grarup, N., Skaaby, T., Budde, K., Pedersen, Oluf Borbye, Nauck, M. & Linneberg, Allan René, 2017, In: PLOS ONE. 12, 3, 17 p., e0173078.

    Research output: Contribution to journalJournal articleResearchpeer-review

  14. Published

    Model-Based Discovery of Synthetic Agonists for the Zn2+-Sensing G-Protein-Coupled Receptor 39 (GPR39) Reveals Novel Biological Functions.

    Frimurer, Thomas Michael, Mende, F., Graae, A., Engelstoft, M. S., Egerod, Kristoffer Lihme, Nygaard, R., Gerlach, L., Hansen, J. B., Schwartz, Thue W. & Holst, Birgitte, 2017, In: Journal of Medicinal Chemistry. 60, 3, p. 886-898 13 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  15. Published

    Estimates of insulin sensitivity and β-cell function in children and adolescents with and without components of the metabolic syndrome

    Frithioff-Bøjsøe, C., Trier, C., Fonvig, Cilius Esmann, Nissen, A., Kloppenborg, J. T., Mollerup, P. M., Bjerrum, P. J., Pedersen, Oluf Borbye, Hansen, Torben & Holm, Jens-Christian, 2017, In: Pediatric Endocrinology, Diabetes and Metabolism. 23, 3, p. 122-129 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  16. Published

    The Limits of Exercise Physiology: From Performance to Health

    Gabriel, B. M. & Zierath, Juleen R, 2 May 2017, In: Cell Metabolism. 25, 5, p. 1000-1011 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  17. Published

    Unchanged mitochondrial phenotype, but accumulation of lipids in the myometrium in obese pregnant women

    Gam, C. M. B. F., Larsen, L. H., Mortensen, Ole Hartvig, pjx571, pjx571, Poulsen, Steen Seier, Qvortrup, Klaus, Mathiesen, Elisabeth, Damm, Peter & Quistorff, B., Dec 2017, In: Journal of Physiology. 595, 23, p. 7109-7122 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  18. Published

    Objective assessment of dietary patterns by use of metabolic phenotyping: a randomised, controlled, crossover trial

    Garcia-Perez, I., Posma, J. M., Gibson, R., Chambers, E. S., Hansen, T. H., drb459, drb459, Hansen, Torben, Beckmann, M., Pedersen, Oluf Borbye, Elliott, P., Stamler, J., Nicholson, J. K., Draper, J., Mathers, J. C., Holmes, E. & Frost, G., Mar 2017, In: The Lancet Diabetes & Endocrinology. 5, 3, p. 184-195 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  19. Published

    Sociomics: Using Omic Approaches to Understand Social Evolution

    Ghoul, M., Andersen, Sandra Breum & West, S. A., 1 Jun 2017, In: Trends in Genetics. 33, 6, p. 408-419 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  20. Published
  21. Published

    High Prevalence of Diabetes-Predisposing Variants in MODY Genes Among Danish Women With Gestational Diabetes Mellitus

    Gjesing, A. M. P., Rui, G., Lauenborg, J., Have, C. T., Hollensted, M., Andersson, E., Grarup, N., Sun, J., Quan, S., Brandslund, I., Damm, Peter, Pedersen, Oluf Borbye, Wang, J. & Hansen, Torben, 2017, In: Endocrine Research. 1, 6, p. 681-690 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  22. Published

    Association of childhood body mass index and change in body mass index with first adult ischemic stroke

    Gjærde, L. K., Gamborg, M., Ängquist, Lars, Truelsen, T. C., Sørensen, Thorkild I.A. & Baker, J. L., 1 Nov 2017, In: JAMA Neurology. 74, 11, p. 1312-1318 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  23. Published

    Effect of oral contraceptives and/or metformin on GLP-1 secretion and reactive hypoglycaemia in polycystic ovary syndrome

    Glintborg, D., Mumm, H., Holst, Jens Juul & Andersen, M., May 2017, In: Endocrine Connections. 6, 4, p. 267-277 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  24. Published

    Effect of the interaction between diet composition and the PPM1K genetic variant on insulin resistance and β cell function markers during weight loss: results from the Nutrient Gene Interactions in Human Obesity: implications for dietary guidelines (NUGENOB) randomized trial

    Goni, L., Qi, L., Cuervo, M., Milagro, F. I., Saris, W. H., Macdonald, I. A., Langin, D., Astrup, A., Arner, P., Oppert, J. M., Svendstrup, M., Blaak, E., Sørensen, Thorkild I.A., Hansen, Torben & Martinez, J. A., 2017, In: American Journal of Clinical Nutrition. 106, 3, p. 902-908 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  25. Published

    Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults

    Graff, M., Scott, R. A., Justice, A. E., Young, K. L., Feitosa, M. F., Barata, L., Winkler, T. W., Chu, A. Y., Mahajan, A., Hadley, D., Xue, L., Workalemahu, T., Heard-Costa, N. L., den Hoed, M., Ahluwalia, T. S., Qi, Q., Ngwa, J. S., Renström, F., Quaye, L., Eicher, J. D. & 34 others, Hayes, J. E., Cornelis, M., Kutalik, Z., Lim, E., Luan, J., Huffman, J. E., Zhang, W., Zhao, W., Griffin, P. J., Haller, T., Ahmad, S., Marques-Vidal, P. M., Bien, S., Yengo, L., Teumer, A., Smith, A. V., Kumari, M., Harder, M. N., Justesen, Johanne Marie, Kleber, M. E., Hollensted, M., Aadahl, Mette, Færch, K., Grarup, N., drb459, drb459, Sørensen, Thorkild I.A., Linneberg, Allan René, Hansen, Torben, Pedersen, Oluf Borbye, Loos, Ruth, Kilpeläinen, Tuomas O., CHARGE Consortium, C. C., EPIC-InterAct Consortium, E. C. & PAGE Consortium, P. C., 1 Apr 2017, In: PLOS Genetics. 13, 4, e1006528.

    Research output: Contribution to journalJournal articleResearchpeer-review

  26. Published

    Anti-inflammatory effects of active commuting and leisure time exercise in overweight and obese women and men: A randomized controlled trial

    Gram, A. S., Bladbjerg, E., Quist, Jonas Salling, Blond, Martin Bæk, Rosenkilde, M. & Stallknecht, Bente Merete, Oct 2017, In: Atherosclerosis. 265, p. 318-324 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  27. Published

    TRPV1: A Potential Therapeutic Target in Type 2 Diabetes and Comorbidities?

    Gram, D. X., Holst, Jens Juul & Szallasi, A., Nov 2017, In: Trends in Molecular Medicine. 23, 11, p. 1002-1013 12 p.

    Research output: Contribution to journalReviewResearchpeer-review

  28. Published

    Body mass index trajectories from 2 to 18 years - exploring differences between European cohorts

    Graversen, L., Howe, L. D., Sørensen, Thorkild I.A., Sovio, U., Hohwü, L., Tilling, K., Laitinen, J., Taanila, A., Pouta, A., Järvelin, M. & Obel, C., Apr 2017, In: Pediatric Obesity. 12, 2, p. 102-109 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  29. Published

    Single-molecule analysis of ligand efficacy in β2AR-G-protein activation

    Gregorio, G. G., Masureel, M., Hilger, D., Terry, D. S., Juette, M., Zhao, H., Zhou, Z., Perez-Aguilar, J. M., Hauge, M., Mathiasen, Signe, Javitch, J. A., Weinstein, H., Kobilka, B. K. & Blanchard, S. C., 2017, In: Nature. 547, 7661, p. 68–73

    Research output: Contribution to journalJournal articleResearchpeer-review

  30. Published

    Genetic invalidation of Lp-PLA2 as a therapeutic target: Large-scale study of five functional Lp-PLA2-lowering alleles

    Gregson, J. M., Freitag, D. F., Surendran, P., Stitziel, N. O., Chowdhury, R., Burgess, S., Kaptoge, S., Gao, P., Staley, J. R., Willeit, P., Nielsen, S. F., Caslake, M., Trompet, S., Polfus, L. M., Kuulasmaa, K., Kontto, J., Perola, M., Blankenberg, S., Veronesi, G., Gianfagna, F. & 41 others, Männistö, S., Kimura, A., Lin, H., Reilly, D. F., Gorski, M., Mijatovic, V., Munroe, P. B., Ehret, G. B., Thompson, A., Uria-Nickelsen, M., Malarstig, A., Dehghan, A., Vogt, T. F., Sasaoka, T., Takeuchi, F., Kato, N., Yamada, Y., Kee, F., Müller-Nurasyid, M., Ferrières, J., Arveiler, D., Amouyel, P., Salomaa, V., Boerwinkle, E., Thompson, S. G., Ford, I., Wouter Jukema, J., Sattar, N., Packard, C. J., Shafi Majumder, A. A., Alam, D. S., Deloukas, P., Schunkert, H., Samani, N. J., Kathiresan, S., Nordestgaard, Børge, Saleheen, D., Howson, J. M., Di Angelantonio, E., Butterworth, A. S. & Danesh, J., 2017, In: European Journal of Preventive Cardiology. 24, 5, p. 492-504

    Research output: Contribution to journalJournal articleResearchpeer-review

  31. Published

    Current Therapies That Modify Glucagon Secretion: What Is the Therapeutic Effect of Such Modifications?

    Grøndahl, M. F., Keating, D. J., Vilsbøll, Tina & Knop, Filip Krag, 2017, In: Current Diabetes Reports. 17, 12, 10 p., 128.

    Research output: Contribution to journalReviewResearchpeer-review

  32. Published

    Overexpressing the novel autocrine/endocrine adipokine WISP2 induces hyperplasia of the heart, white and brown adipose tissues and prevents insulin resistance

    Grünberg, J. R., Hoffmann, J. M., Hedjazifar, S., Nerstedt, A., Jenndahl, L., Elvin, J., Castellot, J., Wei, L., Movérare-Skrtic, S., Ohlsson, C., Holm, L. M., Bäckhed, G. F., Syed, I., Bosch, F., Saghatelian, A., Kahn, B. B., Hammarstedt, A. & Smith, U., 27 Feb 2017, In: Scientific Reports. 7, 15 p., 43515.

    Research output: Contribution to journalJournal articleResearchpeer-review

  33. Published

    Gastric Bypass Surgery Recruits a Gut PPAR-α-Striatal D1R Pathway to Reduce Fat Appetite in Obese Rats

    Hankir, M. K., Seyfried, F., Hintschich, C. A., Diep, T., Kleberg, K., Kranz, M., Deuther-Conrad, W., Tellez, L. A., Rullmann, M., Patt, M., Teichert, J., Hesse, S., Sabri, O., Brust, P., Hansen, Harald S., de Araujo, I. E., Krügel, U. & Fenske, W. K., 7 Feb 2017, In: Cell Metabolism. 25, 2, p. 335-344 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  34. Published

    Acute effects of glucagon-like peptide-1, GLP-19-36 amide, and exenatide on mesenteric blood flow, cardiovascular parameters, and biomarkers in healthy volunteers

    Hansen, Lasse Bremholm, Andersen, U. B., Hornum, Mads, Hilsted, L., Veedfald, S., Hartmann, Bolette & Holst, Jens Juul, Feb 2017, In: Physiological Reports. 5, 4, 12 p., e13102.

    Research output: Contribution to journalJournal articleResearchpeer-review

  35. Published

    Bile acid sequestrants for glycemic control in patients with type 2 diabetes: A systematic review with meta-analysis of randomized controlled trials

    Hansen, M., Sonne, David Peick, Mikkelsen, K. H., Gluud, Lise Lotte, Vilsbøll, Tina & Knop, Filip Krag, May 2017, In: Journal of Diabetes and its Complications. 31, 5, p. 918-927 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  36. Published

    A Proposal of the European Association for the Study of Obesity to Improve the ICD-11 Diagnostic Criteria for Obesity Based on the Three Dimensions Etiology, Degree of Adiposity and Health Risk

    Hebebrand, J., Holm, Jens-Christian, Woodward, E., Baker, J. L., Blaak, E., Durrer Schutz, D., Farpour-Lambert, N. J., Frühbeck, G., Halford, J. G. C., Lissner, L., Micic, D., Mullerova, D., Roman, G., Schindler, K., Toplak, H., Visscher, T. L. S. & Yumuk, V., 2017, In: Obesity Facts. 10, 4, p. 284-307 24 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  37. Published

    Roles of RFRP-3 in the Daily and Seasonal Regulation of Reproductive Activity in Female Syrian Hamsters

    Henningsen, J. B., Ancel, C., Mikkelsen, Jens D., Gauer, F. & Simonneaux, V., 1 Mar 2017, In: Endocrinology. 158, 3, p. 652-663 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  38. Published

    Dysregulation of a novel miR-23b/27b-p53 axis impairs muscle stem cell differentiation of humans with type 2 diabetes

    Henriksen, T. I., Davidsen, P. K., Pedersen, M., Schultz, H. S., Hansen, N. S., Larsen, T. J., Vaag, Allan, Pedersen, Bente Klarlund, Nielsen, S. & Schéele, Camilla Charlotte Nielsen, 2017, In: Molecular Metabolism. 6, 7, p. 770-779 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  39. Published

    Normal values of regional left ventricular myocardial thickness, mass and distribution-assessed by 320-detector computed tomography angiography in the Copenhagen General Population Study

    Hindsø, L., Fuchs, A., Kühl, J. T., Nilsson, E. J. P., Sigvardsen, P. E., Køber, Lars Valeur, Nordestgaard, Børge & Kofoed, Klaus Fuglsang, Mar 2017, In: International Journal of Cardiovascular Imaging. 33, 3, p. 421–429

    Research output: Contribution to journalJournal articleResearchpeer-review

  40. Published

    NFIA co-localizes with PPARγ and transcriptionally controls the brown fat gene program

    Hiraike, Y., Waki, H., Yu, J., Nakamura, M., Miyake, K., Nagano, G., Nakaki, R., Suzuki, K., Kobayashi, H., Yamamoto, S., Sun, W., Aoyama, T., Hirota, Y., Ohno, H., Oki, K., Yoneda, M., White, A. P., Tseng, Y-H., Cypess, A. M., Larsen, T. J. & 6 others, Jespersen, N. Z., Schéele, Camilla Charlotte Nielsen, Tsutsumi, S., Aburatani, H., Yamauchi, T. & Kadowaki, T., Sep 2017, In: Nature Cell Biology. 19, 9, p. 1081-1092 12 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  41. Published

    Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials

    Hjorth, Mads Fiil, Ritz, C., Blaak, E., Saris, W. H., Langin, D., Poulsen, S. K., Larsen, T. M., Sørensen, Thorkild I.A., Zohar, Y. & Astrup, A., 2017, In: American Journal of Clinical Nutrition. 106, 2, p. 499-505 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  42. Published

    Glucagon and Amino Acids Are Linked in a Mutual Feedback Cycle: The Liver-α-Cell Axis

    Holst, Jens Juul, Albrechtsen, Nicolai Jacob Wewer, Pedersen, Jens & Knop, Filip Krag, Feb 2017, In: Diabetes. 66, 2, p. 235-240 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  43. Published

    Insulin and Glucagon: Partners for Life

    Holst, Jens Juul, Holland, W., Gromada, J., Lee, Y., Unger, R. H., Yan, H., Sloop, K. W., Kieffer, T. J., Damond, N. & Herrera, P. L., 1 Apr 2017, In: Endocrinology. 158, 4, p. 696-701 6 p.

    Research output: Contribution to journalReviewResearchpeer-review

  44. Published

    The Gut: A Key to the Pathogenesis of Type 2 Diabetes?

    Holst, Jens Juul, Pedersen, Jens, Albrechtsen, Nicolai Jacob Wewer & Knop, Filip Krag, Aug 2017, In: Metabolic Syndrome and Related Disorders. 15, 6, p. 259-262 4 p.

    Research output: Contribution to journalReviewResearchpeer-review

  45. Published

    Intake and sources of gluten in 20- to 75-year-old Danish adults: a national dietary survey

    Hoppe, C., Gøbel, R. J., Kristensen, M. B., Lind, M. V., Matthiessen, J., Christensen, T., Trolle, E., Fagt, S., Madsen, M. L. & Husby, S., 2017, In: European Journal of Nutrition. 56, 1, p. 107-117 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  46. Published

    Analysis of case-parent trios for imprinting effect using a loglinear model with adjustment for sex-of-parent-specific transmission ratio distortion

    Huang, L. O., Infante-Rivard, C. & Labbe, A., Aug 2017, In: Human Genetics. 136, 8, p. 951-961 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  47. Published

    Stella modulates transcriptional and endogenous retrovirus programs during maternal-to-zygotic transition

    Huang, Yun, Kim, J. K., Do, D. V., Lee, C., Penfold, C. A., Zylicz, Jan Jakub, Marioni, J. C., Hackett, J. A. & Surani, M. A., 21 Mar 2017, In: eLife. 6, e22345.

    Research output: Contribution to journalJournal articleResearchpeer-review

  48. Published

    Heterogeneity in glucose response curves during an oral glucose tolerance test and associated cardiometabolic risk

    Hulman, A., Simmons, R. K., Vistisen, D., Tabák, A. G., Dekker, J. M., Alssema, M., Rutters, F., Koopman, A. D. M., Solomon, T. P. J., Kirwan, J. P., Hansen, Torben, Jonsson, Anna Elisabet, Gjesing, A. M. P., Eiberg, Hans Rudolf Lytchoff, Astrup, A., Pedersen, Oluf Borbye, Sørensen, Thorkild I.A., Witte, D. & Færch, K., 2017, In: Endocrine. 55, 2, p. 427-434 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  49. Published

    Seen and Unseen: The representation of visible and hidden disease in the waxworks of Joseph Towne at the Gordon Museum

    Hussey, Kristin D., 2017, In: 19. Interdisciplinary Studies in the Long Nineteenth Century. 1, 24, 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  50. Published

    GPCR-Mediated Signaling of Metabolites

    Husted, Anna Sofie, Trauelsen, Mette, Rudenko, Olga, Hjorth, Siv Annegrethe & Schwartz, Thue W., 4 Apr 2017, In: Cell Metabolism. 25, 4, p. 777-796 20 p.

    Research output: Contribution to journalReviewResearchpeer-review

  51. Published

    Glucose ingestion causes cardiac repolarization disturbances in type 1 long QT syndrome patients and healthy subjects

    Hyltén-Cavallius, L., Iepsen, E. W., Christiansen, M., Graff, C., Linneberg, Allan René, Pedersen, Oluf Borbye, Holst, Jens Juul, Hansen, Torben, Torekov, Signe Sørensen & Kanters, Jørgen K., Aug 2017, In: Heart Rhythm. 14, 8, p. 1165-1170 6 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  52. Published
  53. Published

    No cognitive-enhancing effect of GLP-1 receptor agonism in antipsychotic-treated, obese patients with schizophrenia

    Ishøy, P. L., Fagerlund, Birgitte, Broberg, B. V., Bak, N., Knop, Filip Krag, Glenthøj, Birte Yding & Ebdrup, Bjørn, Jul 2017, In: Acta Psychiatrica Scandinavica. 136, 1, p. 52-62

    Research output: Contribution to journalJournal articleResearchpeer-review

  54. Published

    Effect of GLP-1 Receptor Agonist Treatment on Body weight in Obese Antipsychotic-treated Patients with Schizophrenia: a Randomized, Placebo-controlled Trial Byline

    Ishøy, P. L., Knop, Filip Krag, Broberg, B. V., Bak, N., Andersen, U. B., Jørgensen, N. R., Holst, Jens Juul, Glenthøj, Birte Yding & Ebdrup, Bjørn, Feb 2017, In: Diabetes, Obesity and Metabolism. 19, 2, p. 162-171

    Research output: Contribution to journalJournal articleResearchpeer-review

  55. Published

    Dietary intake and adipose tissue content of long-chain n-3 PUFAs and subsequent 5-y change in body weight and waist circumference

    Jakobsen, M. U., Madsen, L., Skjøth, F., Berentzen, T. L., Halkjaer, J., Tjønneland, A., Schmidt, E. B., Sørensen, Thorkild I.A., Kristiansen, Karsten & Overvad, K., May 2017, In: The American Journal of Clinical Nutrition. 105, 5, p. 1148-1157 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  56. Published

    Association between birthweight and later body mass index: an individual-based pooled analysis of 27 twin cohorts participating in the CODATwins project

    Jelenkovic, A., Yokoyama, Y., Sund, R., Pietiläinen, K. H., Hur, Y-M., Willemsen, G., Bartels, M., van Beijsterveldt, T. C., Ooki, S., Saudino, K. J., Stazi, M. A., Fagnani, C., D'Ippolito, C., Nelson, T. L., Whitfield, K. E., Knafo-Noam, A., Mankuta, D., Abramson, L., Heikkilä, K., Cutler, T. L. & 46 others, Hopper, J. L., Wardle, J., Llewellyn, C. H., Fisher, A., Corley, R. P., Huibregtse, B. M., Derom, C. A., Vlietinck, R. F., Loos, R. J., Bjerregaard-Andersen, M., Beck-Nielsen, H., Sodemann, M., Tarnoki, A. D., Tarnoki, D. L., Burt, S. A., Klump, K. L., Ordoñana, J. R., Sánchez-Romera, J. F., Colodro-Conde, L., Dubois, L., Boivin, M., Brendgen, M., Dionne, G., Vitaro, F., Harris, J. R., Brandt, I., Nilsen, T. S., Craig, J. M., Saffery, R., Rasmussen, F., Tynelius, P., Bayasgalan, G., Narandalai, D., Haworth, C. M., Plomin, R., Ji, F., Ning, F., Pang, Z., Rebato, E., Krueger, R. F., McGue, M., Pahlen, S., Boomsma, D. I., Sørensen, Thorkild I.A., Kaprio, J. & Silventoinen, K., Nov 2017, In: International Journal of Epidemiology. 46, 5, p. 1488-1498 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  57. Published

    Childhood body mass index and height in relation to site-specific risks of colorectal cancers in adult life

    Jensen, B. W., Gamborg, M., Gögenur, Ismail, Renehan, A. G., Sørensen, Thorkild I.A. & Baker, J. L., Dec 2017, In: European Journal of Epidemiology. 32, 12, p. 1097-1106

    Research output: Contribution to journalJournal articleResearchpeer-review

  58. Published

    Neonatal Vitamin D Levels in Relation to Risk of Overweight at 7 Years in the Danish D-Tect Case-Cohort Study

    Jensen, C. B., Lundqvist, M., Sørensen, Thorkild I.A. & Heitmann, Berit, Jun 2017, In: Obesity Facts. 10, 3, p. 273-283 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  59. Published

    Assembly and analysis of 100 full MHC haplotypes from the Danish population

    Jensen, J. M., Villesen, P., Friborg, R. M., Mailund, T., Besenbacher, S., Sørensen, L. M., Petersen, B., Sibbesen, J. A., Liu, S., Skov, L., Belling, K. G., Have, C. T., Izarzugaza, J. M. G., Grosjean, M., Bork-Jensen, J., Grove, J., Als, T. D., Huang, S., Chang, Y., Xu, R. & 39 others, Ye, W., Rao, J., Guo, X., Sun, J., Cao, H., Ye, C., Beusekom, J. V., Espeseth, T., Flindt, E., Halager, A. E., Hellard, S. L., Hultman, C. M., Lescai, F., Li, S., Lund, O., Løngren, P., Matey-Hernandez, M. L., Mors, O., Pedersen, C. N. S., Sicheritz-Pontén, T., Sullivan, P., Syed, A., Westergaard, D., Yadav, R., Li, N., Xu, X., Hansen, Torben, Bolund, L., Krogh, Anders, Sørensen, Thorkild I.A., Pedersen, Oluf Borbye, Gupta, R., Rasmussen, Simon, Børglum, A. D., Wang, J., Eiberg, Hans Rudolf Lytchoff, Kristiansen, Karsten, Brunak, Søren & Schierup, M. H., Sep 2017, In: Genome Research. 27, 9, p. 1597-1607 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  60. Published

    RCR - A Danish textbook for courses in Responsible Conduct of Research

    Jensen, Karsten Klint (ed.), Whiteley, Louise (ed.) & Sandøe, Peter (ed.), 2017, 2 ed. Frederiksberg: Department of Food and Resource Economics, University of Copenhagen. 109 p.

    Research output: Book/ReportBookEducation

  61. Published

    25(OH)D levels in trained versus sedentary university students at 64° north

    Jerome, S., Sticka, K., Schnurr, T. M., Magnum, S., Reynolds, A. & Dunlap , K. L., 28 Apr 2017, In: International Journal of Circumpolar Health. 76, 1, 8 p., 1314414.

    Research output: Contribution to journalJournal articleResearchpeer-review

  62. Published

    Efficacy and immunogenicity of a Vi-tetanus toxoid conjugate vaccine in the prevention of typhoid fever using a controlled human infection model of Salmonella Typhi: a randomised controlled, phase 2b trial

    Jin, C., Gibani, M. M., Moore, M., Juel, H. B., Jones, E., Meiring, J., Harris, V., Gardner, J., Nebykova, A., Kerridge, S. A., Hill, J., Thomaides-Brears, H., Blohmke, C. J., Yu, L. M., Angus, B. & Pollard, A. J., 2 Dec 2017, In: The Lancet. 390, 10111, p. 2472-2480 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  63. Published

    Vagal Blocking for Obesity Control: a Possible Mechanism-Of-Action

    Johannessen, H., Revesz, D., Kodama, Y., Cassie, N., Skibicka, K. P., Barrett, P., Dickson, S., Holst, Jens Juul, Rehfeld, Jens Frederik, van der Plasse, G., Adan, R., Kulseng, B., Ben-Menachem, E., Zhao, C. & Chen, D., Jan 2017, In: Obesity Surgery. 27, 1, p. 177-185 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  64. Published

    Role of gut microbiota in atherosclerosis

    Jonsson, A. L. & Bäckhed, G. F., Feb 2017, In: Nature Reviews. Cardiology. 14, 2, p. 79-87 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  65. Published

    Genetic Variations in the Human G Protein-coupled Receptor Class C, Group 6, Member A (GPRC6A) Control Cell Surface Expression and Function

    Jorgensen, S., Have, C. T., Underwood, C. R., Johansen, L. D., Wellendorph, Petrine, Gjesing, A. P., Jorgensen, C. V., Quan, S., Rui, G., Inoue, A., Linneberg, Allan René, Grarup, N., Jun, W., Pedersen, Oluf Borbye, Hansen, Torben & Bräuner, Hans, 2017, In: The Journal of Biological Chemistry. 292, 4, p. 1524-1534 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  66. Published

    Cardiorespiratory Fitness and Adiposity as Determinants of Metabolic Health-Pooled Analysis of Two Twin Cohorts

    Jukarainen, S., Holst, R., Dalgård, C., Piirilä, P., Lundbom, J., Hakkarainen, A., Lundbom, N., Rissanen, A., Kaprio, J., Kyvik, K. O., Sørensen, Thorkild I.A. & Pietiläinen, K. H., 1 May 2017, In: The Journal of clinical endocrinology and metabolism. 102, 5, p. 1520-1528 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  67. Published

    RAIN: RNA-protein Association and Interaction Networks

    Junge, A., Refsgaard, J. C., Garde, C., Pan, X., Santos, A., Alkan, F., Anthon, Christian, von Mering, C., Workman, C. T., Jensen, Lars Juhl & Gorodkin, Jan, 2017, In: Database: The Journal of Biological Databases and Curation. 2017, 9 p., baw167.

    Research output: Contribution to journalJournal articleResearchpeer-review

  68. Published

    Legacy Effects on the Recovery of Soil Bacterial Communities from Extreme Temperature Perturbation

    Jurburg, S. D., Nunes, I. M., Brejnrod, A. D., Jacquiod, S. J. A., Priemé, Anders, Sørensen, Søren Johannes, Van Elsas, J. D. & Salles, J. F., 2017, In: Frontiers in Microbiology. 8, 13 p., 1832.

    Research output: Contribution to journalJournal articleResearchpeer-review

  69. Published

    Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits

    Justice, A. E., Winkler, T. W., Feitosa, M. F., Graff, M., Fisher, V. A., Young, K. L., Barata, L., Deng, X., Czajkowski, J., Hadley, D., Ngwa, J. S., Ahluwalia, T. S., Chu, A. Y., Heard-Costa, N. L., Lim, E., Perez, J., Eicher, J. D., Kutalik, Z., Xue, L., Mahajan, A. & 297 others, Renström, F., Wu, J. C., Qi, Q., Ahmad, S., Alfred, T., Amin, N., Bielak, L. F., Bonnefond, A., Bragg-Gresham, J. L., Cadby, G., Chittani, M., Coggeshall, S., Corre, T., Direk, N., Eriksson, J., Fischer, K., Gorski, M., Neergaard Harder, M., Horikoshi, M., Huang, T., Huffman, J. E., Jackson, A. U., Justesen, Johanne Marie, Kanoni, S., Kinnunen, L., Kleber, M. E., Komulainen, P., Kumari, M., Lim, U., Luan, J., Lyytikäinen, L., Mangino, M., Manichaikul, A., Marten, J., Middelberg, R. P. S., Müller-Nurasyid, M., Navarro, P., Pérusse, L., Pervjakova, N., Sarti, C., Smith, A. V., Smith, J. A., Stančáková, A., Strawbridge, R. J., Stringham, H. M., Sung, Y. J., Tanaka, T., Teumer, A., Trompet, S., van der Laan, S. W., van der Most, P. J., van Vliet-Ostaptchouk, J. V., Vedantam, S. L., Verweij, N., Vink, J. M., Vitart, V., Wu, Y., Yengo, L., Zhang, W., Hua Zhao, J., Zimmermann, M. E., Zubair, N., Abecasis, G. R., Adair, L. S., Afaq, S., Afzal, U., Bakker, S. J. L., Bartz, T. M., Beilby, J., Bergman, R. N., Bergmann, S., Biffar, R., Blangero, J., Boerwinkle, E., Bonnycastle, L. L., Bottinger, E. P., Braga, D., Buckley, B. M., Buyske, S., Campbell, H., Chambers, J. C., Collins, F. S., Curran, J. E., de Borst, G. J., De Craen, A. J. M., de Geus, E. J. C., Dedoussis, G., Delgado, G. E., den Ruijter, H. M., Eiriksdottir, G., Eriksson, A. L., Esko, T., Faul, J. D., Ford, I., Forrester, T., Gertow, K., Gigante, B., Glorioso, N., Gong, J., Grallert, H., Grammer, T. B., Grarup, N., Haitjema, S., Hallmans, G., Hamsten, A., Hansen, Torben, Harris, T. B., Hartman, C. A., Hassinen, M., Hastie, N. D., Heath, A. C., Hernandez, D., Hindorff, L. A., Hocking, L. J., Hollensted, M., Holmen, O. L., Homuth, G., Jan Hottenga, J., Huang, J., Hung, J., Hutri-Kähönen, N., Ingelsson, E., James, A. L., Jansson, J., Jarvelin, M. R., Jhun, M. A., Jørgensen, M. E., Juonala, M., Kähönen, M., Karlsson, M., Koistinen, H. A., Kolcic, I., Kolovou, G., Kooperberg, C., Krämer, B. K., Kuusisto, J., Kvaløy, K., Lakka, T. A., Langenberg, C., Launer, L. J., Leander, K., Lee, N. R., Lind, L., Lindgren, C. M., Linneberg, Allan René, Lobbens, S., Loh, M., Lorentzon, M., Luben, R., Lubke, G., Ludolph-Donislawski, A., Lupoli, S., Madden, P. A. F., Männikkö, R., Marques-Vidal, P., Martin, N. G., Mckenzie, C. A., McKnight, B., Mellström, D., Menni, C., Montgomery, G. W., Musk, A. B., Narisu, N., Nauck, M., Nolte, I. M., Oldehinkel, A. J., Olden, M., Ong, K. K., Padmanabhan, S., Peyser, P. A., Pisinger, C., Porteous, D. J., Raitakari, O. T., Rankinen, T., Rao, D. C., Rasmussen-Torvik, L. J., Rawal, R., Rice, T. K., Ridker, P. M., Rose, L. M., Bien, S. A., Rudan, I., Sanna, S., Sarzynski, M. A., Sattar, N., Savonen, K., Schlessinger, D., Scholtens, S., Schurmann, C., Scott, R. A., Sennblad, B., Siemelink, M. A., Silbernagel, G., Slagboom, P. E., Snieder, H., Staessen, J. A., Stott, D. J., Swertz, M. A., Swift, A. J., Taylor, K. D., Tayo, B. O., Thorand, B., Thuillier, D., Tuomilehto, J., Uitterlinden, A. G., Vandenput, L., Vohl, M., Völzke, H., Vonk, J. M., Waeber, G., Waldenberger, M., Westendorp, R. G. J., Wild, S., Willemsen, G., Wolffenbuttel, B. H. R., Wong, A., Wright, A. F., Zhao, W., Zillikens, M. C., Baldassarre, D., Balkau, B., Bandinelli, S., Böger, C. A., Boomsma, D. I., Bouchard, C., Bruinenberg, M., Chasman, D. I., Chen, Y., Chines, P. S., Cooper, R. S., Cucca, F., Cusi, D., Faire, U. D., Ferrucci, L., Franks, P. W., Froguel, P., Gordon-Larsen, P., Grabe, H. J., Gudnason, V., Haiman, C. A., Hayward, C., Hveem, K., Johnson, A. D., Wouter Jukema, J., Kardia, S. L. R., Kivimaki, M., Kooner, J. S., Kuh, D., Laakso, M., Lehtimäki, T., Marchand, L. L., März, W., McCarthy, M. I., Metspalu, A., Morris, A. P., Ohlsson, C., Palmer, L. J., Pasterkamp, G., Pedersen, Oluf Borbye, Peters, A., Peters, U., Polasek, O., Psaty, B. M., Qi, L., Rauramaa, R., Smith, B. H., Sørensen, Thorkild I.A., Strauch, K., Tiemeier, H., Tremoli, E., van der Harst, P., drb459, drb459, Vollenweider, P., Wareham, N. J., Weir, D. R., Whitfield, J. B., Wilson, J. F., Tyrrell, J., Frayling, T. M., Barroso, I., Boehnke, M., Deloukas, P., Fox, C. S., Hirschhorn, J. N., Hunter, D. J., Spector, T. D., Strachan, D. P., van Duijn, C. M., Heid, I. M., Mohlke, K. L., Marchini, J. L., Loos, R. J. F., Kilpeläinen, Tuomas O., Liu, C., Borecki, I. B., North, K. E. & Cupples, L. A., 26 Apr 2017, In: Nature Communications. 8, 19 p., 14977.

    Research output: Contribution to journalJournal articleResearchpeer-review

  70. Published

    Chronic intrahypothalamic rather than subcutaneous liraglutide treatment reduces body weight gain and stimulates the melanocortin receptor system

    Kaineder, K., Birngruber, T., Rauter, G., Obermüller, B., Eichler, J., Münzker, J., Al-Zoughbi, W., Mautner, S. I., Torekov, Signe Sørensen, Hartmann, Bolette, Kotzbeck, P. & Pieber, T. R., 16 May 2017, In: International Journal of Obesity. 41, p. 1263-1270 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  71. Published

    Addition of rye bran and pea fiber to pork meatballs enhances subjective satiety in healthy men, but does not change glycemic or hormonal responses: A randomized crossover meal test study

    Kehlet, U., Kofod, J., Holst, Jens Juul, Ritz, C., Aaslyng, M. D. & Raben, Anne, 2017, In: Journal of Nutrition. 147, 9, p. 1700-1708 9 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  72. Published

    Cardiovascular and All-Cause Mortality Risk Associated With Urinary Excretion of 8-oxoGuo, a Biomarker for RNA Oxidation, in Patients With Type 2 Diabetes: A Prospective Cohort Study

    Kjær, L. K., Cejvanovic, V., Henriksen, T., Petersen, K. M., Hansen, Torben, Pedersen, Oluf Borbye, Christensen, C. K., Torp-Pedersen, C., Gerds, Thomas Alexander, Brandslund, I., Mandrup-Poulsen, Thomas & Poulsen, Henrik Enghusen, Dec 2017, In: Diabetes Care. 40, 12, p. 1771-1778 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  73. Published

    Enhanced muscle insulin sensitivity after contraction/exercise is mediated by AMPK

    Kjøbsted, Rasmus, Munk-Hansen, N., Birk, Jesper Bratz, Foretz, M., Viollet, B., Björnholm, M., Zierath, Juleen R, Treebak, Jonas Thue & Wojtaszewski, Jørgen F P, 2017, In: Diabetes. 66, 3, p. 598-612 15 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  74. Published

    Exenatide: pharmacokinetics, clinical use, and future directions

    Knop, Filip Krag, Bronden, A. & Vilsbøll, Tina, 2017, In: Expert Opinion on Pharmacotherapy. 18, 6, p. 555-571 17 p.

    Research output: Contribution to journalReviewResearchpeer-review

  75. Published

    Pancreatic Polypeptide in Parkinson's Disease: A Potential Marker of Parasympathetic Denervation

    Knudsen, K., Hartmann, Bolette, Fedorova, T. D., Østergaard, K., Krogh, K., Møller, N., Holst, Jens Juul & Borghammer, P., 2017, In: Journal of Parkinson's Disease. 7, 4, p. 645-652 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  76. Published

    Improvement of Insulin Sensitivity after Lean Donor Feces in Metabolic Syndrome Is Driven by Baseline Intestinal Microbiota Composition

    Kootte, R. S., Levin, E., Salojärvi, J., Smits, L. P., Hartstra, A. V., Udayappan, S. D., Hermes, G., Bouter, K. E., Koopen, A. M., Holst, J. J., Knop, F. K., Blaak, E. E., Zhao, J., Smidt, H., Harms, A. C., Hankemeijer, T., Bergman, J. J. G. H. M., Romijn, H. A., Schaap, F. G., Olde Damink, S. W. M. & 8 others, Ackermans, M. T., Dallinga-Thie, G. M., Zoetendal, E., de Vos, W. M., Serlie, M. J., Stroes, E. S. G., Groen, A. K. & Nieuwdorp, M., Oct 2017, In: Cell Metabolism. 26, 4, p. 611-619.e6 16 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  77. Published

    New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475 000 Individuals

    Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A. E., Fava, C., Ferreira, T., Herzig, K. H., Giri, A. & 31 others, Giulianini, F., Grove, M. L., Guo, X., Harris, S. E., Have, C. T., Havulinna, A. S., Zhang, H., Jørgensen, M. E., Käräjämäki, A. M., Kooperberg, C., Linneberg, Allan René, Little, L., Liu, Y., Bonnycastle, L. L., Lu, Y., Mägi, R., Mahajan, A., Malerba, G., Marioni, R. E., Mei, H., Menni, C., Morrison, A. C., Padmanabhan, S., Palmas, W., Poveda, A., Rauramaa, R., Rayner, N. W., Riaz, M., Hansen, Torben, Pedersen, Oluf Borbye & behalf of the CHARGE EXOME BP, CHD Exome+, Exome BP, GoT2D:T2DGenes Consortia, The UK Biobank Cardio-Metabolic Traits Consortium Blood Pressure Working Group, B. O. T. C. E. B. C. E. E. B. G. C. T. U. B. C. T. C. B. P. W. G., Oct 2017, In: Circulation: Cardiovascular Genetics. 10, 5, 9 p., e001778.

    Research output: Contribution to journalJournal articleResearchpeer-review

  78. Published

    New Blood Pressure-Associated Loci Identified in Meta-Analyses of 475000 Individuals

    Kraja, A. T., Cook, J. P., Warren, H. R., Surendran, P., Liu, C., Evangelou, E., Manning, A. K., Grarup, N., Drenos, F., Sim, X., Smith, A. V., Amin, N., Blakemore, A. I. F., Bork-Jensen, J., Brandslund, I., Farmaki, A-E., Fava, C., Ferreira, T., Herzig, K-H., Giri, A. & 122 others, Giulianini, F., Grove, M. L., Guo, X., Harris, S. E., Have, C. T., Havulinna, A. S., Zhang, H., Jørgensen, M. E., Karajamaki, A., Kooperberg, C., Linneberg, Allan René, Little, L., Liu, Y., Bonnycastle, L. L., Lu, Y., Magi, R., Mahajan, A., Malerba, G., Marioni, R. E., Mei, H., Menni, C., Morrison, A. C., Padmanabhan, S., Palmas, W., Poveda, A., Rauramaa, R., Rayner, N. W., Riaz, M., Rice, K., Richard, M. A., Smith, J. A., Southam, L., Stancakova, A., Stirrups, K. E., Tragante, V., Tuomi, T., Tzoulald, I., V Varga, Tibor, Weiss, S., Yiorkas, A. M., Young, R., Zhang, W., Barnes, M. R., Cabrera, C. P., Gao, H., Boehnke, M., Boerwinkle, E., Chambers, J. C., Connell, J. M., Christensen, C. K., de Boer, R. A., Deary, I. J., Dedoussis, G., Deloukas, P., Dominiczak, A. F., Dorr, M., Joehanes, R., Edwards, T. L., Esko, T., Fornage, M., Franceschini, N., Franks, P. W., Gambaro, G., Groop, L., Hallmans, G., Hansen, Torben, Hayward, C., Heikki, O., Ingelsson, E., Tuomilehto, J., Jarvelin, M., Kardia, S. L. R., Karpe, F., Kooner, J. S., Lakka, T. A., Langenberg, C., Lind, L., Loos, Ruth, Laakso, M., McCarthy, M. I., Melander, O., Mohlke, K. L., Moris, A. P., Palmer, C. N. A., Pedersen, Oluf Borbye, Polasek, O., Poulter, N. R., Province, M. A., Psaty, B. M., Ridker, P. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sever, P. J., Skaaby, T., Stafford, J. M., Starr, J. M., van der Harst, P., van der Meer, P., van Duijn, C. M., Vergnaud, A., Gudnason, V., Wareham, N. J., Wilson, J. G., Willer, C. J., Witte, D. R., Zeggini, E., Saleheen, D., Butterworth, A. S., Danesh, J., Asselbergs, F. W., Wain, L. V., Ehret, G. B., Chasman, D. I., Caulfield, M. J., Elliott, P., Lindgren, C. M., Levy, D., Newton-Cheh, C., Munroe, P. B. & Howson, J. M. M., Oct 2017, In: Circulation: Cardiovascular Genetics. 10, 5

    Research output: Contribution to journalJournal articleResearchpeer-review

  79. Published

    Shared genetic variants suggest common pathways in allergy and autoimmune diseases

    Kreiner, E., Waage, J., Standl, M., Brix, S., Pers, T. H., Couto Alves, A., Warrington, N. M., Tiesler, C. M., Fuertes, E., Franke, L., Hirschhorn, J. N., James, A., Simpson, A., Tung, J. Y., Koppelman, G. H., Postma, D. S., Pennell, C. E., Jarvelin, M-R., Custovic, A., Timpson, N. & 6 others, Ferreira, M. A., Strachan, D. P., Henderson, J., Hinds, D., Bisgaard, H. & Bønnelykke, Klaus, 2017, In: The Journal of allergy and clinical immunology. 140, 3, p. 771-781

    Research output: Contribution to journalJournal articleResearchpeer-review

  80. Published

    Macrophage Area Content and Phenotype in Hepatic and Adipose Tissue in Patients with Obesity Undergoing Roux-en-Y Gastric Bypass

    Kristensen, M. D., Lund, M. T., Hansen, M., Poulsen, Steen Seier, Ploug, Thorkil, Dela, Flemming, Helge, Jørn Wulff & Prats Gavalda, Clara, Nov 2017, In: Obesity. 25, 11, p. 1921-1931 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  81. Published

    On the relationship between glucose absorption and glucose‐stimulated secretion of GLP‐1, neurotensin, and PYY from different intestinal segments in the rat

    Kuhre, Rune Ehrenreich, Christiansen, Charlotte Bayer, Saltiel, M. Y., Albrechtsen, Nicolai Jacob Wewer & Holst, Jens Juul, 3 Dec 2017, In: Physiological Reports. 5, 23, 13 p., e13507.

    Research output: Contribution to journalJournal articleResearchpeer-review

  82. Published
  83. Published

    Effects of exogenous glucagon-like peptide-2 and distal bowel resection on intestinal and systemic adaptive responses in rats

    Lai, S. W., de Heuvel, E., Wallace, L. E., Hartmann, Bolette, Holst, Jens Juul, Brindle, M. E., Chelikani, P. K. & Sigalet, D. L., 2017, In: PloS one. 12, 7, 20 p., e0181453.

    Research output: Contribution to journalJournal articleResearchpeer-review

  84. Published

    Transcriptomic and epigenetic responses to short-term nutrient-exercise stress in humans

    Laker, R. C., Garde, C., Camera, D. M., Smiles, W. J., Zierath, Juleen R, Hawley, J. A. & Barrès, Romain, 9 Nov 2017, In: Scientific Reports. 7, 1, 12 p., 15134.

    Research output: Contribution to journalJournal articleResearchpeer-review

  85. Published

    Extent of undertreatment and overtreatment with cholesterol-lowering therapy according to European guidelines in 92,348 Danes without ischemic cardiovascular disease and diabetes in 2004-2014

    Langsted, A., Freiberg, J. J. & Nordestgaard, Børge, Feb 2017, In: Atherosclerosis. 257, p. 9-15 7 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  86. Published

    Effect of Liraglutide Treatment on Prediabetes and Overweight or Obesity in Clozapine- or Olanzapine-Treated Patients With Schizophrenia Spectrum Disorder: A Randomized Clinical Trial

    Larsen, J. R., Vedtofte, L., Jakobsen, M. S. L., Jespersen, H. R., Jakobsen, M. I., Svensson, C. K., Koyuncu, K., Schjerning, O., Oturai, P. S., Kjær, Andreas, Nielsen, J., Holst, Jens Juul, Ekstrøm, Claus Thorn, Correll, C. U., Vilsbøll, Tina & Fink-Jensen, Anders, 1 Jul 2017, In: J A M A Psychiatry. 74, 7, p. 719-728 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  87. Published

    Glucagon-Like Peptide 1: A Predictor of Type 2 Diabetes?

    Larsen, M. P. & Torekov, Signe Sørensen, 2017, In: Journal of Diabetes Research. 2017, 13 p., 7583506.

    Research output: Contribution to journalReviewResearchpeer-review

  88. Published

    Sociodemographic characteristics of nonparticipants in the Danish colorectal cancer screening program: A nationwide cross-sectional study

    Larsen, Mette, Mikkelsen, E. M., Rasmussen, M., Friis-Hansen, Lennart Jan, Ovesen, A. U., Rahr, H. B. & Andersen, B., 27 Jun 2017, In: Clinical Epidemiology. 9, p. 345-354 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  89. Published

    Reference intervals for C-peptide and insulin derived from a general adult Danish population

    Larsen, P. B., Linneberg, Allan René, Hansen, Torben & Friis-Hansen, L. J., May 2017, In: Clinical Biochemistry. 50, 7-8, p. 408-413

    Research output: Contribution to journalJournal articleResearchpeer-review

  90. Published

    Reference values for fasting serum resistin in healthy children and adolescents

    Lausten-Thomsen, U., Christiansen, M., Hedley, P. L., Nielsen, T. R. H., Fonvig, Cilius Esmann, Pedersen, Oluf Borbye, Hansen, Torben & Holm, Jens-Christian, Jun 2017, In: Clinica Chimica Acta. 469, p. 161-165 5 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  91. Published

    SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function

    Li, M., Li, Y., Weeks, O., Mijatovic, V., Teumer, A., Huffman, J. E., Tromp, G., Fuchsberger, C., Gorski, M., Lyytikäinen, L-P., Nutile, T., Sedaghat, S., Sorice, R., Tin, A., Yang, Q., Ahluwalia, T. S., Arking, D. E., Bihlmeyer, N. A., Böger, C. A., Carroll, R. J. & 31 others, Chasman, D. I., Cornelis, M. C., Dehghan, A., Faul, J. D., Feitosa, M. F., Gambaro, G., Gasparini, P., Giulianini, F., Heid, I., Huang, J., Imboden, M., Jackson, A. U., Jeff, J., Jhun, M. A., Katz, R., Kifley, A., Kilpeläinen, Tuomas O., Kumar, A., Laakso, M., Li-Gao, R., Lohman, K., Lu, Y., Mägi, R., Bork-Jensen, J., Glümer, C., Grarup, N., Husemoen, L. L. N., Jørgensen, T., Linneberg, Allan René, Pedersen, Oluf Borbye & CHARGE Glycemic-T2D Working Group, C. G. W. G., 2017, In: Journal of the American Society of Nephrology. 28, 3, p. 981-994 14 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  92. Published

    Higher intake of fish and fat is associated with lower plasma s-adenosylhomocysteine: a cross-sectional study

    Lind, M. V., Lauritzen, Lotte, Pedersen, Oluf Borbye, drb459, drb459, Stark, K. D., Hansen, Torben, Ross, A. B. & Kristensen, M. B., 2017, In: Nutrition Research. 46, p. 78-87 10 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  93. Published

    Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants

    Linneberg, Allan René, Sørensen, Thorkild I.A., Ängquist, Lars & NCD Risk Factor Collaboration (NCD-RisC), N. R. F. C. (., 2017, In: The Lancet. 389, 10064, p. 37-55 19 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  94. Published

    Exome-wide association study of plasma lipids in >300,000 individuals

    Liu, D. J., Peloso, G. M., Yu, H., Butterworth, A. S., Wang, X., Mahajan, A., Saleheen, D., Emdin, C., Alam, D., Alves, A. C., Amouyel, P., Angelantonio, E. DI., Arveiler, D., Assimes, T. L., Auer, P. L., Baber, U., Ballantyne, C. M., Bang, L. E., Benn, M., Bis, J. C. & 208 others, Boehnke, M., Boerwinkle, E., Bork-Jensen, J., Bottinger, E. P., Brandslund, I., Brown, M., Busonero, F., Caulfield, M. J., Chambers, J. C., Chasman, D. I., Chen, Y. E., Chen, Y. D. I., Chowdhury, R., Christensen, C., Chu, A. Y., Connell, J. M., Cucca, F., Cupples, L. A., Damrauer, S. M., Davies, G., Deary, I. J., Dedoussis, G., Denny, J. C., Dominiczak, A., Dubé, M. P., Ebeling, T., Eiriksdottir, G., Esko, T., Farmaki, A. E., Feitosa, M. F., Ferrario, M., Ferrieres, J., Ford, I., Fornage, M., Franks, P. W., Frayling, T. M., Frikke-Schmidt, Ruth, Fritsche, L. G., Frossard, P., Fuster, V., Ganesh, S. K., Gao, W., Garcia, M. E., Gieger, C., Giulianini, F., Goodarzi, M. O., Grallert, H., Grarup, N., Groop, L., Grove, M. L., Gudnason, V., Hansen, Torben, Harris, T. B., Hayward, C., Hirschhorn, J. N., Holmen, O. L., Huffman, J., Huo, Y., Hveem, K., Jabeen, S., Jackson, A. U., Jakobsdottir, J., Jarvelin, M. R., Jensen, G. B., Jørgensen, M. E., Jukema, J. W., Justesen, Johanne Marie, Kamstrup, P. R., Kanoni, S., Karpe, F., Kee, F., Khera, A. V., Klarin, D., Koistinen, H. A., Kooner, J. S., Kooperberg, C., Kuulasmaa, K., Kuusisto, J., Laakso, M., Lakka, T., Langenberg, C., Langsted, A., Launer, L. J., Lauritzen, T., MLiewald, D. C., Lin, L. A., Linneberg, Allan René, Loos, R. J. F., Lu, Y., Lu, X., Mägi, R., Malarstig, A., Manichaikul, A., Manning, A. K., Mäntyselkä, P., Marouli, E., Masca, N. G. D., Maschio, A., Meigs, J. B., Melander, O., Metspalu, A., Morris, A. P., Morrison, A. C., Mulas, A., Müller-Nurasyid, M., Munroe, P. B., Neville, M. J., Nielsen, S. F., Nielsen, J. B., Nordestgaard, Børge, Ordovas, J. M., Mehran, R., O'Donnell, C. J., Orho-Melander, M., Molony, C. M., Muntendam, P., Padmanabhan, S., Palmer, C. N. A., Pasko, D., Patel, A. P., Pedersen, Oluf Borbye, Perola, M., Peters, A., Pisinger, C., Pistis, G., Polasek, O., Poulter, N., Psaty, B. M., Rader, D. J., Rasheed, A., Rauramaa, R., Reilly, D. F., Reiner, A. P., Renström, F., Rich, S. S., Ridker, P. M., Rioux, J. D., Robertson, N. R., Roden, D. M., Rotter, J. I., Rudan, I., Salomaa, V., Samani, N. J., Sanna, S., Sattar, N., Schmidt, E. M., Scott, R. A., Sever, P., Sevilla, R. S., Shaffer, C. M., Sim, X., Sivapalaratnam, S., Small, K. S., Smith, A. V., Smith, B. H., Somayajula, S., Southam, L., Spector, T. D., Speliotes, E. K., Starr, J. M., Stirrups, K. E., Stitziel, N., Strauch, K., Stringham, H. M., Surendran, P., Tada, H., Tall, A. R., Tang, H., Tardif, J. C., Taylor, K. D., Trompet, S., Tsao, P. S., Tuomilehto, J., Tybjærg-Hansen, Anne, Zuydam, N. R. V., Varbo, A., Varga, T. V., Virtamo, J., Waldenberger, M., Wang, N., Wareham, N. J., Warren, H. R., Weeke, P. E., Weinstock, J., Wessel, J., Wilson, J. G., Wilson, P. W. F., Xu, M., Yaghootkar, H., Young, R., Zeggini, E., Zhang, H., Zheng, N. S., Zhang, W., Zhang, Y., Zhou, W., Zhou, Y., Zoledziewska, M., Howson, J. M. M., Danesh, J., McCarthy, M. I., Cowan, C. A., Abecasis, G., Deloukas, P., Musunuru, K., Willer, C. J., Kathiresan, S. & V Varga, Tibor, 1 Dec 2017, In: Nature Genetics. 49, 12, p. 1758-1766 9 p.

    Research output: Contribution to journalLetterResearchpeer-review

  95. Published

    Glucagon elimination is increased in patients with type 2 diabetes

    Lund, A. B., Grøndahl, M. F., Bagger, J. I., Holst, Jens Juul, Christensen, M., Vilsbøll, Tina & Knop, Filip Krag, 2017, In: Diabetologia. 60, p. S240-S240

    Research output: Contribution to journalConference abstract in journalResearchpeer-review

  96. Published

    Kredsløbet ændres ved overvægt i barndommen

    Lund, Morten Asp Vonsild, Holm, Jens-Christian, Jespersen, Thomas & von Holstein-Rathlou, Niels-Henrik, 2017, In: Ugeskrift for Laeger. 2018, 6, p. 2-6 5 p., V03170265.

    Research output: Contribution to journalJournal articleResearchpeer-review

  97. Published

    Bidirectional manipulation of gene expression in adipocytes using CRISPRa and siRNA

    Lundh, M., Plucinska, Kaja, Isidor, Marie Sophie, Petersen, P. S. S. & Emanuelli, Brice, Oct 2017, In: Molecular Metabolism. 6, 10, p. 1313-1320 8 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  98. Published

    The immunoproteasome is induced by cytokines and regulates apoptosis in human islets

    Lundh, M., Bugliani, M., Dahlby, T., Chou, D. H., Wagner , B., Ghiasi, S. M., De Tata, V., Chen, Z., Lund, Marianne N., Davies, Michael J., Marchetti, P. & Mandrup-Poulsen, Thomas, 2017, In: Journal of Endocrinology. 233, 3, p. 369-379 11 p.

    Research output: Contribution to journalJournal articleResearchpeer-review

  99. Published

    The Microbiota and Epigenetic Regulation of T Helper 17/Regulatory T Cells: In Search of a Balanced Immune System

    Luo, A., Leach, S. T., Barrès, Romain, Hesson, L. B., Grimm, M. C. & Simar, D., 2017, In: Frontiers in Immunology. 8, 14 p., 417.

    Research output: Contribution to journalReviewResearchpeer-review

  100. Published

    The cold-induced lipokine 12,13-diHOME promotes fatty acid transport into brown adipose tissue

    Lynes, M. D., Leiria, L. O., Lundh, M., Bartelt, A., Shamsi, F., Huang, T. L., Takahashi, H., Hirshman, M. F., Schlein, C., Lee, A., Baer, L. A., May, F. J., Narain, N. R., Chen, E. Y., Kiebish, M. A., Cypess, A. M., Blüher, M., Goodyear, L. J., Hotamisligil, G. S., Stanford, K. I. & 1 others, Tseng, Y., May 2017, In: Nature Medicine. 23, 5, p. 631-637 7 p.

    Research output: Contribution to journalLetterResearchpeer-review

  101. Published

    Structure-based discovery of novel US28 small molecule ligands with different modes of action

    Lückmann, Michael, Amarandi, R., Papargyri, N., Jakobsen, M. H., Ulven, Elisabeth Rexen, Jensen, Lars Juhl, Pui, A., Schwartz, Thue W., Rosenkilde, Mette & Frimurer, Thomas Michael, 2017, In: Chemical Biology & Drug Design. 89, 3, p. 289–296

    Research output: Contribution to journalJournal articleResearchpeer-review